mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SYK
Gene summary
Basic gene Info.Gene symbolSYK
Gene namespleen tyrosine kinase
Synonymsp72-Syk
CytomapUCSC genome browser: 9q22
Type of geneprotein-coding
RefGenesNM_001135052.3,
NM_001174167.2,NM_001174168.2,NM_003177.6,
Descriptiontyrosine-protein kinase SYK
Modification date20141222
dbXrefs MIM : 600085
HGNC : HGNC
Ensembl : ENSG00000165025
HPRD : 02514
Vega : OTTHUMG00000020200
ProteinUniProt: P43405
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SYK
BioGPS: 6850
PathwayNCI Pathway Interaction Database: SYK
KEGG: SYK
REACTOME: SYK
Pathway Commons: SYK
ContextiHOP: SYK
ligand binding site mutation search in PubMed: SYK
UCL Cancer Institute: SYK
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0007159leukocyte cell-cell adhesion12885943
GO:0030593neutrophil chemotaxis12885943


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Ligand binding site mutations for SYK
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
G578G578ESKCM2
V385K387NCOAD1
R42R42HPRAD1
I438G437ESKCM1
V385K387RSKCM1
G578E580KSKCM1
R217R217CSKCM1
P535P535LSKCM1
R45R45HSTAD1
A451A451VSTAD1
M448M448LSTAD1
M424Q425HUCEC1
Y525K527NUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for SYK from My Cancer Genome.
Spleen tyrosine kinase (SYK) is a gene that encodes a non-receptor type tyrosine protein kinase. The protein functions in coupling activated immunoreceptors to downstream signaling events to elicit a variety of cellular responses. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.Modified: July 1, 2015

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Protein structure related information for SYK
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
A451A451V0.41415431
M448M448L0.12555117
R217R217C-0.9615085
R42R42H-0.94635904
Y525K527N-0.87209654
P535P535L-0.80437414
I438G437E-0.78977677
M424Q425H-0.48051771
V385K387N-0.46717807
G578G578E-0.46067822
R45R45H-0.42705006
G578E580K-0.42295283
V385K387R-0.099672571
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SYK from PDB
PDB IDPDB titlePDB structure
1XBACrystal structure of apo syk tyrosine kinase domain

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Differential gene expression and gene-gene network for SYK
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SYK and the right PPI network was created from samples without mutations in the LBS of SYK. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for SYK
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0025202Melanoma3AlteredExpression, Biomarker
umls:C0025500Mesothelioma1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for SYK
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB02010StaurosporineSmall molecule
