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mutLBSgeneDB |
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| Gene summary for ST14 |
 Gene summary |
| Basic gene Info. | Gene symbol | ST14 |
| Gene name | suppression of tumorigenicity 14 (colon carcinoma) | |
| Synonyms | ARCI11|HAI|MT-SP1|MTSP1|PRSS14|SNC19|TADG15|TMPRSS14 | |
| Cytomap | UCSC genome browser: 11q24-q25 | |
| Type of gene | protein-coding | |
| RefGenes | NM_021978.3, | |
| Description | membrane-type serine protease 1prostaminserine protease 14serine protease TADG-15suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)suppressor of tumorigenicity 14 proteintumor associated differentially expressed gene 15 protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606797 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000149418 | ||
| HPRD : 06005 | ||
| Vega : OTTHUMG00000165768 | ||
| Protein | UniProt: Q9Y5Y6 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ST14 | |
| BioGPS: 6768 | ||
| Pathway | NCI Pathway Interaction Database: ST14 | |
| KEGG: ST14 | ||
| REACTOME: ST14 | ||
| Pathway Commons: ST14 | ||
| Context | iHOP: ST14 | |
| ligand binding site mutation search in PubMed: ST14 | ||
| UCL Cancer Institute: ST14 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006508 | proteolysis | 19911255 |
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| Ligand binding site mutations for ST14 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Q783 | I784V | COAD | 1 | H656 | H656P | OV | 1 | E625 | E625K | SKCM | 1 | R728 | R728W | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ST14 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E625 | E625K | -1.2080611 | Q783 | I784V | -0.91756576 | R728 | R728W | -0.70044591 | H656 | H656P | -0.49408183 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ST14 from PDB |
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| Differential gene expression and gene-gene network for ST14 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ST14 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1835851 | Ichthyosis with hypotrichosis, autosomal recessive | 5 | Biomarker, GeneticVariation |
| umls:C0033578 | Prostatic Neoplasms | 5 | AlteredExpression, Biomarker |
| umls:C0265962 | Netherton Syndrome | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ST14 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational|withdrawn | DB00013 | Urokinase | Biotech |  |
| Experimental | DB03127 | Benzamidine | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ST14 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of ST14 |
| Multiple alignments for Q9Y5Y6 in multiple species |
| LBS | AA sequence | # species | Species | C641 | GQGHICGASLI | 1 | Homo sapiens | C641 | GHGHLCGASLI | 1 | Bos taurus | C641 | GQGHLCGASLI | 1 | Mus musculus | C657 | VSAAHCYIDDR | 1 | Homo sapiens | C657 | ISAAHCFVDDR | 1 | Bos taurus | C657 | VSAAHCFQDDK | 1 | Mus musculus | C731 | MVRPICLPDAS | 1 | Homo sapiens | C731 | TIRPICLPAAD | 1 | Bos taurus | C731 | VVRPICLPDAT | 1 | Mus musculus | C801 | GGVDSCQGDSG | 2 | Homo sapiens, Mus musculus | C801 | GGVDACQGDSG | 1 | Bos taurus | C830 | SWGEGCAQRNK | 2 | Bos taurus, Mus musculus | C830 | SWGDGCAQRNK | 1 | Homo sapiens | D661 | HCYIDDRGFRY | 1 | Homo sapiens | D661 | HCFVDDRGFRY | 1 | Bos taurus | D661 | HCFQDDKNFKY | 1 | Mus musculus | D799 | LSGGVDSCQGD | 2 | Homo