mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for STK3
Gene summary
Basic gene Info.Gene symbolSTK3
Gene nameserine/threonine kinase 3
SynonymsKRS1|MST2
CytomapUCSC genome browser: 8q22.2
Type of geneprotein-coding
RefGenesNM_001256312.1,
NM_001256313.1,NM_006281.3,
DescriptionMST-2STE20-like kinase MST2mammalian STE20-like protein kinase 2serine/threonine kinase 3 (STE20 homolog, yeast)serine/threonine kinase 3 (Ste20, yeast homolog)serine/threonine-protein kinase 3serine/threonine-protein kinase Krs-1
Modification date20141207
dbXrefs MIM : 605030
HGNC : HGNC
Ensembl : ENSG00000104375
HPRD : 05433
Vega : OTTHUMG00000164651
ProteinUniProt: Q13188
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_STK3
BioGPS: 6788
PathwayNCI Pathway Interaction Database: STK3
KEGG: STK3
REACTOME: STK3
Pathway Commons: STK3
ContextiHOP: STK3
ligand binding site mutation search in PubMed: STK3
UCL Cancer Institute: STK3
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006468protein phosphorylation20086174
GO:0032092positive regulation of protein binding22292086
GO:0035329hippo signaling20412773
GO:0035556intracellular signal transduction8566796


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Ligand binding site mutations for STK3
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L478,A480D479HBLCA1
N151G150VBRCA1
A54A54TCOAD1
K473A472VCOAD1
Y470T471ASTAD1
Y101Y101DSTAD1
S106S106YSTAD1
E462R461QUCEC1
I71E70DUCEC1
L33E31DUCEC1
A480A480VUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for STK3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Y101Y101D-1.4681754
Y470T471A-1.411606
E462R461Q-0.94985612
I71E70D-0.89113449
A480A480V-0.80662562
L478D479H-0.758799
A480D479H-0.758799
L33E31D-0.70187499
A54A54T-0.60516292
N151G150V-0.44197919
S106S106Y-0.21832801
K473A472V-0.04544274
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for STK3 from PDB

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Differential gene expression and gene-gene network for STK3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of STK3 and the right PPI network was created from samples without mutations in the LBS of STK3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for STK3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for STK3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of STK3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ANPAMP-PNP4lgdBA54 S106 N151
ANPAMP-PNP4lgdCA54 Y101 S106 N151
ANPAMP-PNP4lgdDA54 Y101 S106 N151
IIIPeptide ligand (ASP,ALA,PHE,SER,ILE,PRO,GLU,LEU,GLN,ASN,PHE,LEU,THR,ILE,LEU,GLU,LYS,GLU,GLU,GLN,ASP,LYS,ILE,GLN,GLN,VAL,GLN,LYS,LYS)4lgdBE462 Y470 K473 L478 A480
IIIPeptide ligand (ASP,ALA,PHE,SER,ILE,PRO,GLU,LEU,GLN,ASN,PHE,LEU,THR,ILE,LEU,GLU,LYS,GLU,GLU,GLN,ASP,LYS,ILE,GLN,GLN,VAL,GLN,LYS,LYS)4lgdAI71
ANPAMP-PNP4lgdAL33 A54 Y101 S106


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Conservation information for LBS of STK3
Multiple alignments for Q13188 in multiple species
LBSAA sequence# speciesSpecies
A480QPILDAMDAKK4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
A480QPILDVIEIKK1Caenorhabditis elegans
A480QPIVDAMNAKR1Drosophila melanogaster
A54SGQVVAIKQVP4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
