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mutLBSgeneDB |
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| Gene summary for STK10 |
 Gene summary |
| Basic gene Info. | Gene symbol | STK10 |
| Gene name | serine/threonine kinase 10 | |
| Synonyms | LOK|PRO2729 | |
| Cytomap | UCSC genome browser: 5q35.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005990.3, | |
| Description | lymphocyte-oriented kinaseserine/threonine-protein kinase 10 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603919 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000072786 | ||
| HPRD : 06796 | ||
| Vega : OTTHUMG00000163265 | ||
| Protein | UniProt: O94804 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_STK10 | |
| BioGPS: 6793 | ||
| Pathway | NCI Pathway Interaction Database: STK10 | |
| KEGG: STK10 | ||
| REACTOME: STK10 | ||
| Pathway Commons: STK10 | ||
| Context | iHOP: STK10 | |
| ligand binding site mutation search in PubMed: STK10 | ||
| UCL Cancer Institute: STK10 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0046777 | protein autophosphorylation | 12639966 |
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| Ligand binding site mutations for STK10 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H155 | R156Q | BLCA | 1 | L85 | L85Q | COAD | 1 | E72 | E72K | HNSC | 1 | A174 | A174S | LUAD | 1 | L85 | L85P | OV | 1 | A120 | A120D | SKCM | 1 | E266,S264 | V265I | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for STK10 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | L85 | L85Q | -1.1085685 | A174 | A174S | -1.1032066 | L85 | L85P | -0.96915654 | E72 | E72K | -0.58025062 | A120 | A120D | -0.57252245 | H155 | R156Q | -0.54599346 | E266 | V265I | -0.52107728 | S264 | V265I | -0.52107728 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for STK10 from PDB |
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| Differential gene expression and gene-gene network for STK10 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for STK10 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1336708 | Testicular Germ Cell Tumor | 1 | GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for STK10 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of STK10 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 274 | MET KINASE INHIBITOR | 2j7t | A | A120 | GW8 | GW830263A | 4aot | A | A120 | R09 | 4-{5-(6-METHOXYNAPHTHALEN-2-YL)-1-METHYL-2- [2-METHYL-4-(METHYLSULFONYL)PHENYL]-1H- IMIDAZOL-4-YL}PYRIDINE | 4usd | A | A120 A174 | R09 | 4-{5-(6-METHOXYNAPHTHALEN-2-YL)-1-METHYL-2- [2-METHYL-4-(METHYLSULFONYL)PHENYL]-1H- IMIDAZOL-4-YL}PYRIDINE | 4usd | B | A120 A174 | G6I | N-{3-[(3-{4-[(4-METHOXYPHENYL)AMINO]-1,3,5-TRIAZIN-2- YL}PYRIDIN-2-YL)AMINO]-4-METHYLPHENYL}-3- (TRIFLUOROMETHYL)BENZAMIDE | 4equ | B | L85 A174 | G6I | N-{3-[(3-{4-[(4-METHOXYPHENYL)AMINO]-1,3,5-TRIAZIN-2- YL}PYRIDIN-2-YL)AMINO]-4-METHYLPHENYL}-3- (TRIFLUOROMETHYL)BENZAMIDE | 4equ | A | L85 H155 A174 | CA | CALCIUM(2+) | 2j7t | A | S264 E266 |
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| Conservation information for LBS of STK10 |
| Multiple alignments for O94804 in multiple species |
| LBS | AA sequence | # species | Species | A117 | FCPGGAVDAIM | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | A120 | GGAVDAIMLEL | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | A174 | GDIRLADFGVS | 2 | Homo sapiens, Mus musculus | A174 | GDIKLADFGVS | 2 | Danio rerio, Xenopus tropicalis | A310 | ELVAEAKAEVM | 3 | Homo sapiens, Danio rerio, Mus musculus | A310 | DLVAEAKAEVL | 1 | Xenopus tropicalis | A63 | TGALAAAKVIE | 2 | Homo sapiens, Mus musculus | A63 | TGVLAAAKVIE | 1 | Danio rerio | A63 | TGILAAAKVIE | 1 | Xenopus tropicalis | A64 | GALAAAKVIET | 2 | Homo sapiens, Mus musculus | A64 | GVLAAAKVIET | 1 | Danio rerio | A64 | GILAAAKVIET | 1 | Xenopus tropicalis | C113 | IMIEFCPGGAV | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | D119 | PGGAVDAIMLE | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | D175 | DIRLADFGVSA | 2 | Homo sapiens, Mus musculus | D175 | DIKLADFGVSA | 2 | Danio rerio, Xenopus tropicalis | E111 | LWIMIEFCPGG | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | E111 | LSIMIEFCPGG | 1 | Danio rerio | E124 | DAIMLELDRGL | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | E266 | SKWSVEFRDFL | 2 | Homo sapiens, Mus musculus | E266 | SKWSMDFNDFL | 1 | Danio rerio | E266 | SKWSPEFHNFL | 1 | Xenopus tropicalis | E313 | AEAKAEVMEEI | 3 | Homo sapiens, Danio rerio, Mus musculus | E313 | AEAKAEVLDEI | 1 | Xenopus tropicalis | E72 | IETKSEEELED | 3 | Homo sapiens, Danio rerio, Mus musculus | E72 | IETKNEEELED | 1 | Xenopus tropicalis | E81 | EDYIVEIEILA | 2 | Homo sapiens, Mus musculus | E81 | EDYMVEIDILA | 1 | Danio rerio | E81 | EDYMVEIEILA | 1 | Xenopus tropicalis | F112 | WIMIEFCPGGA | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | F112 | SIMIEFCPGGA | 1 | Danio rerio | F176 | IRLADFGVSAK | 2 | Homo sapiens, Mus musculus | F176 | IKLADFGVSAK | 2 | Danio rerio, Xenopus tropicalis | F47 | LGDGAFGKVYK | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | G116 | EFCPGGAVDAI | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | G161 | RDLKAGNVLMT | 2 | Homo sapiens, Mus musculus | G161 | RDLKAGNILLT | 1 | Danio rerio | G161 | RDLKAGNVLLT | 1 | Xenopus tropicalis | G43 | IVGELGDGAFG | 2 | Homo sapiens, Mus musculus | G43 | IIGELGDGAFG | 2 | Danio rerio, Xenopus tropicalis | H155 | SKRIIHRDLKA | 1 | Homo sapiens | H155 | SMKIIHRDLKA | 1 | Danio rerio | H155 | SMKMIHRDLKA | 1 | Xenopus tropicalis | H155 | GKRIIHRDLKA | 1 | Mus musculus | I108 | DGKLWIMIEFC | 2 | Homo sapiens, Mus musculus | I108 | DNKLSIMIEFC | 1 | Danio rerio | I108 | EGKLWIMIEFC | 1 | Xenopus tropicalis | I110 | KLWIMIEFCPG | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | I110 | KLSIMIEFCPG | 1 | Danio rerio | I67 | AAAKVIETKSE | 3 | Homo sapiens, Danio rerio, Mus musculus | I67 | AAAKVIETKNE | 1 | Xenopus tropicalis | I93 | CDHPYIVKLLG | 2 | Homo sapiens, Mus musculus | I93 | CNHQYIVKLLD | 1 | Danio rerio | I93 | CNHHFIVKLLG | 1 | Xenopus tropicalis | K65 | ALAAAKVIETK | 2 | Homo sapiens, Mus musculus | K65 | VLAAAKVIETK | 1 | Danio rerio | K65 | ILAAAKVIETK | 1 | Xenopus tropicalis | L164 | KAGNVLMTLEG | 2 | Homo sapiens, Mus musculus | L164 | KAGNILLTLDG | 1 | Danio rerio | L164 | KAGNVLLTLDG | 1 | Xenopus tropicalis | L42 | EIVGELGDGAF | 2 | Homo sapiens, Mus musculus | L42 | EIIGELGDGAF | 2 | Danio rerio, Xenopus tropicalis | L85 | VEIEILATCDH | 2 | Homo sapiens, Mus musculus | L85 | VEIDILASCNH | 1 | Danio rerio | L85 | VEIEILATCNH | 1 | Xenopus tropicalis | N162 | DLKAGNVLMTL | 2 | Homo sapiens, Mus musculus | N162 | DLKAGNILLTL | 1 | Danio rerio | N162 | DLKAGNVLLTL | 1 | Xenopus tropicalis | P114 | MIEFCPGGAVD | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | Q135 | TEPQIQVVCRQ | 2 | Homo sapiens, Mus musculus | Q135 | QEPQIRVICKQ | 1 | Danio rerio | Q135 | KEPEIRTICRQ | 1 | Xenopus tropicalis | S264 | TPSKWSVEFRD | 2 | Homo sapiens, Mus musculus | S264 | QPSKWSMDFND | 1 | Danio rerio | S264 | SPSKWSPEFHN | 1 | Xenopus tropicalis | V178 | LADFGVSAKNL | 2 | Homo sapiens, Mus musculus | V178 | LADFGVSAKNT | 1 | Danio rerio | V178 | LADFGVSAKNV | 1 | Xenopus tropicalis | V314 | EAKAEVMEEIE | 3 | Homo sapiens, Danio rerio, Mus musculus | V314 | EAKAEVLDEIE | 1 | Xenopus tropicalis | V50 | GAFGKVYKAKN | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | V50 | GAFGKVYKAQN | 1 | Danio rerio | V94 | DHPYIVKLLGA | 2 | Homo sapiens, Mus musculus | V94 | NHQYIVKLLDA | 1 | Danio rerio | V94 | NHHFIVKLLGS | 1 | Xenopus tropicalis | Y78 | EELEDYIVEIE | 2 | Homo sapiens, Mus musculus | Y78 | EELEDYMVEID | 1 | Danio rerio | Y78 | EELEDYMVEIE | 1 | Xenopus tropicalis |
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