mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SSB
Gene summary
Basic gene Info.Gene symbolSSB
Gene nameSjogren syndrome antigen B (autoantigen La)
CytomapUCSC genome browser: 2q31.1
Type of geneprotein-coding
DescriptionLa ribonucleoprotein domain family, member 3SS-BSS-B/La proteinautoantigen Lala autoantigenlupus La antigenlupus La proteinsjoegren syndrome type B antigen
Modification date20141207
dbXrefs MIM : 109090
Ensembl : ENSG00000138385
HPRD : 00168
Vega : OTTHUMG00000132212
ProteinUniProt: P05455
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SSB
BioGPS: 6741
PathwayNCI Pathway Interaction Database: SSB
Pathway Commons: SSB
ContextiHOP: SSB
ligand binding site mutation search in PubMed: SSB
UCL Cancer Institute: SSB
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for SSB

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for SSB
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SSB from PDB

Differential gene expression and gene-gene network for SSB
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SSB and the right PPI network was created from samples without mutations in the LBS of SSB. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for SSB
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for SSB
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SSB go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids1zh5BF35
NUCNucleic Acids2vodAF35 N139
NUCNucleic Acids2vodBF35 N139
NUCNucleic Acids2vonAF35 N139
NUCNucleic Acids2vonBF35 N139
NUCNucleic Acids2vooAF35 N139
NUCNucleic Acids2vooBF35 N139
NUCNucleic Acids2vopAF35 N139
NUCNucleic Acids1ytyAR32 N139
NUCNucleic Acids1ytyBR32 N139

Conservation information for LBS of SSB
Multiple alignments for P05455 in multiple species
LBSAA sequence# speciesSpecies
D33FNLPRDKFLKE3Homo sapiens, Mus musculus, Bos taurus
D33ANLNRDKFLRE1Drosophila melanogaster
F28YYFGDFNLPRD3Homo sapiens, Mus musculus, Bos taurus
F28YYFGDANLNRD1Drosophila melanogaster
F35LPRDKFLKEQI3Homo sapiens, Mus musculus, Bos taurus
F35LNRDKFLREQI1Drosophila melanogaster
F55EIMIKFNRLNR2Homo sapiens, Bos taurus
F55SVLVTFKRLAS1Drosophila melanogaster
F55ETMIKFNRLNR1Mus musculus
I140GQVLNIQMRRT2Homo sapiens, Bos taurus
I140DKVVNLTMRKH1Drosophila melanogaster
I140GQILNIQMRRT1Mus musculus
K105VTDEYKNDVKN3Homo sapiens, Mus musculus, Bos taurus
K105HNEERRKEIQE1Drosophila melanogaster
K185LLILFKDDYFA1Homo sapiens
K185LLRKWQVDYLK1Drosophila melanogaster
K185LLILFKEDYFA1Mus musculus
K185LLILFKEDYFT1Bos taurus
K34NLPRDKFLKEQ3Homo sapiens, Mus musculus, Bos taurus
K34NLNRDKFLREQ1Drosophila melanogaster
K54LEIMIKFNRLN2Homo sapiens, Bos taurus
K54LSVLVTFKRLA1Drosophila melanogaster
K54LETMIKFNRLN1Mus musculus
L124PTDATLDDIKE2Homo sapiens, Mus musculus
L124PLDSQISELLD1Drosophila melanogaster
L124PTDAALDDIKE1Bos taurus
L146QMRRTLHKA--2Homo sapiens, Bos taurus
L146TMRKHYDKPTK1Drosophila melanogaster
L146QMRRTLHKT--1Mus musculus
N139KGQVLNIQMRR2Homo sapiens, Bos taurus
N139YDKVVNLTMRK1Drosophila melanogaster
N139KGQILNIQMRR1Mus musculus
N56IMIKFNRLNRL2Homo sapiens, Bos taurus
N56VLVTFKRLASL1Drosophila melanogaster
N56TMIKFNRLNRL1Mus musculus
Q141QVLNIQMRRTL2Homo sapiens, Bos taurus
Q141KVVNLTMRKHY1Drosophila melanogaster
Q141QILNIQMRRTL1Mus musculus
Q20AKICHQIEYYF3Homo sapiens, Mus musculus, Bos taurus
Q20RAIIRQVEYYF1Drosophila melanogaster
R32DFNLPRDKFLK3Homo sapiens, Mus musculus, Bos taurus
R32DANLNRDKFLR1Drosophila melanogaster
R57MIKFNRLNRLT3Homo sapiens, Mus musculus, Bos taurus
R57LVTFKRLASLS1Drosophila melanogaster
V100KPLPEVTDEYK2Homo sapiens, Bos taurus
V100RPIPEHNEERR1Drosophila melanogaster
V100RPLPEVTDEYK1Mus musculus
V108EYKNDVKNRSV3Homo sapiens, Mus musculus, Bos taurus
V108ERRKEIQERTA1Drosophila melanogaster
Y104EVTDEYKNDVK3Homo sapiens, Mus musculus, Bos taurus
Y104EHNEERRKEIQ1Drosophila melanogaster
Y23CHQIEYYFGDF3Homo sapiens, Mus musculus, Bos taurus
Y23IRQVEYYFGDA1Drosophila melanogaster
Y24HQIEYYFGDFN3Homo sapiens, Mus musculus, Bos taurus
Y24RQVEYYFGDAN1Drosophila melanogaster

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