A54SGHVLAIKKVP1Caenorhabditis elegans
A54SSSIVAIKLVP1Drosophila melanogaster
C102IVMEYCGAGSV4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
C102IVMEYCGAGSI1Caenorhabditis elegans
C102ICMEYCGAGSV1Drosophila melanogaster
D109AGSVSDIIRLR4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
D109AGSISDIMRAR1Caenorhabditis elegans
D109AGSVSDIMRLR1Drosophila melanogaster
D164HAKLADFGVAG4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
D164IAKLADFGVAG1Caenorhabditis elegans
D164YAKLADFGVAG1Drosophila melanogaster
E100LWIVMEYCGAG5Homo sapiens, Caenorhabditis elegans, Danio rerio, Mus musculus, Rattus norvegicus
E100LWICMEYCGAG1Drosophila melanogaster
E16LKKLSEDSLTK4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
E16GFKLDSSALNK1Caenorhabditis elegans
E16LKKLSEESLLQ1Drosophila melanogaster
E35LEKLGEGSYGS4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
E35VGKLGEGSYGS1Caenorhabditis elegans
E35MYKLGEGSYGS1Drosophila melanogaster
E462PMMEREIEELR2Homo sapiens, Danio rerio
E462PMMEREIEELH2Mus musculus, Rattus norvegicus
E462SEMEEEIRELQ1Caenorhabditis elegans
E462HEMELEIEQLN1Drosophila melanogaster
F90YYGSYFKNTDL4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
F90YYGSYFKHSDL1Caenorhabditis elegans
F90YYGSYFKQYDL1Drosophila melanogaster
G105EYCGAGSVSDI5Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
G105EYCGAGSISDI1Caenorhabditis elegans
G34VLEKLGEGSYG4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
G34IVGKLGEGSYG1Caenorhabditis elegans
G34IMYKLGEGSYG1Drosophila melanogaster
G36EKLGEGSYGSV4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
G36GKLGEGSYGSV1Caenorhabditis elegans
G36YKLGEGSYGSV1Drosophila melanogaster
G39GEGSYGSVFKA4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
G39GEGSYGSVHKA1Caenorhabditis elegans
G39GEGSYGSVYKA1Drosophila melanogaster
I463MMEREIEELRQ2Homo sapiens, Danio rerio
I463MMEREIEELHQ2Mus musculus, Rattus norvegicus
I463EMEEEIRELQR1Caenorhabditis elegans
I463EMELEIEQLNK1Drosophila melanogaster
I477AKRQPILDAMD4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
I477TKRQPILDVIE1Caenorhabditis elegans
I477AKRQPIVDAMN1Drosophila melanogaster
I68DLQEIIKEISI4Homo sapiens, Caenorhabditis elegans, Danio rerio, Mus musculus
I68DLHEIIKEISI1Drosophila melanogaster
I68DVQEIIKEISI1Rattus norvegicus
I71EIIKEISIMQQ6Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
K473QRYTAKRQPIL2Homo sapiens, Danio rerio
K473QRYSAKRQPIL2Mus musculus, Rattus norvegicus
K473RRYKTKRQPIL1Caenorhabditis elegans
K473KKYNAKRQPIV1Drosophila melanogaster
K484DAMDAKKRRQQ4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
K484DVIEIKKRLQ-1Caenorhabditis elegans
K484DAMNAKRKRQQ1Drosophila melanogaster
K56QVVAIKQVPVE4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
K56HVLAIKKVPVD1Caenorhabditis elegans
K56SIVAIKLVPVE1Drosophila melanogaster
L153KAGNILLNTEG4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
L153KAGNILLNTDG1Caenorhabditis elegans
L153KAANILLNTEG1Drosophila melanogaster
L19LSEDSLTKQPE4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
L19LDSSALNKPPE1Caenorhabditis elegans
L19LSEESLLQPPE1Drosophila melanogaster
L33DVLEKLGEGSY4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
