mutLBSgeneDB |
Gene summary for SSB |
Gene summary |
Basic gene Info. | Gene symbol | SSB |
Gene name | Sjogren syndrome antigen B (autoantigen La) | |
Synonyms | LARP3|La|La/SSB | |
Cytomap | UCSC genome browser: 2q31.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001294145.1, NM_003142.4, | |
Description | La ribonucleoprotein domain family, member 3SS-BSS-B/La proteinautoantigen Lala autoantigenlupus La antigenlupus La proteinsjoegren syndrome type B antigen | |
Modification date | 20141207 | |
dbXrefs | MIM : 109090 | |
HGNC : HGNC | ||
Ensembl : ENSG00000138385 | ||
HPRD : 00168 | ||
Vega : OTTHUMG00000132212 | ||
Protein | UniProt: P05455 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SSB | |
BioGPS: 6741 | ||
Pathway | NCI Pathway Interaction Database: SSB | |
KEGG: SSB | ||
REACTOME: SSB | ||
Pathway Commons: SSB | ||
Context | iHOP: SSB | |
ligand binding site mutation search in PubMed: SSB | ||
UCL Cancer Institute: SSB | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for SSB |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | N139 | V137L | PRAD | 1 | R32 | R32Q | UCEC | 1 | F35 | L36P | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for SSB |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R32 | R32Q | -1.5325287 | F35 | L36P | -1.3539768 | N139 | V137L | -0.75050023 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for SSB from PDB |
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Differential gene expression and gene-gene network for SSB |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for SSB |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for SSB |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of SSB go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 1zh5 | B | F35 | NUC | Nucleic Acids | 2vod | A | F35 N139 | NUC | Nucleic Acids | 2vod | B | F35 N139 | NUC | Nucleic Acids | 2von | A | F35 N139 | NUC | Nucleic Acids | 2von | B | F35 N139 | NUC | Nucleic Acids | 2voo | A | F35 N139 | NUC | Nucleic Acids | 2voo | B | F35 N139 | NUC | Nucleic Acids | 2vop | A | F35 N139 | NUC | Nucleic Acids | 1yty | A | R32 N139 | NUC | Nucleic Acids | 1yty | B | R32 N139 |
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Conservation information for LBS of SSB |
Multiple alignments for P05455 in multiple species |
LBS | AA sequence | # species | Species | D33 | FNLPRDKFLKE | 3 | Homo sapiens, Mus musculus, Bos taurus | D33 | ANLNRDKFLRE | 1 | Drosophila melanogaster | F28 | YYFGDFNLPRD | 3 | Homo sapiens, Mus musculus, Bos taurus | F28 | YYFGDANLNRD | 1 | Drosophila melanogaster | F35 | LPRDKFLKEQI | 3 | Homo sapiens, Mus musculus, Bos taurus | F35 | LNRDKFLREQI | 1 | Drosophila melanogaster | F55 | EIMIKFNRLNR | 2 | Homo sapiens, Bos taurus | F55 | SVLVTFKRLAS | 1 | Drosophila melanogaster | F55 | ETMIKFNRLNR | 1 | Mus musculus | I140 | GQVLNIQMRRT | 2 | Homo sapiens, Bos taurus | I140 | DKVVNLTMRKH | 1 | Drosophila melanogaster | I140 | GQILNIQMRRT | 1 | Mus musculus | K105 | VTDEYKNDVKN | 3 | Homo sapiens, Mus musculus, Bos taurus | K105 | HNEERRKEIQE | 1 | Drosophila melanogaster | K185 | LLILFKDDYFA | 1 | Homo sapiens | K185 | LLRKWQVDYLK | 1 | Drosophila melanogaster | K185 | LLILFKEDYFA | 1 | Mus musculus | K185 | LLILFKEDYFT | 1 | Bos taurus | K34 | NLPRDKFLKEQ | 3 | Homo sapiens, Mus musculus, Bos taurus | K34 | NLNRDKFLREQ | 1 | Drosophila melanogaster | K54 | LEIMIKFNRLN | 2 | Homo sapiens, Bos taurus | K54 | LSVLVTFKRLA | 1 | Drosophila melanogaster | K54 | LETMIKFNRLN | 1 | Mus musculus | L124 | PTDATLDDIKE | 2 | Homo sapiens, Mus musculus | L124 | PLDSQISELLD | 1 | Drosophila melanogaster | L124 | PTDAALDDIKE | 1 | Bos taurus | L146 | QMRRTLHKA-- | 2 | Homo sapiens, Bos taurus | L146 | TMRKHYDKPTK | 1 | Drosophila melanogaster | L146 | QMRRTLHKT-- | 1 | Mus musculus | N139 | KGQVLNIQMRR | 2 | Homo sapiens, Bos taurus | N139 | YDKVVNLTMRK | 1 | Drosophila melanogaster | N139 | KGQILNIQMRR | 1 | Mus musculus | N56 | IMIKFNRLNRL | 2 | Homo sapiens, Bos taurus | N56 | VLVTFKRLASL | 1 | Drosophila melanogaster | N56 | TMIKFNRLNRL | 1 | Mus musculus | Q141 | QVLNIQMRRTL | 2 | Homo sapiens, Bos taurus | Q141 | KVVNLTMRKHY | 1 | Drosophila melanogaster | Q141 | QILNIQMRRTL | 1 | Mus musculus | Q20 | AKICHQIEYYF | 3 | Homo sapiens, Mus musculus, Bos taurus | Q20 | RAIIRQVEYYF | 1 | Drosophila melanogaster | R32 | DFNLPRDKFLK | 3 | Homo sapiens, Mus musculus, Bos taurus | R32 | DANLNRDKFLR | 1 | Drosophila melanogaster | R57 | MIKFNRLNRLT | 3 | Homo sapiens, Mus musculus, Bos taurus | R57 | LVTFKRLASLS | 1 | Drosophila melanogaster | V100 | KPLPEVTDEYK | 2 | Homo sapiens, Bos taurus | V100 | RPIPEHNEERR | 1 | Drosophila melanogaster | V100 | RPLPEVTDEYK | 1 | Mus musculus | V108 | EYKNDVKNRSV | 3 | Homo sapiens, Mus musculus, Bos taurus | V108 | ERRKEIQERTA | 1 | Drosophila melanogaster | Y104 | EVTDEYKNDVK | 3 | Homo sapiens, Mus musculus, Bos taurus | Y104 | EHNEERRKEIQ | 1 | Drosophila melanogaster | Y23 | CHQIEYYFGDF | 3 | Homo sapiens, Mus musculus, Bos taurus | Y23 | IRQVEYYFGDA | 1 | Drosophila melanogaster | Y24 | HQIEYYFGDFN | 3 | Homo sapiens, Mus musculus, Bos taurus | Y24 | RQVEYYFGDAN | 1 | Drosophila melanogaster |
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