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mutLBSgeneDB |
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| Gene summary for SRC |
 Gene summary |
| Basic gene Info. | Gene symbol | SRC |
| Gene name | SRC proto-oncogene, non-receptor tyrosine kinase | |
| Synonyms | ASV|SRC1|c-SRC|p60-Src | |
| Cytomap | UCSC genome browser: 20q12-q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005417.4, NM_198291.2, | |
| Description | proto-oncogene c-Srcproto-oncogene tyrosine-protein kinase Srcprotooncogene SRC, Rous sarcomatyrosine kinase pp60c-srctyrosine-protein kinase SRC-1v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 190090 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000197122 | ||
| HPRD : 01819 | ||
| Vega : OTTHUMG00000032417 | ||
| Protein | UniProt: P12931 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SRC | |
| BioGPS: 6714 | ||
| Pathway | NCI Pathway Interaction Database: SRC | |
| KEGG: SRC | ||
| REACTOME: SRC | ||
| Pathway Commons: SRC | ||
| Context | iHOP: SRC | |
| ligand binding site mutation search in PubMed: SRC | ||
| UCL Cancer Institute: SRC | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0018108 | peptidyl-tyrosine phosphorylation | 22732588 | GO:0035556 | intracellular signal transduction | 15248232 | GO:0046777 | protein autophosphorylation | 16441665 |
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| Ligand binding site mutations for SRC |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D407 | D407H | OV | 3 | E181 | E181K | BLCA | 1 | R391 | R391C | BLCA | 1 | D407 | D407H | COAD | 1 | I339,T341 | V340I | COAD | 1 | G347 | G347E | GBM | 1 | Q278 | Q278E | GBM | 1 | T218 | R220S | LUAD | 1 | E342 | E342K | SKCM | 1 | T218 | R220S | STAD | 1 | Y134 | G133C | UCEC | 1 | W121 | W121R | UCEC | 1 | T341 | T341A | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Clinical information for SRC from My Cancer Genome. |
| SRC proto-oncogene, non-receptor tyrosine kinase (SRC) is a gene that encodes a protein that functions in the regulation of embryonic development and cell growth. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.Related Pathways: Cellular architecture and microenvironment, MAP kinase signaling.Modified: December 4, 2015 |
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| Protein structure related information for SRC |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | G347 | G347E | 0.21066801 | D407 | D407H | -0.99559609 | E342 | E342K | -0.9846787 | R391 | R391C | -0.87244935 | Q278 | Q278E | -0.7424231 | T218 | R220S | -0.73327049 | I339 | V340I | -0.5216996 | T341 | V340I | -0.5216996 | E181 | E181K | -0.43972086 | T341 | T341A | -0.43953865 | Y134 | G133C | -0.42103568 | W121 | W121R | -0.056642361 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SRC from PDB |
| PDB ID | PDB title | PDB structure | 1A07 | C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-MALONYL TYR-GLU-(N,N-DIPENTYL AMINE) |  |
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| Differential gene expression and gene-gene network for SRC |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SRC |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1458155 | Breast Neoplasms | 14 | AlteredExpression, Biomarker |
| umls:C0009375 | Colonic Neoplasms | 7 | AlteredExpression, Biomarker, PostTranslationalModification |
| umls:C0027626 | Neoplasm Invasiveness | 2 | Biomarker |
| umls:C0005695 | Urinary Bladder Neoplasms | 2 | Biomarker |
| umls:C0038220 | Status Epilepticus | 1 | Biomarker |
| umls:C0018800 | Cardiomegaly | 1 | Biomarker |
| umls:C0009319 | Colitis | 1 | Biomarker |
| umls:C0085548 | Polycystic Kidney, Autosomal Recessive | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SRC |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational | DB01254 | Dasatinib | Small molecule |  |
| Experimental | DB01678 | RU84687 | Small molecule |  |
| Experimental | DB01866 | RU79256 | Small molecule |  |
| Experimental | DB01893 | N6-Benzyl Adenosine-5'-Diphosphate | Small molecule |  |
| Experimental | DB01908 | RU85493 | Small molecule |  |
| Experimental | DB01947 | RU78262 | Small molecule |  |
| Experimental | DB01962 | Phosphonotyrosine | Small molecule |  |
| Experimental | DB02175 | Malonic acid | Small molecule |  |
