mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TLR2
Gene summary
Basic gene Info.Gene symbolTLR2
Gene nametoll-like receptor 2
CytomapUCSC genome browser: 4q32
Type of geneprotein-coding
Descriptiontoll/interleukin 1 receptor-like 4toll/interleukin-1 receptor-like protein 4
Modification date20141222
dbXrefs MIM : 603028
HPRD : 04323
ProteinUniProt: O60603
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TLR2
BioGPS: 7097
PathwayNCI Pathway Interaction Database: TLR2
Pathway Commons: TLR2
ContextiHOP: TLR2
ligand binding site mutation search in PubMed: TLR2
UCL Cancer Institute: TLR2
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0007252I-kappaB phosphorylation19740627
GO:0032722positive regulation of chemokine production19740627
GO:0032755positive regulation of interleukin-6 production19740627
GO:0032757positive regulation of interleukin-8 production17128265
GO:0034123positive regulation of toll-like receptor signaling pathway17128265
GO:0042346positive regulation of NF-kappaB import into nucleus19740627
GO:0042495detection of triacyl bacterial lipopeptide19931471
GO:0042496detection of diacyl bacterial lipopeptide19931471
GO:0050830defense response to Gram-positive bacterium11521063
GO:0051092positive regulation of NF-kappaB transcription factor activity12594207
GO:0071223cellular response to lipoteichoic acid12594207
GO:0071726cellular response to diacyl bacterial lipopeptide19931471
GO:0071727cellular response to triacyl bacterial lipopeptide19931471

Ligand binding site mutations for TLR2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for TLR2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TLR2 from PDB

Differential gene expression and gene-gene network for TLR2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TLR2 and the right PPI network was created from samples without mutations in the LBS of TLR2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for TLR2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0021368Inflammation10AlteredExpression, Biomarker, GeneticVariation
umls:C0023343Leprosy10Biomarker, GeneticVariation
umls:C0009404Colorectal Neoplasms3Biomarker, GeneticVariation
umls:C0270611Brain Injuries2Biomarker
umls:C0017661Glomerulonephritis, IGA1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for TLR2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|withdrawnDB00045OspA lipoproteinBiotech
ExperimentalDB03963S-(Dimethylarsenic)CysteineSmall molecule
InvestigationalDB05475SCV-07Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TLR2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of TLR2
Multiple alignments for O60603 in multiple species
LBSAA sequence# speciesSpecies
D327FYLFYDLSTLY2Homo sapiens, Pan troglodytes
D327FYLFFDLEGIE1Gallus gallus
D327FYLFYDLSTVY1Mus musculus
D327FFLFHDLSSIY1Bos taurus
D327FYSFNDLSTLY1Macaca mulatta
F322LHIPRFYLFYD2Homo sapiens, Pan troglodytes
F322MTILDFYLFFD1Gallus gallus
F322LHIPQFYLFYD1Mus musculus
F322LHIPQFFLFHD1Bos taurus
F322LHIPQFYSFND1Macaca mulatta
F325PRFYLFYDLST2Homo sapiens, Pan troglodytes
F325LDFYLFFDLEG1Gallus gallus
F325PQFYLFYDLST1Mus musculus
F325PQFFLFHDLSS1Bos taurus
F325PQFYSFNDLST1Macaca mulatta
F349ENSKVFLVPCL4Homo sapiens, Bos taurus, Pan troglodytes, Macaca mulatta
F349ASSKVFMVPCR1Gallus gallus
F349ENSKVFLVPCS1Mus musculus
K347TVENSKVFLVP4Homo sapiens, Mus musculus, Pan troglodytes, Macaca mulatta
K347SIASSKVFMVP1Gallus gallus
K347TIENSKVFLVP1Bos taurus
L282SGLLELEFDDC3Homo sapiens, Pan troglodytes, Macaca mulatta
L282RSLRELEAIDC1Gallus gallus
L282LELSEVEFDDC1Mus musculus
L282SGILEVEFDDC1Bos taurus
L312GKVETLTIRRL3Homo sapiens, Pan troglodytes, Macaca mulatta
L312SSIETLSITNM1Gallus gallus
L312GKVETVTIRRL1Mus musculus
L312GNVETLTIRKL1Bos taurus
L317LTIRRLHIPRF2Homo sapiens, Pan troglodytes
L317LSITNMTILDF1Gallus gallus
L317VTIRRLHIPQF1Mus musculus
L317LTIRKLHIPQF1Bos taurus
L317LTIRRLHIPQF1Macaca mulatta
L328YLFYDLSTLYS2Homo sapiens, Pan troglodytes
L328YLFFDLEGIET1Gallus gallus
L328YLFYDLSTVYS1Mus musculus
L328FLFHDLSSIYP1Bos taurus
L328YSFNDLSTLYP1Macaca mulatta
L334STLYSLTERVK2Homo sapiens, Pan troglodytes
L334EGIETQVGKLK1Gallus gallus
L334STVYSLLEKVK1Mus musculus
L334SSIYPLTGRVK1Bos taurus
L334STLYPLTERVK1Macaca mulatta
L350NSKVFLVPCLL4Homo sapiens, Bos taurus, Pan troglodytes, Macaca mulatta
L350SSKVFMVPCRL1Gallus gallus
L350NSKVFLVPCSF1Mus musculus
M270SLFQVMKLLNQ2Homo sapiens, Pan troglodytes
M270YISQIAVLLKE1Gallus gallus
M270SFNELLKLLRY1Mus musculus
M270SFVEVVKLFNY1Bos taurus
M270SLFQVMKLLSQ1Macaca mulatta
N294LNGVGNFRASD2Homo sapiens, Pan troglodytes
N294LEGKGAWDMTE1Gallus gallus
N294LNGLGDFNPSE1Mus musculus
N294HDGIGDFRALS1Bos taurus
N294LNGVGDFRGSD1Macaca mulatta
P352KVFLVPCLLSQ3Homo sapiens, Bos taurus, Pan troglodytes
P352KVFMVPCRLAR1Gallus gallus
P352KVFLVPCSFSQ1Mus musculus
P352KVFLVPCLLSR1Macaca mulatta
S346ITVENSKVFLV4Homo sapiens, Mus musculus, Pan troglodytes, Macaca mulatta
S346LSIASSKVFMV1Gallus gallus
S346VTIENSKVFLV1Bos taurus
V348VENSKVFLVPC4Homo sapiens, Mus musculus, Pan troglodytes, Macaca mulatta
V348IASSKVFMVPC1Gallus gallus
V348IENSKVFLVPC1Bos taurus
V351SKVFLVPCLLS4Homo sapiens, Bos taurus, Pan troglodytes, Macaca mulatta
V351SKVFMVPCRLA1Gallus gallus
V351SKVFLVPCSFS1Mus musculus
Y326RFYLFYDLSTL2Homo sapiens, Pan troglodytes
Y326DFYLFFDLEGI1Gallus gallus
Y326QFYLFYDLSTV1Mus musculus
Y326QFFLFHDLSSI1Bos taurus
Y326QFYSFNDLSTL1Macaca mulatta
Y376LMVEEYLKNSA3Homo sapiens, Mus musculus, Macaca mulatta
Y376LLVNNRLGETI1Gallus gallus
Y376LMSEETLKNSA1Bos taurus
Y376LIVEEYLKNSA1Pan troglodytes

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas