mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for AURKA
Gene summary
Basic gene Info.Gene symbolAURKA
Gene nameaurora kinase A
SynonymsAIK|ARK1|AURA|AURORA2|BTAK|PPP1R47|STK15|STK6|STK7
CytomapUCSC genome browser: 20q13
Type of geneprotein-coding
RefGenesNM_003600.2,
NM_198433.1,NM_198434.1,NM_198435.1,NM_198436.1,
NM_198437.1,
DescriptionARK-1Aurora-A kinaseIPL1-related kinaseaurora 2aurora-related kinase 1aurora/IPL1-like kinaseaurora/IPL1-related kinase 1breast tumor-amplified kinasebreast-tumor-amplified kinasehARK1protein phosphatase 1, regulatory subunit 47serine/threonine
Modification date20141222
dbXrefs MIM : 603072
HGNC : HGNC
Ensembl : ENSG00000087586
HPRD : 04066
HPRD : 04352
Vega : OTTHUMG00000032796
ProteinUniProt: O14965
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AURKA
BioGPS: 6790
PathwayNCI Pathway Interaction Database: AURKA
KEGG: AURKA
REACTOME: AURKA
Pathway Commons: AURKA
ContextiHOP: AURKA
ligand binding site mutation search in PubMed: AURKA
UCL Cancer Institute: AURKA
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006468protein phosphorylation21600873
GO:0032091negative regulation of protein binding21820309


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Ligand binding site mutations for AURKA
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S155S155GCOAD2
S266G265ECOAD1
A273A273TCOAD1
S155S155NCOAD1
G276W277LLUAD1
G276G276WLUSC1
G216G216RSKCM1
E211E211DSTAD1
H176H176YSTAD1
V206V206ASTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for AURKA from My Cancer Genome.
Aurora kinase A (AURKA) is a gene that encodes a protein that functions as a cell cycle-regulated kinase that regulates microtubule formation during mitosis. Missense, nonsense, and silent mutations are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer. Related Pathways: Cell cycle control. Modified: December 4, 2015

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Protein structure related information for AURKA
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S155S155G-1.689534
S155S155N-1.5384723
E211E211D-1.5101865
A273A273T-1.4226644
V206V206A-1.2671458
G276G276W-0.7321789
S266G265E-0.58125095
G216G216R-0.40804082
G276W277L-0.35510764
H176H176Y-0.11217344
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for AURKA from PDB
PDB IDPDB titlePDB structure
1MQ4Crystal Structure of Aurora-A Protein Kinase

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Differential gene expression and gene-gene network for AURKA
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of AURKA and the right PPI network was created from samples without mutations in the LBS of AURKA. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for AURKA
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1458155Breast Neoplasms15AlteredExpression, Biomarker, GeneticVariation
umls:C0027819Neuroblastoma6Biomarker
umls:C0025202Melanoma4Biomarker
umls:C0009404Colorectal Neoplasms2Biomarker, PostTranslationalModification
umls:C0022665Kidney Neoplasms2Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms2Biomarker, GeneticVariation
umls:C0017661Glomerulonephritis, IGA1Biomarker
umls:C0024668Mammary Neoplasms, Experimental1Biomarker
umls:C0031117Peripheral Nervous System Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for AURKA
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB02482PhosphonothreonineSmall molecule
InvestigationalDB05169AT9283Small molecule
InvestigationalDB05198CYC116Small molecule
InvestigationalDB05220MLN8237Small molecule
ExperimentalDB071864-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDESmall molecule
ExperimentalDB072668-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4',3':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-oneSmall molecule
ExperimentalDB073601-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]ureaSmall molecule
ExperimentalDB073611-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}ureaSmall molecule
ExperimentalDB073621-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]ureaSmall molecule
ExperimentalDB07545N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDESmall molecule
ExperimentalDB07801N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamideSmall molecule
ExperimentalDB080652-(1H-pyrazol-3-yl)-1H-benzimidazoleSmall molecule
ExperimentalDB08066N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of AURKA go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ADPADP1mq4AE211
ADNADENOSINE1muoAE211
ADPADP1ol5AE211
ATPATP1ol6AE211
ADPADP1ol7AE211
MPYPHA-6806322bmcFE211
ANPAMP-PNP2dwbAE211
ADPADP2wqeAE211
0BX4-{[4-(PHENYLAMINO)PYRIMIDIN-2-YL]AMINO}BENZOIC ACID3uo5AE211
ADPADP4deeAE211
ADPADP4bn1AE211
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4c3pAE211
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4c3pDE211
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4c3rAE211
ADNADENOSINE4o0sAE211
ADNADENOSINE4o0uAE211
ADNADENOSINE4o0wAE211
ADPADP4cegAE211
AK81-[3-METHYL-4-({3-[2-(METHYLAMINO)PYRIMIDIN-4-YL]PYRIDIN-2-YL}OXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA3efwAE211 A273
AK81-[3-METHYL-4-({3-[2-(METHYLAMINO)PYRIMIDIN-4-YL]PYRIDIN-2-YL}OXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA3efwBE211 A273
JVE(4S)-4-(2-FLUOROPHENYL)-2,4,6,7,8,9- HEXAHYDRO-5H-PYRAZOLO[3,4-B][1,7]NAPHTHYRIDIN-5- ONE4uzhAE211 A273
MPYPHA-6806322bmcAE211 G216
MPYPHA-6806322bmcBE211 G216
MPYPHA-6806322bmcCE211 G216
MPYPHA-6806322bmcDE211 G216
MPYPHA-6806322bmcEE211 G216
CC3N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE2np8AE211 G216
L0C4-{[2-(4-{[(4-FLUOROPHENYL)CARBONYL]AMINO}-1H-PYRAZOL-3-YL)-1H-BENZIMIDAZOL-6-YL]METHYL}MORPHOLIN-4-IUM2w1cAE211 G216
L0D2-(1H-PYRAZOL-3-YL)-1H-BENZIMIDAZOLE2w1dAE211 G216
L0E4-[(2-{4-[(PHENYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-5-YL)METHYL]MORPHOLIN-4-IUM2w1eAE211 G216
L0FN-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE2w1fAE211 G216
L0G2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-6-(MORPHOLIN-4-IUM-4-YLMETHYL)-1H-3,1-BENZIMIDAZOL-3-IUM2w1gAE211 G216
X6D6-BROMO-7-[4-(4-CHLOROBENZYL)PIPERAZIN-1-YL]-2-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]-3H-IMIDAZO[4,5-B]PYRIDINECTT1374442x6dAE211 G216
YM46-BROMO-7-{4-[(5-METHYLISOXAZOL-3-YL)METHYL]PIPERAZIN-1-YL}-2-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-IMIDAZO[4,5-B]PYRIDINE2x6eAE211 G216
ASH3-CHLORO-N-(4-MORPHOLIN-4-YLPHENYL)-6-PYRIDIN-3-YLIMIDAZO[1,2-A]PYRAZIN-8-AMINE2xneAE211 G216
A0HN-(3-{3-CHLORO-8-[(4-MORPHOLIN-4-YLPHENYL)AMINO]IMIDAZO[1,2-A]PYRAZIN-6-YL}BENZYL)METHANESULFONAMIDE2xngAE211 G216
400PHA-8283002xruAE211 G216
83H8-ETHYL-2,5,6,12-TETRAHYDRO-3,10,10-TRIMETHYL-9-OXO-PYRAZOLO[4'3':6,7]CYCLOHEPTA[1,2-B]PYRROLO[2,3-F]INDOLE3cohAE211 G216
83H8-ETHYL-2,5,6,12-TETRAHYDRO-3,10,10-TRIMETHYL-9-OXO-PYRAZOLO[4'3':6,7]CYCLOHEPTA[1,2-B]PYRROLO[2,3-F]INDOLE3cohBE211 G216
MMH(E)-N-(3-ACETAMIDOPHENYL)-5-(2-(4-METHOXYBENZYLIDENE)HYDRAZINYL)-3-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE3fdnAE211 G216
48B2-CHLORO-N-[4-({5-FLUORO-2-[(4-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)PHENYL]BENZAMIDE3h0yAE211 G216
45B4-{[2-({4-[2-(4-ACETYLPIPERAZIN-1-YL)-2-OXOETHYL]PHENYL}AMINO)-5-FLUOROPYRIMIDIN-4-YL]AMINO}-N-(2-CHLOROPHENYL)BENZAMIDE3h0zAE211 G216
45B4-{[2-({4-[2-(4-ACETYLPIPERAZIN-1-YL)-2-OXOETHYL]PHENYL}AMINO)-5-FLUOROPYRIMIDIN-4-YL]AMINO}-N-(2-CHLOROPHENYL)BENZAMIDE3h0zBE211 G216
45B4-{[2-({4-[2-(4-ACETYLPIPERAZIN-1-YL)-2-OXOETHYL]PHENYL}AMINO)-5-FLUOROPYRIMIDIN-4-YL]AMINO}-N-(2-CHLOROPHENYL)BENZAMIDE3h0zCE211 G216
2JZN~2~-(3,4-DIMETHOXYPHENYL)-N~4~-[2-(2-FLUOROPHENYL)ETHYL]-N~6~-QUINOLIN-6-YL-1,3,5-TRIAZINE-2,4,6-TRIAMINE3ha6AE211 G216
OFIN-[6-(4-HYDROXYPHENYL)-1H-INDAZOL-3-YL]BUTANAMIDE3lauAE211 G216
AKI1-(4-{2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHYL}PHENYL)-3-PHENYLUREA3m11AE211 G216
EMLSCH 14737593mygAE211 G216
P9J4-[(5-METHYL-1H-PYRAZOL-3-YL)AMINO]-2-PHENYLPHTHALAZIN-1(2H)-ONE3p9jAE211 G216
D36N-(2-AMINOETHYL)-N-{5-[(1-CYCLOHEPTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-YL)AMINO]PYRIDIN-2-YL}METHANESULFONAMIDE3r21AE211 G216
D37N-{5-[(1-CYCLOHEPTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-YL)AMINO]PYRIDIN-2-YL}METHANESULFONAMIDE3r22AE211 G216
0BZ4-({4-[(2-FLUOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZOIC ACID3unzAE211 G216
0BZ4-({4-[(2-FLUOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZOIC ACID3unzBE211 G216
0C92-({2-[(4-CARBOXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZOIC ACID3up7AE211 G216
0FY3-(1-{2-[(3-FLUOROPYRIDINIUM-4-YL)AMINO]-2-OXOETHYL}-1H-PYRAZOL-4-YL)-6-METHYL-8-[(3-{[(1R,3R)-3-METHYLPIPERIDINIUM-1-YL]METHYL}-1,2-THIAZOL-5-YL)AMINO]IMIDAZO[1,2-A]PYRAZIN-1-IUM3vapAE211 G216
NHI4,4'-(PYRIMIDINE-2,4-DIYLDIIMINO)DIBENZOIC ACID4deaAE211 G216
NHJ4-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2- YL)AMINO]BENZAMIDE4debAE211 G216
NHU2-({2-[(4-CARBAMOYLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO) BENZAMIDE4dedAE211 G216
0K67-CYCLOPENTYL-2-({1-METHYL-5-[(4-METHYLPIPERAZIN-1-YL) CARBONYL]-1H-PYRROL-3-YL}AMINO)-7H-PYRROLO[2,3- D]PYRIMIDINE-6-CARBOXAMIDE4dhfAE211 G216
0K67-CYCLOPENTYL-2-({1-METHYL-5-[(4-METHYLPIPERAZIN-1-YL) CARBONYL]-1H-PYRROL-3-YL}AMINO)-7H-PYRROLO[2,3- D]PYRIMIDINE-6-CARBOXAMIDE4dhfBE211 G216
VEK6-BROMO-2-(1-METHYL-1H-IMIDAZOL-5-YL)-7-{4- [(5-METHYL-1,2-OXAZOL-3-YL)METHYL]PIPERAZIN-1- YL}-1H-IMIDAZO[4,5-B]PYRIDINE4b0gAE211 G216
XU1BENZO[C][1,8]NAPHTHYRIDIN-6(5H)-ONE4jajAE211 G216
FH3(S)-N-((1-(6-CHLORO-2-(1,3-DIMETHYL-1H- PYRAZOL-4-YL)-3H-IMIDAZO[4,5-B]PYRIDIN-7-YL) PYRROLIDIN-3-YL)METHYL)ACETAMIDE4byiAE211 G216
FH5(S)-N-(1-(6-CHLORO-2-(1,3-DIMETHYL-1H- PYRAZOL-4-YL)-3H-IMIDAZO[4,5-B]PYRIDIN-7-YL) PYRROLIDIN-3-YL)ACETAMIDE4byjAE211 G216
CJ51-[4-[[4-[(5-CYCLOPENTYL-1H-PYRAZOL-3-YL) AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]-3-[3- (TRIFLUOROMETHYL)PHENYL]UREA4j8mAE211 G216
5GX7-(1-BENZYL-1H-PYRAZOL-4-YL)-6-CHLORO-2-(1,3- DIMETHYL-1H-PYRAZOL-4-YL)-3H-IMIDAZO[4,5-B] PYRIDINE5aadAE211 G216
7HD3-((4-(6-CHLORO-2-(1,3-DIMETHYL-1H-PYRAZOL-4- YL)-3H-IMIDAZO[4,5-B]PYRIDIN-7-YL)-1H- PYRAZOL-1-YL)METHYL)-5-METHYLISOXAZOLE5aaeAE211 G216
NL43-((4-(6-CHLORO-2-(1,3-DIMETHYL-1H-PYRAZOL-4- YL)-3H-IMIDAZO[4,5-B]PYRIDIN-7-YL)-1H- PYRAZOL-1-YL)METHYL)-N,N-DIMETHYLBENZAMIDE5aafAE211 G216
