mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TCEB1
Gene summary
Basic gene Info.Gene symbolTCEB1
Gene nametranscription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
SynonymsSIII|eloC
CytomapUCSC genome browser: 8q21.11
Type of geneprotein-coding
RefGenesNM_001204857.1,
NM_001204858.1,NM_001204859.1,NM_001204860.1,NM_001204861.1,
NM_001204862.1,NM_001204863.1,NM_001204864.1,NM_005648.3,
DescriptionRNA polymerase II transcription factor SIII subunit CSIII p15elongin 15 kDa subunittranscription elongation factor B polypeptide 1
Modification date20141207
dbXrefs MIM : 600788
HGNC : HGNC
Ensembl : ENSG00000154582
HPRD : 02875
Vega : OTTHUMG00000164501
ProteinUniProt: Q15369
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TCEB1
BioGPS: 6921
PathwayNCI Pathway Interaction Database: TCEB1
KEGG: TCEB1
REACTOME: TCEB1
Pathway Commons: TCEB1
ContextiHOP: TCEB1
ligand binding site mutation search in PubMed: TCEB1
UCL Cancer Institute: TCEB1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for TCEB1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Y79Y79FKIRC1
Y79Y79SKIRC1
Y79Y79NKIRC1
S86S86GUCEC1
Y83R82CUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TCEB1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Y83R82C-1.2114828
Y79Y79N-1.1931549
Y79Y79S-1.1243212
Y79Y79F-0.81948235
S86S86G-0.78140416
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TCEB1 from PDB

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Differential gene expression and gene-gene network for TCEB1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TCEB1 and the right PPI network was created from samples without mutations in the LBS of TCEB1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TCEB1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007134Carcinoma, Renal Cell1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TCEB1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TCEB1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (ASN,LYS,VAL,GLY,SER,LEU,GLN,TYR,LEU,ALA,LEU,ALA,ALA,LEU,ILE,LYS)3dcgBY79 Y83 S86
IIIPeptide ligand (ASN,LYS,VAL,GLY,SER,LEU,GLN,TYR,LEU,ALA,LEU,ALA,ALA,LEU,ILE,LYS,PRO)3dcgDY79 Y83 S86


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Conservation information for LBS of TCEB1
Multiple alignments for Q15369 in multiple species
LBSAA sequence# speciesSpecies
A100IAPEIALELLM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A107ELLMAANFLDC4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C11KTYGGCEGPDA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E89TNSSTEIPEFP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F93TEIPEFPIAPE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I90NSSTEIPEFPI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I95IPEFPIAPEIA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K80MYFTYKVRYTN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L103EIALELLMAAN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L104IALELLMAANF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N108LLMAANFLDC4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N85KVRYTNSSTEI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S86VRYTNSSTEIP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T84YKVRYTNSSTE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y76SKVCMYFTYKV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y79CMYFTYKVRYT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y83TYKVRYTNSST4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus


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