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mutLBSgeneDB |
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| Gene summary for TKT |
 Gene summary |
| Basic gene Info. | Gene symbol | TKT |
| Gene name | transketolase | |
| Synonyms | HEL107|TK|TKT1 | |
| Cytomap | UCSC genome browser: 3p14.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001064.3, NM_001135055.2,NM_001258028.1,NR_047580.1,NM_001135056.1, NR_047579.1, | |
| Description | epididymis luminal protein 107 | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 606781 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000163931 | ||
| HPRD : 06001 | ||
| Vega : OTTHUMG00000158192 | ||
| Protein | UniProt: P29401 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TKT | |
| BioGPS: 7086 | ||
| Pathway | NCI Pathway Interaction Database: TKT | |
| KEGG: TKT | ||
| REACTOME: TKT | ||
| Pathway Commons: TKT | ||
| Context | iHOP: TKT | |
| ligand binding site mutation search in PubMed: TKT | ||
| UCL Cancer Institute: TKT | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process | 9611778 |
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| Ligand binding site mutations for TKT |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Q428 | A430T | UCEC | 1 | H258 | S256Y | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TKT |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H258 | S256Y | -0.9239579 | Q428 | A430T | -0.63511754 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TKT from PDB |
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| Differential gene expression and gene-gene network for TKT |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TKT |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0349464 | Korsakoff Syndrome | 5 | Biomarker |
| umls:C0043121 | Wernicke Encephalopathy | 3 | Biomarker |
| umls:C0003130 | Anoxia | 1 | Biomarker |
| umls:C0007097 | Carcinoma | 1 | Biomarker |
| umls:C0024667 | Mammary Neoplasms, Animal | 1 | Biomarker |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | Biomarker |
| umls:C0027626 | Neoplasm Invasiveness | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TKT |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TKT go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | TPP | THIAMINE(1+) DIPHOSPHATE(3-) | 3mos | A | H258 | TDP | THIAMINE(1+) DIPHOSPHATE | 3ooy | A | H258 | TDP | THIAMINE(1+) DIPHOSPHATE | 3ooy | B | H258 | S6P | SORBITOL 6-PHOSPHATE | 4kxu | A | H258 | TDP | THIAMINE(1+) DIPHOSPHATE | 4kxu | A | H258 | TDP | THIAMINE(1+) DIPHOSPHATE | 4kxv | A | H258 | DX5 | D-XYLITOL-5-PHOSPHATE | 4kxv | A | H258 | TDP | THIAMINE(1+) DIPHOSPHATE | 4kxw | A | H258 | DX5 | D-XYLITOL-5-PHOSPHATE | 4kxw | A | H258 | DX5 | D-XYLITOL-5-PHOSPHATE | 4kxw | A | H258 | 1Y7 | (2R,3R,4S,5R,6S)-2,3,4,5,6,7-HEXAHYDROXYHEPTYL DIHYDROGEN PHOSPHATE | 4kxx | A | H258 | TDP | THIAMINE(1+) DIPHOSPHATE | 4kxx | A | H258 | 1U0 | 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-5-[(1R)- 1,2-DIHYDROXYETHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL TRIHYDROGEN DIPHOSPHATE | 4kxy | A | H258 | 1U0 | 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-5-[(1R)- 1,2-DIHYDROXYETHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL TRIHYDROGEN DIPHOSPHATE | 4kxy | B | H258 | TDP | THIAMINE(1+) DIPHOSPHATE | 3ooy | A | Q428 | TDP | THIAMINE(1+) DIPHOSPHATE | 3ooy | B | Q428 | 1U0 | 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-5-[(1R)- 1,2-DIHYDROXYETHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL TRIHYDROGEN DIPHOSPHATE | 4kxy | A | Q428 | 1U0 | 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-5-[(1R)- 1,2-DIHYDROXYETHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL TRIHYDROGEN DIPHOSPHATE | 4kxy | B | Q428 |
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| Conservation information for LBS of TKT |
| Multiple alignments for P29401 in multiple species |
| LBS | AA sequence | # species | Species | D155 | YCLLGDGELSE | 2 | Homo sapiens, Pan troglodytes | D155 | YCMLGDGEVSE | 2 | Mus musculus, Rattus norvegicus | D155 | YCMLGDGELSE | 1 | Bos taurus | D341 | IALDGDTKNST | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | E157 | LLGDGELSEGS | 2 | Homo sapiens, Pan troglodytes | E157 | MLGDGEVSEGS | 2 | Mus musculus, Rattus norvegicus | E157 | MLGDGELSEGS | 1 | Bos taurus | E160 | DGELSEGSVWE | 3 | Homo sapiens, Bos taurus, Pan troglodytes | E160 | DGEVSEGSVWE | 2 | Mus musculus, Rattus norvegicus | E366 | ECYIAEQNMVS | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | F392 | STFAAFFTRAF | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | G123 | TDVATGSLGQG | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | G154 | VYCLLGDGELS | 2 | Homo sapiens, Pan troglodytes | G154 | VYCMLGDGEVS | 2 | Mus musculus, Rattus norvegicus | G154 | VYCMLGDGELS | 1 | Bos taurus | G156 | CLLGDGELSEG | 2 | Homo sapiens, Pan troglodytes | G156 | CMLGDGEVSEG | 2 | Mus musculus, Rattus norvegicus | G156 | CMLGDGELSEG | 1 | Bos taurus | G188 | DINRLGQSDPA | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | H110 | SDLDGHPVPKQ | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | H258 | DKESWHGKPLP | 2 | Homo sapiens, Bos taurus | H258 | DKEAWHGKPLP | 2 | Mus musculus, Rattus norvegicus | H258 | GKESWHGKPFP | 1 | Pan troglodytes | H37 | AAGSGHPTSCC | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | H77 | VLSKGHAAPIL | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | I364 | FIECYIAEQNM | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | K244 | IAKTFKGRGIT | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | K75 | RFVLSKGHAAP | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | L125 | VATGSLGQGLG | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | L187 | LDINRLGQSDP | 3 | Homo sapiens, Bos taurus, Pan troglodytes | L187 | FDINRLGQSDP | 2 | Mus musculus, Rattus norvegicus | N185 | AILDINRLGQS | 3 | Homo sapiens, Bos taurus, Pan troglodytes | N185 | AIFDINRLGQS | 2 | Mus musculus, Rattus norvegicus | Q189 | INRLGQSDPAP | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | Q428 | EDGPSQMALED | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | R395 | AAFFTRAFDQI | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | S124 | DVATGSLGQGL | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | S40 | SGHPTSCCSAA | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus | T342 | ALDGDTKNSTF | 5 | Homo sapiens, Bos taurus, Pan troglodytes, Mus musculus, Rattus norvegicus |
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