mutLBSgeneDB |
Gene summary for SULT1C2 |
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Basic gene Info. | Gene symbol | SULT1C2 |
Gene name | sulfotransferase family, cytosolic, 1C, member 2 | |
Synonyms | ST1C1|ST1C2|SULT1C1|humSULTC2 | |
Cytomap | UCSC genome browser: 2q12.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001056.3, NM_176825.2, | |
Description | SULT1C#1sulfotransferase 1C1sulfotransferase 1C2sulfotransferase family, cytosolic, 1C, member 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 602385 | |
HGNC : HGNC | ||
Ensembl : ENSG00000198203 | ||
HPRD : 03858 | ||
Vega : OTTHUMG00000153215 | ||
Protein | UniProt: O00338 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SULT1C2 | |
BioGPS: 6819 | ||
Pathway | NCI Pathway Interaction Database: SULT1C2 | |
KEGG: SULT1C2 | ||
REACTOME: SULT1C2 | ||
Pathway Commons: SULT1C2 | ||
Context | iHOP: SULT1C2 | |
ligand binding site mutation search in PubMed: SULT1C2 | ||
UCL Cancer Institute: SULT1C2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0051923 | sulfation | 20056724 |
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Ligand binding site mutations for SULT1C2 |
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LBS | AAchange of nsSNV | Cancer type | # samples | Y194 | E195G | KIRC | 1 | R131 | R131Q | SKCM | 1 | R131 | R131Q | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for SULT1C2 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y194 | E195G | -1.2611898 | R131 | R131Q | -1.0609611 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for SULT1C2 |
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Phenotype information for SULT1C2 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for SULT1C2 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3bfx | A | R131 Y194 |
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Conservation information for LBS of SULT1C2 |
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LBS | AA sequence | # species | Species |
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