6F2[3-[[4-[6-CHLORANYL-2-(1,3-DIMETHYLPYRAZOL-4- YL)-3H-IMIDAZO[4,5-B]PYRIDIN-7-YL]PYRAZOL-1- YL]METHYL]PHENYL]-(4-METHYLPIPERAZIN-1-YL) METHANONE5aagAE211 G216
6264-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE2j4zAE211 G216 A273
6264-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE2j4zBE211 G216 A273
627N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE2j50AE211 G216 A273
627N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE2j50BE211 G216 A273
ZZL4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID2wtwAE211 G216 A273
ZZL4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID2x81AE211 G216 A273
VX6CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE3e5aAE211 G216 A273
PFQ2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL3k5uAE211 G216 A273
NRMN-(3-METHYLISOTHIAZOL-5-YL)-3-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZIN-8-AMINE3nrmAE211 G216 A273
0C04-{[4-(BIPHENYL-2-YLAMINO)PYRIMIDIN-2-YL]AMINO}BENZOICACID3uo4AE211 G216 A273
0BY4-({4-[(2-CHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZOIC ACID3uo6AE211 G216 A273
0BY4-({4-[(2-CHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZOIC ACID3uo6BE211 G216 A273
0C34-[(4-{[2-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]BENZOIC ACID3uodAE211 G216 A273
0C44-({4-[(2-BROMOPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZOIC ACID3uohAE211 G216 A273
0C44-({4-[(2-BROMOPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZOIC ACID3uohBE211 G216 A273
0C54-({4-[(2-CYANOPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZOIC ACID3uojAE211 G216 A273
0C54-({4-[(2-CYANOPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZOIC ACID3uojBE211 G216 A273
0C64-({4-[(2-CHLOROPHENYL)AMINO]-5-FLUOROPYRIMIDIN-2-YL}AMINO)BENZOIC ACID3uokAE211 G216 A273
0C64-({4-[(2-CHLOROPHENYL)AMINO]-5-FLUOROPYRIMIDIN-2-YL}AMINO)BENZOIC ACID3uokBE211 G216 A273
0C7N~4~-(2-CHLOROPHENYL)-N~2~-[4-(1H-TETRAZOL-5-YL)PHENYL]PYRIMIDINE-2,4-DIAMINE3uolAE211 G216 A273
0C7N~4~-(2-CHLOROPHENYL)-N~2~-[4-(1H-TETRAZOL-5-YL)PHENYL]PYRIMIDINE-2,4-DIAMINE3uolBE211 G216 A273
0C84-[(4-{[2-(TRIFLUOROMETHOXY)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]BENZOIC ACID3up2AE211 G216 A273
XU2N-{4-[(6-OXO-5,6-DIHYDROBENZO[C][1,8]NAPHTHYRIDIN-1- YL)AMINO]PHENYL}BENZAMIDE4jaiAE211 G216 A273
VX6CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE4jbqAE211 G216 A273
2VUN-[1-(3-CYANOBENZYL)-1H-PYRAZOL-4-YL]-6-(1H-PYRAZOL-4- YL)-1H-INDAZOLE-3-CARBOXAMIDE4prjAE211 G216 A273
Y3METHYL (9S)-9-[5-(1H-BENZIMIDAZOL-2- YLSULFANYL)FURAN-2-YL]-8-HYDROXY-5,6,7,9-TETRAHYDRO-2H PYRROLO[3,4-B]QUINOLINE-3-CARBOXYLATE4uynAE211 G216 A273
QMNETHYL (9S)-9-[3-(1H-BENZIMIDAZOL-2-YLOXY) PHENYL]-8-OXO-4,5,6,7,8,9-HEXAHYDRO-2H-PYRROLO[3, 4-B]QUINOLINE-3-CARBOXYLATE4uzdAE211 G216 A273
ZZL4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID2wtvAE211 G216 A273 G276
ZZL4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID2wtvBE211 G216 A273 G276
ZZL4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID2wtvCE211 G216 A273 G276
ZZL4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID2wtvDE211 G216 A273 G276
97B9-CHLORO-7-(2,6-DIFLUOROPHENYL)-N-{4-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]PHENYL}-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-AMINE3h10DE211 G216 A273 G276
QMNETHYL (9S)-9-[3-(1H-BENZIMIDAZOL-2-YLOXY) PHENYL]-8-OXO-4,5,6,7,8,9-HEXAHYDRO-2H-PYRROLO[3, 4-B]QUINOLINE-3-CARBOXYLATE4uzdBE211 G216 A273 G276
97B9-CHLORO-7-(2,6-DIFLUOROPHENYL)-N-{4-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]PHENYL}-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-AMINE3h10AE211 G216 G276
WPH1-(4-{2-[(6-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}FURO[2, 3-D]PYRIMIDIN-4-YL)AMINO]ETHYL}PHENYL)-3-PHENYLUREA4jboAE211 G216 G276
YPH1-(4-{2-[(6-{4-[2-(4-HYDROXYPIPERIDIN-1-YL) ETHOXY]PHENYL}FURO[2,3-D]PYRIMIDIN-4-YL) AMINO]ETHYL}PHENYL)-3-PHENYLUREA4jbpAE211 G216 G276
97B9-CHLORO-7-(2,6-DIFLUOROPHENYL)-N-{4-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]PHENYL}-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-AMINE3h10BE211 G276
E9Z5-CHLORO-N~4~-CYCLOPROPYL-N~2~-[4-(2-METHOXYETHOXY)PHENYL]PYRIMIDINE-2,4-DIAMINE3qbnAG216
MGMAGNESIUM(2+)3r21AG276
IIIPeptide ligand (VAL,LYS,SER,SER,TYR,SER,TYR,ASP,ALA,PRO,SER,ASP,PHE,ILE,ASN,PHE,SER)4c3pAH176
IIIPeptide ligand (VAL,LYS,SER,SER,TYR,SER,TYR,ASP,ALA,PRO,SER,ASP,PHE,ILE,ASN,PHE,SER)4c3pDS155
IIIPeptide ligand (SER,TYR,SER,TYR,ASP,ALA,PRO,SER,ASP,PHE,ILE,ASN,PHE,SER,SER)1ol5AS155 V206
IIIPeptide ligand (SER,SER,TYR,SER,TYR,ASP,ALA,PRO,SER,ASP,PHE,ILE,ASN,PHE,SER,SER)3e5aAS155 V206
IIIPeptide ligand (GLY,MET,SER,GLN,VAL,LYS,SER,SER,TYR,SER,TYR,ASP,ALA,PRO,SER,ASP,PHE,ILE,ASN,PHE,SER,SER,LEU)3ha6AS155 V206
IIIPeptide ligand (SER,SER,TYR,SER,TYR,ASP,ALA,PRO,SER,ASP,PHE,ILE,ASN,PHE,SER,SER,LEU)4c3pAS155 V206
ADPADP2wqeAS266


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Conservation information for LBS of AURKA
Multiple alignments for O14965 in multiple species
LBSAA sequence# speciesSpecies
A160SKFILALKVLF3Homo sapiens, Mus musculus, Bos taurus
A160GHFHVAIKVLF1Caenorhabditis elegans
A160SNHVVALKVLF1Arabidopsis thaliana
A160SDHIVALKVLF1Arabidopsis thaliana
A213LILEYAPLGTV2Homo sapiens, Mus musculus
A213LVLEYAPGGEM1Caenorhabditis elegans
A213LILEYAARGEL1Arabidopsis thaliana
A213LILEYAVRGEL1Arabidopsis thaliana
A213LILEYAPLGAV1Bos taurus
A273GELKIADFGWS5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
A273GELKIGDFGWS1Caenorhabditis elegans
A281GWSVHAPSSRR3Homo sapiens, Mus musculus, Bos taurus
A281GWSVHT-FNRR2Arabidopsis thaliana, Arabidopsis thaliana
A281GWSVHAPSNKR1Caenorhabditis elegans
D132QWALEDFEIGR2Homo sapiens, Bos taurus
D132KFTINDFEIGR1Caenorhabditis elegans
D132RWTLSDFDIGK1Arabidopsis thaliana
D132RWTTSDFDIGK1Arabidopsis thaliana
D132QWTLEDFDIGR1Mus musculus
D274ELKIADFGWSV5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
D274ELKIGDFGWSV1Caenorhabditis elegans
E152VYLAREKQSKF2Homo sapiens, Bos taurus
E152VYLARTKTGHF1Caenorhabditis elegans
E152VYLAREKRSNH1Arabidopsis thaliana
E152VYLAREKRSDH1Arabidopsis thaliana
E152VYLARERQSKF1Mus musculus
E170FKAQLEKAGVE2Homo sapiens, Bos taurus
E170FKSQLISGGVE1Caenorhabditis elegans
E170FKSQLQQSQVE1Arabidopsis thaliana
E170FKAQLQQSQVE1Arabidopsis thaliana
E170FKTQLEKANVE1Mus musculus
E175EKAGVEHQLRR2Homo sapiens, Bos taurus
E175QQSQVEHQLRR2Arabidopsis thaliana, Arabidopsis thaliana
E175ISGGVEHQLER1Caenorhabditis elegans
E175EKANVEHQLRR1Mus musculus
E181HQLRREVEIQS5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
E181HQLEREIEIQS1Caenorhabditis elegans
E183LRREVEIQSHL5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
E183LEREIEIQSHL1Caenorhabditis elegans
E211VYLILEYAPLG3Homo sapiens, Mus musculus, Bos taurus
E211IYLVLEYAPGG1Caenorhabditis elegans
E211VYLILEYAARG1Arabidopsis thaliana
E211VYLILEYAVRG1Arabidopsis thaliana
E221GTVYRELQKLS2Homo sapiens, Mus musculus
E221GEMYKQLTVSK1Caenorhabditis elegans
