mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for KLF10
Gene summary
Basic gene Info.Gene symbolKLF10
Gene nameKruppel-like factor 10
CytomapUCSC genome browser: 8q22.2
Type of geneprotein-coding
DescriptionKrueppel-like factor 10TGFB-inducible early growth response protein 1early growth response-alphatransforming growth factor-beta-inducible early growth response protein 1zinc finger transcription factor TIEG
Modification date20141207
dbXrefs MIM : 601878
Ensembl : ENSG00000155090
HPRD : 03527
Vega : OTTHUMG00000164735
ProteinUniProt: Q13118
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KLF10
BioGPS: 7071
PathwayNCI Pathway Interaction Database: KLF10
Pathway Commons: KLF10
ContextiHOP: KLF10
ligand binding site mutation search in PubMed: KLF10
UCL Cancer Institute: KLF10
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for KLF10
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for KLF10
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for KLF10 from PDB

Differential gene expression and gene-gene network for KLF10
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of KLF10 and the right PPI network was created from samples without mutations in the LBS of KLF10. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for KLF10
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for KLF10
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of KLF10 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of KLF10
Multiple alignments for Q13118 in multiple species
LBSAA sequence# speciesSpecies
C371VRSHICSHPGC2Mus musculus, Rattus norvegicus
C371IRSHICSHPGC1Homo sapiens
C376CSHPGCGKTYF3Homo sapiens, Mus musculus, Rattus norvegicus
H389SHLKAHVRTHT2Mus musculus, Rattus norvegicus
H389SHLKAHTRTHT1Homo sapiens
H393AHVRTHTGEKP2Mus musculus, Rattus norvegicus
H393AHTRTHTGEKP1Homo sapiens

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