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mutLBSgeneDB |
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| Gene summary for SULT1A1 |
 Gene summary |
| Basic gene Info. | Gene symbol | SULT1A1 |
| Gene name | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | |
| Synonyms | HAST1/HAST2|P-PST|PST|ST1A1|ST1A3|STP|STP1|TSPST1 | |
| Cytomap | UCSC genome browser: 16p12.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001055.3, NM_177529.2,NM_177530.2,NM_177534.2,NM_177536.3, | |
| Description | P-PST 1aryl sulfotransferase 1phenol-sulfating phenol sulfotransferase 1sulfotransferase 1A1thermostable phenol sulfotransferase1ts-PST | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 171150 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000196502 | ||
| HPRD : 01372 | ||
| Vega : OTTHUMG00000131765 | ||
| Protein | UniProt: P50225 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SULT1A1 | |
| BioGPS: 6817 | ||
| Pathway | NCI Pathway Interaction Database: SULT1A1 | |
| KEGG: SULT1A1 | ||
| REACTOME: SULT1A1 | ||
| Pathway Commons: SULT1A1 | ||
| Context | iHOP: SULT1A1 | |
| ligand binding site mutation search in PubMed: SULT1A1 | ||
| UCL Cancer Institute: SULT1A1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006805 | xenobiotic metabolic process | 12471039 | GO:0008210 | estrogen metabolic process | 16221673 | GO:0009812 | flavonoid metabolic process | 20056724 | GO:0051923 | sulfation | 20056724 |
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| Ligand binding site mutations for SULT1A1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | I21 | P19L | KIRC | 2 | M77 | R78W | COAD | 1 | T51 | T51S | COAD | 1 | H108,K106 | T107A | OV | 1 | K197 | E198K | SKCM | 1 | M232 | M232I | SKCM | 1 | P90 | P90S | SKCM | 1 | F255 | P254H | SKCM | 1 | M77 | M77I | UCEC | 1 | P244 | V243I | UCEC | 1 | H149 | P150H | UCEC | 1 | T227 | T227M | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for SULT1A1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | I21 | P19L | 0.21192881 | M232 | M232I | -1.4898216 | T51 | T51S | -1.2384974 | K106 | T107A | -1.2016868 | H108 | T107A | -1.2016868 | F255 | P254H | -1.0100322 | M77 | M77I | -0.96341859 | P90 | P90S | -0.86716596 | P244 | V243I | -0.83765769 | K197 | E198K | -0.80113954 | H149 | P150H | -0.62033247 | M77 | R78W | -0.54830287 | T227 | T227M | -0.30068789 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SULT1A1 from PDB |
| PDB ID | PDB title | PDB structure | 4GRA | Crystal structure of SULT1A1 bound with PAP |  |
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| Differential gene expression and gene-gene network for SULT1A1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SULT1A1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0033578 | Prostatic Neoplasms | 3 | Biomarker, GeneticVariation |
| umls:C0042076 | Urologic Neoplasms | 2 | Biomarker, GeneticVariation |
| umls:C0008625 | Chromosome Aberrations | 1 | Biomarker |
| umls:C0009375 | Colonic Neoplasms | 1 | Biomarker |
| umls:C0151744 | Myocardial Ischemia | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SULT1A1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB01812 | Adenosine-3'-5'-Diphosphate | Small molecule |  |
