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mutLBSgeneDB |
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| Gene summary for TCEB1 |
 Gene summary |
| Basic gene Info. | Gene symbol | TCEB1 |
| Gene name | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) | |
| Synonyms | SIII|eloC | |
| Cytomap | UCSC genome browser: 8q21.11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001204857.1, NM_001204858.1,NM_001204859.1,NM_001204860.1,NM_001204861.1, NM_001204862.1,NM_001204863.1,NM_001204864.1,NM_005648.3, | |
| Description | RNA polymerase II transcription factor SIII subunit CSIII p15elongin 15 kDa subunittranscription elongation factor B polypeptide 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600788 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000154582 | ||
| HPRD : 02875 | ||
| Vega : OTTHUMG00000164501 | ||
| Protein | UniProt: Q15369 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TCEB1 | |
| BioGPS: 6921 | ||
| Pathway | NCI Pathway Interaction Database: TCEB1 | |
| KEGG: TCEB1 | ||
| REACTOME: TCEB1 | ||
| Pathway Commons: TCEB1 | ||
| Context | iHOP: TCEB1 | |
| ligand binding site mutation search in PubMed: TCEB1 | ||
| UCL Cancer Institute: TCEB1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for TCEB1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y79 | Y79F | KIRC | 1 | Y79 | Y79S | KIRC | 1 | Y79 | Y79N | KIRC | 1 | S86 | S86G | UCEC | 1 | Y83 | R82C | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TCEB1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y83 | R82C | -1.2114828 | Y79 | Y79N | -1.1931549 | Y79 | Y79S | -1.1243212 | Y79 | Y79F | -0.81948235 | S86 | S86G | -0.78140416 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TCEB1 from PDB |
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| Differential gene expression and gene-gene network for TCEB1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TCEB1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007134 | Carcinoma, Renal Cell | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TCEB1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TCEB1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ASN,LYS,VAL,GLY,SER,LEU,GLN,TYR,LEU,ALA,LEU,ALA,ALA,LEU,ILE,LYS) | 3dcg | B | Y79 Y83 S86 | III | Peptide ligand (ASN,LYS,VAL,GLY,SER,LEU,GLN,TYR,LEU,ALA,LEU,ALA,ALA,LEU,ILE,LYS,PRO) | 3dcg | D | Y79 Y83 S86 |
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| Conservation information for LBS of TCEB1 |
| Multiple alignments for Q15369 in multiple species |
| LBS | AA sequence | # species | Species | A100 | IAPEIALELLM | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | A107 | ELLMAANFLDC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C11 | KTYGGCEGPDA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E89 | TNSSTEIPEFP | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F93 | TEIPEFPIAPE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I90 | NSSTEIPEFPI | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I95 | IPEFPIAPEIA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K80 | MYFTYKVRYTN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L103 | EIALELLMAAN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L104 | IALELLMAANF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N108 | LLMAANFLDC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N85 | KVRYTNSSTEI | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S86 | VRYTNSSTEIP | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T84 | YKVRYTNSSTE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y76 | SKVCMYFTYKV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y79 | CMYFTYKVRYT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y83 | TYKVRYTNSST | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
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