mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SRP14
Gene summary
Basic gene Info.Gene symbolSRP14
Gene namesignal recognition particle 14kDa (homologous Alu RNA binding protein)
CytomapUCSC genome browser: 15q22
Type of geneprotein-coding
Description18 kDa Alu RNA-binding proteinsignal recognition particle 14 kDa protein
Modification date20141207
dbXrefs MIM : 600708
Ensembl : ENSG00000140319
HPRD : 02831
Vega : OTTHUMG00000172391
ProteinUniProt: P37108
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SRP14
BioGPS: 6727
PathwayNCI Pathway Interaction Database: SRP14
Pathway Commons: SRP14
ContextiHOP: SRP14
ligand binding site mutation search in PubMed: SRP14
UCL Cancer Institute: SRP14
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0042493response to drug18089836

Ligand binding site mutations for SRP14
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for SRP14
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SRP14 from PDB

Differential gene expression and gene-gene network for SRP14
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SRP14 and the right PPI network was created from samples without mutations in the LBS of SRP14. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for SRP14
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for SRP14
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SRP14 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids1e8oDL57
NUCNucleic Acids1ry1DL57
NUCNucleic Acids4uyjDL57
NUCNucleic Acids5aoxBL57
NUCNucleic Acids5aoxEL57

Conservation information for LBS of SRP14
Multiple alignments for P37108 in multiple species
LBSAA sequence# speciesSpecies
G24KCRLSGSVFIT2Canis lupus familiaris, Bos taurus
G24KCRTSGSVYIT1Homo sapiens
G24KCRSSGSVFIT1Mus musculus
G63LRATDGKKKIS3Homo sapiens, Canis lupus familiaris, Bos taurus
G63LRATDGKRKIS1Mus musculus
K31VFITLKKYDGR3Mus musculus, Canis lupus familiaris, Bos taurus
K31VYITLKKYDGR1Homo sapiens
K64RATDGKKKIST3Homo sapiens, Canis lupus familiaris, Bos taurus
K64RATDGKRKIST1Mus musculus
K66TDGKKKISTVV3Homo sapiens, Canis lupus familiaris, Bos taurus
K66TDGKRKISTVV1Mus musculus
L57SDNKCLLRATD2Canis lupus familiaris, Bos taurus
L57ADNKCLLRATD1Homo sapiens
L57AENKCLLRATD1Mus musculus
M14Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
N77SSKEVNKFQMA4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
Q80EVNKFQMAYSN4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
R36KKYDGRTKPIP4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
R59NKCLLRATDGK4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
S23QKCRLSGSVFI2Canis lupus familiaris, Bos taurus
S23QKCRTSGSVYI1Homo sapiens
S23QKCRSSGSVFI1Mus musculus
S25CRLSGSVFITL2Canis lupus familiaris, Bos taurus
S25CRTSGSVYITL1Homo sapiens
S25CRSSGSVFITL1Mus musculus
S73STVVSSKEVNK4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
V24Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
V76VSSKEVNKFQM4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus
Y27LSGSVFITLKK2Canis lupus familiaris, Bos taurus
Y27TSGSVYITLKK1Homo sapiens
Y27SSGSVFITLKK1Mus musculus
Y33ITLKKYDGRTK4Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus

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