mutLBSgeneDB |
Gene summary for SRP9 |
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Basic gene Info. | Gene symbol | SRP9 |
Gene name | signal recognition particle 9kDa | |
Synonyms | ALURBP | |
Cytomap | UCSC genome browser: 1q42.12 | |
Type of gene | protein-coding | |
RefGenes | NM_001130440.1, NM_003133.5, | |
Description | signal recognition particle 9 kDa proteinsignal recognition particle 9kD | |
Modification date | 20141207 | |
dbXrefs | MIM : 600707 | |
HGNC : HGNC | ||
Ensembl : ENSG00000143742 | ||
HPRD : 02830 | ||
Vega : OTTHUMG00000037738 | ||
Protein | UniProt: P49458 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SRP9 | |
BioGPS: 6726 | ||
Pathway | NCI Pathway Interaction Database: SRP9 | |
KEGG: SRP9 | ||
REACTOME: SRP9 | ||
Pathway Commons: SRP9 | ||
Context | iHOP: SRP9 | |
ligand binding site mutation search in PubMed: SRP9 | ||
UCL Cancer Institute: SRP9 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for SRP9 |
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LBS | AAchange of nsSNV | Cancer type | # samples | R26 | A25T | KIRC | 1 | K60 | K61E | LUAD | 1 | K41 | V40L | SKCM | 1 | R26 | R26H | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for SRP9 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R26 | R26H | -1.3043111 | K41 | V40L | -1.2536114 | R26 | A25T | -0.9159277 | K60 | K61E | -0.22637246 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for SRP9 |
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Phenotype information for SRP9 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for SRP9 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 1e8o | A | K60 | NUC | Nucleic Acids | 1e8o | C | R26 | NUC | Nucleic Acids | 1ry1 | C | R26 | NUC | Nucleic Acids | 1ry1 | C | R26 | NUC | Nucleic Acids | 4uyj | A | R26 | NUC | Nucleic Acids | 4uyj | C | R26 K41 | NUC | Nucleic Acids | 4uyk | A | R26 K41 | NUC | Nucleic Acids | 5aox | A | R26 K41 | NUC | Nucleic Acids | 5aox | D | R26 K41 |
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Conservation information for LBS of SRP9 |
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LBS | AA sequence | # species | Species |
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