mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SULT2A1
Gene summary
Basic gene Info.Gene symbolSULT2A1
Gene namesulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
SynonymsDHEA-ST|DHEAS|HST|ST2|ST2A1|ST2A3|STD|hSTa
CytomapUCSC genome browser: 19q13.3
Type of geneprotein-coding
RefGenesNM_003167.3,
Descriptionalcohol/hydroxysteroid sulfotransferasebile salt sulfotransferasebile-salt sulfotranasferase 2A1
Modification date20141211
dbXrefs MIM : 125263
HGNC : HGNC
Ensembl : ENSG00000105398
HPRD : 00502
Vega : OTTHUMG00000162469
ProteinUniProt: Q06520
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SULT2A1
BioGPS: 6822
PathwayNCI Pathway Interaction Database: SULT2A1
KEGG: SULT2A1
REACTOME: SULT2A1
Pathway Commons: SULT2A1
ContextiHOP: SULT2A1
ligand binding site mutation search in PubMed: SULT2A1
UCL Cancer Institute: SULT2A1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0051923sulfation20056724


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Ligand binding site mutations for SULT2A1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F139K141NCOAD1
F139,M137K138TCOAD1
P14,M16T15IHNSC1
S129S129YLUAD1
Y238V239ELUAD1
G46G46VLUAD1
F18F18LLUSC1
W49L50MLUSC1
W72R74QSKCM1
R121L119FSKCM1
W134W134CSTAD1
W72P70TSTAD1
C55L54IUCEC1
F18,M16G17SUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for SULT2A1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R121L119F-1.5460942
W49L50M-1.3718157
Y238V239E-1.3416746
W72R74Q-1.3381508
W134W134C-1.1016642
W72P70T-1.0788959
F139K141N-0.90987887
F139K138T-0.89726169
M137K138T-0.89726169
F18G17S-0.71116746
M16G17S-0.71116746
F18F18L-0.56718693
G46G46V-0.48348457
C55L54I-0.44396636
M16T15I-0.43675392
P14T15I-0.43675392
S129S129Y-0.23443919
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SULT2A1 from PDB

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Differential gene expression and gene-gene network for SULT2A1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SULT2A1 and the right PPI network was created from samples without mutations in the LBS of SULT2A1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for SULT2A1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0023893Liver Cirrhosis, Experimental1Biomarker
umls:C0033578Prostatic Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for SULT2A1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
NutraceuticalDB01708DehydroepiandrosteroneSmall molecule
ExperimentalDB01812Adenosine-3'-5'-DiphosphateSmall molecule
ExperimentalDB02854AetiocholanoloneSmall molecule
ExperimentalDB04445Mercury DiiodideSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SULT2A1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
HGIMERCURY DIIODIDE1j99AC55
AE23ALPHA-HYDROXY-5BETA-ANDROSTAN-17-ONE2qp4AF18 W134 Y238
AE23ALPHA-HYDROXY-5BETA-ANDROSTAN-17-ONE1ov4AF18 W72 W134
AE23ALPHA-HYDROXY-5BETA-ANDROSTAN-17-ONE2qp3AF18 W72 W134
A3PADENOSINE 3',5'-BISPHOSPHATE1efhAG46 W49 R121 S129
A3PADENOSINE 3',5'-BISPHOSPHATE1efhBG46 W49 R121 S129
A3PADENOSINE 3',5'-BISPHOSPHATE3f3yAG46 W49 R121 S129
A3PADENOSINE 3',5'-BISPHOSPHATE3f3yBG46 W49 R121 S129
A3PADENOSINE 3',5'-BISPHOSPHATE3f3yCG46 W49 R121 S129
A3PADENOSINE 3',5'-BISPHOSPHATE3f3yDG46 W49 R121 S129
PPS3'-PHOSPHATE-ADENOSINE-5'-PHOSPHATE SULFATE4ifbAG46 W49 R121 S129
PPS3'-PHOSPHATE-ADENOSINE-5'-PHOSPHATE SULFATE4ifbBG46 W49 R121 S129
4OALITHOCHOLIC ACID3f3yAP14 F18 W72 M137 F139 Y238
4OALITHOCHOLIC ACID3f3yCP14 F18 W72 M137 Y238
4OALITHOCHOLIC ACID3f3yDP14 F18 W72 W134 F139 Y238
4OALITHOCHOLIC ACID3f3yBP14 F18 W72 W134 M137 F139 Y238
ANDDEHYDROEPIANDROSTERONE1j99AP14 M16 M137 Y238


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Conservation information for LBS of SULT2A1
Multiple alignments for Q06520 in multiple species
LBSAA sequence# speciesSpecies
C154YFEWFCQGTVL1Homo sapiens
C154YFEWFLKGNVL1Mus musculus
C154YVEWFLKGNVL1Rattus norvegicus
C154YVEWFLKGYVP1Rattus norvegicus
C199TIKKICDFLGK3Mus musculus, Rattus norvegicus, Rattus norvegicus
C199TIEKICQFLGK1Homo sapiens
C55LIEIVCLIQTK3Mus musculus, Rattus norvegicus, Rattus norvegicus
C55LAEILCLMHSK1Homo sapiens
D265VAQAEAFDKVF2Mus musculus, Rattus norvegicus
D265VAQAEDFDKLF1Homo sapiens
D265VSQAEAFDKVF1Rattus norvegicus
F133VSGYFFWKNMK1Homo sapiens
F133VSGYFFWGNTN1Mus musculus
F133VSGYYFWGNST1Rattus norvegicus
F133VSGYYFWGKTT1Rattus norvegicus
F139WKNMKFIKKPK1Homo sapiens
F139WGNTNLVKNPG1Mus musculus
F139WGNSTLVKKPD1Rattus norvegicus
F139WGKTTLAKKPD1Rattus norvegicus
F150SLGTYVEWFLK2Rattus norvegicus, Rattus norvegicus
F150SWEEYFEWFCQ1Homo sapiens
F150SLGTYFEWFLK1Mus musculus
F18FPTMGFRSETL1Homo sapiens
F18FPAISYQREIL1Mus musculus
F18FHAFGISKETL1Rattus norvegicus
F18FPAFGIPKETL1Rattus norvegicus
F220LKYSSFQVMKE2Rattus norvegicus, Rattus norvegicus
F220LKNSSFQSMKE1Homo sapiens
F220LKYSSFQAMKE1Mus musculus
F266AQAEAFDKVFQ2Mus musculus, Rattus norvegicus
F266AQAEDFDKLFQ1Homo sapiens
F266SQAEAFDKVFQ1Rattus norvegicus
G203ICDFLGKKLEP2Rattus norvegicus, Rattus norvegicus
G203ICQFLGKTLEP1Homo sapiens
G203ICDFLGKNLGP1Mus musculus
G249QLLRKGVSGDW1Homo sapiens
G249KLMRKGTIGDW1Mus musculus
G249GLMRKGTIGDW1Rattus norvegicus
G249TFMRNGTTGDW1Rattus norvegicus
G46TYPKSGTNWLI2Mus musculus, Rattus norvegicus
G46TYPKSGTNWLA1Homo sapiens
G46AYPKSGTNWLI1Rattus norvegicus
H99RLFSSHLPIQL1Homo sapiens
H99RLITSHLPIHL1Mus musculus
H99RLMTSHLPMHL1Rattus norvegicus
H99RLITSHLPMHL1Rattus norvegicus
I82WVESEIGYTAL1Homo sapiens
I82WIETDIGYSAL1Mus musculus
I82WIETDVGYDIL1Rattus norvegicus
I82WIETDLGYDML1Rattus norvegicus
K204CDFLGKKLEPD2Rattus norvegicus, Rattus norvegicus
K204CQFLGKTLEPE1Homo sapiens
K204CDFLGKNLGPD1Mus musculus
K248AQLLRKGVSGD1Homo sapiens
K248LKLMRKGTIGD1Mus musculus
K248IGLMRKGTIGD1Rattus norvegicus
K248FTFMRNGTTGD1Rattus norvegicus
K44ILTYPKSGTNW2Homo sapiens, Mus musculus
K44LLAYPKSGTNW1Rattus norvegicus
K44LLTYPKSGTNW1Rattus norvegicus
L206FLGKKLEPDEL2Rattus norvegicus, Rattus norvegicus
L206FLGKTLEPEEL1Homo sapiens
L206FLGKNLGPDEL1Mus musculus
L234SNYSLLSVDYV1Homo sapiens
L234SNFSLIKEDQV1Mus musculus
L234SNYSLLMKKSI1Rattus norvegicus
L234SNYNLMEKELI1Rattus norvegicus
L245VDKAQLLRKGV1Homo sapiens
L245TNGLKLMRKGT1Mus musculus
L245FTGIGLMRKGT1Rattus norvegicus
