mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SLC2A3
Gene summary
Basic gene Info.Gene symbolSLC2A3
Gene namesolute carrier family 2 (facilitated glucose transporter), member 3
SynonymsGLUT3
CytomapUCSC genome browser: 12p13.3
Type of geneprotein-coding
RefGenesNM_006931.2,
DescriptionGLUT-3glucose transporter type 3, brainsolute carrier family 2, facilitated glucose transporter member 3
Modification date20141222
dbXrefs MIM : 138170
HGNC : HGNC
Ensembl : ENSG00000059804
HPRD : 00686
Vega : OTTHUMG00000133685
ProteinUniProt: P11169
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SLC2A3
BioGPS: 6515
PathwayNCI Pathway Interaction Database: SLC2A3
KEGG: SLC2A3
REACTOME: SLC2A3
Pathway Commons: SLC2A3
ContextiHOP: SLC2A3
ligand binding site mutation search in PubMed: SLC2A3
UCL Cancer Institute: SLC2A3
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for SLC2A3

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
P8P8SCOAD2
N315I317MBLCA1
P8P8TCOAD1
R228R228QGBM1
R228R228WHNSC1
W386W386GKIRC1
P203P203TKIRC1
V416G417VLUAD1
L278Q277KLUSC1
W386I388TLUSC1
F107G109VOV1
P203P203LSKCM1
T411,N413S412FSKCM1
F79F79ISKCM1
V163V163ASTAD1
N286A287VUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for SLC2A3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
V416G417V0.34744622
V163V163A-1.5524607
N315I317M-1.4122323
W386W386G-1.3982107
R228R228Q-1.2271171
W386I388T-1.2216138
R228R228W-0.89343734
P203P203T-0.71538064
N286A287V-0.61827431
P8P8S-0.59790882
P8P8T-0.59325695
F107G109V-0.55521093
T411S412F-0.48257211
N413S412F-0.48257211
L278Q277K-0.31422593
P203P203L-0.23072009
F79F79I-0.025037325
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SLC2A3 from PDB
PDB IDPDB titlePDB structure
5C65Structure of the human glucose transporter GLUT3 / SLC2A3

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Differential gene expression and gene-gene network for SLC2A3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SLC2A3 and the right PPI network was created from samples without mutations in the LBS of SLC2A3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for SLC2A3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0023794Lipidoses2Biomarker
umls:C0162820Dermatitis, Allergic Contact1Biomarker
umls:C0027658Neoplasms, Germ Cell and Embryonal1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for SLC2A3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SLC2A3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
37XOCTYL GLUCOSE NEOPENTYL GLYCOL5c65AF107
37XOCTYL GLUCOSE NEOPENTYL GLYCOL5c65AF79
Y01CHOLESTEROL HYDROGEN SUCCINATE5c65BF79 L278 T411
Y01CHOLESTEROL HYDROGEN SUCCINATE5c65AF79 L278 T411 V416
MALMALTOSE4zwcAN315 W386 N413
37XOCTYL GLUCOSE NEOPENTYL GLYCOL5c65AP203
37XOCTYL GLUCOSE NEOPENTYL GLYCOL5c65BP203
37XOCTYL GLUCOSE NEOPENTYL GLYCOL5c65AP8 R228
GLCALPHA-D-GLUCOSE4zw9AV163 N286 N315 W386
BGCBETA-D-GLUCOSE4zw9AV163 N286 N315 W386
MALMALTOSE4zwbAV163 N286 N315 W386 N413
MALMALTOSE4zwcBW386 N413


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Conservation information for LBS of SLC2A3
Multiple alignments for P11169 in multiple species
LBSAA sequence# speciesSpecies
A114GFAKIAESVEM3Mus musculus, Rattus norvegicus, Rattus norvegicus
A114GLCKVAKSVEM1Homo sapiens
A114FFS---NSYLQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A114FNS---NSYRG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A114FLCATAQSVQT1Arabidopsis thaliana
A114GFTKVSHSYEM1Drosophila melanogaster
A114ALSKIAKAVEM1Gallus gallus
A114GFCKIAQSVEM1Canis lupus familiaris
A114STSKLFNFYPM1Caenorhabditis elegans
A114GLAKSVGAYPM1Caenorhabditis elegans
