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mutLBSgeneDB |
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| Gene summary for ZFP36L2 |
 Gene summary |
| Basic gene Info. | Gene symbol | ZFP36L2 |
| Gene name | ZFP36 ring finger protein-like 2 | |
| Synonyms | BRF2|ERF-2|ERF2|RNF162C|TIS11D | |
| Cytomap | UCSC genome browser: 2p22.3-p21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006887.4, | |
| Description | EGF-response factor 2ZFP36-like 2butyrate response factor 2zinc finger protein 36, C3H type-like 1zinc finger protein 36, C3H type-like 2zinc finger protein 36, C3H1 type-like 2zinc finger protein, C3H type, 36-like 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612053 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000152518 | ||
| HPRD : 18319 | ||
| Vega : OTTHUMG00000128642 | ||
| Protein | UniProt: P47974 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZFP36L2 | |
| BioGPS: 678 | ||
| Pathway | NCI Pathway Interaction Database: ZFP36L2 | |
| KEGG: ZFP36L2 | ||
| REACTOME: ZFP36L2 | ||
| Pathway Commons: ZFP36L2 | ||
| Context | iHOP: ZFP36L2 | |
| ligand binding site mutation search in PubMed: ZFP36L2 | ||
| UCL Cancer Institute: ZFP36L2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for ZFP36L2 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E157 | E157K | BLCA | 1 | K155 | K155N | BLCA | 1 | E157 | E157K | BRCA | 1 | L158 | L158P | KIRC | 1 | E157 | E157Q | LUSC | 1 | P161 | P161R | LUSC | 1 | C168 | C168Y | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ZFP36L2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | L158 | L158P | -1.4146827 | E157 | E157Q | -1.2185839 | E157 | E157K | -1.1593041 | K155 | K155N | -0.69218729 | P161 | P161R | -0.60303323 | C168 | C168Y | -0.30105815 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ZFP36L2 from PDB |
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| Differential gene expression and gene-gene network for ZFP36L2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ZFP36L2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0033578 | Prostatic Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ZFP36L2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ZFP36L2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 1rgo | A | C168 | NUC | Nucleic Acids | 1rgo | A | K155 E157 L158 P161 |
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| Conservation information for LBS of ZFP36L2 |
| Multiple alignments for P47974 in multiple species |
| LBS | AA sequence | # species | Species | C159 | YKTELCRPFEE | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | C168 | EESGTCKYGEK | 2 | Homo sapiens, Mus musculus | C168 | EESGACKYGEK | 1 | Xenopus tropicalis | C174 | KYGEKCQFAHG | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | C197 | YKTELCRTFHT | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | C212 | PYGPRCHFIHN | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | E157 | TRYKTELCRPF | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | E195 | PKYKTELCRTF | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | F176 | GEKCQFAHGFH | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | F214 | GPRCHFIHNAD | 2 | Homo sapiens, Mus musculus | F214 | GPRCHFIHNAE | 1 | Xenopus tropicalis | H178 | KCQFAHGFHEL | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | H189 | RSLTRHPKYKT | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | H213 | YGPRCHFIHNA | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | K155 | NSTRYKTELCR | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | K169 | ESGTCKYGEKC | 2 | Homo sapiens, Mus musculus | K169 | ESGACKYGEKC | 1 | Xenopus tropicalis | K173 | CKYGEKCQFAH | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | K191 | LTRHPKYKTEL | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | L158 | RYKTELCRPFE | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | L196 | KYKTELCRTFH | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | P161 | TELCRPFEESG | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | Q175 | YGEKCQFAHGF | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | R153 | QINSTRYKTEL | 2 | Homo sapiens, Mus musculus | R153 | QVNSTRYKTEL | 1 | Xenopus tropicalis | R160 | KTELCRPFEES | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | R198 | KTELCRTFHTI | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | R211 | CPYGPRCHFIH | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | T156 | STRYKTELCRP | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | Y170 | SGTCKYGEKCQ | 2 | Homo sapiens, Mus musculus | Y170 | SGACKYGEKCQ | 1 | Xenopus tropicalis | Y208 | IGFCPYGPRCH | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus |
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