mutLBSgeneDB |
Gene summary for STIM1 |
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Basic gene Info. | Gene symbol | STIM1 |
Gene name | stromal interaction molecule 1 | |
Synonyms | D11S4896E|GOK|IMD10|STRMK|TAM|TAM1 | |
Cytomap | UCSC genome browser: 11p15.5 | |
Type of gene | protein-coding | |
RefGenes | NM_001277961.1, NM_001277962.1,NM_003156.3, | |
Description | - | |
Modification date | 20141222 | |
dbXrefs | MIM : 605921 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167323 | ||
HPRD : 05803 | ||
Vega : OTTHUMG00000133360 | ||
Protein | UniProt: Q13586 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_STIM1 | |
BioGPS: 6786 | ||
Pathway | NCI Pathway Interaction Database: STIM1 | |
KEGG: STIM1 | ||
REACTOME: STIM1 | ||
Pathway Commons: STIM1 | ||
Context | iHOP: STIM1 | |
ligand binding site mutation search in PubMed: STIM1 | ||
UCL Cancer Institute: STIM1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0005513 | detection of calcium ion | 16005298 | GO:0032237 | activation of store-operated calcium channel activity | 16005298 | GO:0051924 | regulation of calcium ion transport | 16005298 |
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Ligand binding site mutations for STIM1 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | Y362 | Y361C | COAD | 1 | L351 | W350L | LUAD | 1 | E87 | E87Q | LUAD | 1 | A343 | A343V | SKCM | 1 | R6 | V5I | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for STIM1 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R6 | V5I | 0.23964216 | Y362 | Y361C | -1.4790617 | E87 | E87Q | -0.96067209 | A343 | A343V | -0.38550657 | L351 | W350L | -0.37110396 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for STIM1 |
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Phenotype information for STIM1 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0410207 | MYOPATHY, TUBULAR AGGREGATE | 3 | Biomarker, GeneticVariation |
umls:C2748557 | Immune dysfunction with T-cell inactivation due to calcium entry defect 2 | 2 | Biomarker, GeneticVariation |
umls:C1861451 | Stormorken Syndrome | 2 | Biomarker, GeneticVariation |
umls:C0020538 | Hypertension | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for STIM1 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (GLY,SER,GLU,LEU,ASN,GLU,LEU,ALA,GLU,PHE,ALA,ARG,LEU,GLN,ASP,GLN,LEU,ASP,HIS,ARG,GLY,ASP,HIS) | 2mak | A | A343 L351 Y362 | III | Peptide ligand (GLY,SER,GLU,LEU,ASN,GLU,LEU,ALA,GLU,PHE,ALA,ARG,LEU,GLN,ASP,GLN,LEU,ASP,HIS,ARG,GLY,ASP,HIS) | 2mak | C | A343 L351 Y362 | CA | CALCIUM(2+) | 2k60 | A | E87 | III | Peptide ligand (GLY,SER,GLU,LEU,ASN,GLU,LEU,ALA,GLU,PHE,ALA,ARG,LEU,GLN,ASP,GLN,LEU,ASP,HIS,ARG,GLY,ASP,HIS) | 2mak | A | Y362 | III | Peptide ligand (GLY,SER,GLU,LEU,ASN,GLU,LEU,ALA,GLU,PHE,ALA,ARG,LEU,GLN,ASP,GLN,LEU,ASP,HIS,ARG,GLY,ASP,HIS) | 2mak | C | Y362 |
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Conservation information for LBS of STIM1 |
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LBS | AA sequence | # species | Species |
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