A200AILQSAALPFC4Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus
A200AVANILAWLKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A200AVLNFFMWFIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A200SVLLAIGMAFS1Arabidopsis thaliana
A200AILQLILLPVC1Drosophila melanogaster
A200AVLQCVALLFC1Gallus gallus
A200AVLQSAALPFC1Canis lupus familiaris
A200TFLQLATIPFC1Caenorhabditis elegans
A200AVLQLALLMLC1Caenorhabditis elegans
A201ILQSAALPFCP4Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus
A201VANILAWLKVD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A201VLNFFMWFIVD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A201VLLAIGMAFSP1Arabidopsis thaliana
A201ILQLILLPVCP1Drosophila melanogaster
A201VLQCVALLFCP1Gallus gallus
A201VLQSAALPFCP1Canis lupus familiaris
A201FLQLATIPFCV1Caenorhabditis elegans
A201VLQLALLMLCP1Caenorhabditis elegans
A52EERLEDLPREG2Rattus norvegicus, Rattus norvegicus
A52TDKGNAPPSEV1Homo sapiens
A52VGQHGLKQCIA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A52LGKRGYKQCIP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A52KDLG---IAEN1Arabidopsis thaliana
A52KDRYGEDISEE1Drosophila melanogaster
A52SQRSGETISPE1Gallus gallus
A52EERLEDLPSEG1Mus musculus
A52EEKSENLPTEV1Canis lupus familiaris
A52FELFGEVLSQY1Caenorhabditis elegans
A52KDLFDKELSRE1Caenorhabditis elegans
A9AKVTPSLVFA-2Rattus norvegicus, Rattus norvegicus
A9QKVTPALIFA-1Homo sapiens
A9PLITGHLILG-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A9HKITKALCYA-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A9NGIQSVMSFSS1Arabidopsis thaliana
A9PGLTFFLTYS-1Drosophila melanogaster
A9KKITASLIYA-1Gallus gallus
A9TKVTPSLVFA-1Mus musculus
A9QKVTVSLIFA-1Canis lupus familiaris
A9ENWTPFLFFC-1Caenorhabditis elegans
A9GKLTKCLAFS-1Caenorhabditis elegans
C106AILGGCLMGFA2Rattus norvegicus, Rattus norvegicus
C106AVTGGCFMGLC1Homo sapiens
C106CMVSSLLLFFS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C106NIVGSLIIFNS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C106LAIGA---FLC1Arabidopsis thaliana
C106GIAGACLMGFT1Drosophila melanogaster
C106AFAGGALMALS1Gallus gallus
C106AIIAGCLMGFA1Mus musculus
C106AVAGGCLMGFC1Canis lupus familiaris
C106ALLAAVCLSTS1Caenorhabditis elegans
C106ALAAAALMGLA1Caenorhabditis elegans
E118IAESVEMLILG3Mus musculus, Rattus norvegicus, Rattus norvegicus
E118VAKSVEMLILG1Homo sapiens
E118--NSYLQLLFG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E118--NSYRGLIIG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E118TAQSVQTMIVG1Arabidopsis thaliana
E118VSHSYEMLFLG1Drosophila melanogaster
E118IAKAVEMLIIG1Gallus gallus
E118IAQSVEMLILG1Canis lupus familiaris
E118LFNFYPMIVFG1Caenorhabditis elegans
E118SVGAYPMVILG1Caenorhabditis elegans
E378YVAFFEIGPGP3Mus musculus, Rattus norvegicus, Rattus norvegicus
E378FVAFFEIGPGP2Homo sapiens, Canis lupus familiaris
E378YIAAFAIGLGP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E378YMGVFTMGLNP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E378YVLSFSLGAGP1Arabidopsis thaliana
E378FVVFFAVGPGS1Drosophila melanogaster
E378FVALFEIGPGP1Gallus gallus
E378FVVTFAFGPGP1Caenorhabditis elegans
E378FVISFATGPGA1Caenorhabditis elegans
F107ILGGCLMGFAK2Rattus norvegicus, Rattus norvegicus
F107VTGGCFMGLCK1Homo sapiens
F107MVSSLLLFFS-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F107IVGSLIIFNS-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F107AIGA---FLCA1Arabidopsis thaliana
F107IAGACLMGFTK1Drosophila melanogaster
F107FAGGALMALSK1Gallus gallus
F107IIAGCLMGFAK1Mus musculus
F107VAGGCLMGFCK1Canis lupus familiaris
F107LLAAVCLSTSK1Caenorhabditis elegans
F107LAAAALMGLAK1Caenorhabditis elegans
F12TPSLVFA----3Mus musculus, Rattus norvegicus, Rattus norvegicus
F12TPALIFA----1Homo sapiens
F12TGHLILG----1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F12TKALCYA----1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F12QSVMSFSSVKA1Arabidopsis thaliana
F12TFFLTYS----1Drosophila melanogaster
F12TASLIYA----1Gallus gallus
F12TVSLIFA----1Canis lupus familiaris
F12TPFLFFC----1Caenorhabditis elegans
F12TKCLAFS----1Caenorhabditis elegans
F204SAALPFCPESP5Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
F204ILAWLKVDESP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F204FFMWFIVDESP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F204AIGMAFSPESP1Arabidopsis thaliana
F204LILLPVCPESP1Drosophila melanogaster
F204CVALLFCPESP1Gallus gallus
F204LATIPFCVESP1Caenorhabditis elegans
F204LALLMLCPESP1Caenorhabditis elegans
F289GINAVFYYSTG6Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
F289GINSIIFYGVK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F289GINSIVLYGTK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F289GINAVVYYSTS1Arabidopsis thaliana
F289GINAVFYYSTS1Drosophila melanogaster
F289GISAVTFYSTL1Caenorhabditis elegans
F289GINVAMFYSTV1Caenorhabditis elegans
F377VFVAFFEIGPG2Homo sapiens, Canis lupus familiaris
F377VYVAFFEIGPG2Rattus norvegicus, Rattus norvegicus
F377VYIAAFAIGLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F377IYMGVFTMGLN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F377LYVLSFSLGAG1Arabidopsis thaliana
F377GFVVFFAVGPG1Drosophila melanogaster
F377GFVALFEIGPG1Gallus gallus
F377IYVAFFEIGPG1Mus musculus
F377SFVVTFAFGPG1Caenorhabditis elegans
F377LFVISFATGPG1Caenorhabditis elegans
F79GMIGSFSVGLF5Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
F79GLFGSYYAGNW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F79GILGSYFATSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F79ATVGSFTGGAL1Arabidopsis thaliana
F79GMLGGFSGGWM1Drosophila melanogaster
F79GMIGSFSVSLF1Gallus gallus
F79GMFGSFCSGFL1Caenorhabditis elegans
F79GMIGGLSSGWL1Caenorhabditis elegans
G382FEIGPGPIPWF6Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
G382FAIGLGPIPFL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G382FTMGLNPLPFI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G382FSLGAGPVPAL1Arabidopsis thaliana
G382FAVGPGSIPWM1Drosophila melanogaster
G382FAFGPGPIPWF1Caenorhabditis elegans
G382FATGPGAIPWF1Caenorhabditis elegans
I121SVEMLILGRLI3Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
I121SVEMLILGRLV1Homo sapiens
I121SYLQLLFGRFL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I121SYRGLIIGRIL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I121SVQTMIVGRLL1Arabidopsis thaliana
I121SYEMLFLGRFI1Drosophila melanogaster
I121AVEMLIIGRFI1Gallus gallus
I121SVEMLILGRLL1Mus musculus
I121FYPMIVFGRFL1Caenorhabditis elegans
I121AYPMVILGRLI1Caenorhabditis elegans
I162LNQLGIVVGIL5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Rattus norvegicus
I162MNQVSINLGIL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I162MTQICIRLGVL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I162VNQLFICIGIL1Arabidopsis thaliana
I162VNQLAVTVGLL1Drosophila melanogaster
I162LNQLGIVIGIL1Canis lupus familiaris
I162FHQLNISVAIV1Caenorhabditis elegans
I162LHQLLVTIAIL1Caenorhabditis elegans
I166GIVVGILVAQI3Homo sapiens, Gallus gallus, Mus musculus
I166GIVVGILVAQV2Rattus norvegicus, Rattus norvegicus
I166SINLGILLTQT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I166CIRLGVLLTQG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I166FICIGILAALI1Arabidopsis thaliana
I166AVTVGLLLSQV1Drosophila melanogaster
I166GIVIGILVAQI1Canis lupus familiaris
I166NISVAIVLSQA1Caenorhabditis elegans
I166LVTIAILVSQI1Caenorhabditis elegans