| Experimental | DB02336 | RU83876 | Small molecule |  |
| Experimental | DB02432 | RU90395 | Small molecule |  |
| Experimental | DB02762 | RU79072 | Small molecule |  |
| Experimental | DB02908 | RU78783 | Small molecule |  |
| Experimental | DB03023 | 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine | Small molecule |  |
| Experimental | DB03078 | PASBN | Small molecule |  |
| Experimental | DB03104 | RU82129 | Small molecule |  |
| Experimental | DB03114 | PAS219 | Small molecule |  |
| Experimental | DB03217 | DPI59 | Small molecule |  |
| Experimental | DB03268 | RU82197 | Small molecule |  |
| Experimental | DB03298 | Phenylphosphate | Small molecule |  |
| Experimental | DB03306 | RU78300 | Small molecule |  |
| Experimental | DB03525 | RU79073 | Small molecule |  |
| Experimental | DB03591 | RU82209 | Small molecule |  |
| Experimental | DB03628 | ISO24 | Small molecule |  |
| Experimental | DB03712 | RU85053 | Small molecule |  |
| Experimental | DB03828 | RU78299 | Small molecule |  |
| Experimental | DB03902 | Oxalic Acid | Small molecule |  |
| Experimental | DB04080 | RU78191 | Small molecule |  |
| Nutraceutical|vet_approved | DB04272 | Citric Acid | Small molecule |  |
| Experimental | DB04495 | RU81843 | Small molecule |  |
| Experimental | DB04739 | 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE | Small molecule |  |
| Experimental | DB04751 | Purvalanol A | Small molecule |  |
| Investigational | DB05184 | XL228 | Small molecule |  |
| Approved | DB06616 | Bosutinib | Small molecule |  |
| Experimental | DB06882 | 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea | Small molecule |  |
| Experimental | DB06883 | 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea | Small molecule |  |
| Experimental | DB07335 | 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL | Small molecule |  |
| Experimental | DB07662 | N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE | Small molecule |  |
| Experimental | DB07966 | [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile | Small molecule |  |
| Experimental | DB08052 | 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Small molecule |  |
| Experimental | DB08053 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Small molecule |  |
| Experimental | DB08054 | 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Small molecule |  |
| Experimental | DB08192 | 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE | Small molecule |  |
| Experimental | DB08462 | N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE | Small molecule |  |
| Experimental | DB08564 | (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide | Small molecule |  |
| Approved | DB08901 | Ponatinib | Small molecule |  |
| Approved | DB09079 | Nintedanib | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SRC go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ACE,TYR,GLU,DIP) | 1a08 | B | E181 | III | Peptide ligand (ACE,TYR,GLU,DIP) | 1a1a | A | E181 | PO4 | PHOSPHATE ION | 4f5a | A | E181 | PTR | O(4)-PHOSPHO-L-TYROSINE | 4f5b | A | E181 | III | Peptide ligand (ACE,TYR,GLU,DIP) | 1a08 | A | E181 T218 | III | Peptide ligand (ACE,TYR,GLU,DIP) | 1a09 | A | E181 T218 | III | Peptide ligand (ACE,TYR,GLU,DIP) | 1a09 | B | E181 T218 | III | Peptide ligand (ACE,TYR,GLU,DIP) | 1a1a | B | E181 T218 | III | Peptide ligand (ACE,TYR,GLU,DIP) | 1a1b | A | E181 T218 | III | Peptide ligand (ACE,TYR,GLU,DIP) | 1a1b | B | E181 T218 | III | Peptide ligand (ACE,TYR,GLU,DIX) | 1a1c | A | E181 T218 | III | Peptide ligand (ACE,TYR,GLU,DIX) | 1a1c | B | E181 T218 | III | Peptide ligand (ACE,TYR,GLU,DIY) | 1a1e | A | E181 T218 | III | Peptide ligand (ACE,TYR,GLU,DIY) | 1a1e | B | E181 T218 | III | Peptide ligand (ACE,TYR,GLU,DIP) | 1a07 | A | T218 | III | Peptide ligand (ACE,TYR,GLU,DIP) | 1a07 | B | T218 | III | Peptide ligand (ACE,TYR,GLU,GLU,ILE) | 1shd | A | T218 |
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| Conservation information for LBS of SRC |
| Multiple alignments for P12931 in multiple species |
