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mutLBSgeneDB |
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| Gene summary for SRP68 |
 Gene summary |
| Basic gene Info. | Gene symbol | SRP68 |
| Gene name | signal recognition particle 68kDa | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 17q25.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001260502.1, NM_001260503.1,NM_014230.3,NR_048541.1, | |
| Description | signal recognition particle 68 kDa proteinsignal recognition particle 68kDsignal recognition particle subunit SRP68 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604858 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000167881 | ||
| HPRD : 05331 | ||
| Vega : OTTHUMG00000180054 | ||
| Protein | UniProt: Q9UHB9 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SRP68 | |
| BioGPS: 6730 | ||
| Pathway | NCI Pathway Interaction Database: SRP68 | |
| KEGG: SRP68 | ||
| REACTOME: SRP68 | ||
| Pathway Commons: SRP68 | ||
| Context | iHOP: SRP68 | |
| ligand binding site mutation search in PubMed: SRP68 | ||
| UCL Cancer Institute: SRP68 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0042493 | response to drug | 18089836 |
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| Ligand binding site mutations for SRP68 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Q81 | Q81R | BLCA | 1 | R150 | R150Q | COAD | 1 | R133 | W135C | HNSC | 1 | K161 | R160L | STAD | 1 | F153,K151 | R152Q | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for SRP68 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R150 | R150Q | -0.97661503 | K161 | R160L | -0.95370887 | F153 | R152Q | -0.87080409 | K151 | R152Q | -0.87080409 | R133 | W135C | -0.67696873 | Q81 | Q81R | -0.5767916 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SRP68 from PDB |
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| Differential gene expression and gene-gene network for SRP68 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SRP68 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0311375 | Arsenic Poisoning | 1 | Biomarker |
| umls:C0376634 | Craniofacial Abnormalities | 1 | Biomarker |
| umls:C0037274 | Skin Diseases | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SRP68 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SRP68 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 4p3e | C | R150 |
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| Conservation information for LBS of SRP68 |
| Multiple alignments for Q9UHB9 in multiple species |
| LBS | AA sequence | # species | Species | F153 | -PRKRFHLLSR | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | F153 | KSRKKFSMINS | 1 | Caenorhabditis elegans | F153 | -PRKRFHLVNK | 1 | Drosophila melanogaster | H154 | PRKRFHLLSRL | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | H154 | SRKKFSMINSL | 1 | Caenorhabditis elegans | H154 | PRKRFHLVNKL | 1 | Drosophila melanogaster | K151 | TE-PRKRFHLL | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | K151 | PEKSRKKFSMI | 1 | Caenorhabditis elegans | K151 | TE-PRKRFHLV | 1 | Drosophila melanogaster | K161 | LSRLRKAVKHA | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | K161 | INSLRKAVLHA | 1 | Caenorhabditis elegans | K161 | VNKLRRACFYA | 1 | Drosophila melanogaster | K164 | LRKAVKHAEEL | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | K164 | LRKAVLHATNL | 1 | Caenorhabditis elegans | K164 | LRRACFYALQL | 1 | Drosophila melanogaster | Q81 | RHGDFQRYRGY | 4 | Homo sapiens, Drosophila melanogaster, Mus musculus, Canis lupus familiaris | Q81 | RHGDYARYRKY | 1 | Caenorhabditis elegans | Q91 | YCSRRQRRLRK | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | Q91 | YCAAKLERMRK | 1 | Caenorhabditis elegans | Q91 | YCSRRIRRLRK | 1 | Drosophila melanogaster | R122 | ---DNRYLLLV | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | R122 | ---NVQFLNFG | 1 | Caenorhabditis elegans | R122 | KKADERFIHIP | 1 | Drosophila melanogaster | R133 | LMDAERAWSYA | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | R133 | IFESERRYAEA | 1 | Caenorhabditis elegans | R133 | LICAERAWAYA | 1 | Drosophila melanogaster | R150 | NTE-PRKRFHL | 4 | Homo sapiens, Drosophila melanogaster, Mus musculus, Canis lupus familiaris | R150 | NPEKSRKKFSM | 1 | Caenorhabditis elegans | R158 | FHLLSRLRKAV | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | R158 | FSMINSLRKAV | 1 | Caenorhabditis elegans | R158 | FHLVNKLRRAC | 1 | Drosophila melanogaster | R82 | HGDFQRYRGYC | 4 | Homo sapiens, Drosophila melanogaster, Mus musculus, Canis lupus familiaris | R82 | HGDYARYRKYC | 1 | Caenorhabditis elegans | R84 | DFQRYRGYCSR | 4 | Homo sapiens, Drosophila melanogaster, Mus musculus, Canis lupus familiaris | R84 | DYARYRKYCAA | 1 | Caenorhabditis elegans | R89 | RGYCSRRQRRL | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | R89 | RKYCAAKLERM | 1 | Caenorhabditis elegans | R89 | RGYCSRRIRRL | 1 | Drosophila melanogaster | R90 | GYCSRRQRRLR | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | R90 | KYCAAKLERMR | 1 | Caenorhabditis elegans | R90 | GYCSRRIRRLR | 1 | Drosophila melanogaster | R92 | CSRRQRRLRKT | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | R92 | CAAKLERMRKA | 1 | Caenorhabditis elegans | R92 | CSRRIRRLRKA | 1 | Drosophila melanogaster | R93 | SRRQRRLRKTL | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | R93 | AAKLERMRKAL | 1 | Caenorhabditis elegans | R93 | SRRIRRLRKAL | 1 | Drosophila melanogaster | R95 | RQRRLRKTLNF | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | R95 | KLERMRKALKF | 1 | Caenorhabditis elegans | R95 | RIRRLRKALKY | 1 | Drosophila melanogaster | S157 | RFHLLSRLRKA | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | S157 | KFSMINSLRKA | 1 | Caenorhabditis elegans | S157 | RFHLVNKLRRA | 1 | Drosophila melanogaster | S88 | YRGYCSRRQRR | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | S88 | YRKYCAAKLER | 1 | Caenorhabditis elegans | S88 | YRGYCSRRIRR | 1 | Drosophila melanogaster | Y86 | QRYRGYCSRRQ | 3 | Homo sapiens, Mus musculus, Canis lupus familiaris | Y86 | ARYRKYCAAKL | 1 | Caenorhabditis elegans | Y86 | QRYRGYCSRRI | 1 | Drosophila melanogaster |
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