I274PLLISVVLQLS2Rattus norvegicus, Rattus norvegicus
I274PIIISIVLQLS1Homo sapiens
I274PRTVILAILSC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I274SRHVITVLLFG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I274VVSVGAALFLF1Arabidopsis thaliana
I274PLIIGIVMQLS1Drosophila melanogaster
I274PIIISITLQLS1Gallus gallus
I274PLLISIVLQLS1Mus musculus
I274PIIISIMLQLS1Canis lupus familiaris
I274PMIVSILMMFS1Caenorhabditis elegans
I274PMSIAIMMMLA1Caenorhabditis elegans
I76SVGGMIGSFSV6Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
I76SIGGLFGSYYA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I76CIGGILGSYFA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I76LAGATVGSFTG1Arabidopsis thaliana
I76AIGGMLGGFSG1Drosophila melanogaster
I76SVGGMFGSFCS1Caenorhabditis elegans
I76AVGGMIGGLSS1Caenorhabditis elegans
I96RNSMLLVNLIA2Rattus norvegicus, Rattus norvegicus
I96RNSMLIVNLLA1Homo sapiens
I96KYVSMGASAMC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I96KFSSLINCTLN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I96TRTFQLDAIPL1Arabidopsis thaliana
I96KGGLLLNNVLG1Drosophila melanogaster
I96RNSMLLVNVLA1Gallus gallus
I96RNSMLLVNLLA1Mus musculus
I96RNSMLMVNLLA1Canis lupus familiaris
I96KSTLLYNNILA1Caenorhabditis elegans
I96RGALFYNNLLA1Caenorhabditis elegans
L100LLVNLIAILGG2Rattus norvegicus, Rattus norvegicus
L100LIVNLLAVTGG1Homo sapiens
L100MGASAMCMVSS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L100LINCTLNIVGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L100QLDAIPLAIGA1Arabidopsis thaliana
L100LLNNVLGIAGA1Drosophila melanogaster
L100LLVNVLAFAGG1Gallus gallus
L100LLVNLLAIIAG1Mus musculus
L100LMVNLLAVAGG1Canis lupus familiaris
L100LYNNILALLAA1Caenorhabditis elegans
L100FYNNLLALAAA1Caenorhabditis elegans
L125LILGRLIIGIF2Rattus norvegicus, Rattus norvegicus
L125LILGRLVIGLF1Homo sapiens
L125LLFGRFLVGMS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L125LIIGRILVGIS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L125MIVGRLLAGIG1Arabidopsis thaliana
L125LFLGRFIIGVN1Drosophila melanogaster
L125LIIGRFIIGLF1Gallus gallus
L125LILGRLLIGIF1Mus musculus
L125LILGRLIIGLF1Canis lupus familiaris
L125IVFGRFLVGLN1Caenorhabditis elegans
L125VILGRLIIGLN1Caenorhabditis elegans
L129RLIIGIFCGLC2Rattus norvegicus, Rattus norvegicus
L129RLVIGLFCGLC1Homo sapiens
L129RFLVGMSCGTA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L129RILVGISCGSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L129RLLAGIGIGIS1Arabidopsis thaliana
L129RFIIGVNCGLN1Drosophila melanogaster
L129RFIIGLFCGLC1Gallus gallus
L129RLLIGIFCGLC1Mus musculus
L129RLIIGLFCGLC1Canis lupus familiaris
L129RFLVGLNCGIT1Caenorhabditis elegans
L129RLIIGLNCGFS1Caenorhabditis elegans
L278SIVLQLSQQLS2Homo sapiens, Mus musculus
L278SVVLQLSQQFS2Rattus norvegicus, Rattus norvegicus
L278ILAILSCQQFC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L278ITVLLFGQQFC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L278GAALFLFQQLA1Arabidopsis thaliana
L278GIVMQLSQQFS1Drosophila melanogaster
L278SITLQLSQQLS1Gallus gallus
L278SIMLQLSQQLS1Canis lupus familiaris
L278SILMMFSQQFS1Caenorhabditis elegans
L278AIMMMLAQQLS1Caenorhabditis elegans
L282QLSQQLSGINA4Homo sapiens, Gallus gallus, Mus musculus, Canis lupus familiaris
L282QLSQQFSGINA3Drosophila melanogaster, Rattus norvegicus, Rattus norvegicus
L282LSCQQFCGINS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L282LFGQQFCGINS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L282FLFQQLAGINA1Arabidopsis thaliana
L282MFSQQFSGISA1Caenorhabditis elegans
L282MLAQQLSGINV1Caenorhabditis elegans
L46-LNYTLEERLE3Mus musculus, Rattus norvegicus, Rattus norvegicus
L46-INKTLTDKGN1Homo sapiens