E221GELYKDLQKCK1Arabidopsis thaliana
E221GELYKELQKCK1Arabidopsis thaliana
E221GAVYRELQKLS1Bos taurus
E260RDIKPENLLLG3Homo sapiens, Mus musculus, Bos taurus
E260RDIKPENLLIG3Caenorhabditis elegans, Arabidopsis thaliana, Arabidopsis thaliana
F144LGKGKFGNVYL3Homo sapiens, Mus musculus, Bos taurus
F144LGRGKFGHVYL2Arabidopsis thaliana, Arabidopsis thaliana
F144LGKGKFGSVYL1Caenorhabditis elegans
F157EKQSKFILALK2Homo sapiens, Bos taurus
F157TKTGHFHVAIK1Caenorhabditis elegans
F157EKRSNHVVALK1Arabidopsis thaliana
F157EKRSDHIVALK1Arabidopsis thaliana
F157ERQSKFILALK1Mus musculus
F275LKIADFGWSVH5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
F275LKIGDFGWSVH1Caenorhabditis elegans
G140IGRPLGKGKFG4Homo sapiens, Caenorhabditis elegans, Mus musculus, Bos taurus
G140IGKPLGRGKFG2Arabidopsis thaliana, Arabidopsis thaliana
G142RPLGKGKFGNV3Homo sapiens, Mus musculus, Bos taurus
G142KPLGRGKFGHV2Arabidopsis thaliana, Arabidopsis thaliana
G142RPLGKGKFGSV1Caenorhabditis elegans
G145GKGKFGNVYLA3Homo sapiens, Mus musculus, Bos taurus
G145GRGKFGHVYLA2Arabidopsis thaliana, Arabidopsis thaliana
G145GKGKFGSVYLA1Caenorhabditis elegans
G198ILRLYGYFHDA3Homo sapiens, Mus musculus, Bos taurus
G198ILRLYGYFYDQ2Arabidopsis thaliana, Arabidopsis thaliana
G198IIKLYTYFWDA1Caenorhabditis elegans
G216EYAPLGTVYRE2Homo sapiens, Mus musculus
G216EYAPGGEMYKQ1Caenorhabditis elegans
G216EYAARGELYKD1Arabidopsis thaliana
G216EYAVRGELYKE1Arabidopsis thaliana
G216EYAPLGAVYRE1Bos taurus
G276KIADFGWSVHA3Homo sapiens, Mus musculus, Bos taurus
G276KIADFGWSVHT2Arabidopsis thaliana, Arabidopsis thaliana
G276KIGDFGWSVHA1Caenorhabditis elegans
H176KAGVEHQLRRE2Homo sapiens, Bos taurus
H176QSQVEHQLRRE2Arabidopsis thaliana, Arabidopsis thaliana
H176SGGVEHQLERE1Caenorhabditis elegans
H176KANVEHQLRRE1Mus musculus
H187VEIQSHLRHPN5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
H187IEIQSHLNHPN1Caenorhabditis elegans
H201LYGYFHDATRV3Homo sapiens, Mus musculus, Bos taurus
H201LYGYFYDQKRV2Arabidopsis thaliana, Arabidopsis thaliana
H201LYTYFWDAKKI1Caenorhabditis elegans
H280FGWSVHAPSSR3Homo sapiens, Mus musculus, Bos taurus
H280FGWSVHT-FNR2Arabidopsis thaliana, Arabidopsis thaliana
H280FGWSVHAPSNK1Caenorhabditis elegans
I158KQSKFILALKV2Homo sapiens, Bos taurus
I158KTGHFHVAIKV1Caenorhabditis elegans
I158KRSNHVVALKV1Arabidopsis thaliana
I158KRSDHIVALKV1Arabidopsis thaliana
I158RQSKFILALKV1Mus musculus
I184RREVEIQSHLR5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
I184EREIEIQSHLN1Caenorhabditis elegans
K125NEESKKRQWAL2Homo sapiens, Bos taurus
K125NTPQKGGKFTI1Caenorhabditis elegans
K125SAAAAQKRWTL1Arabidopsis thaliana
K125ASEAAQKRWTT1Arabidopsis thaliana
K125TEDTKKRQWTL1Mus musculus
K141GRPLGKGKFGN3Homo sapiens, Mus musculus, Bos taurus
K141GKPLGRGKFGH2Arabidopsis thaliana, Arabidopsis thaliana
K141GRPLGKGKFGS1Caenorhabditis elegans
K143PLGKGKFGNVY3Homo sapiens, Mus musculus, Bos taurus
K143PLGRGKFGHVY2Arabidopsis thaliana, Arabidopsis thaliana
K143PLGKGKFGSVY1Caenorhabditis elegans
K162FILALKVLFKA2Homo sapiens, Bos taurus
K162FHVAIKVLFKS1Caenorhabditis elegans
K162HVVALKVLFKS1Arabidopsis thaliana
K162HIVALKVLFKA1Arabidopsis thaliana
K162FILALKVLFKT1Mus musculus
K166LKVLFKAQLEK2Homo sapiens, Bos taurus
K166IKVLFKSQLIS1Caenorhabditis elegans
K166LKVLFKSQLQQ1Arabidopsis thaliana
K166LKVLFKAQLQQ1Arabidopsis thaliana
K166LKVLFKTQLEK1Mus musculus
K224YRELQKLSKFD3Homo sapiens, Mus musculus, Bos taurus
K224YKQLTVSKRFS1Caenorhabditis elegans
