mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for BUB1B
Gene summary
Basic gene Info.Gene symbolBUB1B
Gene nameBUB1 mitotic checkpoint serine/threonine kinase B
CytomapUCSC genome browser: 15q15
Type of geneprotein-coding
DescriptionMAD3/BUB1-related protein kinasebudding uninhibited by benzimidazoles 1 homolog betamitotic checkpoint kinase MAD3Lmitotic checkpoint serine/threonine-protein kinase BUB1 beta
Modification date20141207
dbXrefs MIM : 602860
Ensembl : ENSG00000156970
HPRD : 04176
Vega : OTTHUMG00000129877
ProteinUniProt: O60566
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_BUB1B
BioGPS: 701
PathwayNCI Pathway Interaction Database: BUB1B
Pathway Commons: BUB1B
ContextiHOP: BUB1B
ligand binding site mutation search in PubMed: BUB1B
UCL Cancer Institute: BUB1B
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for BUB1B
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for BUB1B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for BUB1B from PDB

Differential gene expression and gene-gene network for BUB1B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of BUB1B and the right PPI network was created from samples without mutations in the LBS of BUB1B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for BUB1B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1850343Mosaic variegated aneuploidy syndrome8Biomarker, GeneticVariation
umls:C0009404Colorectal Neoplasms4AlteredExpression, Biomarker, GeneticVariation
umls:C0206656Rhabdomyosarcoma, Embryonal2Biomarker, GeneticVariation
umls:C0279626Esophageal Squamous Cell Carcinoma2Biomarker
umls:C0017661Glomerulonephritis, IGA1Biomarker
umls:C0018273Growth Disorders1Biomarker
umls:C0699790Colon Carcinoma1Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs
137512R130Cnot providedGermlineMedGen:CN169374

Pharmacological information for BUB1B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of BUB1B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of BUB1B
Multiple alignments for O60566 in multiple species
LBSAA sequence# speciesSpecies
C132KLGRLCNEPLD1Homo sapiens
C132EYAEHCADAEV1Arabidopsis thaliana
C132KLGHLCNEPLD1Mus musculus
D137CNEPLDMYSYL2Homo sapiens, Mus musculus
D137CADAEVIYKFL1Arabidopsis thaliana
E103MSTLLERAVEA1Homo sapiens
E103LLVIYEQCVRK1Arabidopsis thaliana
E103MSALVERAIEA1Mus musculus
E107LERAVEALQGE1Homo sapiens
E107YEQCVRKFWHS1Arabidopsis thaliana
E107VERAIEALQGE1Mus musculus
L128NLWLKLGRLCN1Homo sapiens
L128KVWLEYAEHCA1Arabidopsis thaliana
L128SLWIKLGHLCN1Mus musculus
L131LKLGRLCNEPL1Homo sapiens
L131LEYAEHCADAE1Arabidopsis thaliana
L131IKLGHLCNEPL1Mus musculus
M138NEPLDMYSYLH1Homo sapiens
M138ADAEVIYKFLE1Arabidopsis thaliana
M138NEPLDMYSYLQ1Mus musculus
N133LGRLCNEPLDM1Homo sapiens
N133YAEHCADAEVI1Arabidopsis thaliana
N133LGHLCNEPLDM1Mus musculus
S99KESNMSTLLER1Homo sapiens
S99ECSGLLVIYEQ1Arabidopsis thaliana
S99KESNMSALVER1Mus musculus
V106LLERAVEALQG1Homo sapiens
V106IYEQCVRKFWH1Arabidopsis thaliana
V106LVERAIEALQG1Mus musculus
W125RFLNLWLKLGR1Homo sapiens
W125RYLKVWLEYAE1Arabidopsis thaliana
W125RFLSLWIKLGH1Mus musculus
Y141LDMYSYLHNQG1Homo sapiens
Y141EVIYKFLEVNE1Arabidopsis thaliana
Y141LDMYSYLQSQG1Mus musculus

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas