mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TARS
Gene summary
Basic gene Info.Gene symbolTARS
Gene namethreonyl-tRNA synthetase
SynonymsThrRS
CytomapUCSC genome browser: 5p13.2
Type of geneprotein-coding
RefGenesNM_001258437.1,
NM_001258438.1,NM_152295.4,NR_047676.1,NR_047677.1,
NR_047678.1,
Descriptionthreonine tRNA ligase 1, cytoplasmicthreonine--tRNA ligase, cytoplasmicthreonyl-tRNA synthetase, cytoplasmic
Modification date20141207
dbXrefs MIM : 187790
HGNC : HGNC
Ensembl : ENSG00000113407
HPRD : 01762
Vega : OTTHUMG00000090683
ProteinUniProt: P26639
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TARS
BioGPS: 6897
PathwayNCI Pathway Interaction Database: TARS
KEGG: TARS
REACTOME: TARS
Pathway Commons: TARS
ContextiHOP: TARS
ligand binding site mutation search in PubMed: TARS
UCL Cancer Institute: TARS
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for TARS

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R442E444ABRCA1
D545D545YLUAD1
H464H464DOV1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TARS
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H464H464D-1.1248287
R442E444A-1.0256776
D545D545Y-0.904778
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TARS from PDB

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Differential gene expression and gene-gene network for TARS
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TARS and the right PPI network was created from samples without mutations in the LBS of TARS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TARS
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TARS
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00156L-ThreonineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TARS go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)4p3nAH464
ZNZINC(2+)4p3nBH464
ZNZINC(2+)4p3nCH464
ZNZINC(2+)4p3nDH464
ZNZINC(2+)4ttvAH464
ZNZINC(2+)4ttvBH464
ZNZINC(2+)4ttvCH464
ZNZINC(2+)4ttvDH464
2CRBORRELIDIN(1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-CYANO-8, 16-DIHYDROXY-9,11,13,15-TETRAMETHYL-18- OXOOXACYCLOOCTADECA-4,6-DIEN-2- YL]CYCLOPENTANECARBOXYLIC ACID4p3nAR442
2CRBORRELIDIN(1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-CYANO-8, 16-DIHYDROXY-9,11,13,15-TETRAMETHYL-18- OXOOXACYCLOOCTADECA-4,6-DIEN-2- YL]CYCLOPENTANECARBOXYLIC ACID4p3nBR442
2CRBORRELIDIN(1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-CYANO-8, 16-DIHYDROXY-9,11,13,15-TETRAMETHYL-18- OXOOXACYCLOOCTADECA-4,6-DIEN-2- YL]CYCLOPENTANECARBOXYLIC ACID4p3nCR442
2CRBORRELIDIN(1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-CYANO-8, 16-DIHYDROXY-9,11,13,15-TETRAMETHYL-18- OXOOXACYCLOOCTADECA-4,6-DIEN-2- YL]CYCLOPENTANECARBOXYLIC ACID4p3nDR442
BC9(1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-CYANO-8,16- DIHYDROXY-9,11,13,15-TETRAMETHYL-18- OXOOXACYCLOOCTADEC-6-EN-2-YL]CYCLOBUTANECARBOXYLIC ACID4ttvAR442
BC9(1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-CYANO-8,16- DIHYDROXY-9,11,13,15-TETRAMETHYL-18- OXOOXACYCLOOCTADEC-6-EN-2-YL]CYCLOBUTANECARBOXYLIC ACID4ttvBR442
BC9(1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-CYANO-8,16- DIHYDROXY-9,11,13,15-TETRAMETHYL-18- OXOOXACYCLOOCTADEC-6-EN-2-YL]CYCLOBUTANECARBOXYLIC ACID4ttvCR442
BC9(1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-CYANO-8,16- DIHYDROXY-9,11,13,15-TETRAMETHYL-18- OXOOXACYCLOOCTADEC-6-EN-2-YL]CYCLOBUTANECARBOXYLIC ACID4ttvDR442


