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mutLBSgeneDB |
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| Gene summary for TDG |
 Gene summary |
| Basic gene Info. | Gene symbol | TDG |
| Gene name | thymine-DNA glycosylase | |
| Synonyms | hTDG | |
| Cytomap | UCSC genome browser: 12q24.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003211.4, NM_001008411.1, | |
| Description | G/T mismatch-specific thymine DNA glycosylase | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 601423 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000139372 | ||
| HPRD : 03251 | ||
| Vega : OTTHUMG00000168418 | ||
| Protein | UniProt: Q13569 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TDG | |
| BioGPS: 6996 | ||
| Pathway | NCI Pathway Interaction Database: TDG | |
| KEGG: TDG | ||
| REACTOME: TDG | ||
| Pathway Commons: TDG | ||
| Context | iHOP: TDG | |
| ligand binding site mutation search in PubMed: TDG | ||
| UCL Cancer Institute: TDG | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006284 | base-excision repair | 21862836 | GO:0006298 | mismatch repair | 22573813 |
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| Ligand binding site mutations for TDG |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K201 | K201T | COAD | 1 | S273 | S273R | GBM | 1 | F252 | F252I | GBM | 1 | K201 | K201T | KIRC | 1 | S273 | S273I | LUAD | 1 | R275 | R275I | LUAD | 1 | D202 | D202Y | OV | 1 | N230 | F229S | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TDG |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S273 | S273I | 0.21967836 | S273 | S273R | 0.070070195 | K201 | K201T | 0.051207937 | R275 | R275I | -0.81436879 | N230 | F229S | -0.7040596 | F252 | F252I | -0.45066146 | D202 | D202Y | -0.38750937 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TDG from PDB |
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| Differential gene expression and gene-gene network for TDG |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TDG |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TDG |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TDG go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3uob | A | F252 S273 R275 | NUC | Nucleic Acids | 4jgc | A | F252 S273 R275 | NUC | Nucleic Acids | 4z7z | A | F252 S273 R275 | NUC | Nucleic Acids | 5cys | A | F252 S273 R275 | NUC | Nucleic Acids | 3uo7 | B | K201 | NUC | Nucleic Acids | 3ufj | A | K201 D202 R275 | NUC | Nucleic Acids | 3uob | B | K201 F252 S273 | NUC | Nucleic Acids | 4fnc | A | K201 F252 S273 R275 | NUC | Nucleic Acids | 4xeg | A | K201 F252 S273 R275 | NUC | Nucleic Acids | 4z47 | A | K201 F252 S273 R275 | NUC | Nucleic Acids | 3ufj | B | K201 R275 | NUC | Nucleic Acids | 4fnc | A | K201 R275 | NUC | Nucleic Acids | 4z3a | A | K201 R275 | NUC | Nucleic Acids | 3uo7 | A | K201 S273 R275 | NUC | Nucleic Acids | 4z3a | A | K201 S273 R275 | NUC | Nucleic Acids | 4z7b | A | K201 S273 R275 | HMU | 5-HYDROXYMETHYLURACIL | 4fnc | A | N230 | 1RT | 4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE-5-CARBOXYLIC ACID | 4jgc | A | N230 | NUC | Nucleic Acids | 2rba | B | R275 | NUC | Nucleic Acids | 2rba | B | R275 | NUC | Nucleic Acids | 3ufj | A | R275 | NUC | Nucleic Acids | 3ufj | B | R275 | NUC | Nucleic Acids | 4jgc | A | R275 | NUC | Nucleic Acids | 4xeg | A | R275 | NUC | Nucleic Acids | 4z47 | A | R275 | NUC | Nucleic Acids | 4z7b | A | R275 | NUC | Nucleic Acids | 4z7z | A | R275 | NUC | Nucleic Acids | 5cys | A | R275 | NUC | Nucleic Acids | 2rba | A | S273 R275 | NUC | Nucleic Acids | 3ufj | A | S273 R275 | NUC | Nucleic Acids | 3ufj | B | S273 R275 |
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| Conservation information for LBS of TDG |
| Multiple alignments for Q13569 in multiple species |
| LBS | AA sequence | # species | Species |
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