mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ST14
Gene summary
Basic gene Info.Gene symbolST14
Gene namesuppression of tumorigenicity 14 (colon carcinoma)
CytomapUCSC genome browser: 11q24-q25
Type of geneprotein-coding
Descriptionmembrane-type serine protease 1prostaminserine protease 14serine protease TADG-15suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)suppressor of tumorigenicity 14 proteintumor associated differentially expressed gene 15 protein
Modification date20141207
dbXrefs MIM : 606797
Ensembl : ENSG00000149418
HPRD : 06005
Vega : OTTHUMG00000165768
ProteinUniProt: Q9Y5Y6
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ST14
BioGPS: 6768
PathwayNCI Pathway Interaction Database: ST14
Pathway Commons: ST14
ContextiHOP: ST14
ligand binding site mutation search in PubMed: ST14
UCL Cancer Institute: ST14
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for ST14
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ST14
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ST14 from PDB

Differential gene expression and gene-gene network for ST14
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ST14 and the right PPI network was created from samples without mutations in the LBS of ST14. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ST14
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1835851Ichthyosis with hypotrichosis, autosomal recessive5Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms5AlteredExpression, Biomarker
umls:C0265962Netherton Syndrome1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ST14
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB03127BenzamidineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ST14 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ST14
Multiple alignments for Q9Y5Y6 in multiple species
LBSAA sequence# speciesSpecies
C641GQGHICGASLI1Homo sapiens
C641GHGHLCGASLI1Bos taurus
C641GQGHLCGASLI1Mus musculus
C657VSAAHCYIDDR1Homo sapiens
C657ISAAHCFVDDR1Bos taurus
C657VSAAHCFQDDK1Mus musculus
C731MVRPICLPDAS1Homo sapiens
C731TIRPICLPAAD1Bos taurus
C731VVRPICLPDAT1Mus musculus
C801GGVDSCQGDSG2Homo sapiens, Mus musculus
C801GGVDACQGDSG1Bos taurus
C830SWGEGCAQRNK2Bos taurus, Mus musculus
C830SWGDGCAQRNK1Homo sapiens
D661HCYIDDRGFRY1Homo sapiens
D661HCFVDDRGFRY1Bos taurus
D661HCFQDDKNFKY1Mus musculus
D799LSGGVDSCQGD2Homo sapiens, Mus musculus
D799LSGGVDACQGD1Bos taurus
D804DSCQGDSGGPL2Homo sapiens, Mus musculus
D804DACQGDSGGPL1Bos taurus
D828VVSWGEGCAQR2Bos taurus, Mus musculus
D828VVSWGDGCAQR1Homo sapiens
E625DADEGEWPWQV1Homo sapiens
E625NSDQGEWPWQV1Bos taurus
E625NADEGEWPWQV1Mus musculus
F706PFFNDFTFDYD2Homo sapiens, Bos taurus
F706PSFNDFTFDYD1Mus musculus
F708FNDFTFDYDIA3Homo sapiens, Bos taurus, Mus musculus
G624TDADEGEWPWQ1Homo sapiens
G624ENSDQGEWPWQ1Bos taurus
G624TNADEGEWPWQ1Mus musculus
G803VDSCQGDSGGP2Homo sapiens, Mus musculus
G803VDACQGDSGGP1Bos taurus
G816SVEADGRIFQA1Homo sapiens
G816SPEEDGRMFQA1Bos taurus
G816SAEKDGRMFQA1Mus musculus
G827GVVSWGEGCAQ2Bos taurus, Mus musculus
G827GVVSWGDGCAQ1Homo sapiens
G829VSWGEGCAQRN2Bos taurus, Mus musculus
G829VSWGDGCAQRN1Homo sapiens
G837QRNKPGVYTRL3Homo sapiens, Bos taurus, Mus musculus
H656LVSAAHCYIDD1Homo sapiens
H656MISAAHCFVDD1Bos taurus
H656LVSAAHCFQDD1Mus musculus
I640LGQGHICGASL1Homo sapiens
I640QGHGHLCGASL1Bos taurus
I640LGQGHLCGASL1Mus musculus
I659AAHCYIDDRGF1Homo sapiens
I659AAHCFVDDRGF1Bos taurus
I659AAHCFQDDKNF1Mus musculus
I730SMVRPICLPDA1Homo sapiens
I730ATIRPICLPAA1Bos taurus
I730TVVRPICLPDA1Mus musculus
I818EADGRIFQAGV1Homo sapiens
I818EEDGRMFQAGV1Bos taurus
I818EKDGRMFQAGV1Mus musculus
P627DEGEWPWQVSL2Homo sapiens, Mus musculus
P627DQGEWPWQVSL1Bos taurus
P729SSMVRPICLPD1Homo sapiens
P729SATIRPICLPA1Bos taurus
P729STVVRPICLPD1Mus musculus
Q783NLLPQQITPRM1Homo sapiens
Q783HLLPQQITPRM1Bos taurus
Q783DLMPQQITPRM1Mus musculus
Q802GVDSCQGDSGG2Homo sapiens, Mus musculus
Q802GVDACQGDSGG1Bos taurus
R728YSSMVRPICLP1Homo sapiens
R728YSATIRPICLP1Bos taurus
R728YSTVVRPICLP1Mus musculus
R817VEADGRIFQAG1Homo sapiens
R817PEEDGRMFQAG1Bos taurus
R817AEKDGRMFQAG1Mus musculus
S800SGGVDSCQGDS2Homo sapiens, Mus musculus
S800SGGVDACQGDS1Bos taurus
S805SCQGDSGGPLS2Homo sapiens, Mus musculus
S805ACQGDSGGPLS1Bos taurus
S825QAGVVSWGEGC2Bos taurus, Mus musculus
S825QAGVVSWGDGC1Homo sapiens
T707FFNDFTFDYDI2Homo sapiens, Bos taurus
T707SFNDFTFDYDI1Mus musculus
V824FQAGVVSWGEG2Bos taurus, Mus musculus
V824FQAGVVSWGDG1Homo sapiens
W628EGEWPWQVSLH2Homo sapiens, Mus musculus
W628QGEWPWQVSLH1Bos taurus
W826AGVVSWGEGCA2Bos taurus, Mus musculus
W826AGVVSWGDGCA1Homo sapiens
Y666DRGFRYSDPTQ1Homo sapiens
Y666DRGFRYSEHSV1Bos taurus
Y666DKNFKYSDYTM1Mus musculus
Y723EKPAEYSSMVR1Homo sapiens
Y723DRPVEYSATIR1Bos taurus
Y723EKSVEYSTVVR1Mus musculus
Y755WGHTQYGGTGA1Homo sapiens
Y755WGHTQEAGQGA1Bos taurus
Y755WGHTKEGGTGA1Mus musculus

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