ExperimentalDB06834N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamideSmall molecule
ExperimentalDB071596-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-oneSmall molecule
ExperimentalDB071942-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamideSmall molecule
ExperimentalDB083612-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamideSmall molecule
InvestigationalDB08846Ellagic AcidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SYK go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
0JE3-[5-(5-ETHOXY-6-FLUORO-1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]-1,1-DIETHYLUREA3vf8AA451
4773-{2-[5-(DIFLUOROMETHYL)-2H-THIENO[3,2-C]PYRAZOL-3-YL]-1H-INDOL-6-YL}PENTAN-3-OL3vf9AM448 A451
0VH6-{[(1R,2S)-2-AMINOCYCLOHEXYL]AMINO}-4-[(6- ETHYLPYRIDIN-2-YL)AMINO]PYRIDAZINE-3-CARBOXAMIDE4fz7AM448 A451
0XF6-{[(1R,2S)-2-AMINOCYCLOHEXYL]AMINO}-4-[(5,6- DIMETHYLPYRIDIN-2-YL)AMINO]PYRIDAZINE-3-CARBOXAMIDE4gfgAM448 A451
1B4N-(PROPAN-2-YL)-2-(3,4,5-TRIMETHOXYPHENYL)-5H- PYRROLO[2,3-B]PYRAZINE-7-CARBOXAMIDE4i0rAM448 A451
1B6N-TERT-BUTYL-2-(5,6,7,8-TETRAHYDROIMIDAZO[1,5- A]PYRIDIN-1-YL)-5H-PYRROLO[2,3-B]PYRAZINE-7- CARBOXAMIDE4i0tAM448 A451
2X67-{[(1R,2S)-2-AMINOCYCLOHEXYL]AMINO}-5-(1H-INDOL-7- YLAMINO)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE4px6AM448 A451
3YT2-{[(1R,2S)-2-AMINOCYCLOHEXYL]AMINO}-4-{[3-(2H-1,2,3- TRIAZOL-2-YL)PHENYL]AMINO}PYRIMIDINE-5-CARBOXAMIDE4rx9AM448 A451
4DF5-CHLORO-N~2~-(1,1-DIOXIDO-2,3-DIHYDRO-1,2- BENZOTHIAZOL-6-YL)-N~4~-ETHYL-N~4~-(1H-INDAZOL-4-YL) PYRIMIDINE-2,4-DIAMINE4yjoAM448 A451
X5G1-({1-[2-({3,5-DIMETHYL-4-[2-(PYRROLIDIN-1-YL) ETHOXY]PHENYL}AMINO)PYRIMIDIN-4-YL]-4-METHYL-1H- PYRROL-3-YL}METHYL)AZETIDIN-3-OL4xg5AM448 A451
X5G1-({1-[2-({3,5-DIMETHYL-4-[2-(PYRROLIDIN-1-YL) ETHOXY]PHENYL}AMINO)PYRIMIDIN-4-YL]-4-METHYL-1H- PYRROL-3-YL}METHYL)AZETIDIN-3-OL4xg5BM448 A451
IIIPeptide ligand (GLU,VAL,TYR,GLU,SER,PRO)5c26AP535 G578
IIIPeptide ligand (GLU,VAL,TYR,GLU,SER)5c27AP535 G578
IIIPeptide ligand (PRO,ASP,TYR,GLU,PRO,ILE,ARG,LYS,GLY,GLN,ARG,ASP,LEU,TYR,SER,GLY,LEU,ASN)1a81IR42
IIIPeptide ligand (PRO,ASP,TYR,GLU,PRO,ILE,ARG,LYS,GLY,GLN,ARG,ASP,LEU,TYR,SER,GLY,LEU,ASN)1a81AR42 R217
IIIPeptide ligand (PRO,ASP,TYR,GLU,PRO,ILE,ARG,LYS,GLY,GLN,ARG,ASP,LEU,TYR,SER,GLY,LEU,ASN)1a81CR42 R217
IIIPeptide ligand (PRO,ASP,TYR,GLU,PRO,ILE,ARG,LYS,GLY,GLN,ARG,ASP,LEU,TYR,SER,GLY,LEU,ASN)1a81ER42 R217
IIIPeptide ligand (PRO,ASP,TYR,GLU,PRO,ILE,ARG,LYS,GLY,GLN,ARG,ASP,LEU,TYR,SER,GLY,LEU,ASN)1a81KR42 R217
IIIPeptide ligand (PRO,ASP,TYR,GLU,PRO,ILE,ARG,LYS,GLY,GLN,ARG,ASP,LEU,TYR,SER,GLY,LEU,ASN)1a81GR42 R45 R217
5856-({5-FLUORO-2-[(3,4,5-TRIMETHOXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE3fqsAV385 A451
