mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPL11
Gene summary
Basic gene Info.Gene symbolMRPL11
Gene namemitochondrial ribosomal protein L11
SynonymsL11MT|MRP-L11
CytomapUCSC genome browser: 11q13.3
Type of geneprotein-coding
RefGenesNM_016050.4,
NM_170738.3,NM_170739.3,NR_120588.1,NR_120589.1,
Description39S ribosomal protein L11, mitochondrial
Modification date20141207
dbXrefs MIM : 611826
HGNC : HGNC
Ensembl : ENSG00000174547
HPRD : 14739
Vega : OTTHUMG00000167097
ProteinUniProt: Q9Y3B7
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPL11
BioGPS: 65003
PathwayNCI Pathway Interaction Database: MRPL11
KEGG: MRPL11
REACTOME: MRPL11
Pathway Commons: MRPL11
ContextiHOP: MRPL11
ligand binding site mutation search in PubMed: MRPL11
UCL Cancer Institute: MRPL11
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MRPL11

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
K99E98QBRCA1
K92L91POV1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MRPL11
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K92L91P-1.4147285
K99E98Q-0.69810831
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPL11 from PDB

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Differential gene expression and gene-gene network for MRPL11
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPL11 and the right PPI network was created from samples without mutations in the LBS of MRPL11. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MRPL11
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MRPL11
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPL11 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7yJK92 K99