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Conservation information for LBS of TARS
Multiple alignments for P26639 in multiple species
LBSAA sequence# speciesSpecies
A559RYHQCATIQLD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A559RKFQCATLQLD1Arabidopsis thaliana
A559RWHQCATIQLD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A559RQHQCATIQLD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A559RNFQCATIQLD1Caenorhabditis elegans
C413LKPMNCPGHCL7Homo sapiens, Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
C413LKPMNCPGHCV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C558GRYHQCATIQL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C558NRKFQCATLQL1Arabidopsis thaliana
C558RRWHQCATIQL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C558KRQHQCATIQL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C558KRNFQCATIQL1Caenorhabditis elegans
D462RFQQDDAHIFC8Homo sapiens, Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
D545YGPKIDIQIKD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D545YGPKIDITVSD1Arabidopsis thaliana
D545YGPKIDIMISD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D545YGPKIDITVFD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D545YGPKIDITIQD1Caenorhabditis elegans
D564ATIQLDFQLPI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D564ATIQLDFQLPN2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans
D564ATLQLDFQLPI1Arabidopsis thaliana
D564ATIQLDFQLPE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F539PGDGAFYGPKI4Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
F539AGDGAFYGPKI2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F539SGDGAFYGPKI1Homo sapiens
F539EGDGAFYGPKI1Arabidopsis thaliana
G387LWMTSGHWQHY3Homo sapiens, Mus musculus, Rattus norvegicus
G387LWQTSGHADNY1Arabidopsis thaliana
G387LWETSGHWANY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G387LWKTSGHWNNY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G387LWETSGHWQHY1Caenorhabditis elegans
G387LWVTSGHWEHY1Bos taurus
H388WMTSGHWQHYS3Homo sapiens, Mus musculus, Rattus norvegicus
H388WQTSGHADNYK1Arabidopsis thaliana
H388WETSGHWANYK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H388WKTSGHWNNYS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H388WETSGHWQHYS1Caenorhabditis elegans
H388WVTSGHWEHYS1Bos taurus
H391SGHWQHYSENM3Homo sapiens, Mus musculus, Rattus norvegicus
H391SGHADNYKDNM1Arabidopsis thaliana
H391SGHWANYKENM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H391SGHWNNYSENM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H391SGHWQHYSEDM1Caenorhabditis elegans
H391SGHWEHYSENM1Bos taurus
H464QQDDAHIFCAM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H464QQDDAHIFCTT1Arabidopsis thaliana
H464QQDDAHIFCTH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H464QQDDAHIFCTP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H464QQDDAHIFCRQ1Caenorhabditis elegans
H590RPVIVHRAILG3Homo sapiens, Mus musculus, Rattus norvegicus
H590RPVMIHRAVLG2Arabidopsis thaliana, Caenorhabditis elegans
H590RPVMIHRAILG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H590RPVMVHRAILG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H590KPVIIHRAILG1Bos taurus
I546GPKIDIQIKDA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I546GPKIDITVSDA1Arabidopsis thaliana
I546GPKIDIMISDA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I546GPKIDITVFDA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I546GPKIDITIQDA1Caenorhabditis elegans
L567QLDFQLPIRFN5Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus
L567QLDFQLPNRFE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L567QLDFQLPERFQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L567QLDFQLPNQFD1Caenorhabditis elegans
M411FALKPMNCPGH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M411FGLKPMNCPGH3Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans
M411YALKPMNCPGH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q460VRRFQQDDAHI8Homo sapiens, Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
Q557IGRYHQCATIQ4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q557MNRKFQCATLQ1Arabidopsis thaliana
Q557LRRWHQCATIQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q557LKRQHQCATIQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q557LKRNFQCATIQ1Caenorhabditis elegans
Q562QCATIQLDFQL7Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
Q562QCATLQLDFQL1Arabidopsis thaliana
Q566IQLDFQLPIRF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q566LQLDFQLPIRF1Arabidopsis thaliana
Q566IQLDFQLPNRF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q566IQLDFQLPERF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q566IQLDFQLPNQF1Caenorhabditis elegans
R442FGVLHRNELSG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R442FGVLHRNEASG1Arabidopsis thaliana
R442FGVIHRNEFSG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R442FGVLHRNEFSG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R442FGVLHRNEMSG1Caenorhabditis elegans
R591PVIVHRAILGS3Homo sapiens, Mus musculus, Rattus norvegicus
R591PVMIHRAVLGS2Arabidopsis thaliana, Caenorhabditis elegans
R591PVMIHRAILGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R591PVMVHRAILGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R591PVIIHRAILGS1Bos taurus
S386RLWMTSGHWQH3Homo sapiens, Mus musculus, Rattus norvegicus
S386ELWQTSGHADN1Arabidopsis thaliana
S386KLWETSGHWAN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S386NLWKTSGHWNN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S386KLWETSGHWQH1Caenorhabditis elegans
S386RLWVTSGHWEH1Bos taurus
T560YHQCATIQLDF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T560KFQCATLQLDF1Arabidopsis thaliana
T560WHQCATIQLDF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T560QHQCATIQLDF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T560NFQCATIQLDF1Caenorhabditis elegans
Y540GDGAFYGPKID8Homo sapiens, Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus


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