L46SYDDTWVGQHG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L46PYDRTWLGKRG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L46-LEYLAKDLG-1Arabidopsis thaliana
L46-MKDVYKDRYG1Drosophila melanogaster
L46-YNRTLSQRSG1Gallus gallus
L46-LNYTLEEKSE1Canis lupus familiaris
L46-IKKCHFELFG1Caenorhabditis elegans
L46-IIGSHKDLFD1Caenorhabditis elegans
L62VLLTSLWSLSV2Homo sapiens, Canis lupus familiaris
L62GLLTTLWSLCV2Rattus norvegicus, Rattus norvegicus
L62ALTDSQYGAIT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L62PLNDEQIGIVT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L62NTVLQGW--IV1Arabidopsis thaliana
L62EFIQQLYSVAV1Drosophila melanogaster
L62ELLTSLWSLSV1Gallus gallus
L62GLLTALWSLCV1Mus musculus
L62YQADFIWSVAV1Caenorhabditis elegans
L62ENADLAWSVAV1Caenorhabditis elegans
L83SFSVGLFVNRF5Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
L83SYYAGNWANRY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L83SYFATSLANIY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L83SFTGGALADKF1Arabidopsis thaliana
L83GFSGGWMANRF1Drosophila melanogaster
L83SFSVSLFFNRF1Gallus gallus
L83SFCSGFLADKF1Caenorhabditis elegans
L83GLSSGWLADKV1Caenorhabditis elegans
M119AESVEMLILGR3Mus musculus, Rattus norvegicus, Rattus norvegicus
M119AKSVEMLILGR1Homo sapiens
M119-NSYLQLLFGR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M119-NSYRGLIIGR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M119AQSVQTMIVGR1Arabidopsis thaliana
M119SHSYEMLFLGR1Drosophila melanogaster
M119AKAVEMLIIGR1Gallus gallus
M119AQSVEMLILGR1Canis lupus familiaris
M119FNFYPMIVFGR1Caenorhabditis elegans
M119VGAYPMVILGR1Caenorhabditis elegans
N286QLSGINAVFYY4Homo sapiens, Gallus gallus, Mus musculus, Canis lupus familiaris
N286QFSGINAVFYY3Drosophila melanogaster, Rattus norvegicus, Rattus norvegicus
N286QFCGINSIIFY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N286QFCGINSIVLY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N286QLAGINAVVYY1Arabidopsis thaliana
N286QFSGISAVTFY1Caenorhabditis elegans
N286QLSGINVAMFY1Caenorhabditis elegans
N315GAGVVNTIFTV5Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
N315AISILNVVVTL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N315FISMVNVLVTI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N315LVGASNVFGTA1Arabidopsis thaliana
N315GIGAIMVVMTL1Drosophila melanogaster
N315GAGVVNTVFTV1Gallus gallus
N315GFGCIKLIATF1Caenorhabditis elegans
N315GMGAVNVIMTL1Caenorhabditis elegans
N32NTGVINAPETI4Mus musculus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
N32NTGVINAPEKI2Homo sapiens, Gallus gallus
N32HIAELNAPQEF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N32HLSELNAPQQV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N32HLGVVNGA---1Arabidopsis thaliana
N32NTGVINAPEKN1Drosophila melanogaster
N32QIGCINAPGPL1Caenorhabditis elegans
N32HIGCVNAPGGL1Caenorhabditis elegans
N413SNWTSNFLVGM3Gallus gallus, Rattus norvegicus, Rattus norvegicus
N413SNWTSNFLVGL2Homo sapiens, Canis lupus familiaris
N413CNWLATFIVGY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N413CNWVGTFIIAY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N413MHWISNFVIGL1Arabidopsis thaliana
N413VNWMANFVVGI1Drosophila melanogaster
N413CNWTSNFLVGM1Mus musculus
N413SNWVANWMVGL1Caenorhabditis elegans
N413VNWAANLLVGL1Caenorhabditis elegans
P203QSAALPFCPES5Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
P203NILAWLKVDES1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P203NFFMWFIVDES1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P203LAIGMAFSPES1Arabidopsis thaliana
P203QLILLPVCPES1Drosophila melanogaster
P203QCVALLFCPES1Gallus gallus
P203QLATIPFCVES1Caenorhabditis elegans
P203QLALLMLCPES1Caenorhabditis elegans