FPW1-BENZYL-N-{5-[(6,7-DIMETHOXYQUINOLIN-4-YL)OXY]PYRIDIN- 2-YL}-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE3tucAV385 M424 I438 M448 A451
FPU1-{5-[(6,7-DIMETHOXYQUINOLIN-4-YL)OXY]PYRIDIN-2-YL}-3- [(1R,2S)-2-PHENYLCYCLOPROPYL]UREA3tubAV385 M424 M448 A451
FPXN-{4-METHYL-3-[8-METHYL-7-OXO-2-(PHENYLAMINO)-7,8- DIHYDROPYRIDO[2,3-D]PYRIMIDIN-6-YL]PHENYL}-3- (TRIFLUOROMETHYL)BENZAMIDE3tudAV385 M424 M448 A451
STIIMATINIB1xbbAV385 M448 A451
STUSTAUROSPORINE1xbcAV385 M448 A451
6852-{2-[(3,5-DIMETHYLPHENYL)AMINO]PYRIMIDIN-4-YL}-N-[(2S)-1-HYDROXYPROPAN-2-YL]-4-METHYL-1,3-THIAZOLE-5-CARBOXAMIDE3emgAV385 M448 A451
P5C2-{[(1R,2S)-2-AMINOCYCLOHEXYL]AMINO}-4-[(3-METHYLPHENYL)AMINO]PYRIMIDINE-5-CARBOXAMIDE3fqeAV385 M448 A451
057N-(2-HYDROXY-1,1-DIMETHYLETHYL)-1-METHYL-3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-INDOLE-5-CARBOXAMIDE3fqhAV385 M448 A451
057N-(2-HYDROXY-1,1-DIMETHYLETHYL)-1-METHYL-3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-INDOLE-5-CARBOXAMIDE3fqhBV385 M448 A451
S19GSK1433srvAV385 M448 A451
S19GSK1433srvBV385 M448 A451
0K03-AMINO-6-{3-[(METHYLSULFONYL)AMINO]PHENYL}-N-(PIPERIDIN-4-YLMETHYL)PYRAZINE-2-CARBOXAMIDE4dflAV385 M448 A451
0K13-AMINO-6-[3-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL]-N-[(1R,2R,3S,5S,7S)-5-HYDROXYADAMANTAN-2-YL]PYRAZINE-2-CARBOXAMIDE4dfnAV385 M448 A451
0SBN-{6-[3-(PIPERAZIN-1-YL)PHENYL]PYRIDIN-2-YL}-4- (TRIFLUOROMETHYL)PYRIDIN-2-AMINE4f4pAV385 M448 A451
ANPAMP-PNP4fl1AV385 M448 A451
ANPAMP-PNP4fl3AV385 M448 A451
0VE3-[8-({4-[ETHYL(2-HYDROXYETHYL)AMINO]PHENYL}AMINO) IMIDAZO[1,2-A]PYRAZIN-5-YL]PHENOL4fynAV385 M448 A451
0VF4-{[(3S)-1-{7-[(3,4-DIMETHOXYPHENYL)AMINO][1, 3]THIAZOLO[5,4-D]PYRIMIDIN-5-YL}PYRROLIDIN-3- YL]CARBAMOYL}BENZOIC ACID4fyoAV385 M448 A451
0VGN-{6-[(2S)-2-METHYLPYRROLIDIN-1-YL]PYRIDIN-2-YL}-6- PHENYLIMIDAZO[1,2-B]PYRIDAZIN-8-AMINE4fz6AV385 M448 A451
1B52-(6-CHLORO-1-METHYL-1H-INDAZOL-3-YL)-N-(PROPAN-2-YL)- 5H-PYRROLO[2,3-B]PYRAZINE-7-CARBOXAMIDE4i0sAV385 M448 A451
CG96-(1H-INDAZOL-6-YL)-N-[4-(MORPHOLIN-4-YL) PHENYL]IMIDAZO[1,2-A]PYRAZIN-8-AMINE4puzAV385 M448 A451
CG96-(1H-INDAZOL-6-YL)-N-[4-(MORPHOLIN-4-YL) PHENYL]IMIDAZO[1,2-A]PYRAZIN-8-AMINE4puzBV385 M448 A451
CG44-[(3-{8-[(3,4-DIMETHOXYPHENYL)AMINO]IMIDAZO[1,2- A]PYRAZIN-6-YL}BENZOYL)AMINO]BENZOIC ACID4pv0AV385 M448 A451
3YV3-{[(1R,2S)-2-AMINOCYCLOHEXYL]AMINO}-5-{[3-(2H-1,2,3- TRIAZOL-2-YL)PHENYL]AMINO}-1,2,4-TRIAZINE-6- CARBOXAMIDE4rx7AV385 M448 A451
3YX3-{[(1R,2S)-2-AMINOCYCLOHEXYL]AMINO}-5-(1H-INDOL-7- YLAMINO)-1,2,4-TRIAZINE-6-CARBOXAMIDE4rx8AV385 M448 A451
55UN-{7-[4-(DIMETHYLAMINO)PHENYL]-1,6-NAPHTHYRIDIN-5- YL}PROPANE-1,3-DIAMINE5cxzAV385 M448 A451
55M(4R)-4-[(1R)-1-{[6-(3,4-DIMETHOXYPHENYL)[1, 3]THIAZOLO[5,4-C]PYRIDIN-4-YL]OXY}ETHYL]PYRROLIDIN-2- ONE5cxhAV385 M448 A451
55Y(5R)-5-[(1R)-1-{[6-(1-METHYL-1H-PYRAZOL-4-YL)-2,1- BENZOTHIAZOL-4-YL]OXY}ETHYL]-1,3-OXAZOLIDIN-2-ONE5cy3AV385 M448 A451
4DL2-[{2-[(1,1-DIOXIDO-2,3-DIHYDRO-1,2-BENZOTHIAZOL-6-YL) AMINO]PYRIMIDIN-4-YL}(1H-INDAZOL-4-YL)AMINO]ETHANOL4yjpAV385 M448 A451
4DK3-[1H-INDAZOL-4-YL(2-{[3-(4-METHYL-1,3-OXAZOL-5-YL) PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PROPAN-1-OL4yjqAV385 M448 A451
4DJ3-(1H-INDAZOL-4-YL{2-[(1-METHYL-1H-INDAZOL-5-YL) AMINO]PYRIMIDIN-4-YL}AMINO)PROPAN-1-OL4yjrAV385 M448 A451
4DN3-[{2-[(1,1-DIOXIDO-2,3-DIHYDRO-1,2-BENZOTHIAZOL-6-YL) AMINO]PYRIMIDIN-4-YL}(1H-INDAZOL-4-YL)AMINO]PROPAN-1- OL4yjsAV385 M448 A451
4DQN~2~-(1,1-DIOXIDO-2,3-DIHYDRO-1,2-BENZOTHIAZOL-6-YL)- N~4~-ETHYL-5-FLUORO-N~4~-(1H-INDAZOL-4-YL)PYRIMIDINE- 2,4-DIAMINE4yjtAV385 M448 A451
4DON~2~-(1,1-DIOXIDO-2,3-DIHYDRO-1,2-BENZOTHIAZOL-6-YL)-5- FLUORO-N~4~-(1H-INDAZOL-4-YL)-N~4~-METHYLPYRIMIDINE-2, 4-DIAMINE4yjuAV385 M448 A451
50H3-{8-[(3,4-DIMETHOXYPHENYL)AMINO]IMIDAZO[1,2-A]PYRAZIN- 6-YL}BENZAMIDE5c26AV385 M448 A451
50J3-{8-[(3,4-DIMETHOXYPHENYL)AMINO]IMIDAZO[1,2-A]PYRAZIN- 6-YL}-N-[4-(METHYLCARBAMOYL)PHENYL]BENZAMIDE5c27AV385 M448 A451
4DT3-[6-({4-[ETHYL(1H-INDAZOL-4-YL)AMINO]-5- FLUOROPYRIMIDIN-2-YL}AMINO)-2,4-DIHYDRO-1H-INDAZOL-1- YL]PROPAN-1-OL4yjvAV385 M448 A451
4MG1-[(3-METHYL-1-{2-[(1,2,3-TRIMETHYL-1H-INDOL-5-YL) AMINO]PYRIMIDIN-4-YL}-1H-PYRAZOL-4-YL)METHYL]AZETIDIN- 3-OL4rssAV385 M448 A451
X3G4-{[5-FLUORO-4-(3-{[(3R)-3-HYDROXYPYRROLIDIN-1- YL]METHYL}-4-METHYL-1H-PYRROL-1-YL)PYRIMIDIN-2- YL]AMINO}-2,6-DIMETHYLPHENYL METHANESULFONATE4xg3AV385 M448 A451
X3G4-{[5-FLUORO-4-(3-{[(3R)-3-HYDROXYPYRROLIDIN-1- YL]METHYL}-4-METHYL-1H-PYRROL-1-YL)PYRIMIDIN-2- YL]AMINO}-2,6-DIMETHYLPHENYL METHANESULFONATE4xg3BV385 M448 A451
X4G(3R)-1-{[1-(5-FLUORO-2-{[4-(2-HYDROXYETHOXY)-3,5- DIMETHYLPHENYL]AMINO}PYRIMIDIN-4-YL)-4-METHYL-1H- PYRROL-3-YL]METHYL}PYRROLIDIN-3-OL4xg4AV385 M448 A451
X6G1-[(1-{2-[(3,5-DIMETHYLPHENYL)AMINO]PYRIMIDIN-4-YL}-3- METHYL-1H-PYRAZOL-4-YL)METHYL]AZETIDIN-3-OL4xg6AV385 M448 A451
X7G1-[(3-METHYL-1-{2-[(1-METHYL-1H-INDAZOL-5-YL) AMINO]PYRIMIDIN-4-YL}-1H-PYRAZOL-4-YL)METHYL]AZETIDIN- 3-OL4xg7AV385 M448 A451
X8G1-[(1-{2-[(3-CHLORO-1-METHYL-1H-INDAZOL-5-YL) AMINO]PYRIMIDIN-4-YL}-3-METHYL-1H-PYRAZOL-4-YL) METHYL]AZETIDIN-3-OL4xg8AV385 M448 A451
X8G1-[(1-{2-[(3-CHLORO-1-METHYL-1H-INDAZOL-5-YL) AMINO]PYRIMIDIN-4-YL}-3-METHYL-1H-PYRAZOL-4-YL) METHYL]AZETIDIN-3-OL4xg8CV385 M448 A451
X9G1-[(1-{2-[(3-CHLORO-1,2-DIMETHYL-1H-INDOL-5-YL) AMINO]PYRIMIDIN-4-YL}-3-METHYL-1H-PYRAZOL-4-YL) METHYL]AZETIDIN-3-OL4xg9AV385 M448 A451
X9G1-[(1-{2-[(3-CHLORO-1,2-DIMETHYL-1H-INDOL-5-YL) AMINO]PYRIMIDIN-4-YL}-3-METHYL-1H-PYRAZOL-4-YL) METHYL]AZETIDIN-3-OL4xg9BV385 M448 A451