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Conservation information for LBS of MRPL11
Multiple alignments for Q9Y3B7 in multiple species
LBSAA sequence# speciesSpecies
A101GIEKGARQTG-2Homo sapiens, Rattus norvegicus
A101GIGRGKASK--1Caenorhabditis elegans
A101GIQRGTMTPG-1Drosophila melanogaster
A101GIEKGARHTG-1Mus musculus
A101GIEKGARNTG-1Bos taurus
A101KMDKGHGQPNV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A101DLEKGSSSPL-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A129KAQDEAFALQD1Homo sapiens
A129KSRDK--ALQH1Caenorhabditis elegans
A129KIQDPPNVL--1Drosophila melanogaster
A129KAKDEAFAMQD1Rattus norvegicus
A129KAKDDAFAMQD1Mus musculus
A129KAQDDAFALQD1Bos taurus
A129KKSDERHSL--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A129KSTDP--SLQG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A131QDEAFALQDVP1Homo sapiens
A131RDK--ALQHVP1Caenorhabditis elegans
A131QDPPNVL--LT1Drosophila melanogaster
A131KDEAFAMQDVP1Rattus norvegicus
A131KDDAFAMQDVP1Mus musculus
A131QDDAFALQDVP1Bos taurus
A131SDERHSL--LE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A131TDP--SLQGIE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D134AFALQDVPLSS2Homo sapiens, Bos taurus
D134AFAMQDVPLSS2Rattus norvegicus, Mus musculus
D134--ALQHVPLEQ1Caenorhabditis elegans
D134PNVL--LTMQQ1Drosophila melanogaster
D134RHSL--LEMEG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D134--SLQGIELLS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F130AQDEAFALQDV1Homo sapiens
F130SRDK--ALQHV1Caenorhabditis elegans
F130IQDPPNVL--L1Drosophila melanogaster
F130AKDEAFAMQDV1Rattus norvegicus
F130AKDDAFAMQDV1Mus musculus
F130AQDDAFALQDV1Bos taurus
F130KSDERHSL--L1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F130STDP--SLQGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G100AGIEKGARQTG2Homo sapiens, Rattus norvegicus
G100AGIGRGKASK-1Caenorhabditis elegans
G100AGIQRGTMTPG1Drosophila melanogaster
G100AGIEKGARHTG1Mus musculus
G100AGIEKGARNTG1Bos taurus
G100LKMDKGHGQPN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G100LDLEKGSSSPL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G146VRSIIGSARSL4Homo sapiens, Rattus norvegicus, Mus musculus, Bos taurus
G146CRMLIKTCRTL1Caenorhabditis elegans
G146CEMLISIARTC1Drosophila melanogaster
G146VKSIVGVAKSM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G146CKSVIGTAKSM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I23GVIRSIVRAGQ2Rattus norvegicus, Mus musculus
I23GVIRAIVRAGL1Homo sapiens
I23ALLRTNIKAQM1Caenorhabditis elegans
I23SKLKTNIPAGM1Drosophila melanogaster
I23GVIRTILRAGQ1Bos taurus
I23-IVKLIVGAGQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I23-IIKLIVPAGK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K106-----KEVAGL4Homo sapiens, Rattus norvegicus, Mus musculus, Bos taurus
K106-----DEIVGK1Caenorhabditis elegans
K106-----KEVAGM1Drosophila melanogaster
K106PAKGPTRALGE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K106-----HDIKGQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K92VSYFLKAAAGI3Homo sapiens, Mus musculus, Bos taurus
K92TTWLLKQAAGI1Caenorhabditis elegans
K92ATFFLKQAAGI1Drosophila melanogaster
K92ISYFLKAAAGI1Rattus norvegicus
K92TGYLLLKALKM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K92TSWLISKTLDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K99AAGIEKGARQT2Homo sapiens, Rattus norvegicus
K99AAGIGRGKASK1Caenorhabditis elegans
K99AAGIQRGTMTP1Drosophila melanogaster
K99AAGIEKGARHT1Mus musculus
K99AAGIEKGARNT1Bos taurus
K99ALKMDKGHGQP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K99TLDLEKGSSSP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L132DEAFALQDVPL1Homo sapiens
L132DK--ALQHVPL1Caenorhabditis elegans
L132DPPNVL--LTM1Drosophila melanogaster
L132DEAFAMQDVPL1Rattus norvegicus
L132DDAFAMQDVPL1Mus musculus
L132DDAFALQDVPL1Bos taurus
L132DERHSL--LEM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L132DP--SLQGIEL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L151GSARSLGIRV-4Homo sapiens, Rattus norvegicus, Mus musculus, Bos taurus
L151KTCRTLGIDVQ1Caenorhabditis elegans
L151SIARTCGIKV-1Drosophila melanogaster
L151GVAKSMGIKV-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L151GTAKSMGVKV-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q103EKGARQTG---2Homo sapiens, Rattus norvegicus
Q103GRGKASK----1Caenorhabditis elegans
Q103QRGTMTPG---1Drosophila melanogaster
Q103EKGARHTG---1Mus musculus
Q103EKGARNTG---1Bos taurus
Q103DKGHGQPNVGT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q103EKGSSSPL---1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q41GPILGQRGVSI3Rattus norvegicus, Mus musculus, Bos taurus
Q41GPVLGQRGVSI1Homo sapiens
Q41GPQLGQRGLNV1Caenorhabditis elegans
Q41GPMLGQRAINI1Drosophila melanogaster
Q41GPALGSKGIKA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q41GPALGARGLKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R102IEKGARQTG--2Homo sapiens, Rattus norvegicus
R102IGRGKASK---1Caenorhabditis elegans
R102IQRGTMTPG--1Drosophila melanogaster
R102IEKGARHTG--1Mus musculus
R102IEKGARNTG--1Bos taurus
R102MDKGHGQPNVG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R102LEKGSSSPL--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R142LSSVVRSIIGS3Homo sapiens, Mus musculus, Bos taurus
R142LEQICRMLIKT1Caenorhabditis elegans
R142MQQMCEMLISI1Drosophila melanogaster
R142LSSIVRSIIGS1Rattus norvegicus
R142MEGIVKSIVGV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R142LLSLCKSVIGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R21AGGVIRSIVRA2Rattus norvegicus, Mus musculus
R21VGGVIRAIVRA1Homo sapiens
R21HGALLRTNIKA1Caenorhabditis elegans
R21HTSKLKTNIPA1Drosophila melanogaster
R21AEGVIRTILRA1Bos taurus
R21---IVKLIVGA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R21---IIKLIVPA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R42PILGQRGVSIN3Rattus norvegicus, Mus musculus, Bos taurus
R42PVLGQRGVSIN1Homo sapiens
R42PQLGQRGLNVA1Caenorhabditis elegans
R42PMLGQRAINIA1Drosophila melanogaster
R42PALGSKGIKAI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R42PALGARGLKSI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S139DVPLSSVVRSI3Homo sapiens, Mus musculus, Bos taurus
S139HVPLEQICRML1Caenorhabditis elegans
S139-LTMQQMCEML1Drosophila melanogaster
S139DVPLSSIVRSI1Rattus norvegicus
S139-LEMEGIVKSI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S139GIELLSLCKSV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S143SSVVRSIIGSA3Homo sapiens, Mus musculus, Bos taurus
S143EQICRMLIKTC1Caenorhabditis elegans
S143QQMCEMLISIA1Drosophila melanogaster
S143SSIVRSIIGSA1Rattus norvegicus
S143EGIVKSIVGVA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S143LSLCKSVIGTA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S147RSIIGSARSLG4Homo sapiens, Rattus norvegicus, Mus musculus, Bos taurus
S147RMLIKTCRTLG1Caenorhabditis elegans
S147EMLISIARTCG1Drosophila melanogaster
S147KSIVGVAKSMG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S147KSVIGTAKSMG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S150IGSARSLGIRV4Homo sapiens, Rattus norvegicus, Mus musculus, Bos taurus
S150IKTCRTLGIDV1Caenorhabditis elegans
S150ISIARTCGIKV1Drosophila melanogaster
S150VGVAKSMGIKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S150IGTAKSMGVKV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S88GQPTVSYFLKA3Homo sapiens, Mus musculus, Bos taurus
S88CTPTTTWLLKQ1Caenorhabditis elegans
S88HHPPATFFLKQ1Drosophila melanogaster
S88GQPTISYFLKA1Rattus norvegicus
S88KSPPTGYLLLK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S88HTPPTSWLISK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T104KGARQTG----2Homo sapiens, Rattus norvegicus
T104RGKASK-----1Caenorhabditis elegans
T104RGTMTPG----1Drosophila melanogaster
T104KGARHTG----1Mus musculus
T104KGARNTG----1Bos taurus
T104KGHGQPNVGTM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T104KGSSSPL----1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T86KIGQPTVSYFL3Homo sapiens, Mus musculus, Bos taurus
T86EICTPTTTWLL1Caenorhabditis elegans
T86AIHHPPATFFL1Drosophila melanogaster
T86KIGQPTISYFL1Rattus norvegicus
T86EMKSPPTGYLL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T86TIHTPPTSWLI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V38PPLGPILGQRG3Rattus norvegicus, Mus musculus, Bos taurus
V38PPLGPVLGQRG1Homo sapiens
V38PPLGPQLGQRG1Caenorhabditis elegans
V38PPLGPMLGQRA1Drosophila melanogaster
V38PPVGPALGSKG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V38PPIGPALGARG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V87IGQPTVSYFLK3Homo sapiens, Mus musculus, Bos taurus
V87ICTPTTTWLLK1Caenorhabditis elegans
V87IHHPPATFFLK1Drosophila melanogaster
V87IGQPTISYFLK1Rattus norvegicus
V87MKSPPTGYLLL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V87IHTPPTSWLIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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