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mutLBSgeneDB |
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| Gene summary for TAL1 |
 Gene summary |
| Basic gene Info. | Gene symbol | TAL1 |
| Gene name | T-cell acute lymphocytic leukemia 1 | |
| Synonyms | SCL|TCL5|bHLHa17|tal-1 | |
| Cytomap | UCSC genome browser: 1p32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001287347.2, NM_001290403.1,NM_001290404.1,NM_001290405.1,NM_001290406.1, NM_003189.5, | |
| Description | T-cell acute lymphocytic leukemia protein 1T-cell leukemia/lymphoma protein 5class A basic helix-loop-helix protein 17stem cell proteintal-1 product | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 187040 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000162367 | ||
| HPRD : 01753 | ||
| Vega : OTTHUMG00000007847 | ||
| Protein | UniProt: P17542 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TAL1 | |
| BioGPS: 6886 | ||
| Pathway | NCI Pathway Interaction Database: TAL1 | |
| KEGG: TAL1 | ||
| REACTOME: TAL1 | ||
| Pathway Commons: TAL1 | ||
| Context | iHOP: TAL1 | |
| ligand binding site mutation search in PubMed: TAL1 | ||
| UCL Cancer Institute: TAL1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0031334 | positive regulation of protein complex assembly | 20855495 | GO:0045648 | positive regulation of erythrocyte differentiation | 20028976 | GO:0045893 | positive regulation of transcription, DNA-templated | 20028976 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 20855495 |
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| Ligand binding site mutations for TAL1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | N193,R195 | S194R | LUSC | 1 | N204 | A206D | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TAL1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | N204 | A206D | -1.2166225 | N193 | S194R | -0.070081418 | R195 | S194R | -0.070081418 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TAL1 from PDB |
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| Differential gene expression and gene-gene network for TAL1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TAL1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 73 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TAL1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TAL1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 2ypa | A | N193 N204 | NUC | Nucleic Acids | 2ypb | A | N193 N204 | NUC | Nucleic Acids | 2ypa | A | R195 | NUC | Nucleic Acids | 2ypb | A | R195 |
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| Conservation information for LBS of TAL1 |
| Multiple alignments for P17542 in multiple species |
| LBS | AA sequence | # species | Species | E196 | FTNSRERWRQQ | 4 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus | K225 | DKKLSKNEILR | 4 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus | N193 | RRIFTNSRERW | 4 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus | N204 | RQQNVNGAFAE | 4 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus | Q201 | ERWRQQNVNGA | 4 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus | R189 | TKVVRRIFTNS | 3 | Homo sapiens, Gallus gallus, Mus musculus | R189 | PKIVRRIFTNS | 1 | Danio rerio | R195 | IFTNSRERWRQ | 4 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus | R197 | TNSRERWRQQN | 4 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus | R199 | SRERWRQQNVN | 4 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus | S224 | PDKKLSKNEIL | 4 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus |
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