L33DIVGKLGEGSY1Caenorhabditis elegans
L33DIMYKLGEGSY1Drosophila melanogaster
L466REIEELRQRYT2Homo sapiens, Danio rerio
L466REIEELHQRYS2Mus musculus, Rattus norvegicus
L466EEIRELQRRYK1Caenorhabditis elegans
L466LEIEQLNKKYN1Drosophila melanogaster
L478KRQPILDAMDA4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
L478KRQPILDVIEI1Caenorhabditis elegans
L478KRQPIVDAMNA1Drosophila melanogaster
L64PVESDLQEIIK3Homo sapiens, Danio rerio, Mus musculus
L64PVDTDLQEIIK1Caenorhabditis elegans
L64PVESDLHEIIK1Drosophila melanogaster
L64PVESDVQEIIK1Rattus norvegicus
L95FKNTDLWIVME4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
L95FKHSDLWIVME1Caenorhabditis elegans
L95FKQYDLWICME1Drosophila melanogaster
M481PILDAMDAKKR4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
M481PILDVIEIKKR1Caenorhabditis elegans
M481PIVDAMNAKRK1Drosophila melanogaster
M99DLWIVMEYCGA5Homo sapiens, Caenorhabditis elegans, Danio rerio, Mus musculus, Rattus norvegicus
M99DLWICMEYCGA1Drosophila melanogaster
N151DIKAGNILLNT5Homo sapiens, Caenorhabditis elegans, Danio rerio, Mus musculus, Rattus norvegicus
N151DIKAANILLNT1Drosophila melanogaster
Q36Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
Q75EISIMQQCDSP5Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
Q75EISIMQQCKSK1Caenorhabditis elegans
R467EIEELRQRYTA2Homo sapiens, Danio rerio
R467EIEELHQRYSA2Mus musculus, Rattus norvegicus
R467EIRELQRRYKT1Caenorhabditis elegans
R467EIEQLNKKYNA1Drosophila melanogaster
R474RYTAKRQPILD2Homo sapiens, Danio rerio
R474RYSAKRQPILD2Mus musculus, Rattus norvegicus
R474RYKTKRQPILD1Caenorhabditis elegans
R474KYNAKRQPIVD1Drosophila melanogaster
S106YCGAGSVSDII4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
S106YCGAGSISDIM1Caenorhabditis elegans
S106YCGAGSVSDIM1Drosophila melanogaster
S37KLGEGSYGSVF4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
S37KLGEGSYGSVH1Caenorhabditis elegans
S37KLGEGSYGSVY1Drosophila melanogaster
T20SEDSLTKQPEE4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
T20DSSALNKPPEE1Caenorhabditis elegans
T20SEESLLQPPEK1Drosophila melanogaster
T93SYFKNTDLWIV4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
T93SYFKHSDLWIV1Caenorhabditis elegans
T93SYFKQYDLWIC1Drosophila melanogaster
V41GSYGSVFKAIH4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
V41GSYGSVHKAIH1Caenorhabditis elegans
V41GSYGSVYKAVH1Drosophila melanogaster
V60IKQVPVESDLQ3Homo sapiens, Danio rerio, Mus musculus
V60IKKVPVDTDLQ1Caenorhabditis elegans
V60IKLVPVESDLH1Drosophila melanogaster
V60IKQVPVESDVQ1Rattus norvegicus
V83DSPYVVKYYGS4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
V83KSKYVVKYYGS1Caenorhabditis elegans
V83DSPYVVRYYGS1Drosophila melanogaster
Y101WIVMEYCGAGS5Homo sapiens, Caenorhabditis elegans, Danio rerio, Mus musculus, Rattus norvegicus
Y101WICMEYCGAGS1Drosophila melanogaster
Y38LGEGSYGSVFK4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
Y38LGEGSYGSVHK1Caenorhabditis elegans
Y38LGEGSYGSVYK1Drosophila melanogaster
Y470ELRQRYTAKRQ2Homo sapiens, Danio rerio
Y470ELHQRYSAKRQ2Mus musculus, Rattus norvegicus
Y470ELQRRYKTKRQ1Caenorhabditis elegans
Y470QLNKKYNAKRQ1Drosophila melanogaster


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