mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ZFP36L2
Gene summary
Basic gene Info.Gene symbolZFP36L2
Gene nameZFP36 ring finger protein-like 2
SynonymsBRF2|ERF-2|ERF2|RNF162C|TIS11D
CytomapUCSC genome browser: 2p22.3-p21
Type of geneprotein-coding
RefGenesNM_006887.4,
DescriptionEGF-response factor 2ZFP36-like 2butyrate response factor 2zinc finger protein 36, C3H type-like 1zinc finger protein 36, C3H type-like 2zinc finger protein 36, C3H1 type-like 2zinc finger protein, C3H type, 36-like 2
Modification date20141207
dbXrefs MIM : 612053
HGNC : HGNC
Ensembl : ENSG00000152518
HPRD : 18319
Vega : OTTHUMG00000128642
ProteinUniProt: P47974
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ZFP36L2
BioGPS: 678
PathwayNCI Pathway Interaction Database: ZFP36L2
KEGG: ZFP36L2
REACTOME: ZFP36L2
Pathway Commons: ZFP36L2
ContextiHOP: ZFP36L2
ligand binding site mutation search in PubMed: ZFP36L2
UCL Cancer Institute: ZFP36L2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for ZFP36L2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E157E157KBLCA1
K155K155NBLCA1
E157E157KBRCA1
L158L158PKIRC1
E157E157QLUSC1
P161P161RLUSC1
C168C168YSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ZFP36L2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
L158L158P-1.4146827
E157E157Q-1.2185839
E157E157K-1.1593041
K155K155N-0.69218729
P161P161R-0.60303323
C168C168Y-0.30105815
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ZFP36L2 from PDB

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Differential gene expression and gene-gene network for ZFP36L2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ZFP36L2 and the right PPI network was created from samples without mutations in the LBS of ZFP36L2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ZFP36L2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0033578Prostatic Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ZFP36L2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ZFP36L2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)1rgoAC168
NUCNucleic Acids1rgoAK155 E157 L158 P161


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Conservation information for LBS of ZFP36L2
Multiple alignments for P47974 in multiple species
LBSAA sequence# speciesSpecies
C159YKTELCRPFEE3Homo sapiens, Xenopus tropicalis, Mus musculus
C168EESGTCKYGEK2Homo sapiens, Mus musculus
C168EESGACKYGEK1Xenopus tropicalis
C174KYGEKCQFAHG3Homo sapiens, Xenopus tropicalis, Mus musculus
C197YKTELCRTFHT3Homo sapiens, Xenopus tropicalis, Mus musculus
C212PYGPRCHFIHN3Homo sapiens, Xenopus tropicalis, Mus musculus
E157TRYKTELCRPF3Homo sapiens, Xenopus tropicalis, Mus musculus
E195PKYKTELCRTF3Homo sapiens, Xenopus tropicalis, Mus musculus
F176GEKCQFAHGFH3Homo sapiens, Xenopus tropicalis, Mus musculus
F214GPRCHFIHNAD2Homo sapiens, Mus musculus
F214GPRCHFIHNAE1Xenopus tropicalis
H178KCQFAHGFHEL3Homo sapiens, Xenopus tropicalis, Mus musculus
H189RSLTRHPKYKT3Homo sapiens, Xenopus tropicalis, Mus musculus
H213YGPRCHFIHNA3Homo sapiens, Xenopus tropicalis, Mus musculus
K155NSTRYKTELCR3Homo sapiens, Xenopus tropicalis, Mus musculus
K169ESGTCKYGEKC2Homo sapiens, Mus musculus
K169ESGACKYGEKC1Xenopus tropicalis
K173CKYGEKCQFAH3Homo sapiens, Xenopus tropicalis, Mus musculus
K191LTRHPKYKTEL3Homo sapiens, Xenopus tropicalis, Mus musculus
L158RYKTELCRPFE3Homo sapiens, Xenopus tropicalis, Mus musculus
L196KYKTELCRTFH3Homo sapiens, Xenopus tropicalis, Mus musculus
P161TELCRPFEESG3Homo sapiens, Xenopus tropicalis, Mus musculus
Q175YGEKCQFAHGF3Homo sapiens, Xenopus tropicalis, Mus musculus
R153QINSTRYKTEL2Homo sapiens, Mus musculus
R153QVNSTRYKTEL1Xenopus tropicalis
R160KTELCRPFEES3Homo sapiens, Xenopus tropicalis, Mus musculus
R198KTELCRTFHTI3Homo sapiens, Xenopus tropicalis, Mus musculus
R211CPYGPRCHFIH3Homo sapiens, Xenopus tropicalis, Mus musculus
T156STRYKTELCRP3Homo sapiens, Xenopus tropicalis, Mus musculus
Y170SGTCKYGEKCQ2Homo sapiens, Mus musculus
Y170SGACKYGEKCQ1Xenopus tropicalis
Y208IGFCPYGPRCH3Homo sapiens, Xenopus tropicalis, Mus musculus


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