L245LPGFTFMRNGT1Rattus norvegicus
L246DKAQLLRKGVS1Homo sapiens
L246NGLKLMRKGTI1Mus musculus
L246TGIGLMRKGTI1Rattus norvegicus
L246PGFTFMRNGTT1Rattus norvegicus
L95TESPRLFSSHL1Homo sapiens
L95KEGPRLITSHL1Mus musculus
L95KKGPRLMTSHL1Rattus norvegicus
L95KKGPRLITSHL1Rattus norvegicus
M137FFWKNMKFIKK1Homo sapiens
M137FFWGNTNLVKN1Mus musculus
M137YFWGNSTLVKK1Rattus norvegicus
M137YFWGKTTLAKK1Rattus norvegicus
M16IAFPTMGFRSE1Homo sapiens
M16IPFPAISYQRE1Mus musculus
M16IPFHAFGISKE1Rattus norvegicus
M16IPFPAFGIPKE1Rattus norvegicus
M223SSFQSMKENKM1Homo sapiens
M223SSFQAMKENNM1Mus musculus
M223SSFQVMKENDM1Rattus norvegicus
M223SSFQVMKENNM1Rattus norvegicus
N48PKSGTNWLIEI3Mus musculus, Rattus norvegicus, Rattus norvegicus
N48PKSGTNWLAEI1Homo sapiens
P14EGIAFPTMGFR1Homo sapiens
P14EGIPFPAISYQ1Mus musculus
P14EGIPFHAFGIS1Rattus norvegicus
P14EGIPFPAFGIP1Rattus norvegicus
P43IILTYPKSGTN1Homo sapiens
P43LILTYPKSGTN1Mus musculus
P43ILLAYPKSGTN1Rattus norvegicus
P43ILLTYPKSGTN1Rattus norvegicus
Q200IKKICDFLGKK2Rattus norvegicus, Rattus norvegicus
Q200IEKICQFLGKT1Homo sapiens
Q200IKKICDFLGKN1Mus musculus
R121VIYLIRNPRDV2Rattus norvegicus, Rattus norvegicus
R121VIYLMRNPRDV1Homo sapiens
R121AIYLVRNPRDI1Mus musculus
R247KAQLLRKGVSG1Homo sapiens
R247GLKLMRKGTIG1Mus musculus
R247GIGLMRKGTIG1Rattus norvegicus
R247GFTFMRNGTTG1Rattus norvegicus
S129RDVLVSGYYFW2Rattus norvegicus, Rattus norvegicus
S129RDVLVSGYFFW1Homo sapiens
S129RDILVSGYFFW1Mus musculus
S218LVLKYSSFQVM2Rattus norvegicus, Rattus norvegicus
S218LILKNSSFQSM1Homo sapiens
S218LVLKYSSFQAM1Mus musculus
S219VLKYSSFQVMK2Rattus norvegicus, Rattus norvegicus
S219ILKNSSFQSMK1Homo sapiens
S219VLKYSSFQAMK1Mus musculus
S45LTYPKSGTNWL3Homo sapiens, Mus musculus, Rattus norvegicus
S45LAYPKSGTNWL1Rattus norvegicus
S80SPWVESEIGYT1Homo sapiens
S80SPWIETDIGYS1Mus musculus
S80SPWIETDVGYD1Rattus norvegicus
S80SPWIETDLGYD1Rattus norvegicus
T205DFLGKKLEPDE2Rattus norvegicus, Rattus norvegicus
T205QFLGKTLEPEE1Homo sapiens
T205DFLGKNLGPDE1Mus musculus
T47YPKSGTNWLIE3Mus musculus, Rattus norvegicus, Rattus norvegicus
T47YPKSGTNWLAE1Homo sapiens
W134SGYFFWKNMKF1Homo sapiens
W134SGYFFWGNTNL1Mus musculus
W134SGYYFWGNSTL1Rattus norvegicus
W134SGYYFWGKTTL1Rattus norvegicus
W49KSGTNWLIEIV3Mus musculus, Rattus norvegicus, Rattus norvegicus
W49KSGTNWLAEIL1Homo sapiens
W65KGDPKWIQSVT2Rattus norvegicus, Rattus norvegicus
W65KGDAKWIQSVP1Homo sapiens
W65KGDPKWIQTVP1Mus musculus
W72QSVTIWDRSPW2Rattus norvegicus, Rattus norvegicus
W72QSVPIWERSPW1Homo sapiens
W72QTVPIWNRSPW1Mus musculus
W77WERSPWVESEI1Homo sapiens
W77WNRSPWIETDI1Mus musculus
W77WDRSPWIETDV1Rattus norvegicus
W77WDRSPWIETDL1Rattus norvegicus
Y184FLLLYYEDMKK2Rattus norvegicus, Rattus norvegicus
Y184FLLLSYEELKQ1Homo sapiens
Y184FLVLYYEDIKK1Mus musculus
Y231NKMSNYSLLSV1Homo sapiens
Y231NNMSNFSLIKE1Mus musculus
Y231NDMSNYSLLMK1Rattus norvegicus
Y231NNMSNYNLMEK1Rattus norvegicus
Y238LLSVDYVVDKA1Homo sapiens
Y238LIKEDQVTNGL1Mus musculus
Y238LLMKKSIFTGI1Rattus norvegicus
Y238LMEKELILPGF1Rattus norvegicus


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