| Experimental | DB04417 | P-Nitrophenol | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SULT1A1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NPO | 4-NITROPHENOL | 1ls6 | A | I21 K106 H108 H149 | 03V | 2-NAPHTHOL | 3u3k | A | I21 K106 H108 H149 | 03V | 2-NAPHTHOL | 3u3k | B | I21 K106 H108 H149 | NPO | 4-NITROPHENOL | 3u3r | A | I21 K106 H108 H149 | EST | ESTRADIOL | 2d06 | A | K106 H108 | EST | ESTRADIOL | 2d06 | B | K106 H108 | 3QV | 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBONITRILE | 3qvv | A | K106 H108 | 3QV | 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBONITRILE | 3qvv | B | K106 H108 | 3QV | 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBONITRILE | 3u3o | A | K106 H108 | NPO | 4-NITROPHENOL | 3qvu | A | K106 H108 H149 | NPO | 4-NITROPHENOL | 3qvu | B | K106 H108 H149 | 3QV | 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBONITRILE | 3u3m | A | K106 H108 H149 | 3QV | 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBONITRILE | 3u3o | A | M77 P90 P244 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 1ls6 | A | T51 K197 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3qvv | B | T51 K197 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3u3j | B | T51 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3qvu | B | T51 T227 M232 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 1z28 | A | T51 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 2d06 | A | T51 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 2d06 | B | T51 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3qvu | A | T51 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3qvv | A | T51 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3u3j | A | T51 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3u3k | A | T51 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3u3k | B | T51 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3u3m | A | T51 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3u3o | A | T51 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3u3r | A | T51 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 4gra | A | T51 T227 M232 F255 | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 4gra | B | T51 T227 M232 F255 |
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| Conservation information for LBS of SULT1A1 |
| Multiple alignments for P50225 in multiple species |
| LBS | AA sequence | # species | Species | A146 | HFYHMAKVHPE | 1 | Homo sapiens | A146 | HFDRMNIVEPD | 1 | Danio rerio | A146 | HFDRMNMGQPE | 1 | Danio rerio | F142 | VSYYHFYHMAK | 1 | Homo sapiens | F142 | VSYFHFDRMNI | 1 | Danio rerio | F142 | VSYFHFDRMNM | 1 | Danio rerio | F229 | VQHTSFKEMKK | 1 | Homo sapiens | F229 | TKDVQFDAMKQ | 1 | Danio rerio | F229 | TKGVQFDVMKQ | 1 | Danio rerio | F24 | PLIKYFAEALG | 1 | Homo sapiens | F24 | SMINHFTENWE | 1 | Danio rerio | F24 | SMTRYFTDNWE | 1 | Danio rerio | F247 | TLP--VMDFKI | 2 | Danio rerio, Danio rerio | F247 | TVPQEFMDHSI | 1 | Homo sapiens | F255 | FKISPFMRKGK | 2 | Danio rerio, Danio rerio | F255 | HSISPFMRKGM | 1 | Homo sapiens | F76 | TSQPIYMRVPF | 2 | Danio rerio, Danio rerio | F76 | RA-PIFMRVPF | 1 | Homo sapiens | F81 | FMRVPFLEFKA | 1 | Homo sapiens | F81 | YMRVPFLESCF | 1 | Danio rerio | F81 | YMRVPFLEMCF | 1 | Danio rerio | F84 | VPFLEFKAPGI | 1 | Homo sapiens | F84 | VPFLESCFKVI | 1 | Danio rerio | F84 | VPFLEMCFQGL | 1 | Danio rerio | G259 | PFMRKGKVGDW | 2 | Danio rerio, Danio rerio | G259 | PFMRKGMAGDW | 1 | Homo sapiens | G50 | TYPKAGTTWVS | 2 | Danio rerio, Danio rerio | G50 | TYPKSGTTWVS | 1 | Homo sapiens | H108 | RLLKTHLPLAL | 1 | Homo sapiens | H108 | RLIKTHLPVQL | 1 | Danio rerio | H108 | RPIKTHLPVQL | 1 | Danio rerio | H149 | HMAKVHPEPGT | 1 | Homo sapiens | H149 | RMNIVEPDPGD | 1 | Danio rerio | H149 | RMNMGQPEPGD | 1 | Danio rerio | I21 | KGVPLIKYFAE | 1 | Homo sapiens | I21 | EGISMINHFTE | 1 | Danio rerio | I21 | EGVSMTRYFTD | 1 | Danio rerio | I89 | FKAPGIPSGME | 1 | Homo sapiens | I89 | SCFKVIASGTE | 1 | Danio rerio | I89 | MCFQGLPLGTE | 1 | Danio rerio | K106 | APRLLKTHLPL | 1 | Homo sapiens | K106 | SPRLIKTHLPV | 1 | Danio rerio | K106 | SPRPIKTHLPV | 1 | Danio rerio | K197 | FYEDMKENPKR | 1 | Homo sapiens | K197 | FYEDLVEDTGR | 1 | Danio rerio | K197 | FYEDMVEDTGR | 1 | Danio rerio | K258 | SPFMRKGKVGD | 2 | Danio rerio, Danio rerio | K258 | SPFMRKGMAGD | 1 | Homo sapiens | K48 | IATYPKAGTTW | 2 | Danio rerio, Danio rerio | K48 | ISTYPKSGTTW | 1 | Homo sapiens | M232 | TSFKEMKKNPM | 1 | Homo sapiens | M232 | VQFDAMKQNKM | 1 | Danio rerio | M232 | VQFDVMKQNKM | 1 | Danio rerio | M248 | LP--VMDFKIS | 2 | Danio rerio, Danio rerio | M248 | VPQEFMDHSIS | 1 | Homo sapiens | M256 | KISPFMRKGKV | 2 | Danio rerio, Danio rerio | M256 | SISPFMRKGMA | 1 | Homo sapiens | M77 | SQPIYMRVPFL | 2 | Danio rerio, Danio rerio | M77 | A-PIFMRVPFL | 1 | Homo sapiens | P244 | NYSTLP--VMD | 2 | Danio rerio, Danio rerio | P244 | NYTTVPQEFMD | 1 | Homo sapiens | P47 | LIATYPKAGTT | 2 | Danio rerio, Danio rerio | P47 | LISTYPKSGTT | 1 | Homo sapiens | P90 | KAPGIPSGMET | 1 | Homo sapiens | P90 | CFKVIASGTEL | 1 | Danio rerio | P90 | CFQGLPLGTEL | 1 | Danio rerio | R130 | VVYVARNAKDN | 2 | Danio rerio, Danio rerio | R130 | VVYVARNAKDV | 1 | Homo sapiens | R257 | ISPFMRKGKVG | 2 | Danio rerio, Danio rerio | R257 | ISPFMRKGMAG | 1 | Homo sapiens | S138 | KDVAVSYYHFY | 1 | Homo sapiens | S138 | KDNVVSYFHFD | 1 | Danio rerio | S138 | KDNAVSYFHFD | 1 | Danio rerio | S228 | VVQHTSFKEMK | 1 | Homo sapiens | S228 | ITKDVQFDAMK | 1 | Danio rerio | S228 | ITKGVQFDVMK | 1 | Danio rerio | S49 | ATYPKAGTTWV | 2 | Danio rerio, Danio rerio | S49 | STYPKSGTTWV | 1 | Homo sapiens | T227 | FVVQHTSFKEM | 1 | Homo sapiens | T227 | KITKDVQFDAM | 1 | Danio rerio | T227 | RITKGVQFDVM | 1 | Danio rerio | T51 | YPKAGTTWVSY | 2 | Danio rerio, Danio rerio | T51 | YPKSGTTWVSQ | 1 | Homo sapiens | T52 | PKAGTTWVSYI | 2 | Danio rerio, Danio rerio | T52 | PKSGTTWVSQI | 1 | Homo sapiens | V148 | YHMAKVHPEPG | 1 | Homo sapiens | V148 | DRMNIVEPDPG | 1 | Danio rerio | V148 | DRMNMGQPEPG | 1 | Danio rerio | W53 | KAGTTWVSYIL | 2 | Danio rerio, Danio rerio | W53 | KSGTTWVSQIL | 1 | Homo sapiens | Y193 | VLYLFYEDMKE | 1 | Homo sapiens | Y193 | LLYLFYEDLVE | 1 | Danio rerio | Y193 | ILYMFYEDMVE | 1 | Danio rerio | Y240 | NKMTNYSTLP- | 2 | Danio rerio, Danio rerio | Y240 | NPMTNYTTVPQ | 1 | Homo sapiens |
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