mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SNRPG
Gene summary
Basic gene Info.Gene symbolSNRPG
Gene namesmall nuclear ribonucleoprotein polypeptide G
CytomapUCSC genome browser: 2p13.3
Type of geneprotein-coding
Descriptionsm protein Gsmall nuclear ribonucleoprotein GsnRNP-G
Modification date20141215
dbXrefs MIM : 603542
Ensembl : ENSG00000143977
HPRD : 04646
Vega : OTTHUMG00000129670
ProteinUniProt: P62308
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SNRPG
BioGPS: 6637
PathwayNCI Pathway Interaction Database: SNRPG
Pathway Commons: SNRPG
ContextiHOP: SNRPG
ligand binding site mutation search in PubMed: SNRPG
UCL Cancer Institute: SNRPG
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0000387spliceosomal snRNP assembly18984161

Ligand binding site mutations for SNRPG

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for SNRPG
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SNRPG from PDB

Differential gene expression and gene-gene network for SNRPG
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SNRPG and the right PPI network was created from samples without mutations in the LBS of SNRPG. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for SNRPG
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for SNRPG
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SNRPG go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids4pjoGR63
NUCNucleic Acids4pjogR63
NUCNucleic Acids4pjoUR63
NUCNucleic Acids4pjouR63

Conservation information for LBS of SNRPG
Multiple alignments for P62308 in multiple species
LBSAA sequence# speciesSpecies
F37RGFDPFMNLVI2Homo sapiens, Bos taurus
F37RGFDPFMNMVI1Caenorhabditis elegans
F37RGFDPFMNVVL1Drosophila melanogaster
G64MVVIRGNSIIM2Homo sapiens, Bos taurus
G64MTVIRGNSVVI1Caenorhabditis elegans
G64MVVIRGNSIVM1Drosophila melanogaster
H54Homo sapiens, Caenorhabditis elegans, Bos taurus, Drosophila melanogaster
K34Homo sapiens, Caenorhabditis elegans, Bos taurus, Drosophila melanogaster
M38GFDPFMNLVID2Homo sapiens, Bos taurus
M38GFDPFMNMVID1Caenorhabditis elegans
M38GFDPFMNVVLD1Drosophila melanogaster
N39FDPFMNLVIDE2Homo sapiens, Bos taurus
N39FDPFMNMVIDE1Caenorhabditis elegans
N39FDPFMNVVLDD1Drosophila melanogaster
N65VVIRGNSIIML2Homo sapiens, Bos taurus
N65TVIRGNSVVIM1Caenorhabditis elegans
N65VVIRGNSIVMV1Drosophila melanogaster
P36LRGFDPFMNLV2Homo sapiens, Bos taurus
P36LRGFDPFMNMV1Caenorhabditis elegans
P36LRGFDPFMNVV1Drosophila melanogaster
R63GMVVIRGNSII2Homo sapiens, Bos taurus
R63GMTVIRGNSVV1Caenorhabditis elegans
R63GMVVIRGNSIV1Drosophila melanogaster

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