mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SUPT4H1
Gene summary
Basic gene Info.Gene symbolSUPT4H1
Gene namesuppressor of Ty 4 homolog 1 (S. cerevisiae)
CytomapUCSC genome browser: 17q22
Type of geneprotein-coding
DescriptionDRB sensitivity-inducing factor 14 kDa subunitDSIF p14small hSpt4 subunittranscription elongation factor SPT4
Modification date20141207
dbXrefs MIM : 603555
Ensembl : ENSG00000213246
HPRD : 16026
Vega : OTTHUMG00000178926
ProteinUniProt: P63272
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SUPT4H1
BioGPS: 6827
PathwayNCI Pathway Interaction Database: SUPT4H1
Pathway Commons: SUPT4H1
ContextiHOP: SUPT4H1
ligand binding site mutation search in PubMed: SUPT4H1
UCL Cancer Institute: SUPT4H1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0000122negative regulation of transcription from RNA polymerase II promoter9450929
GO:0006368transcription elongation from RNA polymerase II promoter9450929
GO:0032785negative regulation of DNA-templated transcription, elongation9450929
GO:0032786positive regulation of DNA-templated transcription, elongation9450929
GO:0045944positive regulation of transcription from RNA polymerase II promoter9450929

Ligand binding site mutations for SUPT4H1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for SUPT4H1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SUPT4H1 from PDB

Differential gene expression and gene-gene network for SUPT4H1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SUPT4H1 and the right PPI network was created from samples without mutations in the LBS of SUPT4H1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for SUPT4H1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for SUPT4H1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SUPT4H1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of SUPT4H1
Multiple alignments for P63272 in multiple species
LBSAA sequence# speciesSpecies
C16RHLRACLLCSL4Homo sapiens, Bos taurus, Mus musculus, Danio rerio
C16RYLRACMVCSI1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C16RNLRACLLCSL1Caenorhabditis elegans
C16RGLRACLVCSL1Drosophila melanogaster
C19RACLLCSLVKT4Homo sapiens, Bos taurus, Mus musculus, Danio rerio
C19RACMVCSIVMT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C19RACLLCSLVKS1Caenorhabditis elegans
C19RACLVCSLVKS1Drosophila melanogaster
C33FEYDGCDNCDA3Homo sapiens, Bos taurus, Mus musculus
C33FRDEGCPNCED1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C33FQKEGCENCED1Caenorhabditis elegans
C33FETDGCENCEE1Drosophila melanogaster
C33FEYDGCDNCES1Danio rerio
C36DGCDNCDAYLQ3Homo sapiens, Bos taurus, Mus musculus
C36EGCPNCEDFLH1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C36EGCENCEDVLH1Caenorhabditis elegans
C36DGCENCEEFLR1Drosophila melanogaster
C36DGCDNCESYLQ1Danio rerio

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