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mutLBSgeneDB |
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| Gene summary for OCM |
 Gene summary |
| Basic gene Info. | Gene symbol | OCM |
| Gene name | oncomodulin | |
| Synonyms | OCM1|OM|ONCM | |
| Cytomap | UCSC genome browser: 7p22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001097622.1, | |
| Description | hCG18255oncomodulin 1oncomodulin-1parvalbumin beta | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 164795 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000122543 | ||
| Vega : OTTHUMG00000155499 | ||
| Protein | UniProt: P0CE72 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_OCM | |
| BioGPS: 654231 | ||
| Pathway | NCI Pathway Interaction Database: OCM | |
| KEGG: OCM | ||
| REACTOME: OCM | ||
| Pathway Commons: OCM | ||
| Context | iHOP: OCM | |
| ligand binding site mutation search in PubMed: OCM | ||
| UCL Cancer Institute: OCM | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for OCM |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y58,S56 | G57R | COAD | 1 | D52 | F50V | LUAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for OCM |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D52 | F50V | -0.82732029 | S56 | G57R | -0.13271577 | Y58 | G57R | -0.13271577 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for OCM from PDB |
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| Differential gene expression and gene-gene network for OCM |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for OCM |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for OCM |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of OCM go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 1ttx | A | D52 S56 Y58 |
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| Conservation information for LBS of OCM |
| Multiple alignments for P0CE72 in multiple species |
| LBS | AA sequence | # species | Species | D52 | VFRFIDNDQSG | 1 | Homo sapiens | D52 | IFQFIDNDQSG | 1 | Mus musculus | D52 | IFRFIDNDQSG | 1 | Rattus norvegicus | D54 | RFIDNDQSGYL | 2 | Homo sapiens, Rattus norvegicus | D54 | QFIDNDQSGYL | 1 | Mus musculus | D60 | QSGYLDEEELK | 1 | Homo sapiens | D60 | QSGYLDEDELK | 1 | Mus musculus | D60 | QSGYLDGDELK | 1 | Rattus norvegicus | D91 | LMDAADNDGDG | 2 | Mus musculus, Rattus norvegicus | D91 | LMAAADNDGDG | 1 | Homo sapiens | D93 | DAADNDGDGKI | 2 | Mus musculus, Rattus norvegicus | D93 | AAADNDGDGKI | 1 | Homo sapiens | D95 | ADNDGDGKIGA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E102 | KIGADEFQEMV | 2 | Mus musculus, Rattus norvegicus | E102 | KIGAEEFQEMV | 1 | Homo sapiens | E63 | YLDEEELKFFL | 1 | Homo sapiens | E63 | YLDEDELKYFL | 1 | Mus musculus | E63 | YLDGDELKYFL | 1 | Rattus norvegicus | I98 | DGDGKIGADEF | 2 | Mus musculus, Rattus norvegicus | I98 | DGDGKIGAEEF | 1 | Homo sapiens | K97 | NDGDGKIGADE | 2 | Mus musculus, Rattus norvegicus | K97 | NDGDGKIGAEE | 1 | Homo sapiens | S56 | IDNDQSGYLDE | 2 | Homo sapiens, Mus musculus | S56 | IDNDQSGYLDG | 1 | Rattus norvegicus | Y58 | NDQSGYLDEEE | 1 | Homo sapiens | Y58 | NDQSGYLDEDE | 1 | Mus musculus | Y58 | NDQSGYLDGDE | 1 | Rattus norvegicus |
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