mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SULT1E1
Gene summary
Basic gene Info.Gene symbolSULT1E1
Gene namesulfotransferase family 1E, estrogen-preferring, member 1
SynonymsEST|EST-1|ST1E1|STE
CytomapUCSC genome browser: 4q13.1
Type of geneprotein-coding
RefGenesNM_005420.2,
Descriptionestrogen sulfotransferaseestrone sulfotransferasesulfotransferase 1E1sulfotransferase, estrogen-preferring
Modification date20141207
dbXrefs MIM : 600043
HGNC : HGNC
Ensembl : ENSG00000109193
HPRD : 08966
Vega : OTTHUMG00000129403
ProteinUniProt: P49888
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SULT1E1
BioGPS: 6783
PathwayNCI Pathway Interaction Database: SULT1E1
KEGG: SULT1E1
REACTOME: SULT1E1
Pathway Commons: SULT1E1
ContextiHOP: SULT1E1
ligand binding site mutation search in PubMed: SULT1E1
UCL Cancer Institute: SULT1E1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0008210estrogen metabolic process11884392
GO:0051923sulfation20056724


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Ligand binding site mutations for SULT1E1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
I246E245KSKCM3
F75R77QUCEC3
I246E245KBRCA1
S137A135TBRCA1
M255M255VCOAD1
Y20L18ILUAD1
P46P46HLUSC1
Y168P167SSKCM1
Y168S170YSKCM1
M89M89ISKCM1
R129R129QUCEC1
F141F141LUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for SULT1E1
Protein structure of wild type (WT) and mutant type (MT) of SULT1E1
Wild type SULT1E1
Mutant type SULT1E1

Free energy of binding of drugs to wild type and mutant tpye of SULT1E1
Gene symbolDrug nameFree energy of binding (kcal/mol) of wild typeFree energy of binding (kcal/mol) of mutant type
SULT1E1Acetaminophen-6.9-6.9
SULT1E1Cyclizine-8-8

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
I246E245K-1.411489
M89M89I-1.181146
Y168P167S-1.168531
R129R129Q-1.1202951
M255M255V-1.0795796
P46P46H-1.0026541
Y20L18I-0.81700241
F75R77Q-0.77286788
S137A135T-0.71152304
Y168S170Y-0.46748981
F141F141L-0.12447063
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SULT1E1 from PDB
PDB IDPDB titlePDB structure
4JVLCrystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and estradiol (E2)

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Differential gene expression and gene-gene network for SULT1E1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SULT1E1 and the right PPI network was created from samples without mutations in the LBS of SULT1E1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for SULT1E1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0033578Prostatic Neoplasms2Biomarker
umls:C0023893Liver Cirrhosis, Experimental1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for SULT1E1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB01176CyclizineSmall molecule
ExperimentalDB01812Adenosine-3'-5'-DiphosphateSmall molecule
ExperimentalDB029023'-Phosphate-Adenosine-5'-Phosphate SulfateSmall molecule
ExperimentalDB033463,5,3',5'-Tetrachloro-Biphenyl-4,4'-DiolSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SULT1E1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
XDI4,4'-PROPANE-2,2-DIYLBIS(2,6-DIBROMOPHENOL)4jvmAP46 M89 F141 I246
PPS3'-PHOSPHATE-ADENOSINE-5'-PHOSPHATE SULFATE1hy3BP46 R129 S137 M255
PPS3'-PHOSPHATE-ADENOSINE-5'-PHOSPHATE SULFATE1hy3AR129 S137 F141 M255
