mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TCEB3
Gene summary
Basic gene Info.Gene symbolTCEB3
Gene nametranscription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
SynonymsEloA|SIII|SIII p110|TCEB3A
CytomapUCSC genome browser: 1p36.1
Type of geneprotein-coding
RefGenesNM_003198.2,
DescriptionRNA polymerase II transcription factor SIII subunit A1elongin 110 kDa subunitelongin-Atranscription elongation factor B alpha subunittranscription elongation factor B polypeptide 3
Modification date20141207
dbXrefs MIM : 600786
HGNC : HGNC
Ensembl : ENSG00000011007
HPRD : 02873
Vega : OTTHUMG00000002957
ProteinUniProt: Q14241
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TCEB3
BioGPS: 6924
PathwayNCI Pathway Interaction Database: TCEB3
KEGG: TCEB3
REACTOME: TCEB3
Pathway Commons: TCEB3
ContextiHOP: TCEB3
ligand binding site mutation search in PubMed: TCEB3
UCL Cancer Institute: TCEB3
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for TCEB3

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L667R666WBRCA1
R617R617HCOAD1
C610C610RUCEC1
Q660R658QUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TCEB3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R617R617H-1.2964584
Q660R658Q-1.1619356
C610C610R-0.79957209
L667R666W-0.51529122
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TCEB3 from PDB

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Differential gene expression and gene-gene network for TCEB3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TCEB3 and the right PPI network was created from samples without mutations in the LBS of TCEB3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TCEB3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TCEB3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TCEB3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of TCEB3
Multiple alignments for Q14241 in multiple species
LBSAA sequence# speciesSpecies


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