K224YKDLQKCKYFS1Arabidopsis thaliana
K224YKELQKCKYFS1Arabidopsis thaliana
K250SYCHSKRVIHR3Homo sapiens, Mus musculus, Bos taurus
K250IYCHGKHVIHR2Arabidopsis thaliana, Arabidopsis thaliana
K250SYCHRKNVIHR1Caenorhabditis elegans
L139EIGRPLGKGKF3Homo sapiens, Caenorhabditis elegans, Bos taurus
L139DIGKPLGRGKF2Arabidopsis thaliana, Arabidopsis thaliana
L139DIGRPLGKGKF1Mus musculus
L159QSKFILALKVL3Homo sapiens, Mus musculus, Bos taurus
L159TGHFHVAIKVL1Caenorhabditis elegans
L159RSNHVVALKVL1Arabidopsis thaliana
L159RSDHIVALKVL1Arabidopsis thaliana
L164LALKVLFKAQL2Homo sapiens, Bos taurus
L164VAIKVLFKSQL1Caenorhabditis elegans
L164VALKVLFKSQL1Arabidopsis thaliana
L164VALKVLFKAQL1Arabidopsis thaliana
L164LALKVLFKTQL1Mus musculus
L169LFKAQLEKAGV2Homo sapiens, Bos taurus
L169LFKSQLISGGV1Caenorhabditis elegans
L169LFKSQLQQSQV1Arabidopsis thaliana
L169LFKAQLQQSQV1Arabidopsis thaliana
L169LFKTQLEKANV1Mus musculus
L178GVEHQLRREVE2Homo sapiens, Bos taurus
L178QVEHQLRREVE2Arabidopsis thaliana, Arabidopsis thaliana
L178GVEHQLEREIE1Caenorhabditis elegans
L178NVEHQLRREVE1Mus musculus
L188EIQSHLRHPNI5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
L188EIQSHLNHPNI1Caenorhabditis elegans
L194RHPNILRLYGY5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
L194NHPNIIKLYTY1Caenorhabditis elegans
L208ATRVYLILEYA3Homo sapiens, Mus musculus, Bos taurus
L208QKRVYLILEYA2Arabidopsis thaliana, Arabidopsis thaliana
L208AKKIYLVLEYA1Caenorhabditis elegans
L210RVYLILEYAPL3Homo sapiens, Mus musculus, Bos taurus
L210KIYLVLEYAPG1Caenorhabditis elegans
L210RVYLILEYAAR1Arabidopsis thaliana
L210RVYLILEYAVR1Arabidopsis thaliana
L215LEYAPLGTVYR2Homo sapiens, Mus musculus
L215LEYAPGGEMYK1Caenorhabditis elegans
L215LEYAARGELYK1Arabidopsis thaliana
L215LEYAVRGELYK1Arabidopsis thaliana
L215LEYAPLGAVYR1Bos taurus
L263KPENLLLGSAG2Homo sapiens, Bos taurus
L263KPENLLIGAQG2Arabidopsis thaliana, Arabidopsis thaliana
L263KPENLLIGSQG1Caenorhabditis elegans
L263KPENLLLGSNG1Mus musculus
N146KGKFGNVYLAR3Homo sapiens, Mus musculus, Bos taurus
N146RGKFGHVYLAR2Arabidopsis thaliana, Arabidopsis thaliana
N146KGKFGSVYLAR1Caenorhabditis elegans
N261DIKPENLLLGS3Homo sapiens, Mus musculus, Bos taurus
N261DIKPENLLIGA2Arabidopsis thaliana, Arabidopsis thaliana
N261DIKPENLLIGS1Caenorhabditis elegans
P214ILEYAPLGTVY2Homo sapiens, Mus musculus
P214VLEYAPGGEMY1Caenorhabditis elegans
P214ILEYAARGELY1Arabidopsis thaliana
P214ILEYAVRGELY1Arabidopsis thaliana
P214ILEYAPLGAVY1Bos taurus
P282WSVHAPSSRRT3Homo sapiens, Mus musculus, Bos taurus
P282WSVHT-FNRRR2Arabidopsis thaliana, Arabidopsis thaliana
P282WSVHAPSNKRQ1Caenorhabditis elegans
Q127ESKKRQWALED2Homo sapiens, Bos taurus
Q127PQKGGKFTIND1Caenorhabditis elegans
Q127AAAQKRWTLSD1Arabidopsis thaliana
Q127EAAQKRWTTSD1Arabidopsis thaliana
Q127DTKKRQWTLED1Mus musculus
Q154LAREKQSKFIL2Homo sapiens, Bos taurus
Q154LARTKTGHFHV1Caenorhabditis elegans
Q154LAREKRSNHVV1Arabidopsis thaliana
Q154LAREKRSDHIV1Arabidopsis thaliana
Q154LARERQSKFIL1Mus musculus
Q177AGVEHQLRREV2Homo sapiens, Bos taurus
Q177SQVEHQLRREV2Arabidopsis thaliana, Arabidopsis thaliana
Q177GGVEHQLEREI1Caenorhabditis elegans
Q177ANVEHQLRREV1Mus musculus
Q185REVEIQSHLRH5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
Q185REIEIQSHLNH1Caenorhabditis elegans
Q223VYRELQKLSKF3Homo sapiens, Mus musculus, Bos taurus
Q223MYKQLTVSKRF1Caenorhabditis elegans
Q223LYKDLQKCKYF1Arabidopsis thaliana
Q223LYKELQKCKYF1Arabidopsis thaliana
