mutLBSgeneDB |
Gene summary for KLF10 |
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Basic gene Info. | Gene symbol | KLF10 |
Gene name | Kruppel-like factor 10 | |
Synonyms | EGR-alpha|EGRA|TIEG|TIEG1 | |
Cytomap | UCSC genome browser: 8q22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001032282.3, NM_005655.3,NR_103759.1,NR_103760.1, | |
Description | Krueppel-like factor 10TGFB-inducible early growth response protein 1early growth response-alphatransforming growth factor-beta-inducible early growth response protein 1zinc finger transcription factor TIEG | |
Modification date | 20141207 | |
dbXrefs | MIM : 601878 | |
HGNC : HGNC | ||
Ensembl : ENSG00000155090 | ||
HPRD : 03527 | ||
Vega : OTTHUMG00000164735 | ||
Protein | UniProt: Q13118 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KLF10 | |
BioGPS: 7071 | ||
Pathway | NCI Pathway Interaction Database: KLF10 | |
KEGG: KLF10 | ||
REACTOME: KLF10 | ||
Pathway Commons: KLF10 | ||
Context | iHOP: KLF10 | |
ligand binding site mutation search in PubMed: KLF10 | ||
UCL Cancer Institute: KLF10 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for KLF10 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | C376 | P374Q | LUAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for KLF10 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C376 | P374Q | -1.1075836 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for KLF10 |
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Phenotype information for KLF10 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for KLF10 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of KLF10 |
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LBS | AA sequence | # species | Species | C371 | VRSHICSHPGC | 2 | Mus musculus, Rattus norvegicus | C371 | IRSHICSHPGC | 1 | Homo sapiens | C376 | CSHPGCGKTYF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H389 | SHLKAHVRTHT | 2 | Mus musculus, Rattus norvegicus | H389 | SHLKAHTRTHT | 1 | Homo sapiens | H393 | AHVRTHTGEKP | 2 | Mus musculus, Rattus norvegicus | H393 | AHTRTHTGEKP | 1 | Homo sapiens |
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