ANPAMP-PNP4fl2AV385 M448 A451 Y525


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Conservation information for LBS of SYK
Multiple alignments for P43405 in multiple species
LBSAA sequence# speciesSpecies
A204NNGSYALCLLH1Homo sapiens
A204SNGSYALCLLN1Gallus gallus
A204NSGSYALCLLH1Mus musculus
A204NNGSFALCLLH1Rattus norvegicus
A248HYSYKPDGLLR3Gallus gallus, Mus musculus, Rattus norvegicus
A248HYSYKADGLLR1Homo sapiens
A400VVKTVAVKILK3Homo sapiens, Mus musculus, Rattus norvegicus
A400GAKPVAVKILK1Gallus gallus
A421ELLAEANVMQQ3Homo sapiens, Mus musculus, Rattus norvegicus
A421ELLREANVMQQ1Gallus gallus
A451LVMEMAELGPL3Homo sapiens, Gallus gallus, Mus musculus
A451LVMEMAAWGPL1Rattus norvegicus
A77GTYAISGGRAH2Mus musculus, Rattus norvegicus
A77GTYAIAGGRTH1Homo sapiens
A77GTYAIAGGKSH1Gallus gallus
D249YSYKPDGLLRV3Gallus gallus, Mus musculus, Rattus norvegicus
D249YSYKADGLLRV1Homo sapiens
D494NFVHRDLAARN4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
D512YAKISDFGLSK4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
D97HSQESDGLVCL1Homo sapiens
D97HSEEADGLICL1Gallus gallus
D97HSQEPDGLICL1Mus musculus
D97HSQEPEGLVCL1Rattus norvegicus
E23GNITREEAEDY3Homo sapiens, Mus musculus, Rattus norvegicus
E23GNITREEAEEY1Gallus gallus
E230KLSIPEGKKFD3Homo sapiens, Mus musculus, Rattus norvegicus
E230KLSIPDGKRFD1Gallus gallus
E420DELLAEANVMQ3Homo sapiens, Mus musculus, Rattus norvegicus
E420DELLREANVMQ1Gallus gallus
E449WMLVMEMAELG3Homo sapiens, Gallus gallus, Mus musculus
E449WMLVMEMAAWG1Rattus norvegicus
E452VMEMAELGPLN3Homo sapiens, Gallus gallus, Mus musculus
E452VMEMAAWGPLN1Rattus norvegicus
F382LGSGNFGTVKK4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
F490LEESNFVHRDL3Homo sapiens, Mus musculus, Rattus norvegicus
F490LEENNFVHRDL1Gallus gallus
G231LSIPEGKKFDT3Homo sapiens, Mus musculus, Rattus norvegicus
G231LSIPDGKRFDT1Gallus gallus
G250SYKPDGLLRVL3Gallus gallus, Mus musculus, Rattus norvegicus
G250SYKADGLLRVL1Homo sapiens
G378EDNELGSGNFG2Mus musculus, Rattus norvegicus
G378EDKELGSGNFG1Homo sapiens
G378EEGELGSGNFG1Gallus gallus
G380NELGSGNFGTV2Mus musculus, Rattus norvegicus
G380KELGSGNFGTV1Homo sapiens
G380GELGSGNFGTV1Gallus gallus
G383GSGNFGTVKKG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
G454EMAELGPLNKY2Homo sapiens, Mus musculus
G454EMAELGPLNKF1Gallus gallus
G454EMAAWGPLNKY1Rattus norvegicus
G532KAQTHGKWPVK3Homo sapiens, Mus musculus, Rattus norvegicus
G532KAQSHGKWPVK1Gallus gallus
G578YRGMKGSEVTA3Homo sapiens, Mus musculus, Rattus norvegicus
G578YKGMKGGEVAQ1Gallus gallus
G79YAISGGRAHAS2Mus musculus, Rattus norvegicus
G79YAIAGGRTHAS1Homo sapiens
G79YAIAGGKSHAS1Gallus gallus
G98SQESDGLVCLL1Homo sapiens