A3PADENOSINE 3',5'-BISPHOSPHATE1g3mAR129 S137 M255
A3PADENOSINE 3',5'-BISPHOSPHATE1g3mBR129 S137 M255
A3PADENOSINE 3',5'-BISPHOSPHATE4jvlAR129 S137 M255
A3PADENOSINE 3',5'-BISPHOSPHATE4jvlBR129 S137 M255
A3PADENOSINE 3',5'-BISPHOSPHATE4jvmAR129 S137 M255
A3PADENOSINE 3',5'-BISPHOSPHATE4jvmBR129 S137 M255
A3PADENOSINE 3',5'-BISPHOSPHATE4jvnAR129 S137 M255
A3PADENOSINE 3',5'-BISPHOSPHATE4jvnBR129 S137 M255
ESTESTRADIOL4jvlBY20 F141
ESTESTRADIOL4jvlAY20 F141 I246
XDI4,4'-PROPANE-2,2-DIYLBIS(2,6-DIBROMOPHENOL)4jvmBY20 F75 M89 F141 I246
YUG2,6-DIBROMO-3-(2,4-DIBROMOPHENOXY)PHENOL4jvnBY20 P46 F141
PCQ3,3',5,5'-TETRACHLOROBIPHENYL-4,4'-DIOL1g3mBY20 P46 F141 I246
YUG2,6-DIBROMO-3-(2,4-DIBROMOPHENOXY)PHENOL4jvnAY20 P46 F141 I246
PCQ3,3',5,5'-TETRACHLOROBIPHENYL-4,4'-DIOL1g3mAY20 P46 F141 Y168 I246


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Conservation information for LBS of SULT1E1
Multiple alignments for P49888 in multiple species
LBSAA sequence# speciesSpecies
A146FFLMVAGHP--1Homo sapiens
A146FLHKEKSQE--1Arabidopsis thaliana
A146FAHKERSQQ--1Arabidopsis thaliana
A146FLHKERTEL--1Arabidopsis thaliana
A146YINNITSES--1Arabidopsis thaliana
A146YTNNIKSES--1Arabidopsis thaliana
A146YRNMLHRTK--1Arabidopsis thaliana
A146IVCRSLNKE--1Arabidopsis thaliana
A146FNSAKLKIE--1Arabidopsis thaliana
A146FRSKYSNNE--1Arabidopsis thaliana
A146-----------1Arabidopsis thaliana
A146FFTKKQTDE--1Arabidopsis thaliana
A146FFCKKQTDD--1Arabidopsis thaliana
A146FENSMSGEN--1Arabidopsis thaliana
A146FRQSKKITR--1Arabidopsis thaliana
A146FLNANKGVEWG1Arabidopsis thaliana
A146FGKKLAPEE--1Arabidopsis thaliana
A146FMKNLIVKE--1Arabidopsis thaliana
C83VPYIEI-DFPF2Arabidopsis thaliana, Arabidopsis thaliana
C83VPFFEY-KLYA2Arabidopsis thaliana, Arabidopsis thaliana
C83VPYLEL-DLYL2Arabidopsis thaliana, Arabidopsis thaliana
C83IPFLECRKENL1Homo sapiens
C83VPYVEI-DFAF1Arabidopsis thaliana
C83VPFLEV-ELYA1Arabidopsis thaliana
C83LSS--------1Arabidopsis thaliana
C83VPFLEL-RLFT1Arabidopsis thaliana
C83VPFFEF-DMYL1Arabidopsis thaliana
C83FS---------1Arabidopsis thaliana
C83VPYFEI-DLYL1Arabidopsis thaliana
C83SPSLEM-YLYL1Arabidopsis thaliana
C83VPNLEL-DLYL1Arabidopsis thaliana
C83VPFLE--GVYY1Arabidopsis thaliana
C83VTFIE--GFHL1Arabidopsis thaliana
F141VSFYYFFLMVA1Homo sapiens
F141ISMWTFLHKEK1Arabidopsis thaliana
F141VSMWTFAHKER1Arabidopsis thaliana
F141ISMWTFLHKER1Arabidopsis thaliana
F141ISMWHYINNIT1Arabidopsis thaliana
F141ISSWHYTNNIK1Arabidopsis thaliana
F141VSGWHYRNMLH1Arabidopsis thaliana
F141VSRWHIVCRSL1Arabidopsis thaliana
F141VSFWYFNSAKL1Arabidopsis thaliana
F141ISDWHFRSKYS1Arabidopsis thaliana
F141-----------1Arabidopsis thaliana
F141VSYWHFFTKKQ1Arabidopsis thaliana
F141VSYWHFFCKKQ1Arabidopsis thaliana
F141VSLWCFENSMS1Arabidopsis thaliana
F141VSVWYFRQSKK1Arabidopsis thaliana
F141VSLWCFLNANK1Arabidopsis thaliana
F141VSLWHFGKKLA1Arabidopsis thaliana
F141VSLWHFMKNLI1Arabidopsis thaliana
F228VKLCSFETLKN2Arabidopsis thaliana, Arabidopsis thaliana
F228IDLCSLRNLSS2Arabidopsis thaliana, Arabidopsis thaliana
F228IHHTSFQEMKN1Homo sapiens
F228VNLCSFETLKN1Arabidopsis thaliana
F228ADLCSFENLKK1Arabidopsis thaliana
F228AELCSFENLKK1Arabidopsis thaliana
F228LKLCSLRNLSN1Arabidopsis thaliana
F228LEMCSLPNLSS1Arabidopsis thaliana
F228LDLCSLRNLKN1Arabidopsis thaliana
F228LELCSLGNLSG1Arabidopsis thaliana
F228---------DC1Arabidopsis thaliana
F228LELCSLRNLSG1Arabidopsis thaliana
F228LELCSLSNLRS1Arabidopsis thaliana
F228LELCSLSNLSS1Arabidopsis thaliana
F228VKLCSFESLSN1Arabidopsis thaliana
F228IKLCSLENLSK1Arabidopsis thaliana
F23LMYKDFVKYWD1Homo sapiens
F23TQYGGHWWQEC1Arabidopsis thaliana
F23VEYGGHWWLQP1Arabidopsis thaliana
F23IEYGGYWWLPS1Arabidopsis thaliana
F23L-FQGFRCQAK1Arabidopsis thaliana
F23L-FQGFWCQAK1Arabidopsis thaliana
F23N-YKGCWYYPN1Arabidopsis thaliana
F23K-YQGSWYYYN1Arabidopsis thaliana
F23K-YQGCWYDDK1Arabidopsis thaliana
F23K-YQGCWYYHN1Arabidopsis thaliana
F23K-YQGCWYTHH1Arabidopsis thaliana
F23K-YQGCWYTHN1Arabidopsis thaliana
F23K-YQGCWYTPP1Arabidopsis thaliana
F23K-YQGCWYDKD1Arabidopsis thaliana
F23N-YEGYWYSED1Arabidopsis thaliana
F23K-YQGYWYYED1Arabidopsis thaliana
F23E-FQGLWHTQA1Arabidopsis thaliana
F23Q-YQGFWYPPN1Arabidopsis thaliana
F254YANSAYFRKGK3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
F254QKLSPFMRKGI1Homo sapiens
F254YENRFLFRKGE1Arabidopsis thaliana
F254FENRFLFRKGE1Arabidopsis thaliana
F254VDSQVFFRKGE1Arabidopsis thaliana
F254IEYKNHFRKGI1Arabidopsis thaliana
F254ADHKIFFRKGE1Arabidopsis thaliana
F254YDYKSYFRKGE1Arabidopsis thaliana
F254RDNKTFFRKGE1Arabidopsis thaliana
F254RENKMFFRKGE1Arabidopsis thaliana
F254RENKTFFRKGE1Arabidopsis thaliana
F254VSFKSFFRKGE1Arabidopsis thaliana
F254VDFKSYFRKGQ1Arabidopsis thaliana
F254VDYKTYFRKGQ1Arabidopsis thaliana
F254IETKTFFRKGE1Arabidopsis thaliana
F254METKAFFRKGE1Arabidopsis thaliana
F75---VIFNR---1Homo sapiens
F75-ANPLLKRNPH1Arabidopsis thaliana
F75-TNPLLKRNPH1Arabidopsis thaliana
F75-SNPLLKRNPH1Arabidopsis thaliana
F75SDHPLLTSNPH1Arabidopsis thaliana
F75TNHPLFTSNPH1Arabidopsis thaliana
F75-THPLLLQNPH1Arabidopsis thaliana
F75MSHPLLSNNPH1Arabidopsis thaliana
F75-DHPLLLDNPH1Arabidopsis thaliana
F75LTHPLLSDNPH1Arabidopsis thaliana
F75-HHPLLSNNPH1Arabidopsis thaliana
F75-DHPLLSNNPH1Arabidopsis thaliana
F75-HHPLLSDNPH1Arabidopsis thaliana
F75-NHPLLTHNPH1Arabidopsis thaliana
F75-QHPLLHHNPH1Arabidopsis thaliana
F75-HHPLLSHNPH1Arabidopsis thaliana
F75-NHPLLVTNPH1Arabidopsis thaliana
F75-SHPLLDNNPH1Arabidopsis thaliana
F80HEFVPYIEI-D2Arabidopsis thaliana, Arabidopsis thaliana
F80HDLVPFFEY-K2Arabidopsis thaliana, Arabidopsis thaliana
F80---IPFLECRK1Homo sapiens
F80HEFVPYVEI-D1Arabidopsis thaliana
F80HDLVPFLEV-E1Arabidopsis thaliana
F80HNLLSS-----1Arabidopsis thaliana
F80HGLVPFLEL-R1Arabidopsis thaliana
F80HGIVPFFEF-D1Arabidopsis thaliana
F80HVLFS------1Arabidopsis thaliana
F80HVLVPYFEI-D1Arabidopsis thaliana
F80HVLSPSLEM-Y1Arabidopsis thaliana
F80HELVPYLEL-D1Arabidopsis thaliana
F80HEIVPNLEL-D1Arabidopsis thaliana
F80HEIVPYLEL-D1Arabidopsis thaliana
F80HLLVPFLE--G1Arabidopsis thaliana
F80HTLVTFIE--G1Arabidopsis thaliana
G258AYFRKGKVGDW3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G258TFFRKGEVGDW2Arabidopsis thaliana, Arabidopsis thaliana
G258PFMRKGITGDW1Homo sapiens
G258FLFRKGEVSDL1Arabidopsis thaliana
G258FLFRKGEVSDW1Arabidopsis thaliana
G258VFFRKGEVGDW1Arabidopsis thaliana
G258NHFRKGIVGDW1Arabidopsis thaliana
G258IFFRKGEVGDS1Arabidopsis thaliana
G258SYFRKGEVGDW1Arabidopsis thaliana
G258MFFRKGEVGDW1Arabidopsis thaliana
G258SFFRKGEVGDW1Arabidopsis thaliana
G258SYFRKGQVGDW1Arabidopsis thaliana
G258TYFRKGQVGDW1Arabidopsis thaliana
G258TFFRKGEIGGW1Arabidopsis thaliana
G258AFFRKGEIGGW1Arabidopsis thaliana
G49SYPKTGTTWLK3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G49SFPKSGTTWLK3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G49SFPKCGTTWLK3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G49TIPKSGTTWLK2Arabidopsis thaliana, Arabidopsis thaliana
G49SFYKSGTTWLK2Arabidopsis thaliana, Arabidopsis thaliana
G49TYPKSGTTWVS1Homo sapiens
G49SLPKGGTTWLK1Arabidopsis thaliana
G49SYPKSGTLWLK1Arabidopsis thaliana
G49TNPKSGTTWLK1Arabidopsis thaliana
G49SIPKSGTTWLK1Arabidopsis thaliana
H107RLFSTHMPSHT2Arabidopsis thaliana, Arabidopsis thaliana
H107RIVKTHLPPEL1Homo sapiens
H107PLFSTHIPNGL1Arabidopsis thaliana
H107TLFSTHIPYDL1Arabidopsis thaliana
H107TLFSTHIPYEL1Arabidopsis thaliana
H107RTFATHVPFGA1Arabidopsis thaliana
H107RTFATHLPFGS1Arabidopsis thaliana
H107MIFSTHMHLQA1Arabidopsis thaliana
H107RLFSTHTPFHT1Arabidopsis thaliana
H107RLFSTHVAFQT1Arabidopsis thaliana
H107RLFSTHMPLHT1Arabidopsis thaliana
H107RLFSTHVPSHT1Arabidopsis thaliana
H107RLFSTHMSFDA1Arabidopsis thaliana
H107RLFSTHMSLDP1Arabidopsis thaliana
H107RLFSTHMSLDA1Arabidopsis thaliana
H107RLMNTHISHLS1Arabidopsis thaliana
H107RIFSTHIPVGS1Arabidopsis thaliana
H148LMVAGHP----1Homo sapiens
H148HKEKSQE----1Arabidopsis thaliana
H148HKERSQQ----1Arabidopsis thaliana
H148HKERTEL----1Arabidopsis thaliana
H148NNITSES----1Arabidopsis thaliana
H148NNIKSES----1Arabidopsis thaliana
H148NMLHRTK----1Arabidopsis thaliana
H148CRSLNKE----1Arabidopsis thaliana
H148SAKLKIE----1Arabidopsis thaliana
H148SKYSNNE----1Arabidopsis thaliana
H148-----------1Arabidopsis thaliana
H148TKKQTDE----1Arabidopsis thaliana
H148CKKQTDD----1Arabidopsis thaliana
H148NSMSGEN----1Arabidopsis thaliana
H148QSKKITR----1Arabidopsis thaliana
H148NANKGVEWGDF1Arabidopsis thaliana
H148KKLAPEE----1Arabidopsis thaliana
H148KNLIVKE----1Arabidopsis thaliana
I246LPD-EIMNQKL1Homo sapiens
I246EREDRPAVYAN1Arabidopsis thaliana
I246DREDRPAVYAN1Arabidopsis thaliana
I246DREDRPGVYAN1Arabidopsis thaliana
I246LIQ----NYEN1Arabidopsis thaliana
I246SIK----NFEN1Arabidopsis thaliana
I246TRI----GVDS1Arabidopsis thaliana
I246SIN----GIEY1Arabidopsis thaliana
I246TLR----GADH1Arabidopsis thaliana
I246TWM----NYDY1Arabidopsis thaliana
I246LCE----GRDN1Arabidopsis thaliana
I246LNS----GREN1Arabidopsis thaliana
I246LHS---TGREN1Arabidopsis thaliana
I246LSE----GVSF1Arabidopsis thaliana
I246SSR-----VDF1Arabidopsis thaliana
I246LG-----GVDY1Arabidopsis thaliana
I246LPN----GIET1Arabidopsis thaliana
I246LLN----GMET1Arabidopsis thaliana
K105GNTLFSTHIPY2Arabidopsis thaliana, Arabidopsis thaliana
K105SPRLFSTHMSL2Arabidopsis thaliana, Arabidopsis thaliana
K105SPRIVKTHLPP1Homo sapiens
K105KNPLFSTHIPN1Arabidopsis thaliana
K105SPRTFATHVPF1Arabidopsis thaliana
K105SPRTFATHLPF1Arabidopsis thaliana
K105SPMIFSTHMHL1Arabidopsis thaliana
K105SPRLFSTHTPF1Arabidopsis thaliana
K105SPRLFSTHVAF1Arabidopsis thaliana
K105SPRLFSTHMPL1Arabidopsis thaliana
K105SPRLFSTHMPS1Arabidopsis thaliana
K105SPRLFSTHVPS1Arabidopsis thaliana
K105SSRLFSTHMPS1Arabidopsis thaliana
K105SPRLFSTHMSF1Arabidopsis thaliana
K105SPRLMNTHISH1Arabidopsis thaliana