| LBS | AA sequence | # species | Species | A296 | GTTRVAIKTLK | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | A296 | NSIDVAVKTLR | 1 | Drosophila melanogaster | A406 | LVCKVADFGLA | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | A406 | NVAKICDFGLA | 1 | Drosophila melanogaster | C188 | TKGAYCLSVSD | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | C188 | NPNGYSLSVKD | 1 | Drosophila melanogaster | C188 | TKGAYCLSVLD | 1 | Danio rerio | C241 | HADGLCHRLTT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C241 | NALGLCHILSR | 1 | Drosophila melanogaster | C241 | HADGLCHSLTD | 1 | Danio rerio | C241 | HADGLCHRLTN | 1 | Gallus gallus | D120 | ---EGDWWLAH | 3 | Homo sapiens, Gallus gallus, Rattus norvegicus | D120 | ---ESDWWRVV | 1 | Drosophila melanogaster | D120 | ---EGDWWLAR | 1 | Danio rerio | D120 | DVREGDWWLAH | 1 | Mus musculus | D238 | YSKHADGLCHR | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | D238 | YSKNALGLCHI | 1 | Drosophila melanogaster | D238 | YRQHADGLCHS | 1 | Danio rerio | D351 | KGSLLDFLKGE | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | D351 | KGSLLDFLREG | 1 | Drosophila melanogaster | D351 | QGSLLDFLKGD | 1 | Danio rerio | D389 | NYVHRDLRAAN | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | D389 | QLIHRDLAARN | 1 | Drosophila melanogaster | D407 | VCKVADFGLAR | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | D407 | VAKICDFGLAR | 1 | Drosophila melanogaster | E118 | -----EGDWWL | 4 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus | E118 | -----ESDWWR | 1 | Drosophila melanogaster | E118 | KVDVREGDWWL | 1 | Mus musculus | E160 | KITRRESERLL | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | E160 | NVLRKEADKLL | 1 | Drosophila melanogaster | E160 | KITRRDSERLL | 1 | Danio rerio | E181 | LVRESETTKGA | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | E181 | LVRPSEHNPNG | 1 | Drosophila melanogaster | E313 | EAFLQEAQVMK | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | E313 | AAFLQEAAIMK | 1 | Drosophila melanogaster | E342 | IYIVTEYMSKG | 2 | Homo sapiens, Gallus gallus | E342 | IYIVTEYMNKG | 2 | Mus musculus, Rattus norvegicus | E342 | IYIVQEYMSKG | 1 | Drosophila melanogaster | E342 | IYIVTEYMGQG | 1 | Danio rerio | G119 | ----EGDWWLA | 4 | Homo sapiens, Danio rerio, Gallus gallus, Rattus norvegicus | G119 | ----ESDWWRV | 1 | Drosophila melanogaster | G119 | VDVREGDWWLA | 1 | Mus musculus | G239 | SKHADGLCHRL | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | G239 | SKNALGLCHIL | 1 | Drosophila melanogaster | G239 | RQHADGLCHSL | 1 | Danio rerio | G277 | LEVKLGQGCFG | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | G277 | LLRKLGRGNFG | 1 | Drosophila melanogaster | G277 | LDVKLGQGCFG | 1 | Danio rerio | G279 | VKLGQGCFGEV | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | G279 | RKLGRGNFGEV | 1 | Drosophila melanogaster | G347 | EYMSKGSLLDF | 3 | Homo sapiens, Drosophila melanogaster, Gallus gallus | G347 | EYMNKGSLLDF | 2 | Mus musculus, Rattus norvegicus | G347 | EYMGQGSLLDF | 1 | Danio rerio | H204 | GLNVKHYKIRK | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | H204 | GYHVKHYRIKP | 1 | Drosophila melanogaster | I156 | WYFGKITRRES | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | I156 | WFFENVLRKEA | 1 | Drosophila melanogaster | I156 | WYFGKITRRDS | 1 | Danio rerio | I217 | SGGFYITSRTQ | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | I217 | NGGYYIATNQT | 1 | Drosophila melanogaster | I297 | TTRVAIKTLKP | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | I297 | SIDVAVKTLRE | 1 | Drosophila melanogaster | I339 | EEPIYIVTEYM | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | I339 | EEPIYIVQEYM | 1 | Drosophila melanogaster | K155 | EWYFGKITRRE | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | K155 | DWFFENVLRKE | 1 | Drosophila melanogaster | K155 | EWYFGKITRRD | 1 | Danio rerio | K198 | DFDNAKGLNVK | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | K198 | DWEDGRGYHVK | 1 | Drosophila melanogaster | K198 | DYDNVKGLNVK | 1 | Danio rerio | K203 | KGLNVKHYKIR | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | K203 | RGYHVKHYRIK | 1 | Drosophila melanogaster | K206 | NVKHYKIRKLD | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | K206 | HVKHYRIKPLD | 1 | Drosophila melanogaster | K298 | TRVAIKTLKPG | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | K298 | IDVAVKTLREG | 1 | Drosophila melanogaster | K346 | TEYMSKGSLLD | 2 | Homo sapiens, Gallus gallus | K346 | TEYMNKGSLLD | 2 | Mus musculus, Rattus norvegicus | K346 | QEYMSKGSLLD | 1 | Drosophila melanogaster | K346 | TEYMGQGSLLD | 1 | Danio rerio | L240 | KHADGLCHRLT | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | L240 | KNALGLCHILS | 1 | Drosophila melanogaster | L240 | QHADGLCHSLT | 1 | Danio rerio | L276 | RLEVKLGQGCF | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | L276 | QLLRKLGRGNF | 1 | Drosophila melanogaster | L276 | RLDVKLGQGCF | 1 | Danio rerio | L396 | RAANILVGENL | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | L396 | AARNVLIGENN | 1 | Drosophila melanogaster | L396 | RAANILVGDNL | 1 | Danio rerio | M317 | QEAQVMKKLRH | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | M317 | QEAAIMKKFRH | 1 | Drosophila melanogaster | M344 | IVTEYMSKGSL | 2 | Homo sapiens, Gallus gallus | M344 | IVTEYMNKGSL | 2 | Mus musculus, Rattus norvegicus | M344 | IVQEYMSKGSL | 1 | Drosophila melanogaster | M344 | IVTEYMGQGSL | 1 | Danio rerio | N394 | DLRAANILVGE | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | N394 | DLAARNVLIGE | 1 | Drosophila melanogaster | N394 | DLRAANILVGD | 1 | Danio rerio | Q278 | EVKLGQGCFGE | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Q278 | LRKLGRGNFGE | 1 | Drosophila melanogaster | Q278 | DVKLGQGCFGE | 1 | Danio rerio | R158 | FGKITRRESER | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | R158 | FENVLRKEADK | 1 | Drosophila melanogaster | R158 | FGKITRRDSER | 1 | Danio rerio | R178 | GTFLVRESETT | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | R178 | GTFLVRPSEHN | 1 | Drosophila melanogaster | R208 | KHYKIRKLDSG | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | R208 | KHYRIKPLDNG | 1 | Drosophila melanogaster | R391 | VHRDLRAANIL | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | R391 | IHRDLAARNVL | 1 | Drosophila melanogaster | S180 | FLVRESETTKG | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | S180 | FLVRPSEHNPN | 1 | Drosophila melanogaster | S345 | VTEYMSKGSLL | 2 | Homo sapiens, Gallus gallus | S345 | VTEYMNKGSLL | 2 | Mus musculus, Rattus norvegicus | S345 | VQEYMSKGSLL | 1 | Drosophila melanogaster | S345 | VTEYMGQGSLL | 1 | Danio rerio | S348 | YMSKGSLLDFL | 3 | Homo sapiens, Drosophila melanogaster, Gallus gallus | S348 | YMNKGSLLDFL | 2 | Mus musculus, Rattus norvegicus | S348 | YMGQGSLLDFL | 1 | Danio rerio | T182 | VRESETTKGAY | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | T182 | VRPSEHNPNGY | 1 | Drosophila melanogaster | T183 | RESETTKGAYC | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | T183 | RPSEHNPNGYS | 1 | Drosophila melanogaster | T218 | GGFYITSRTQF | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | T218 | GGYYIATNQTF | 1 | Drosophila melanogaster | T341 | PIYIVTEYMSK | 2 | Homo sapiens, Gallus gallus | T341 | PIYIVTEYMNK | 2 | Mus musculus, Rattus norvegicus | T341 | PIYIVQEYMSK | 1 | Drosophila melanogaster | T341 | PIYIVTEYMGQ | 1 | Danio rerio | V284 | GCFGEVWMGTW | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | V284 | GNFGEVFYGKW | 1 | Drosophila melanogaster | V326 | RHEKLVQLYAV | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | V326 | RHNRLVALYAV | 1 | Drosophila melanogaster | W121 | --EGDWWLAHS | 3 | Homo sapiens, Gallus gallus, Rattus norvegicus | W121 | --ESDWWRVVN | 1 | Drosophila melanogaster | W121 | --EGDWWLARS | 1 | Danio rerio | W121 | VREGDWWLAHS | 1 | Mus musculus | Y134 | TGQTGYIPSNY | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Y134 | TRQEGLIPLNF | 1 | Drosophila melanogaster | Y134 | TGESGYIPSNY | 1 | Danio rerio | Y187 | TTKGAYCLSVS | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Y187 | HNPNGYSLSVK | 1 | Drosophila melanogaster | Y187 | TTKGAYCLSVL | 1 | Danio rerio | Y205 | LNVKHYKIRKL | 5 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus | Y205 | YHVKHYRIKPL | 1 | Drosophila melanogaster | Y233 | QLVAYYSKHAD | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Y233 | ALVMAYSKNAL | 1 | Drosophila melanogaster | Y233 | QLVNHYRQHAD | 1 | Danio rerio | Y343 | YIVTEYMSKGS | 2 | Homo sapiens, Gallus gallus | Y343 | YIVTEYMNKGS | 2 | Mus musculus, Rattus norvegicus | Y343 | YIVQEYMSKGS | 1 | Drosophila melanogaster | Y343 | YIVTEYMGQGS | 1 | Danio rerio |
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