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mutLBSgeneDB |
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| Gene summary for SRP14 |
 Gene summary |
| Basic gene Info. | Gene symbol | SRP14 |
| Gene name | signal recognition particle 14kDa (homologous Alu RNA binding protein) | |
| Synonyms | ALURBP | |
| Cytomap | UCSC genome browser: 15q22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003134.4, NR_104021.1, | |
| Description | 18 kDa Alu RNA-binding proteinsignal recognition particle 14 kDa protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600708 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000140319 | ||
| HPRD : 02831 | ||
| Vega : OTTHUMG00000172391 | ||
| Protein | UniProt: P37108 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SRP14 | |
| BioGPS: 6727 | ||
| Pathway | NCI Pathway Interaction Database: SRP14 | |
| KEGG: SRP14 | ||
| REACTOME: SRP14 | ||
| Pathway Commons: SRP14 | ||
| Context | iHOP: SRP14 | |
| ligand binding site mutation search in PubMed: SRP14 | ||
| UCL Cancer Institute: SRP14 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0042493 | response to drug | 18089836 |
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| Ligand binding site mutations for SRP14 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L57 | K55T | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for SRP14 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | L57 | K55T | -0.33014065 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SRP14 from PDB |
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| Differential gene expression and gene-gene network for SRP14 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SRP14 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SRP14 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SRP14 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 1e8o | D | L57 | NUC | Nucleic Acids | 1ry1 | D | L57 | NUC | Nucleic Acids | 4uyj | D | L57 | NUC | Nucleic Acids | 5aox | B | L57 | NUC | Nucleic Acids | 5aox | E | L57 |
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| Conservation information for LBS of SRP14 |
| Multiple alignments for P37108 in multiple species |
| LBS | AA sequence | # species | Species | G24 | KCRLSGSVFIT | 2 | Canis lupus familiaris, Bos taurus | G24 | KCRTSGSVYIT | 1 | Homo sapiens | G24 | KCRSSGSVFIT | 1 | Mus musculus | G63 | LRATDGKKKIS | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | G63 | LRATDGKRKIS | 1 | Mus musculus | K31 | VFITLKKYDGR | 3 | Mus musculus, Canis lupus familiaris, Bos taurus | K31 | VYITLKKYDGR | 1 | Homo sapiens | K64 | RATDGKKKIST | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | K64 | RATDGKRKIST | 1 | Mus musculus | K66 | TDGKKKISTVV | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | K66 | TDGKRKISTVV | 1 | Mus musculus | L57 | SDNKCLLRATD | 2 | Canis lupus familiaris, Bos taurus | L57 | ADNKCLLRATD | 1 | Homo sapiens | L57 | AENKCLLRATD | 1 | Mus musculus | M1 | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | N77 | SSKEVNKFQMA | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | Q80 | EVNKFQMAYSN | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | R36 | KKYDGRTKPIP | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | R59 | NKCLLRATDGK | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | S23 | QKCRLSGSVFI | 2 | Canis lupus familiaris, Bos taurus | S23 | QKCRTSGSVYI | 1 | Homo sapiens | S23 | QKCRSSGSVFI | 1 | Mus musculus | S25 | CRLSGSVFITL | 2 | Canis lupus familiaris, Bos taurus | S25 | CRTSGSVYITL | 1 | Homo sapiens | S25 | CRSSGSVFITL | 1 | Mus musculus | S73 | STVVSSKEVNK | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | V2 | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | V76 | VSSKEVNKFQM | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | Y27 | LSGSVFITLKK | 2 | Canis lupus familiaris, Bos taurus | Y27 | TSGSVYITLKK | 1 | Homo sapiens | Y27 | SSGSVFITLKK | 1 | Mus musculus | Y33 | ITLKKYDGRTK | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus |
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