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mutLBSgeneDB |
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| Gene summary for TIAM1 |
 Gene summary |
| Basic gene Info. | Gene symbol | TIAM1 |
| Gene name | T-cell lymphoma invasion and metastasis 1 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 21q22.11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003253.2, | |
| Description | T-lymphoma invasion and metastasis-inducing protein 1TIAM-1human T-lymphoma invasion and metastasis inducing TIAM1 protein | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 600687 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000156299 | ||
| HPRD : 02820 | ||
| Vega : OTTHUMG00000084869 | ||
| Protein | UniProt: Q13009 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TIAM1 | |
| BioGPS: 7074 | ||
| Pathway | NCI Pathway Interaction Database: TIAM1 | |
| KEGG: TIAM1 | ||
| REACTOME: TIAM1 | ||
| Pathway Commons: TIAM1 | ||
| Context | iHOP: TIAM1 | |
| ligand binding site mutation search in PubMed: TIAM1 | ||
| UCL Cancer Institute: TIAM1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for TIAM1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S864 | S864F | BLCA | 1 | K912 | D913Y | COAD | 1 | E849 | H847R | COAD | 1 | P918 | P918L | SKCM | 1 | E849 | H847N | SKCM | 1 | Y874 | Y874S | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TIAM1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y874 | Y874S | -1.2386957 | E849 | H847N | -1.0880073 | E849 | H847R | -0.64335761 | P918 | P918L | -0.48271159 | S864 | S864F | -0.16847978 | K912 | D913Y | -0.077175997 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TIAM1 from PDB |
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| Differential gene expression and gene-gene network for TIAM1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TIAM1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1862939 | Amyotrophic lateral sclerosis 1 | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TIAM1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TIAM1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (SER,ARG,LYS,GLU,TYR,TYR,ALA) | 3kze | A | E849 P918 | III | Peptide ligand (SER,ARG,LYS,GLU,TYR,TYR,ALA) | 3kze | B | S864 | III | Peptide ligand (ARG,LYS,GLU,TYR,TYR,ALA) | 3kze | C | S864 | III | Peptide ligand (ASN,GLN,LYS,GLU,TYR,PHE,PHE) | 4nxq | A | S864 | III | Peptide ligand (GLN,LYS,GLU,TYR,PHE,PHE) | 4nxq | C | S864 | III | Peptide ligand (ASN,LYS,ASP,LYS,GLU,TYR,TYR,VAL) | 4nxr | A | S864 | III | Peptide ligand (THR,LYS,GLN,GLU,GLU,PHE,TYR,ALA) | 4gvc | A | S864 K912 | III | Peptide ligand (THR,LYS,GLN,GLU,GLU,PHE,TYR,ALA) | 4gvd | A | S864 K912 | III | Peptide ligand (THR,LYS,GLN,GLU,GLU,PHE,TYR,ALA) | 4gvd | B | S864 K912 | ANS | DANSYL ACID | 4nxr | A | Y874 |
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| Conservation information for LBS of TIAM1 |
| Multiple alignments for Q13009 in multiple species |
| LBS | AA sequence | # species | Species |
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