mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for STK10
Gene summary
Basic gene Info.Gene symbolSTK10
Gene nameserine/threonine kinase 10
SynonymsLOK|PRO2729
CytomapUCSC genome browser: 5q35.1
Type of geneprotein-coding
RefGenesNM_005990.3,
Descriptionlymphocyte-oriented kinaseserine/threonine-protein kinase 10
Modification date20141207
dbXrefs MIM : 603919
HGNC : HGNC
Ensembl : ENSG00000072786
HPRD : 06796
Vega : OTTHUMG00000163265
ProteinUniProt: O94804
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_STK10
BioGPS: 6793
PathwayNCI Pathway Interaction Database: STK10
KEGG: STK10
REACTOME: STK10
Pathway Commons: STK10
ContextiHOP: STK10
ligand binding site mutation search in PubMed: STK10
UCL Cancer Institute: STK10
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0046777protein autophosphorylation12639966


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Ligand binding site mutations for STK10
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
H155R156QBLCA1
L85L85QCOAD1
E72E72KHNSC1
A174A174SLUAD1
L85L85POV1
A120A120DSKCM1
E266,S264V265IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for STK10
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
L85L85Q-1.1085685
A174A174S-1.1032066
L85L85P-0.96915654
E72E72K-0.58025062
A120A120D-0.57252245
H155R156Q-0.54599346
E266V265I-0.52107728
S264V265I-0.52107728
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for STK10 from PDB

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Differential gene expression and gene-gene network for STK10
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of STK10 and the right PPI network was created from samples without mutations in the LBS of STK10. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for STK10
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1336708Testicular Germ Cell Tumor1GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for STK10
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of STK10 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
274MET KINASE INHIBITOR2j7tAA120
GW8GW830263A4aotAA120
R094-{5-(6-METHOXYNAPHTHALEN-2-YL)-1-METHYL-2- [2-METHYL-4-(METHYLSULFONYL)PHENYL]-1H- IMIDAZOL-4-YL}PYRIDINE4usdAA120 A174
R094-{5-(6-METHOXYNAPHTHALEN-2-YL)-1-METHYL-2- [2-METHYL-4-(METHYLSULFONYL)PHENYL]-1H- IMIDAZOL-4-YL}PYRIDINE4usdBA120 A174
G6IN-{3-[(3-{4-[(4-METHOXYPHENYL)AMINO]-1,3,5-TRIAZIN-2- YL}PYRIDIN-2-YL)AMINO]-4-METHYLPHENYL}-3- (TRIFLUOROMETHYL)BENZAMIDE4equBL85 A174
G6IN-{3-[(3-{4-[(4-METHOXYPHENYL)AMINO]-1,3,5-TRIAZIN-2- YL}PYRIDIN-2-YL)AMINO]-4-METHYLPHENYL}-3- (TRIFLUOROMETHYL)BENZAMIDE4equAL85 H155 A174
CACALCIUM(2+)2j7tAS264 E266


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Conservation information for LBS of STK10
Multiple alignments for O94804 in multiple species
LBSAA sequence# speciesSpecies
A117FCPGGAVDAIM4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
A120GGAVDAIMLEL4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
A174GDIRLADFGVS2Homo sapiens, Mus musculus
A174GDIKLADFGVS2Danio rerio, Xenopus tropicalis
A310ELVAEAKAEVM3Homo sapiens, Danio rerio, Mus musculus
A310DLVAEAKAEVL1Xenopus tropicalis
A63TGALAAAKVIE2Homo sapiens, Mus musculus
A63TGVLAAAKVIE1Danio rerio
A63TGILAAAKVIE1Xenopus tropicalis
A64GALAAAKVIET2Homo sapiens, Mus musculus
A64GVLAAAKVIET1Danio rerio
A64GILAAAKVIET1Xenopus tropicalis
C113IMIEFCPGGAV4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
D119PGGAVDAIMLE4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
D175DIRLADFGVSA2Homo sapiens, Mus musculus
D175DIKLADFGVSA2Danio rerio, Xenopus tropicalis
E111LWIMIEFCPGG3Homo sapiens, Xenopus tropicalis, Mus musculus
E111LSIMIEFCPGG1Danio rerio
E124DAIMLELDRGL4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
E266SKWSVEFRDFL2Homo sapiens, Mus musculus
E266SKWSMDFNDFL1Danio rerio
E266SKWSPEFHNFL1Xenopus tropicalis
E313AEAKAEVMEEI3Homo sapiens, Danio rerio, Mus musculus
E313AEAKAEVLDEI1Xenopus tropicalis
E72IETKSEEELED3Homo sapiens, Danio rerio, Mus musculus
E72IETKNEEELED1Xenopus tropicalis
E81EDYIVEIEILA2Homo sapiens, Mus musculus
E81EDYMVEIDILA1Danio rerio
E81EDYMVEIEILA1Xenopus tropicalis
F112WIMIEFCPGGA3Homo sapiens, Xenopus tropicalis, Mus musculus
F112SIMIEFCPGGA1Danio rerio
F176IRLADFGVSAK2Homo sapiens, Mus musculus
F176IKLADFGVSAK2Danio rerio, Xenopus tropicalis
F47LGDGAFGKVYK4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
G116EFCPGGAVDAI4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
G161RDLKAGNVLMT2Homo sapiens, Mus musculus
G161RDLKAGNILLT1Danio rerio
G161RDLKAGNVLLT1Xenopus tropicalis
G43IVGELGDGAFG2Homo sapiens, Mus musculus
G43IIGELGDGAFG2Danio rerio, Xenopus tropicalis
H155SKRIIHRDLKA1Homo sapiens
H155SMKIIHRDLKA1Danio rerio
H155SMKMIHRDLKA1Xenopus tropicalis
H155GKRIIHRDLKA1Mus musculus
I108DGKLWIMIEFC2Homo sapiens, Mus musculus
I108DNKLSIMIEFC1Danio rerio
I108EGKLWIMIEFC1Xenopus tropicalis
I110KLWIMIEFCPG3Homo sapiens, Xenopus tropicalis, Mus musculus
I110KLSIMIEFCPG1Danio rerio
I67AAAKVIETKSE3Homo sapiens, Danio rerio, Mus musculus
I67AAAKVIETKNE1Xenopus tropicalis
I93CDHPYIVKLLG2Homo sapiens, Mus musculus
I93CNHQYIVKLLD1Danio rerio
I93CNHHFIVKLLG1Xenopus tropicalis
K65ALAAAKVIETK2Homo sapiens, Mus musculus
K65VLAAAKVIETK1Danio rerio
K65ILAAAKVIETK1Xenopus tropicalis
L164KAGNVLMTLEG2Homo sapiens, Mus musculus
L164KAGNILLTLDG1Danio rerio
L164KAGNVLLTLDG1Xenopus tropicalis
L42EIVGELGDGAF2Homo sapiens, Mus musculus
L42EIIGELGDGAF2Danio rerio, Xenopus tropicalis
L85VEIEILATCDH2Homo sapiens, Mus musculus
L85VEIDILASCNH1Danio rerio
L85VEIEILATCNH1Xenopus tropicalis
N162DLKAGNVLMTL2Homo sapiens, Mus musculus
N162DLKAGNILLTL1Danio rerio
N162DLKAGNVLLTL1Xenopus tropicalis
P114MIEFCPGGAVD4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
Q135TEPQIQVVCRQ2Homo sapiens, Mus musculus
Q135QEPQIRVICKQ1Danio rerio
Q135KEPEIRTICRQ1Xenopus tropicalis
S264TPSKWSVEFRD2Homo sapiens, Mus musculus
S264QPSKWSMDFND1Danio rerio
S264SPSKWSPEFHN1Xenopus tropicalis
V178LADFGVSAKNL2Homo sapiens, Mus musculus
V178LADFGVSAKNT1Danio rerio
V178LADFGVSAKNV1Xenopus tropicalis
V314EAKAEVMEEIE3Homo sapiens, Danio rerio, Mus musculus
V314EAKAEVLDEIE1Xenopus tropicalis
V50GAFGKVYKAKN3Homo sapiens, Xenopus tropicalis, Mus musculus
V50GAFGKVYKAQN1Danio rerio
V94DHPYIVKLLGA2Homo sapiens, Mus musculus
V94NHQYIVKLLDA1Danio rerio
V94NHHFIVKLLGS1Xenopus tropicalis
Y78EELEDYIVEIE2Homo sapiens, Mus musculus
Y78EELEDYMVEID1Danio rerio
Y78EELEDYMVEIE1Xenopus tropicalis


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