mutLBSgeneDB |
Gene summary for SRF |
![]() |
Basic gene Info. | Gene symbol | SRF |
Gene name | serum response factor (c-fos serum response element-binding transcription factor) | |
Synonyms | MCM1 | |
Cytomap | UCSC genome browser: 6p21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001292001.1, NM_003131.3, | |
Description | serum response factor | |
Modification date | 20141207 | |
dbXrefs | MIM : 600589 | |
HGNC : HGNC | ||
Ensembl : ENSG00000112658 | ||
HPRD : 02788 | ||
Vega : OTTHUMG00000014722 | ||
Protein | UniProt: P11831 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SRF | |
BioGPS: 6722 | ||
Pathway | NCI Pathway Interaction Database: SRF | |
KEGG: SRF | ||
REACTOME: SRF | ||
Pathway Commons: SRF | ||
Context | iHOP: SRF | |
ligand binding site mutation search in PubMed: SRF | ||
UCL Cancer Institute: SRF | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID | GO:0001829 | trophectodermal cell differentiation | 17576768 | GO:0006366 | transcription from RNA polymerase II promoter | 3203386 | GO:0009725 | response to hormone | 17975004 | GO:0010735 | positive regulation of transcription via serum response element binding | 3203386 | GO:0045597 | positive regulation of cell differentiation | 17576768 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 17576768 | GO:0045987 | positive regulation of smooth muscle contraction | 17215356 | GO:0051091 | positive regulation of sequence-specific DNA binding transcription factor activity | 19098903 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter | 8887666 |
Top |
Ligand binding site mutations for SRF |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
![]() |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | G142 | M142V | COAD | 1 | S162 | P162L | UCEC | 1 | K154 | Q154R | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for SRF |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for SRF |
![]() |
![]() |
Top |
Top |
Phenotype information for SRF |
![]() |
Disease ID | Disease name | # PubMed | Association type |
umls:C0019693 | HIV Infections | 1 | Biomarker |
umls:C0027651 | Neoplasms | 1 | Therapeutic |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for SRF |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
![]() |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 1hbx | A | G142 | NUC | Nucleic Acids | 1hbx | A | G142 | NUC | Nucleic Acids | 1hbx | B | G142 | NUC | Nucleic Acids | 1hbx | D | G142 | NUC | Nucleic Acids | 1hbx | D | G142 | NUC | Nucleic Acids | 1hbx | E | G142 | NUC | Nucleic Acids | 1k6o | B | G142 | NUC | Nucleic Acids | 1k6o | C | G142 | NUC | Nucleic Acids | 1k6o | C | G142 | NUC | Nucleic Acids | 1srs | A | G142 | NUC | Nucleic Acids | 1srs | A | G142 | NUC | Nucleic Acids | 1srs | B | G142 | NUC | Nucleic Acids | 1hbx | B | G142 K154 S162 | NUC | Nucleic Acids | 1hbx | E | G142 K154 S162 | NUC | Nucleic Acids | 1srs | B | G142 K154 S162 | NUC | Nucleic Acids | 1k6o | B | G142 S162 |
Top |
Conservation information for LBS of SRF |
![]() |
LBS | AA sequence | # species | Species |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |