mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SNRPB2
Gene summary
Basic gene Info.Gene symbolSNRPB2
Gene namesmall nuclear ribonucleoprotein polypeptide B
CytomapUCSC genome browser: 20p12.1
Type of geneprotein-coding
DescriptionU2 small nuclear ribonucleoprotein B''U2 snRNP B''small nuclear ribonucleoprotein polypeptide B2
Modification date20141207
dbXrefs MIM : 603520
Ensembl : ENSG00000125870
HPRD : 04628
Vega : OTTHUMG00000031933
ProteinUniProt: P08579
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SNRPB2
BioGPS: 6629
PathwayNCI Pathway Interaction Database: SNRPB2
Pathway Commons: SNRPB2
ContextiHOP: SNRPB2
ligand binding site mutation search in PubMed: SNRPB2
UCL Cancer Institute: SNRPB2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for SNRPB2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for SNRPB2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SNRPB2 from PDB

Differential gene expression and gene-gene network for SNRPB2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SNRPB2 and the right PPI network was created from samples without mutations in the LBS of SNRPB2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for SNRPB2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for SNRPB2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SNRPB2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of SNRPB2
Multiple alignments for P08579 in multiple species
LBSAA sequence# speciesSpecies
A42VVDIVALKTMK2Homo sapiens, Mus musculus
A42ILDVVALKTPK2Oryza sativa subsp. japonica, Arabidopsis thaliana
A42LLDVVALKTPK1Arabidopsis thaliana
A84MRIQYAKTDSD2Homo sapiens, Mus musculus
A84MRVQYAKTRSD1Oryza sativa subsp. japonica
A84MRLQYAKAKSD1Arabidopsis thaliana
A84MRIQYAKSKSD1Arabidopsis thaliana
D16INNMNDKIKKE2Homo sapiens, Mus musculus
D16LRNLNEKVKKE1Oryza sativa subsp. japonica
D16IQNLNERIKKE1Arabidopsis thaliana
D16IKHINEKIKKE1Arabidopsis thaliana
D87QYAKTDSDIIS2Homo sapiens, Mus musculus
D87QYAKTRSDCLA1Oryza sativa subsp. japonica
D87QYAKAKSDCLA1Arabidopsis thaliana
D87QYAKSKSDYVT1Arabidopsis thaliana
D89AKTDSDIISKM2Homo sapiens, Mus musculus
D89AKTRSDCLATE1Oryza sativa subsp. japonica
D89AKAKSDCLAKA1Arabidopsis thaliana
D89AKSKSDYVTKA1Arabidopsis thaliana
F53MRGQAFVIFKE2Homo sapiens, Mus musculus
F53LRGQAWVVFSE1Oryza sativa subsp. japonica
F53LRGQAWVTFSE1Arabidopsis thaliana
F53LRGQAWVVFTE1Arabidopsis thaliana
G50TMKMRGQAFVI2Homo sapiens, Mus musculus
G50TPKLRGQAWVV2Oryza sativa subsp. japonica, Arabidopsis thaliana
G50TPKLRGQAWVT1Arabidopsis thaliana
I40GHVVDIVALKT2Homo sapiens, Mus musculus
I40GRILDVVALKT2Oryza sativa subsp. japonica, Arabidopsis thaliana
I40GRLLDVVALKT1Arabidopsis thaliana
K17NNMNDKIKKEE2Homo sapiens, Mus musculus
K17RNLNEKVKKEE1Oryza sativa subsp. japonica
K17QNLNERIKKEE1Arabidopsis thaliana
K17KHINEKIKKEE1Arabidopsis thaliana
K19MNDKIKKEELK2Homo sapiens, Mus musculus
K19LNEKVKKEELK1Oryza sativa subsp. japonica
K19LNERIKKEELK1Arabidopsis thaliana
K19INEKIKKEELK1Arabidopsis thaliana