R126EESKKRQWALE2Homo sapiens, Bos taurus
R126TPQKGGKFTIN1Caenorhabditis elegans
R126AAAAQKRWTLS1Arabidopsis thaliana
R126SEAAQKRWTTS1Arabidopsis thaliana
R126EDTKKRQWTLE1Mus musculus
R137DFEIGRPLGKG3Homo sapiens, Caenorhabditis elegans, Bos taurus
R137DFDIGKPLGRG2Arabidopsis thaliana, Arabidopsis thaliana
R137DFDIGRPLGKG1Mus musculus
R179VEHQLRREVEI5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
R179VEHQLEREIEI1Caenorhabditis elegans
R189IQSHLRHPNIL5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
R189IQSHLNHPNII1Caenorhabditis elegans
R195HPNILRLYGYF5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
R195HPNIIKLYTYF1Caenorhabditis elegans
R220LGTVYRELQKL2Homo sapiens, Mus musculus
R220GGEMYKQLTVS1Caenorhabditis elegans
R220RGELYKDLQKC1Arabidopsis thaliana
R220RGELYKELQKC1Arabidopsis thaliana
R220LGAVYRELQKL1Bos taurus
S155AREKQSKFILA2Homo sapiens, Bos taurus
S155ARTKTGHFHVA1Caenorhabditis elegans
S155AREKRSNHVVA1Arabidopsis thaliana
S155AREKRSDHIVA1Arabidopsis thaliana
S155ARERQSKFILA1Mus musculus
S186EVEIQSHLRHP5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
S186EIEIQSHLNHP1Caenorhabditis elegans
S266NLLLGSAGELK2Homo sapiens, Bos taurus
S266NLLIGAQGELK2Arabidopsis thaliana, Arabidopsis thaliana
S266NLLIGSQGELK1Caenorhabditis elegans
S266NLLLGSNGELK1Mus musculus
T217YAPLGTVYREL2Homo sapiens, Mus musculus
T217YAPGGEMYKQL1Caenorhabditis elegans
T217YAARGELYKDL1Arabidopsis thaliana
T217YAVRGELYKEL1Arabidopsis thaliana
T217YAPLGAVYREL1Bos taurus
V147GKFGNVYLARE3Homo sapiens, Mus musculus, Bos taurus
V147GKFGHVYLARE2Arabidopsis thaliana, Arabidopsis thaliana
V147GKFGSVYLART1Caenorhabditis elegans
V174LEKAGVEHQLR2Homo sapiens, Bos taurus
V174LQQSQVEHQLR2Arabidopsis thaliana, Arabidopsis thaliana
V174LISGGVEHQLE1Caenorhabditis elegans
V174LEKANVEHQLR1Mus musculus
V182QLRREVEIQSH5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Bos taurus
V182QLEREIEIQSH1Caenorhabditis elegans
V206HDATRVYLILE3Homo sapiens, Mus musculus, Bos taurus
V206YDQKRVYLILE2Arabidopsis thaliana, Arabidopsis thaliana
V206WDAKKIYLVLE1Caenorhabditis elegans
V252CHSKRVIHRDI3Homo sapiens, Mus musculus, Bos taurus
V252CHGKHVIHRDI2Arabidopsis thaliana, Arabidopsis thaliana
V252CHRKNVIHRDI1Caenorhabditis elegans
V279DFGWSVHAPSS3Homo sapiens, Mus musculus, Bos taurus
V279DFGWSVHT-FN2Arabidopsis thaliana, Arabidopsis thaliana
V279DFGWSVHAPSN1Caenorhabditis elegans
W128SKKRQWALEDF2Homo sapiens, Bos taurus
W128QKGGKFTINDF1Caenorhabditis elegans
W128AAQKRWTLSDF1Arabidopsis thaliana
W128AAQKRWTTSDF1Arabidopsis thaliana
W128TKKRQWTLEDF1Mus musculus
Y197NILRLYGYFHD3Homo sapiens, Mus musculus, Bos taurus
Y197NILRLYGYFYD2Arabidopsis thaliana, Arabidopsis thaliana
Y197NIIKLYTYFWD1Caenorhabditis elegans
Y199LRLYGYFHDAT3Homo sapiens, Mus musculus, Bos taurus
Y199LRLYGYFYDQK2Arabidopsis thaliana, Arabidopsis thaliana
Y199IKLYTYFWDAK1Caenorhabditis elegans
Y212YLILEYAPLGT2Homo sapiens, Mus musculus
Y212YLVLEYAPGGE1Caenorhabditis elegans
Y212YLILEYAARGE1Arabidopsis thaliana
Y212YLILEYAVRGE1Arabidopsis thaliana
Y212YLILEYAPLGA1Bos taurus
Y219PLGTVYRELQK2Homo sapiens, Mus musculus
Y219PGGEMYKQLTV1Caenorhabditis elegans
Y219ARGELYKDLQK1Arabidopsis thaliana
Y219VRGELYKELQK1Arabidopsis thaliana
Y219PLGAVYRELQK1Bos taurus
Y246ANALSYCHSKR3Homo sapiens, Mus musculus, Bos taurus
Y246ARALIYCHGKH2Arabidopsis thaliana, Arabidopsis thaliana
Y246ADALSYCHRKN1Caenorhabditis elegans


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