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mutLBSgeneDB |
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| Gene summary for STK11 |
 Gene summary |
| Basic gene Info. | Gene symbol | STK11 |
| Gene name | serine/threonine kinase 11 | |
| Synonyms | LKB1|PJS|hLKB1 | |
| Cytomap | UCSC genome browser: 19p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000455.4, | |
| Description | liver kinase B1polarization-related protein LKB1renal carcinoma antigen NY-REN-19serine/threonine-protein kinase 11serine/threonine-protein kinase LKB1serine/threonine-protein kinase STK11 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 602216 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000118046 | ||
| HPRD : 03740 | ||
| Protein | UniProt: Q15831 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_STK11 | |
| BioGPS: 6794 | ||
| Pathway | NCI Pathway Interaction Database: STK11 | |
| KEGG: STK11 | ||
| REACTOME: STK11 | ||
| Pathway Commons: STK11 | ||
| Context | iHOP: STK11 | |
| ligand binding site mutation search in PubMed: STK11 | ||
| UCL Cancer Institute: STK11 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 12805220 | GO:0007050 | cell cycle arrest | 12805220 | GO:0032147 | activation of protein kinase activity | 18854309 | GO:0046777 | protein autophosphorylation | 11430832 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 11430832 |
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| Ligand binding site mutations for STK11 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G56 | G56W | LUAD | 2 | M1 | M1V | COAD | 1 | V63 | E65G | COAD | 1 | G58,G56 | E57G | COAD | 1 | Y60 | Y60C | COAD | 1 | K78 | K78R | COAD | 1 | L183 | N181I | LUAD | 1 | L183 | N181Y | LUAD | 1 | G56 | G56V | LUAD | 1 | K78 | K78E | LUAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Clinical information for STK11 from My Cancer Genome. |
| Serine/threonine kinase 11 (STK11) is a gene that encodes a protein that belongs to the serine/threonine kinase family. The protein functions in the regulation of cell polarity and is also a tumor suppressor. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as cervical cancer, gastrointestinal cancer, and lung cancer.Modified: July 1, 2015 |
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| Protein structure related information for STK11 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K78 | K78R | 0.75794265 | K78 | K78E | 0.69569503 | L183 | N181I | 0.036103604 | V63 | E65G | -1.0937975 | G56 | E57G | -0.9040518 | G58 | E57G | -0.9040518 | M1 | M1V | -0.75402661 | G56 | G56W | -0.45690564 | G56 | G56V | -0.42772888 | Y60 | Y60C | -0.26340729 | L183 | N181Y | -0.18829983 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for STK11 from PDB |
| PDB ID | PDB title | PDB structure | 4ZDR | Crystal structure of 14-3-3[zeta]-LKB1 fusion protein |  |
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| Differential gene expression and gene-gene network for STK11 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for STK11 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0031269 | Peutz-Jeghers Syndrome | 181 | Biomarker, GeneticVariation |
| umls:C0001418 | Adenocarcinoma | 29 | AlteredExpression, Biomarker, GeneticVariation |
| umls:C0024121 | Lung Neoplasms | 15 | AlteredExpression, Biomarker, GeneticVariation |
| umls:C0007137 | Carcinoma, Squamous Cell | 7 | AlteredExpression, Biomarker, GeneticVariation |
| umls:C0235974 | Pancreatic Carcinoma | 7 | Biomarker, GeneticVariation |
| umls:C0153594 | Testicular Cancer | 2 | Biomarker, GeneticVariation |
| umls:C0020538 | Hypertension | 1 | Biomarker |
| umls:C0149721 | Hypertrophy, Left Ventricular | 1 | Biomarker |
| umls:C1257915 | Intestinal Polyposis | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for STK11 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of STK11 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ANP | AMP-PNP | 2wtk | F | G56 G58 Y60 K78 L183 | ANP | AMP-PNP | 2wtk | C | G56 G58 Y60 V63 K78 L183 |
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| Conservation information for LBS of STK11 |
| Multiple alignments for Q15831 in multiple species |
| LBS | AA sequence | # species | Species | A76 | TLCRRAVKILK | 3 | Homo sapiens, Gallus gallus, Mus musculus | A76 | TLTRRAVKIMK | 1 | Caenorhabditis elegans | C132 | MVMEYCVCGMQ | 3 | Homo sapiens, Gallus gallus, Mus musculus | C132 | MVFEYCIGSVQ | 1 | Caenorhabditis elegans | E130 | MYMVMEYCVCG | 3 | Homo sapiens, Gallus gallus, Mus musculus | E130 | VYMVFEYCIGS | 1 | Caenorhabditis elegans | E138 | VCGMQEMLDSV | 3 | Homo sapiens, Gallus gallus, Mus musculus | E138 | IGSVQQLLDME | 1 | Caenorhabditis elegans | G56 | MGDLLGEGSYG | 3 | Homo sapiens, Gallus gallus, Mus musculus | G56 | WGGQIGTGSYG | 1 | Caenorhabditis elegans | G58 | DLLGEGSYGKV | 3 | Homo sapiens, Gallus gallus, Mus musculus | G58 | GQIGTGSYGKV | 1 | Caenorhabditis elegans | G61 | GEGSYGKVKEV | 2 | Homo sapiens, Mus musculus | G61 | GTGSYGKVKEC | 1 | Caenorhabditis elegans | G61 | GEGSYGKVKEM | 1 | Gallus gallus | K78 | CRRAVKILKKK | 3 | Homo sapiens, Gallus gallus, Mus musculus | K78 | TRRAVKIMKYD | 1 | Caenorhabditis elegans | L183 | KPGNLLLTTNG | 2 | Gallus gallus, Mus musculus | L183 | KPGNLLLTTGG | 1 | Homo sapiens | L183 | KPGNLLVSIDF | 1 | Caenorhabditis elegans | M1 | -----MEVVDP | 1 | Homo sapiens | M1 | QLNVDPDYDDD | 1 | Caenorhabditis elegans | M1 | -----MDMQES | 1 | Gallus gallus | M1 | -----MDVADP | 1 | Mus musculus | M129 | KMYMVMEYCVC | 3 | Homo sapiens, Gallus gallus, Mus musculus | M129 | KVYMVFEYCIG | 1 | Caenorhabditis elegans | S59 | LLGEGSYGKVK | 3 | Homo sapiens, Gallus gallus, Mus musculus | S59 | QIGTGSYGKVK | 1 | Caenorhabditis elegans | V63 | GSYGKVKEVLD | 2 | Homo sapiens, Mus musculus | V63 | GSYGKVKECID | 1 | Caenorhabditis elegans | V63 | GSYGKVKEMLD | 1 | Gallus gallus | Y60 | LGEGSYGKVKE | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y60 | IGTGSYGKVKE | 1 | Caenorhabditis elegans |
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