mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SRP9
Gene summary
Basic gene Info.Gene symbolSRP9
Gene namesignal recognition particle 9kDa
SynonymsALURBP
CytomapUCSC genome browser: 1q42.12
Type of geneprotein-coding
RefGenesNM_001130440.1,
NM_003133.5,
Descriptionsignal recognition particle 9 kDa proteinsignal recognition particle 9kD
Modification date20141207
dbXrefs MIM : 600707
HGNC : HGNC
Ensembl : ENSG00000143742
HPRD : 02830
Vega : OTTHUMG00000037738
ProteinUniProt: P49458
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SRP9
BioGPS: 6726
PathwayNCI Pathway Interaction Database: SRP9
KEGG: SRP9
REACTOME: SRP9
Pathway Commons: SRP9
ContextiHOP: SRP9
ligand binding site mutation search in PubMed: SRP9
UCL Cancer Institute: SRP9
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for SRP9

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R26A25TKIRC1
K60K61ELUAD1
K41V40LSKCM1
R26R26HSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for SRP9
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R26R26H-1.3043111
K41V40L-1.2536114
R26A25T-0.9159277
K60K61E-0.22637246
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SRP9 from PDB

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Differential gene expression and gene-gene network for SRP9
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SRP9 and the right PPI network was created from samples without mutations in the LBS of SRP9. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for SRP9
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for SRP9
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SRP9 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids1e8oAK60
NUCNucleic Acids1e8oCR26
NUCNucleic Acids1ry1CR26
NUCNucleic Acids1ry1CR26
NUCNucleic Acids4uyjAR26
NUCNucleic Acids4uyjCR26 K41
NUCNucleic Acids4uykAR26 K41
NUCNucleic Acids5aoxAR26 K41
NUCNucleic Acids5aoxDR26 K41


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Conservation information for LBS of SRP9
Multiple alignments for P49458 in multiple species
LBSAA sequence# speciesSpecies


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