K105SPRIFSTHIPV1Arabidopsis thaliana
K257SAYFRKGKVGD3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
K257RFLFRKGEVSD2Arabidopsis thaliana, Arabidopsis thaliana
K257KTFFRKGEVGD2Arabidopsis thaliana, Arabidopsis thaliana
K257SPFMRKGITGD1Homo sapiens
K257QVFFRKGEVGD1Arabidopsis thaliana
K257KNHFRKGIVGD1Arabidopsis thaliana
K257KIFFRKGEVGD1Arabidopsis thaliana
K257KSYFRKGEVGD1Arabidopsis thaliana
K257KMFFRKGEVGD1Arabidopsis thaliana
K257KSFFRKGEVGD1Arabidopsis thaliana
K257KSYFRKGQVGD1Arabidopsis thaliana
K257KTYFRKGQVGD1Arabidopsis thaliana
K257KTFFRKGEIGG1Arabidopsis thaliana
K257KAFFRKGEIGG1Arabidopsis thaliana
K47VCSYPKTGTTW3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
K47VASFPKCGTTW3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
K47LATIPKSGTTW2Arabidopsis thaliana, Arabidopsis thaliana
K47IATYPKSGTTW1Homo sapiens
K47LASLPKGGTTW1Arabidopsis thaliana
K47VASYPKSGTLW1Arabidopsis thaliana
K47IASFPKSGTTW1Arabidopsis thaliana
K47LASFPKSGTTW1Arabidopsis thaliana
K47VASFPKSGTTW1Arabidopsis thaliana
K47LASFYKSGTTW1Arabidopsis thaliana
K47VASFYKSGTTW1Arabidopsis thaliana
K47LVTNPKSGTTW1Arabidopsis thaliana
K47LASIPKSGTTW1Arabidopsis thaliana
K85YIEI-DFPFFP2Arabidopsis thaliana, Arabidopsis thaliana
K85FFEY-KLYANG2Arabidopsis thaliana, Arabidopsis thaliana
K85FLECRKENLMN1Homo sapiens
K85YVEI-DFAFYP1Arabidopsis thaliana
K85FLEV-ELYANS1Arabidopsis thaliana
K85S----------1Arabidopsis thaliana
K85FLEL-RLFTET1Arabidopsis thaliana
K85FFEF-DMYLKT1Arabidopsis thaliana
K85-----------1Arabidopsis thaliana
K85YFEI-DLYLRS1Arabidopsis thaliana
K85SLEM-YLYLCS1Arabidopsis thaliana
K85YLEL-DLYLKS1Arabidopsis thaliana
K85NLEL-DLYLKS1Arabidopsis thaliana
K85YLEL-DLYLNS1Arabidopsis thaliana
K85FLE--GVYYES1Arabidopsis thaliana
K85FIE--GFHLHT1Arabidopsis thaliana
M231CSFETLKNLEA3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
M231CSFENLKKLEV2Arabidopsis thaliana, Arabidopsis thaliana
M231CSLRNLSSLEI2Arabidopsis thaliana, Arabidopsis thaliana
M231TSFQEMKNNPS1Homo sapiens
M231CSLRNLSNLEV1Arabidopsis thaliana
M231CSLPNLSSLEV1Arabidopsis thaliana
M231CSLRNLKNLEI1Arabidopsis thaliana
M231CSLGNLSGLEV1Arabidopsis thaliana
M231------DCLEI1Arabidopsis thaliana
M231CSLRNLSGLEI1Arabidopsis thaliana
M231CSLSNLRSVEI1Arabidopsis thaliana
M231CSLSNLSSLEI1Arabidopsis thaliana
M231CSFESLSNLEV1Arabidopsis thaliana
M231CSLENLSKLEV1Arabidopsis thaliana
M247REDRPAVYANS2Arabidopsis thaliana, Arabidopsis thaliana
M247PD-EIMNQKLS1Homo sapiens
M247REDRPGVYANS1Arabidopsis thaliana
M247IQ----NYENR1Arabidopsis thaliana
M247IK----NFENR1Arabidopsis thaliana
M247RI----GVDSQ1Arabidopsis thaliana
M247IN----GIEYK1Arabidopsis thaliana
M247LR----GADHK1Arabidopsis thaliana
M247WM----NYDYK1Arabidopsis thaliana
M247CE----GRDNK1Arabidopsis thaliana
M247NS----GRENK1Arabidopsis thaliana
M247HS---TGRENK1Arabidopsis thaliana
M247SE----GVSFK1Arabidopsis thaliana
M247SR-----VDFK1Arabidopsis thaliana
M247G-----GVDYK1Arabidopsis thaliana
M247PN----GIETK1Arabidopsis thaliana
M247LN----GMETK1Arabidopsis thaliana
M255ANSAYFRKGKV3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
M255ENRFLFRKGEV2Arabidopsis thaliana, Arabidopsis thaliana
M255KLSPFMRKGIT1Homo sapiens
M255DSQVFFRKGEV1Arabidopsis thaliana
M255EYKNHFRKGIV1Arabidopsis thaliana