P8TAKVTPSLVFA2Rattus norvegicus, Rattus norvegicus
P8TQKVTPALIFA1Homo sapiens
P8KPLITGHLILG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P8KHKITKALCYA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P8DNGIQSVMSFS1Arabidopsis thaliana
P8APGLTFFLTYS1Drosophila melanogaster
P8KKKITASLIYA1Gallus gallus
P8TTKVTPSLVFA1Mus musculus
P8TQKVTVSLIFA1Canis lupus familiaris
P8DENWTPFLFFC1Caenorhabditis elegans
P8DGKLTKCLAFS1Caenorhabditis elegans
Q159FGTLNQLGIVV5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Rattus norvegicus
Q159MGSMNQVSINL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q159LGSMTQICIRL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q159LGSVNQLFICI1Arabidopsis thaliana
Q159LGTVNQLAVTV1Drosophila melanogaster
Q159FGTLNQLGIVI1Canis lupus familiaris
Q159CGSFHQLNISV1Caenorhabditis elegans
Q159LGSLHQLLVTI1Caenorhabditis elegans
Q280VLQLSQQLSGI2Homo sapiens, Mus musculus
Q280VLQLSQQFSGI2Rattus norvegicus, Rattus norvegicus
Q280AILSCQQFCGI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q280VLLFGQQFCGI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q280ALFLFQQLAGI1Arabidopsis thaliana
Q280VMQLSQQFSGI1Drosophila melanogaster
Q280TLQLSQQLSGI1Gallus gallus
Q280MLQLSQQLSGI1Canis lupus familiaris
Q280LMMFSQQFSGI1Caenorhabditis elegans
Q280MMMLAQQLSGI1Caenorhabditis elegans
Q281LQLSQQLSGIN4Homo sapiens, Gallus gallus, Mus musculus, Canis lupus familiaris
Q281LQLSQQFSGIN2Rattus norvegicus, Rattus norvegicus
Q281ILSCQQFCGIN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q281LLFGQQFCGIN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q281LFLFQQLAGIN1Arabidopsis thaliana
Q281MQLSQQFSGIN1Drosophila melanogaster
Q281MMFSQQFSGIS1Caenorhabditis elegans
Q281MMLAQQLSGIN1Caenorhabditis elegans
R228TEILQRLWGT-3Mus musculus, Rattus norvegicus, Rattus norvegicus
R228KQILQRLWGT-1Homo sapiens
R228ETALFKLRPGT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R228KLSLCKLRGVT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R228EKAIKTLYGK-1Arabidopsis thaliana
R228RKALRRLRAS-1Drosophila melanogaster
R228QTVLQKLRGT-1Gallus gallus
R228KEILQRLWGT-1Canis lupus familiaris
R228RRILEKLRGH-1Caenorhabditis elegans
R228ESALKKLRDT-1Caenorhabditis elegans
R91NRFGRRNSMLL4Gallus gallus, Mus musculus, Rattus norvegicus, Rattus norvegicus
R91NRFGRRNSMLI1Homo sapiens
R91NRYGRKYVSMG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R91NIYGRKFSSLI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R91DKFGRTRTFQL1Arabidopsis thaliana
R91NRFGRKGGLLL1Drosophila melanogaster
R91NRFGRRNSMLM1Canis lupus familiaris
R91DKFGRKSTLLY1Caenorhabditis elegans
R91DKVGRRGALFY1Caenorhabditis elegans
S116AKIAESVEMLI3Mus musculus, Rattus norvegicus, Rattus norvegicus
S116CKVAKSVEMLI1Homo sapiens
S116S---NSYLQLL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S116S---NSYRGLI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S116CATAQSVQTMI1Arabidopsis thaliana
S116TKVSHSYEMLF1Drosophila melanogaster
S116SKIAKAVEMLI1Gallus gallus
S116CKIAQSVEMLI1Canis lupus familiaris
S116SKLFNFYPMIV1Caenorhabditis elegans
S116AKSVGAYPMVI1Caenorhabditis elegans
S408AVAGCSNWTSN5Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
S408SFGTVCNWLAT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S408RYGTICNWVGT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S408ALSLGMHWISN1Arabidopsis thaliana
S408AIAVLVNWMAN1Drosophila melanogaster
S408AVAGCCNWTSN1Mus musculus
S408AVSATSNWVAN1Caenorhabditis elegans
S408SIAVMVNWAAN1Caenorhabditis elegans
S80MIGSFSVGLFV5Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
