mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TLN1
Gene summary
Basic gene Info.Gene symbolTLN1
Gene nametalin 1
SynonymsILWEQ|TLN
CytomapUCSC genome browser: 9p13
Type of geneprotein-coding
RefGenesNM_006289.3,
Descriptiontalin-1
Modification date20141222
dbXrefs MIM : 186745
HGNC : HGNC
Ensembl : ENSG00000137076
HPRD : 01726
Vega : OTTHUMG00000019874
ProteinUniProt: Q9Y490
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TLN1
BioGPS: 7094
PathwayNCI Pathway Interaction Database: TLN1
KEGG: TLN1
REACTOME: TLN1
Pathway Commons: TLN1
ContextiHOP: TLN1
ligand binding site mutation search in PubMed: TLN1
UCL Cancer Institute: TLN1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for TLN1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
A360,S362A361VCOAD1
Q381Q381HHNSC1
Y377D375HLUAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TLN1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Q381Q381H-0.66298998
S362A361V-0.51758951
A360A361V-0.51758951
Y377D375H-0.36989751
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TLN1 from PDB

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Differential gene expression and gene-gene network for TLN1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TLN1 and the right PPI network was created from samples without mutations in the LBS of TLN1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TLN1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0027626Neoplasm Invasiveness1Biomarker
umls:C0029456Osteoporosis1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TLN1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TLN1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (ASP,ILE,ASP,GLN,MET,PHE,SER,THR,LEU,LEU,GLY,GLU,MET,ASP,LEU,LEU,THR,GLN,SER,LEU,GLY,VAL,ASP,THR)2mwnBA360 S362 Y377 Q381


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Conservation information for LBS of TLN1
Multiple alignments for Q9Y490 in multiple species
LBSAA sequence# speciesSpecies
A360NIKRWAASPKS3Homo sapiens, Gallus gallus, Mus musculus
D369KSFTLDFGDYQ3Homo sapiens, Gallus gallus, Mus musculus
F366ASPKSFTLDFG3Homo sapiens, Gallus gallus, Mus musculus
K318FLVKEKMKGKN3Homo sapiens, Gallus gallus, Mus musculus
L325KGKNKLVPRLL3Homo sapiens, Gallus gallus, Mus musculus
L368PKSFTLDFGDY3Homo sapiens, Gallus gallus, Mus musculus
N323KMKGKNKLVPR3Homo sapiens, Gallus gallus, Mus musculus
Q381GYYSVQTTEGE3Homo sapiens, Gallus gallus, Mus musculus
R358LTNIKRWAASP3Homo sapiens, Gallus gallus, Mus musculus
S362KRWAASPKSFT3Homo sapiens, Gallus gallus, Mus musculus
S365AASPKSFTLDF3Homo sapiens, Gallus gallus, Mus musculus
S379QDGYYSVQTTE3Homo sapiens, Gallus gallus, Mus musculus
T367SPKSFTLDFGD3Homo sapiens, Gallus gallus, Mus musculus
V380DGYYSVQTTEG3Homo sapiens, Gallus gallus, Mus musculus
Y377DYQDGYYSVQT3Homo sapiens, Gallus gallus, Mus musculus
Y378YQDGYYSVQTT3Homo sapiens, Gallus gallus, Mus musculus


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