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mutLBSgeneDB |
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| Gene summary for SUOX |
 Gene summary |
| Basic gene Info. | Gene symbol | SUOX |
| Gene name | sulfite oxidase | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 12q13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000456.2, NM_001032386.1,NM_001032387.1, | |
| Description | sulfite oxidase, mitochondrial | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606887 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000139531 | ||
| HPRD : 06055 | ||
| Vega : OTTHUMG00000128503 | ||
| Protein | UniProt: P51687 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SUOX | |
| BioGPS: 6821 | ||
| Pathway | NCI Pathway Interaction Database: SUOX | |
| KEGG: SUOX | ||
| REACTOME: SUOX | ||
| Pathway Commons: SUOX | ||
| Context | iHOP: SUOX | |
| ligand binding site mutation search in PubMed: SUOX | ||
| UCL Cancer Institute: SUOX | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for SUOX |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L125 | M126R | BRCA | 1 | H147 | V148A | KIRC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for SUOX |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H147 | V148A | -1.1556073 | L125 | M126R | -0.95023571 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SUOX from PDB |
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| Differential gene expression and gene-gene network for SUOX |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SUOX |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C2931746 | SULFOCYSTEINURIA | 6 | Biomarker, GeneticVariation |
| umls:C0268624 | Sulfite oxidase deficiency | 2 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SUOX |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB03983 | (Molybdopterin-S,S)-Dioxo-Thio-Molybdenum(V) | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SUOX go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of SUOX |
| Multiple alignments for P51687 in multiple species |
| LBS | AA sequence | # species | Species | A128 | SKLMLAAGGPL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A128 | ----------- | 1 | Arabidopsis thaliana | A128 | DKILMAAGSAI | 1 | Drosophila melanogaster | F114 | FDVTKFVDLHP | 2 | Mus musculus, Rattus norvegicus | F114 | FDVTEFVDLHP | 1 | Homo sapiens | F114 | ----------- | 1 | Arabidopsis thaliana | F114 | YDVTDFVENHP | 1 | Drosophila melanogaster | F136 | GPLEPFWALYA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F136 | ----------- | 1 | Arabidopsis thaliana | F136 | SAIDPFWGIYQ | 1 | Drosophila melanogaster | H118 | EFVDLHPGGPS | 1 | Homo sapiens | H118 | ----------- | 1 | Arabidopsis thaliana | H118 | DFVENHPGG-D | 1 | Drosophila melanogaster | H118 | KFVDLHPGGPS | 1 | Mus musculus | H118 | KFVDLHPGGQS | 1 | Rattus norvegicus | H143 | ALYAVHNQPHV | 2 | Mus musculus, Rattus norvegicus | H143 | ALYAVHNQSHV | 1 | Homo sapiens | H143 | ----------- | 1 | Arabidopsis thaliana | H143 | GIYQQHNTLEV | 1 | Drosophila melanogaster | H147 | VHNQPHVRELL | 2 | Mus musculus, Rattus norvegicus | H147 | VHNQSHVRELL | 1 | Homo sapiens | H147 | ----------- | 1 | Arabidopsis thaliana | H147 | QHNTLEVLELL | 1 | Drosophila melanogaster | K124 | PGGPSKLMLAA | 2 | Homo sapiens, Mus musculus | K124 | ----------- | 1 | Arabidopsis thaliana | K124 | PGG-DKILMAA | 1 | Drosophila melanogaster | K124 | PGGQSKLMLAA | 1 | Rattus norvegicus | L125 | GGPSKLMLAAG | 2 | Homo sapiens, Mus musculus | L125 | ----------- | 1 | Arabidopsis thaliana | L125 | GG-DKILMAAG | 1 | Drosophila melanogaster | L125 | GGQSKLMLAAG | 1 | Rattus norvegicus | L133 | AAGGPLEPFWA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L133 | ----------- | 1 | Arabidopsis thaliana | L133 | AAGSAIDPFWG | 1 | Drosophila melanogaster | P119 | FVDLHPGGPSK | 2 | Homo sapiens, Mus musculus | P119 | ----------- | 1 | Arabidopsis thaliana | P119 | FVENHPGG-DK | 1 | Drosophila melanogaster | P119 | FVDLHPGGQSK | 1 | Rattus norvegicus | Q145 | YAVHNQPHVRE | 2 | Mus musculus, Rattus norvegicus | Q145 | YAVHNQSHVRE | 1 | Homo sapiens | Q145 | ----------- | 1 | Arabidopsis thaliana | Q145 | YQQHNTLEVLE | 1 | Drosophila melanogaster | V111 | SEVFDVTKFVD | 2 | Mus musculus, Rattus norvegicus | V111 | SEVFDVTEFVD | 1 | Homo sapiens | V111 | ----------- | 1 | Arabidopsis thaliana | V111 | LGVYDVTDFVE | 1 | Drosophila melanogaster | V142 | WALYAVHNQPH | 2 | Mus musculus, Rattus norvegicus | V142 | WALYAVHNQSH | 1 | Homo sapiens | V142 | ----------- | 1 | Arabidopsis thaliana | V142 | WGIYQQHNTLE | 1 | Drosophila melanogaster | W137 | PLEPFWALYAV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W137 | ----------- | 1 | Arabidopsis thaliana | W137 | AIDPFWGIYQQ | 1 | Drosophila melanogaster | Y140 | PFWALYAVHNQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y140 | ----------- | 1 | Arabidopsis thaliana | Y140 | PFWGIYQQHNT | 1 | Drosophila melanogaster |
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