G98SEEADGLICLL1Gallus gallus
G98SQEPDGLICLL1Mus musculus
G98SQEPEGLVCLL1Rattus norvegicus
H215EGKVLHYRIDR2Mus musculus, Rattus norvegicus
H215EGKVLHYRIDK1Homo sapiens
H215DGKVLHYRIDR1Gallus gallus
H492ESNFVHRDLAA3Homo sapiens, Mus musculus, Rattus norvegicus
H492ENNFVHRDLAA1Gallus gallus
H531YKAQTHGKWPV3Homo sapiens, Mus musculus, Rattus norvegicus
H531YKAQSHGKWPV1Gallus gallus
H62HNRKAHHYTIE2Mus musculus, Rattus norvegicus
H62HGRKAHHYTIE1Homo sapiens
H62YGRKVHHYTIE1Gallus gallus
H63NRKAHHYTIER2Mus musculus, Rattus norvegicus
H63GRKAHHYTIER1Homo sapiens
H63GRKVHHYTIER1Gallus gallus
I228TGKLSIPEGKK3Homo sapiens, Mus musculus, Rattus norvegicus
I228TGKLSIPDGKR1Gallus gallus
I432LDNPYIVRMIG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
I438VRMIGICEAES3Homo sapiens, Mus musculus, Rattus norvegicus
I438VRMIGICEAEA1Gallus gallus
I510QHYAKISDFGL4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
I76NGTYAISGGRA2Mus musculus, Rattus norvegicus
I76NGTYAIAGGRT1Homo sapiens
I76SGTYAIAGGKS1Gallus gallus
K232SIPEGKKFDTL3Homo sapiens, Mus musculus, Rattus norvegicus
K232SIPDGKRFDTL1Gallus gallus
K247EHYSYKPDGLL3Gallus gallus, Mus musculus, Rattus norvegicus
K247EHYSYKADGLL1Homo sapiens
K402KTVAVKILKNE3Homo sapiens, Mus musculus, Rattus norvegicus
K402KPVAVKILKNE1Gallus gallus
K458LGPLNKYLQQN2Homo sapiens, Mus musculus
K458LGPLNKFLQKN1Gallus gallus
K458WGPLNKYLQQN1Rattus norvegicus
K533AQTHGKWPVKW3Homo sapiens, Mus musculus, Rattus norvegicus
K533AQSHGKWPVKW1Gallus gallus
L205NGSYALCLLHE1Homo sapiens
L205NGSYALCLLND1Gallus gallus
L205SGSYALCLLHE1Mus musculus
L205NGSFALCLLHE1Rattus norvegicus
L214HEGKVLHYRID3Homo sapiens, Mus musculus, Rattus norvegicus
L214NDGKVLHYRID1Gallus gallus
L251YKPDGLLRVLT2Mus musculus, Rattus norvegicus
L251YKADGLLRVLT1Homo sapiens
L251YKPDGLLRVLS1Gallus gallus
L252KPDGLLRVLTV2Mus musculus, Rattus norvegicus
L252KADGLLRVLTV1Homo sapiens
L252KPDGLLRVLSI1Gallus gallus
L377LEDNELGSGNF2Mus musculus, Rattus norvegicus
L377LEDKELGSGNF1Homo sapiens
L377LEEGELGSGNF1Gallus gallus
L417ALKDELLAEAN3Homo sapiens, Mus musculus, Rattus norvegicus
L417AIKDELLREAN1Gallus gallus
L427NVMQQLDNPYI4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
L446AESWMLVMEMA3Homo sapiens, Mus musculus, Rattus norvegicus
L446AEAWMLVMEMA1Gallus gallus
L453MEMAELGPLNK3Homo sapiens, Gallus gallus, Mus musculus
L453MEMAAWGPLNK1Rattus norvegicus
L485MGMKYLEESNF3Homo sapiens, Mus musculus, Rattus norvegicus
L485MGMKYLEENNF1Gallus gallus
L501AARNVLLVTQH4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
L99QESDGLVCLLK1Homo sapiens
L99EEADGLICLLR1Gallus gallus
L99QEPDGLICLLK1Mus musculus
L99QEPEGLVCLLK1Rattus norvegicus
M424AEANVMQQLDN3Homo sapiens, Mus musculus, Rattus norvegicus