sapiens, Mus musculus | D799 | LSGGVDACQGD | 1 | Bos taurus | D804 | DSCQGDSGGPL | 2 | Homo sapiens, Mus musculus | D804 | DACQGDSGGPL | 1 | Bos taurus | D828 | VVSWGEGCAQR | 2 | Bos taurus, Mus musculus | D828 | VVSWGDGCAQR | 1 | Homo sapiens | E625 | DADEGEWPWQV | 1 | Homo sapiens | E625 | NSDQGEWPWQV | 1 | Bos taurus | E625 | NADEGEWPWQV | 1 | Mus musculus | F706 | PFFNDFTFDYD | 2 | Homo sapiens, Bos taurus | F706 | PSFNDFTFDYD | 1 | Mus musculus | F708 | FNDFTFDYDIA | 3 | Homo sapiens, Bos taurus, Mus musculus | G624 | TDADEGEWPWQ | 1 | Homo sapiens | G624 | ENSDQGEWPWQ | 1 | Bos taurus | G624 | TNADEGEWPWQ | 1 | Mus musculus | G803 | VDSCQGDSGGP | 2 | Homo sapiens, Mus musculus | G803 | VDACQGDSGGP | 1 | Bos taurus | G816 | SVEADGRIFQA | 1 | Homo sapiens | G816 | SPEEDGRMFQA | 1 | Bos taurus | G816 | SAEKDGRMFQA | 1 | Mus musculus | G827 | GVVSWGEGCAQ | 2 | Bos taurus, Mus musculus | G827 | GVVSWGDGCAQ | 1 | Homo sapiens | G829 | VSWGEGCAQRN | 2 | Bos taurus, Mus musculus | G829 | VSWGDGCAQRN | 1 | Homo sapiens | G837 | QRNKPGVYTRL | 3 | Homo sapiens, Bos taurus, Mus musculus | H656 | LVSAAHCYIDD | 1 | Homo sapiens | H656 | MISAAHCFVDD | 1 | Bos taurus | H656 | LVSAAHCFQDD | 1 | Mus musculus | I640 | LGQGHICGASL | 1 | Homo sapiens | I640 | QGHGHLCGASL | 1 | Bos taurus | I640 | LGQGHLCGASL | 1 | Mus musculus | I659 | AAHCYIDDRGF | 1 | Homo sapiens | I659 | AAHCFVDDRGF | 1 | Bos taurus | I659 | AAHCFQDDKNF | 1 | Mus musculus | I730 | SMVRPICLPDA | 1 | Homo sapiens | I730 | ATIRPICLPAA | 1 | Bos taurus | I730 | TVVRPICLPDA | 1 | Mus musculus | I818 | EADGRIFQAGV | 1 | Homo sapiens | I818 | EEDGRMFQAGV | 1 | Bos taurus | I818 | EKDGRMFQAGV | 1 | Mus musculus | P627 | DEGEWPWQVSL | 2 | Homo sapiens, Mus musculus | P627 | DQGEWPWQVSL | 1 | Bos taurus | P729 | SSMVRPICLPD | 1 | Homo sapiens | P729 | SATIRPICLPA | 1 | Bos taurus | P729 | STVVRPICLPD | 1 | Mus musculus | Q783 | NLLPQQITPRM | 1 | Homo sapiens | Q783 | HLLPQQITPRM | 1 | Bos taurus | Q783 | DLMPQQITPRM | 1 | Mus musculus | Q802 | GVDSCQGDSGG | 2 | Homo sapiens, Mus musculus | Q802 | GVDACQGDSGG | 1 | Bos taurus | R728 | YSSMVRPICLP | 1 | Homo sapiens | R728 | YSATIRPICLP | 1 | Bos taurus | R728 | YSTVVRPICLP | 1 | Mus musculus | R817 | VEADGRIFQAG | 1 | Homo sapiens | R817 | PEEDGRMFQAG | 1 | Bos taurus | R817 | AEKDGRMFQAG | 1 | Mus musculus | S800 | SGGVDSCQGDS | 2 | Homo sapiens, Mus musculus | S800 | SGGVDACQGDS | 1 | Bos taurus | S805 | SCQGDSGGPLS | 2 | Homo sapiens, Mus musculus | S805 | ACQGDSGGPLS | 1 | Bos taurus | S825 | QAGVVSWGEGC | 2 | Bos taurus, Mus musculus | S825 | QAGVVSWGDGC | 1 | Homo sapiens | T707 | FFNDFTFDYDI | 2 | Homo sapiens, Bos taurus | T707 | SFNDFTFDYDI | 1 | Mus musculus | V824 | FQAGVVSWGEG | 2 | Bos taurus, Mus musculus | V824 | FQAGVVSWGDG | 1 | Homo sapiens | W628 | EGEWPWQVSLH | 2 | Homo sapiens, Mus musculus | W628 | QGEWPWQVSLH | 1 | Bos taurus | W826 | AGVVSWGEGCA | 2 | Bos taurus, Mus musculus | W826 | AGVVSWGDGCA | 1 | Homo sapiens | Y666 | DRGFRYSDPTQ | 1 | Homo sapiens | Y666 | DRGFRYSEHSV | 1 | Bos taurus | Y666 | DKNFKYSDYTM | 1 | Mus musculus | Y723 | EKPAEYSSMVR | 1 | Homo sapiens | Y723 | DRPVEYSATIR | 1 | Bos taurus | Y723 | EKSVEYSTVVR | 1 | Mus musculus | Y755 | WGHTQYGGTGA | 1 | Homo sapiens | Y755 | WGHTQEAGQGA | 1 | Bos taurus | Y755 | WGHTKEGGTGA | 1 | Mus musculus |
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