mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for OCM
Gene summary
Basic gene Info.Gene symbolOCM
Gene nameoncomodulin
CytomapUCSC genome browser: 7p22.1
Type of geneprotein-coding
DescriptionhCG18255oncomodulin 1oncomodulin-1parvalbumin beta
Modification date20141207
dbXrefs MIM : 164795
Ensembl : ENSG00000122543
Vega : OTTHUMG00000155499
ProteinUniProt: P0CE72
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_OCM
BioGPS: 654231
PathwayNCI Pathway Interaction Database: OCM
Pathway Commons: OCM
ContextiHOP: OCM
ligand binding site mutation search in PubMed: OCM
UCL Cancer Institute: OCM
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for OCM

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for OCM
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for OCM from PDB

Differential gene expression and gene-gene network for OCM
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of OCM and the right PPI network was created from samples without mutations in the LBS of OCM. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for OCM
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for OCM
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of OCM go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)1ttxAD52 S56 Y58

Conservation information for LBS of OCM
Multiple alignments for P0CE72 in multiple species
LBSAA sequence# speciesSpecies
D52VFRFIDNDQSG1Homo sapiens
D52IFQFIDNDQSG1Mus musculus
D52IFRFIDNDQSG1Rattus norvegicus
D54RFIDNDQSGYL2Homo sapiens, Rattus norvegicus
D54QFIDNDQSGYL1Mus musculus
D60QSGYLDEEELK1Homo sapiens
D60QSGYLDEDELK1Mus musculus
D60QSGYLDGDELK1Rattus norvegicus
D91LMDAADNDGDG2Mus musculus, Rattus norvegicus
D91LMAAADNDGDG1Homo sapiens
D93DAADNDGDGKI2Mus musculus, Rattus norvegicus
D93AAADNDGDGKI1Homo sapiens
D95ADNDGDGKIGA3Homo sapiens, Mus musculus, Rattus norvegicus
E102KIGADEFQEMV2Mus musculus, Rattus norvegicus
E102KIGAEEFQEMV1Homo sapiens
E63YLDEEELKFFL1Homo sapiens
E63YLDEDELKYFL1Mus musculus
E63YLDGDELKYFL1Rattus norvegicus
I98DGDGKIGADEF2Mus musculus, Rattus norvegicus
I98DGDGKIGAEEF1Homo sapiens
K97NDGDGKIGADE2Mus musculus, Rattus norvegicus
K97NDGDGKIGAEE1Homo sapiens
S56IDNDQSGYLDE2Homo sapiens, Mus musculus
S56IDNDQSGYLDG1Rattus norvegicus
Y58NDQSGYLDEEE1Homo sapiens
Y58NDQSGYLDEDE1Mus musculus
Y58NDQSGYLDGDE1Rattus norvegicus

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