K20NDKIKKEELKR2Homo sapiens, Mus musculus
K20NEKVKKEELKR1Oryza sativa subsp. japonica
K20NERIKKEELKR1Arabidopsis thaliana
K20NEKIKKEELKR1Arabidopsis thaliana
K24KKEELKRSLYA3Homo sapiens, Mus musculus, Oryza sativa subsp. japonica
K24KKEELKRSLYC2Arabidopsis thaliana, Arabidopsis thaliana
K44DVVALKTPKLR3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
K44DIVALKTMKMR2Homo sapiens, Mus musculus
K47ALKTPKLRGQA3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
K47ALKTMKMRGQA2Homo sapiens, Mus musculus
K77FPFYGKPMRIQ2Homo sapiens, Mus musculus
K77FDFYGKRMRVQ1Oryza sativa subsp. japonica
K77FPFYDKPMRLQ1Arabidopsis thaliana
K77FPFYDKPMRIQ1Arabidopsis thaliana
K85RIQYAKTDSDI2Homo sapiens, Mus musculus
K85RVQYAKTRSDC1Oryza sativa subsp. japonica
K85RLQYAKAKSDC1Arabidopsis thaliana
K85RIQYAKSKSDY1Arabidopsis thaliana
L43LDVVALKTPKL3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
L43VDIVALKTMKM2Homo sapiens, Mus musculus
M46VALKTPKLRGQ3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
M46VALKTMKMRGQ2Homo sapiens, Mus musculus
M48LKTPKLRGQAW3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
M48LKTMKMRGQAF2Homo sapiens, Mus musculus
N12HTIYINNMNDK2Homo sapiens, Mus musculus
N12QTVYLRNLNEK1Oryza sativa subsp. japonica
N12QSIYIQNLNER1Arabidopsis thaliana
N12QSIYIKHINEK1Arabidopsis thaliana
N13TIYINNMNDKI2Homo sapiens, Mus musculus
N13TVYLRNLNEKV1Oryza sativa subsp. japonica
N13SIYIQNLNERI1Arabidopsis thaliana
N13SIYIKHINEKI1Arabidopsis thaliana
Q51MKMRGQAFVIF2Homo sapiens, Mus musculus
Q51PKLRGQAWVVF2Oryza sativa subsp. japonica, Arabidopsis thaliana
Q51PKLRGQAWVTF1Arabidopsis thaliana
Q82KPMRIQYAKTD2Homo sapiens, Mus musculus
Q82KRMRVQYAKTR1Oryza sativa subsp. japonica
Q82KPMRLQYAKAK1Arabidopsis thaliana
Q82KPMRIQYAKSK1Arabidopsis thaliana
R49KTPKLRGQAWV3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
R49KTMKMRGQAFV2Homo sapiens, Mus musculus
R80YGKPMRIQYAK2Homo sapiens, Mus musculus
R80YGKRMRVQYAK1Oryza sativa subsp. japonica
R80YDKPMRLQYAK1Arabidopsis thaliana
R80YDKPMRIQYAK1Arabidopsis thaliana
S88YAKTDSDIISK2Homo sapiens, Mus musculus
S88YAKTRSDCLAT1Oryza sativa subsp. japonica
S88YAKAKSDCLAK1Arabidopsis thaliana
S88YAKSKSDYVTK1Arabidopsis thaliana
T45VVALKTPKLRG3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
T45IVALKTMKMRG2Homo sapiens, Mus musculus
T86IQYAKTDSDII2Homo sapiens, Mus musculus
T86VQYAKTRSDCL1Oryza sativa subsp. japonica
T86LQYAKAKSDCL1Arabidopsis thaliana
T86IQYAKSKSDYV1Arabidopsis thaliana
V41HVVDIVALKTM2Homo sapiens, Mus musculus
V41RILDVVALKTP2Oryza sativa subsp. japonica, Arabidopsis thaliana
V41RLLDVVALKTP1Arabidopsis thaliana
Y10PNHTIYINNMN2Homo sapiens, Mus musculus
Y10PNQTVYLRNLN1Oryza sativa subsp. japonica
Y10PNQSIYIQNLN1Arabidopsis thaliana
Y10PNQSIYIKHIN1Arabidopsis thaliana
Y83PMRIQYAKTDS2Homo sapiens, Mus musculus
Y83RMRVQYAKTRS1Oryza sativa subsp. japonica
Y83PMRLQYAKAKS1Arabidopsis thaliana
Y83PMRIQYAKSKS1Arabidopsis thaliana

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