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mutLBSgeneDB |
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| Gene summary for TLR3 |
 Gene summary |
| Basic gene Info. | Gene symbol | TLR3 |
| Gene name | toll-like receptor 3 | |
| Synonyms | CD283|IIAE2 | |
| Cytomap | UCSC genome browser: 4q35 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003265.2, | |
| Description | - | |
| Modification date | 20141221 | |
| dbXrefs | MIM : 603029 | |
| HGNC : HGNC | ||
| HPRD : 04324 | ||
| Protein | UniProt: O15455 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TLR3 | |
| BioGPS: 7098 | ||
| Pathway | NCI Pathway Interaction Database: TLR3 | |
| KEGG: TLR3 | ||
| REACTOME: TLR3 | ||
| Pathway Commons: TLR3 | ||
| Context | iHOP: TLR3 | |
| ligand binding site mutation search in PubMed: TLR3 | ||
| UCL Cancer Institute: TLR3 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0007252 | I-kappaB phosphorylation | 19740627 | GO:0032722 | positive regulation of chemokine production | 19740627 | GO:0032755 | positive regulation of interleukin-6 production | 19740627 | GO:0032757 | positive regulation of interleukin-8 production | 17128265 | GO:0034123 | positive regulation of toll-like receptor signaling pathway | 17128265 | GO:0042346 | positive regulation of NF-kappaB import into nucleus | 19740627 | GO:0043330 | response to exogenous dsRNA | 21266579 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process | 16286015 | GO:0045356 | positive regulation of interferon-alpha biosynthetic process | 16286015 | GO:0045359 | positive regulation of interferon-beta biosynthetic process | 16286015 | GO:0097191 | extrinsic apoptotic signaling pathway | 21737330 | GO:0097527 | necroptotic signaling pathway | 21737330 |
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| Ligand binding site mutations for TLR3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y462 | E460K | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TLR3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y462 | E460K | -0.82786617 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TLR3 from PDB |
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| Differential gene expression and gene-gene network for TLR3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TLR3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0276226 | Encephalitis, Herpes Simplex | 12 | Biomarker |
| umls:C2751803 | HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 2 | 1 | GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TLR3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TLR3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GLC | ALPHA-D-GLUCOSE | 2a0z | A | Y462 |
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| Conservation information for LBS of TLR3 |
| Multiple alignments for O15455 in multiple species |
| LBS | AA sequence | # species | Species | D437 | HLEVLDLGLNE | 2 | Homo sapiens, Bos taurus | D437 | QLRILDLGLNE | 1 | Mus musculus | E580 | DEIPVEVFKDL | 1 | Homo sapiens | E580 | DEIPVGVFKNL | 1 | Mus musculus | E580 | DEIPVEAFKDL | 1 | Bos taurus | G439 | EVLDLGLNEIG | 2 | Homo sapiens, Bos taurus | G439 | RILDLGLNEIE | 1 | Mus musculus | K559 | PIYFLKGLSHL | 1 | Homo sapiens | K559 | PVNFLKGLSHL | 1 | Mus musculus | K559 | PVQFLKGLFHL | 1 | Bos taurus | Y462 | NIFEIYLSYNK | 2 | Homo sapiens, Mus musculus | Y462 | NIVEIYLSYNK | 1 | Bos taurus | Y556 | PGGPIYFLKGL | 1 | Homo sapiens | Y556 | PGGPVNFLKGL | 1 | Mus musculus | Y556 | PGGPVQFLKGL | 1 | Bos taurus |
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