M255DHKIFFRKGEV1Arabidopsis thaliana
M255DYKSYFRKGEV1Arabidopsis thaliana
M255DNKTFFRKGEV1Arabidopsis thaliana
M255ENKMFFRKGEV1Arabidopsis thaliana
M255ENKTFFRKGEV1Arabidopsis thaliana
M255SFKSFFRKGEV1Arabidopsis thaliana
M255DFKSYFRKGQV1Arabidopsis thaliana
M255DYKTYFRKGQV1Arabidopsis thaliana
M255ETKTFFRKGEI1Arabidopsis thaliana
M255ETKAFFRKGEI1Arabidopsis thaliana
M89-----------2Arabidopsis thaliana, Arabidopsis thaliana
M89-DLYLKSSKPD2Arabidopsis thaliana, Arabidopsis thaliana
M89RKENLMNGVKQ1Homo sapiens
M89-DFAFYPTVDV1Arabidopsis thaliana
M89-DFPFFPSVDV1Arabidopsis thaliana
M89-DFPFFPEVDV1Arabidopsis thaliana
M89-KLYANGNVPD1Arabidopsis thaliana
M89-KLYANGDVPD1Arabidopsis thaliana
M89-ELYANSQIPD1Arabidopsis thaliana
M89-RLFTETSKPD1Arabidopsis thaliana
M89-DMYLKTSTPD1Arabidopsis thaliana
M89-DLYLRSENPD1Arabidopsis thaliana
M89-YLYLCSENPD1Arabidopsis thaliana
M89-DLYLNSSKPD1Arabidopsis thaliana
M89-GVYYESPDFD1Arabidopsis thaliana
M89-GFHLHTQD--1Arabidopsis thaliana
P46IVASFPKCGTT3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
P46LVCSYPKTGTT2Arabidopsis thaliana, Arabidopsis thaliana
P46VLATIPKSGTT2Arabidopsis thaliana, Arabidopsis thaliana
P46VIATYPKSGTT1Homo sapiens
P46FVCSYPKTGTT1Arabidopsis thaliana
P46ILASLPKGGTT1Arabidopsis thaliana
P46IVASYPKSGTL1Arabidopsis thaliana
P46IIASFPKSGTT1Arabidopsis thaliana
P46ILASFPKSGTT1Arabidopsis thaliana
P46IVASFPKSGTT1Arabidopsis thaliana
P46ILASFYKSGTT1Arabidopsis thaliana
P46VVASFYKSGTT1Arabidopsis thaliana
P46ILVTNPKSGTT1Arabidopsis thaliana
P46VLASIPKSGTT1Arabidopsis thaliana
R129VVYLCRNPFDT2Arabidopsis thaliana, Arabidopsis thaliana
R129IVYVCRNVKDV2Arabidopsis thaliana, Arabidopsis thaliana
R129IIYLCRNAKDV1Homo sapiens
R129MVYIWRDPKDT1Arabidopsis thaliana
R129IVYIWRDPKDT1Arabidopsis thaliana
R129MVYIWREPKDT1Arabidopsis thaliana
R129TVYVCRGIKDT1Arabidopsis thaliana
R129VVYICRDAKDS1Arabidopsis thaliana
R129IVYVWRNVKDV1Arabidopsis thaliana
R129VVYMCRNIKDV1Arabidopsis thaliana
R129VVYICRNMKDT1Arabidopsis thaliana
R129IVYISRNVKDT1Arabidopsis thaliana
R129IVYMSRNVKDT1Arabidopsis thaliana
R129VVYVCRNVKDV1Arabidopsis thaliana
R129IVYCCRNPKDM1Arabidopsis thaliana
R129VVYCCRNPKDA1Arabidopsis thaliana
R256NSAYFRKGKVG3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
R256NRFLFRKGEVS2Arabidopsis thaliana, Arabidopsis thaliana
R256NKTFFRKGEVG2Arabidopsis thaliana, Arabidopsis thaliana
R256LSPFMRKGITG1Homo sapiens
R256SQVFFRKGEVG1Arabidopsis thaliana
R256YKNHFRKGIVG1Arabidopsis thaliana
R256HKIFFRKGEVG1Arabidopsis thaliana
R256YKSYFRKGEVG1Arabidopsis thaliana
R256NKMFFRKGEVG1Arabidopsis thaliana
R256FKSFFRKGEVG1Arabidopsis thaliana
R256FKSYFRKGQVG1Arabidopsis thaliana
R256YKTYFRKGQVG1Arabidopsis thaliana
R256TKTFFRKGEIG1Arabidopsis thaliana
R256TKAFFRKGEIG1Arabidopsis thaliana
S137KDTFISMWTFL2Arabidopsis thaliana, Arabidopsis thaliana
S137KDTLVSYWHFF2Arabidopsis thaliana, Arabidopsis thaliana
S137KDVAVSFYYFF1Homo sapiens
S137KDTFVSMWTFA1Arabidopsis thaliana
S137FDTFISMWHYI1Arabidopsis thaliana
S137FDTFISSWHYT1Arabidopsis thaliana
S137KDTFVSGWHYR1Arabidopsis thaliana
S137KDSLVSRWHIV1Arabidopsis thaliana
S137KDVLVSFWYFN1Arabidopsis thaliana
S137KDVLISDWHFR1Arabidopsis thaliana
S137KDTL-------1Arabidopsis thaliana