S80LFGSYYAGNWA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S80ILGSYFATSLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S80TVGSFTGGALA1Arabidopsis thaliana
S80MLGGFSGGWMA1Drosophila melanogaster
S80MIGSFSVSLFF1Gallus gallus
S80MFGSFCSGFLA1Caenorhabditis elegans
S80MIGGLSSGWLA1Caenorhabditis elegans
T28QFGYNTGVINA7Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
T28QYGYHIAELNA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T28QFGYHLSELNA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T28LFGYHLGVVNG1Arabidopsis thaliana
T28QDGFQIGCINA1Caenorhabditis elegans
T28QFGYHIGCVNA1Caenorhabditis elegans
T411GCSNWTSNFLV5Homo sapiens, Gallus gallus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
T411TVCNWLATFIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T411TICNWVGTFII1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T411LGMHWISNFVI1Arabidopsis thaliana
T411VLVNWMANFVV1Drosophila melanogaster
T411GCCNWTSNFLV1Mus musculus
T411ATSNWVANWMV1Caenorhabditis elegans
T411VMVNWAANLLV1Caenorhabditis elegans
V117KIAESVEMLIL3Mus musculus, Rattus norvegicus, Rattus norvegicus
V117KVAKSVEMLIL1Homo sapiens
V117---NSYLQLLF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V117---NSYRGLII1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V117ATAQSVQTMIV1Arabidopsis thaliana
V117KVSHSYEMLFL1Drosophila melanogaster
V117KIAKAVEMLII1Gallus gallus
V117KIAQSVEMLIL1Canis lupus familiaris
V117KLFNFYPMIVF1Caenorhabditis elegans
V117KSVGAYPMVIL1Caenorhabditis elegans
V126ILGRLIIGIFC2Rattus norvegicus, Rattus norvegicus
V126ILGRLVIGLFC1Homo sapiens
V126LFGRFLVGMSC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V126IIGRILVGISC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V126IVGRLLAGIGI1Arabidopsis thaliana
V126FLGRFIIGVNC1Drosophila melanogaster
V126IIGRFIIGLFC1Gallus gallus
V126ILGRLLIGIFC1Mus musculus
V126ILGRLIIGLFC1Canis lupus familiaris
V126VFGRFLVGLNC1Caenorhabditis elegans
V126ILGRLIIGLNC1Caenorhabditis elegans
V163NQLGIVVGILV5Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Rattus norvegicus
V163NQVSINLGILL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V163TQICIRLGVLL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V163NQLFICIGILA1Arabidopsis thaliana
V163NQLAVTVGLLL1Drosophila melanogaster
V163NQLGIVIGILV1Canis lupus familiaris
V163HQLNISVAIVL1Caenorhabditis elegans
V163HQLLVTIAILV1Caenorhabditis elegans
V257EKQVTVLELFR3Homo sapiens, Mus musculus, Canis lupus familiaris
V257EKQVTVLELFK2Rattus norvegicus, Rattus norvegicus
V257HSGPTLWQYVT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V257SGSNSLWKYLR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V257EPEAGWFDLFS1Arabidopsis thaliana
V257ESHISTMELIC1Drosophila melanogaster
V257EKKATVLELFR1Gallus gallus
V257LHQPGYVSLFK1Caenorhabditis elegans
V257QEKPKMGDMFK1Caenorhabditis elegans
V416TSNFLVGLLFP2Homo sapiens, Canis lupus familiaris
V416TSNFLVGMLFP2Gallus gallus, Mus musculus
V416TSNFLVGMFFP2Rattus norvegicus, Rattus norvegicus
V416LATFIVGYLFP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V416VGTFIIAYTFP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V416ISNFVIGLYFL1Arabidopsis thaliana
V416MANFVVGIGFP1Drosophila melanogaster
V416VANWMVGLTFL1Caenorhabditis elegans
V416AANLLVGLTFL1Caenorhabditis elegans
W386PGPIPWFIVAE6Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Rattus norvegicus, Canis lupus familiaris
W386LGPIPFLIIGE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W386LNPLPFIIMRE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W386AGPVPALLLPE1Arabidopsis thaliana
W386PGSIPWMITAE1Drosophila melanogaster
W386PGPIPWFFTSE1Caenorhabditis elegans
W386PGAIPWFFVSE1Caenorhabditis elegans


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