M424REANVMQQLDN1Gallus gallus
M435PYIVRMIGICE4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
M448SWMLVMEMAEL2Homo sapiens, Mus musculus
M448AWMLVMEMAEL1Gallus gallus
M448SWMLVMEMAAW1Rattus norvegicus
M450MLVMEMAELGP3Homo sapiens, Gallus gallus, Mus musculus
M450MLVMEMAAWGP1Rattus norvegicus
N381ELGSGNFGTVK4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
N457ELGPLNKYLQQ2Homo sapiens, Mus musculus
N457ELGPLNKFLQK1Gallus gallus
N457AWGPLNKYLQQ1Rattus norvegicus
N499DLAARNVLLVT4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
P229GKLSIPEGKKF3Homo sapiens, Mus musculus, Rattus norvegicus
P229GKLSIPDGKRF1Gallus gallus
P455MAELGPLNKYL2Homo sapiens, Mus musculus
P455MAELGPLNKFL1Gallus gallus
P455MAAWGPLNKYL1Rattus norvegicus
P535THGKWPVKWYA3Homo sapiens, Mus musculus, Rattus norvegicus
P535SHGKWPVKWYA1Gallus gallus
Q461LNKYLQQNRHI2Mus musculus, Rattus norvegicus
Q461LNKYLQQNRHV1Homo sapiens
Q461LNKFLQKNRHV1Gallus gallus
R175HGNISRDESEQ2Mus musculus, Rattus norvegicus
R175HGKISREESEQ1Homo sapiens
R175HGRISREESEH1Gallus gallus
R195GKFLIRARDNN2Homo sapiens, Rattus norvegicus
R195GKFLIRERDSN1Gallus gallus
R195GKFLIRARDNS1Mus musculus
R197FLIRARDNNGS2Homo sapiens, Rattus norvegicus
R197FLIRERDSNGS1Gallus gallus
R197FLIRARDNSGS1Mus musculus
R217KVLHYRIDRDK3Gallus gallus, Mus musculus, Rattus norvegicus
R217KVLHYRIDKDK1Homo sapiens
R22FGNITREEAED3Homo sapiens, Mus musculus, Rattus norvegicus
R22FGNITREEAEE1Gallus gallus
R42GLYLLRQSRNY4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R45LLRQSRNYLGG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R498RDLAARNVLLV4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
S202RDNNGSYALCL1Homo sapiens
S202RDSNGSYALCL1Gallus gallus
S202RDNSGSYALCL1Mus musculus
S202RDNNGSFALCL1Rattus norvegicus
S379DNELGSGNFGT2Mus musculus, Rattus norvegicus
S379DKELGSGNFGT1Homo sapiens
S379EGELGSGNFGT1Gallus gallus
S511HYAKISDFGLS4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
T65KAHHYTIEREL3Homo sapiens, Mus musculus, Rattus norvegicus
T65KVHHYTIEREL1Gallus gallus
V385GNFGTVKKGYY3Homo sapiens, Mus musculus, Rattus norvegicus
V385GNFGTVKKGFY1Gallus gallus
V433DNPYIVRMIGI4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
W534QTHGKWPVKWY3Homo sapiens, Mus musculus, Rattus norvegicus
W534QSHGKWPVKWY1Gallus gallus
Y216GKVLHYRIDRD3Gallus gallus, Mus musculus, Rattus norvegicus
Y216GKVLHYRIDKD1Homo sapiens
Y244QLVEHYSYKPD3Gallus gallus, Mus musculus, Rattus norvegicus
Y244QLVEHYSYKAD1Homo sapiens
Y525RADENYYKAQT3Homo sapiens, Mus musculus, Rattus norvegicus
Y525SADENYYKAQS1Gallus gallus
Y64RKAHHYTIERE3Homo sapiens, Mus musculus, Rattus norvegicus
Y64RKVHHYTIERE1Gallus gallus


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