mutLBSgeneDB |
Gene summary for TIAM1 |
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Basic gene Info. | Gene symbol | TIAM1 |
Gene name | T-cell lymphoma invasion and metastasis 1 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 21q22.11 | |
Type of gene | protein-coding | |
RefGenes | NM_003253.2, | |
Description | T-lymphoma invasion and metastasis-inducing protein 1TIAM-1human T-lymphoma invasion and metastasis inducing TIAM1 protein | |
Modification date | 20141222 | |
dbXrefs | MIM : 600687 | |
HGNC : HGNC | ||
Ensembl : ENSG00000156299 | ||
HPRD : 02820 | ||
Vega : OTTHUMG00000084869 | ||
Protein | UniProt: Q13009 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TIAM1 | |
BioGPS: 7074 | ||
Pathway | NCI Pathway Interaction Database: TIAM1 | |
KEGG: TIAM1 | ||
REACTOME: TIAM1 | ||
Pathway Commons: TIAM1 | ||
Context | iHOP: TIAM1 | |
ligand binding site mutation search in PubMed: TIAM1 | ||
UCL Cancer Institute: TIAM1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for TIAM1 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | S864 | S864F | BLCA | 1 | K912 | D913Y | COAD | 1 | E849 | H847R | COAD | 1 | P918 | P918L | SKCM | 1 | E849 | H847N | SKCM | 1 | Y874 | Y874S | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for TIAM1 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y874 | Y874S | -1.2386957 | E849 | H847N | -1.0880073 | E849 | H847R | -0.64335761 | P918 | P918L | -0.48271159 | S864 | S864F | -0.16847978 | K912 | D913Y | -0.077175997 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for TIAM1 |
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Phenotype information for TIAM1 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C1862939 | Amyotrophic lateral sclerosis 1 | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for TIAM1 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (SER,ARG,LYS,GLU,TYR,TYR,ALA) | 3kze | A | E849 P918 | III | Peptide ligand (SER,ARG,LYS,GLU,TYR,TYR,ALA) | 3kze | B | S864 | III | Peptide ligand (ARG,LYS,GLU,TYR,TYR,ALA) | 3kze | C | S864 | III | Peptide ligand (ASN,GLN,LYS,GLU,TYR,PHE,PHE) | 4nxq | A | S864 | III | Peptide ligand (GLN,LYS,GLU,TYR,PHE,PHE) | 4nxq | C | S864 | III | Peptide ligand (ASN,LYS,ASP,LYS,GLU,TYR,TYR,VAL) | 4nxr | A | S864 | III | Peptide ligand (THR,LYS,GLN,GLU,GLU,PHE,TYR,ALA) | 4gvc | A | S864 K912 | III | Peptide ligand (THR,LYS,GLN,GLU,GLU,PHE,TYR,ALA) | 4gvd | A | S864 K912 | III | Peptide ligand (THR,LYS,GLN,GLU,GLU,PHE,TYR,ALA) | 4gvd | B | S864 K912 | ANS | DANSYL ACID | 4nxr | A | Y874 |
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Conservation information for LBS of TIAM1 |
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LBS | AA sequence | # species | Species |
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