S137KDVLVSLWCFE1Arabidopsis thaliana
S137KDVMVSVWYFR1Arabidopsis thaliana
S137KDVLVSLWCFL1Arabidopsis thaliana
S137KDMFVSLWHFG1Arabidopsis thaliana
S137KDAFVSLWHFM1Arabidopsis thaliana
S227VVKLCSFETLK2Arabidopsis thaliana, Arabidopsis thaliana
S227IIDLCSLRNLS2Arabidopsis thaliana, Arabidopsis thaliana
S227IIHHTSFQEMK1Homo sapiens
S227VVNLCSFETLK1Arabidopsis thaliana
S227IADLCSFENLK1Arabidopsis thaliana
S227IAELCSFENLK1Arabidopsis thaliana
S227ILKLCSLRNLS1Arabidopsis thaliana
S227ILEMCSLPNLS1Arabidopsis thaliana
S227ILDLCSLRNLK1Arabidopsis thaliana
S227LLELCSLGNLS1Arabidopsis thaliana
S227----------D1Arabidopsis thaliana
S227ILELCSLRNLS1Arabidopsis thaliana
S227ILELCSLSNLR1Arabidopsis thaliana
S227ILELCSLSNLS1Arabidopsis thaliana
S227IVKLCSFESLS1Arabidopsis thaliana
S227IIKLCSLENLS1Arabidopsis thaliana
S48CSYPKTGTTWL3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
S48ASFPKSGTTWL3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
S48ASFPKCGTTWL3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
S48ATIPKSGTTWL2Arabidopsis thaliana, Arabidopsis thaliana
S48ASFYKSGTTWL2Arabidopsis thaliana, Arabidopsis thaliana
S48ATYPKSGTTWV1Homo sapiens
S48ASLPKGGTTWL1Arabidopsis thaliana
S48ASYPKSGTLWL1Arabidopsis thaliana
S48VTNPKSGTTWL1Arabidopsis thaliana
S48ASIPKSGTTWL1Arabidopsis thaliana
T226KVVKLCSFETL2Arabidopsis thaliana, Arabidopsis thaliana
T226EIIDLCSLRNL2Arabidopsis thaliana, Arabidopsis thaliana
T226KILELCSLSNL2Arabidopsis thaliana, Arabidopsis thaliana
T226RIIHHTSFQEM1Homo sapiens
T226KVVNLCSFETL1Arabidopsis thaliana
T226AIADLCSFENL1Arabidopsis thaliana
T226AIAELCSFENL1Arabidopsis thaliana
T226EILKLCSLRNL1Arabidopsis thaliana
T226KILEMCSLPNL1Arabidopsis thaliana
T226EILDLCSLRNL1Arabidopsis thaliana
T226KLLELCSLGNL1Arabidopsis thaliana
T226-----------1Arabidopsis thaliana
T226KILELCSLRNL1Arabidopsis thaliana
T226EIVKLCSFESL1Arabidopsis thaliana
T226DIIKLCSLENL1Arabidopsis thaliana
T50YPKTGTTWLKA3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T50FPKSGTTWLKA3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T50FPKCGTTWLKA3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T50IPKSGTTWLKA2Arabidopsis thaliana, Arabidopsis thaliana
T50FYKSGTTWLKA2Arabidopsis thaliana, Arabidopsis thaliana
T50YPKSGTTWVSE1Homo sapiens
T50LPKGGTTWLKS1Arabidopsis thaliana
T50YPKSGTLWLKA1Arabidopsis thaliana
T50NPKSGTTWLKA1Arabidopsis thaliana
T50IPKSGTTWLKS1Arabidopsis thaliana
T51PKSGTTWLKAL6Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T51PKTGTTWLKAL3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T51PKCGTTWLKAL3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T51YKSGTTWLKAL2Arabidopsis thaliana, Arabidopsis thaliana
T51PKSGTTWVSEI1Homo sapiens
T51PKGGTTWLKSL1Arabidopsis thaliana
T51PKSGTLWLKAL1Arabidopsis thaliana
T51PKSGTTWLKSL1Arabidopsis thaliana
V145YFFLMVAGHP-1Homo sapiens
V145TFLHKEKSQE-1Arabidopsis thaliana
V145TFAHKERSQQ-1Arabidopsis thaliana
V145TFLHKERTEL-1Arabidopsis thaliana
V145HYINNITSES-1Arabidopsis thaliana
V145HYTNNIKSES-1Arabidopsis thaliana
V145HYRNMLHRTK-1Arabidopsis thaliana
V145HIVCRSLNKE-1Arabidopsis thaliana
V145YFNSAKLKIE-1Arabidopsis thaliana
V145HFRSKYSNNE-1Arabidopsis thaliana
V145-----------1Arabidopsis thaliana
V145HFFTKKQTDE-1Arabidopsis thaliana
V145HFFCKKQTDD-1Arabidopsis thaliana
V145CFENSMSGEN-1Arabidopsis thaliana
V145YFRQSKKITR-1Arabidopsis thaliana
V145CFLNANKGVEW1Arabidopsis thaliana
V145HFGKKLAPEE-1Arabidopsis thaliana
V145HFMKNLIVKE-1Arabidopsis thaliana
W52KSGTTWLKALT6Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
W52KTGTTWLKALT3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
W52KCGTTWLKALT3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
W52KSGTTWVSEIV1Homo sapiens
W52KGGTTWLKSLI1Arabidopsis thaliana
W52KSGTLWLKALT1Arabidopsis thaliana
W52KSGTTWLKALS1Arabidopsis thaliana
W52KSGTTWLKALV1Arabidopsis thaliana
W52KSGTTWLKSLV1Arabidopsis thaliana
Y168GVNF-FGPFWD2Arabidopsis thaliana, Arabidopsis thaliana
Y168GVTL-HGPFWD2Arabidopsis thaliana, Arabidopsis thaliana
Y168GQVP-YGSWYK1Homo sapiens
Y168GLSV-YGPYLD1Arabidopsis thaliana
Y168GLSA-YGPYLD1Arabidopsis thaliana
Y168GLSG-YGPYLN1Arabidopsis thaliana
Y168GLLIGFGPFWE1Arabidopsis thaliana
Y168GVIG-FGPFWE1Arabidopsis thaliana
Y168GVLL-YGPYWE1Arabidopsis thaliana
Y168GVCL-FGPFWD1Arabidopsis thaliana
Y168GVIN-YGPSWE1Arabidopsis thaliana
Y168GVSF-YGPFWD1Arabidopsis thaliana
Y168GVSI-FGPFWD1Arabidopsis thaliana
Y168GVNL-CGPLWE1Arabidopsis thaliana
Y168GKFI-GGPFWD1Arabidopsis thaliana
Y168GSSI-YGPFWD1Arabidopsis thaliana
Y192ILFLKYETMRA2Arabidopsis thaliana, Arabidopsis thaliana
Y192VLFLFYEDLKE1Homo sapiens
Y192ILFLRYETMRA1Arabidopsis thaliana
Y192VLFLKYEDLKE1Arabidopsis thaliana
Y192VFFLRYEDLKD1Arabidopsis thaliana
Y192VLFMKYEEIIE1Arabidopsis thaliana
Y192VLFMRYDEIKT1Arabidopsis thaliana
Y192VLFLKYEELKT1Arabidopsis thaliana
Y192VLFMRYEEMKT1Arabidopsis thaliana
Y192VLFMRFEEMKA1Arabidopsis thaliana
Y192VLFMKFEEMKA1Arabidopsis thaliana
Y192VLFMKFEEMKE1Arabidopsis thaliana
Y192VLFLRYEELKT1Arabidopsis thaliana
Y192FLFMRYEDLKA1Arabidopsis thaliana
Y192FLFMRYEELKA1Arabidopsis thaliana
Y192VLFVTYEELKK1Arabidopsis thaliana
Y192VMFVMYEEMRE1Arabidopsis thaliana
Y20NVCK-YQGCWY2Arabidopsis thaliana, Arabidopsis thaliana
Y20HGILMYKDFVK1Homo sapiens
Y20EILTQYGGHWW1Arabidopsis thaliana
Y20DPFVEYGGHWW1Arabidopsis thaliana
Y20EPLIEYGGYWW1Arabidopsis thaliana
Y20YLYL-FQGFRC1Arabidopsis thaliana
Y20YLYL-FQGFWC1Arabidopsis thaliana
Y20GLYN-YKGCWY1Arabidopsis thaliana
Y20NLCK-YQGSWY1Arabidopsis thaliana
Y20KLFK-YQGCWY1Arabidopsis thaliana
Y20KLCK-YQGCWY1Arabidopsis thaliana
Y20TICK-YQGCWY1Arabidopsis thaliana
Y20KLYK-YQGCWY1Arabidopsis thaliana
Y20KLFN-YEGYWY1Arabidopsis thaliana
Y20KLFK-YQGYWY1Arabidopsis thaliana
Y20EIYE-FQGLWH1Arabidopsis thaliana
Y20YLYQ-YQGFWY1Arabidopsis thaliana
Y239LEANKGEKDRE2Arabidopsis thaliana, Arabidopsis thaliana
Y239NPSTNYTTLPD1Homo sapiens
Y239LEANKGDKERE1Arabidopsis thaliana
Y239LEVNKSSKLIQ1Arabidopsis thaliana
Y239LEVNKSNKSIK1Arabidopsis thaliana
Y239LEVNKNGTTRI1Arabidopsis thaliana
Y239LEVNKTGKSIN1Arabidopsis thaliana
Y239LEINKTGKTLR1Arabidopsis thaliana
Y239LEVNKTGKTWM1Arabidopsis thaliana
Y239LEINKTGKLCE1Arabidopsis thaliana
Y239LEINKTGKLNS1Arabidopsis thaliana
Y239LEINKTGKLHS1Arabidopsis thaliana
Y239LEINKTGSLSE1Arabidopsis thaliana
Y239VEINKTRTSSR1Arabidopsis thaliana
Y239LEINKTGSLG-1Arabidopsis thaliana
Y239LEVNKEGKLPN1Arabidopsis thaliana
Y239LEVNEKGKLLN1Arabidopsis thaliana


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