mutLBSgeneDB |
Gene summary for TCEB1 |
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Basic gene Info. | Gene symbol | TCEB1 |
Gene name | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) | |
Synonyms | SIII|eloC | |
Cytomap | UCSC genome browser: 8q21.11 | |
Type of gene | protein-coding | |
RefGenes | NM_001204857.1, NM_001204858.1,NM_001204859.1,NM_001204860.1,NM_001204861.1, NM_001204862.1,NM_001204863.1,NM_001204864.1,NM_005648.3, | |
Description | RNA polymerase II transcription factor SIII subunit CSIII p15elongin 15 kDa subunittranscription elongation factor B polypeptide 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600788 | |
HGNC : HGNC | ||
Ensembl : ENSG00000154582 | ||
HPRD : 02875 | ||
Vega : OTTHUMG00000164501 | ||
Protein | UniProt: Q15369 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TCEB1 | |
BioGPS: 6921 | ||
Pathway | NCI Pathway Interaction Database: TCEB1 | |
KEGG: TCEB1 | ||
REACTOME: TCEB1 | ||
Pathway Commons: TCEB1 | ||
Context | iHOP: TCEB1 | |
ligand binding site mutation search in PubMed: TCEB1 | ||
UCL Cancer Institute: TCEB1 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for TCEB1 |
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LBS | AAchange of nsSNV | Cancer type | # samples | Y79 | Y79F | KIRC | 1 | Y79 | Y79S | KIRC | 1 | Y79 | Y79N | KIRC | 1 | S86 | S86G | UCEC | 1 | Y83 | R82C | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for TCEB1 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y83 | R82C | -1.2114828 | Y79 | Y79N | -1.1931549 | Y79 | Y79S | -1.1243212 | Y79 | Y79F | -0.81948235 | S86 | S86G | -0.78140416 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for TCEB1 |
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Phenotype information for TCEB1 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0007134 | Carcinoma, Renal Cell | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for TCEB1 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ASN,LYS,VAL,GLY,SER,LEU,GLN,TYR,LEU,ALA,LEU,ALA,ALA,LEU,ILE,LYS) | 3dcg | B | Y79 Y83 S86 | III | Peptide ligand (ASN,LYS,VAL,GLY,SER,LEU,GLN,TYR,LEU,ALA,LEU,ALA,ALA,LEU,ILE,LYS,PRO) | 3dcg | D | Y79 Y83 S86 |
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Conservation information for LBS of TCEB1 |
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LBS | AA sequence | # species | Species | A100 | IAPEIALELLM | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | A107 | ELLMAANFLDC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C11 | KTYGGCEGPDA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E89 | TNSSTEIPEFP | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F93 | TEIPEFPIAPE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I90 | NSSTEIPEFPI | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I95 | IPEFPIAPEIA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K80 | MYFTYKVRYTN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L103 | EIALELLMAAN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L104 | IALELLMAANF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N108 | LLMAANFLDC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N85 | KVRYTNSSTEI | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S86 | VRYTNSSTEIP | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T84 | YKVRYTNSSTE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y76 | SKVCMYFTYKV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y79 | CMYFTYKVRYT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y83 | TYKVRYTNSST | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
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