mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TLR5
Gene summary
Basic gene Info.Gene symbolTLR5
Gene nametoll-like receptor 5
SynonymsMELIOS|SLE1|SLEB1|TIL3
CytomapUCSC genome browser: 1q41-q42
Type of geneprotein-coding
RefGenesNM_003268.5,
Descriptionsystemic lupus erythematosus susceptibility 1toll/interleukin-1 receptor-like protein 3
Modification date20141207
dbXrefs MIM : 603031
HGNC : HGNC
Ensembl : ENSG00000187554
HPRD : 04326
ProteinUniProt: O60602
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TLR5
BioGPS: 7100
PathwayNCI Pathway Interaction Database: TLR5
KEGG: TLR5
REACTOME: TLR5
Pathway Commons: TLR5
ContextiHOP: TLR5
ligand binding site mutation search in PubMed: TLR5
UCL Cancer Institute: TLR5
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0032757positive regulation of interleukin-8 production17128265
GO:0034123positive regulation of toll-like receptor signaling pathway17128265


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Ligand binding site mutations for TLR5
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C36R34HSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TLR5
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C36R34H-1.1619291
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TLR5 from PDB

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Differential gene expression and gene-gene network for TLR5
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TLR5 and the right PPI network was created from samples without mutations in the LBS of TLR5. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TLR5
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0024141Lupus Erythematosus, Systemic9Biomarker, GeneticVariation
umls:C0023241Legionnaires' Disease2Biomarker
umls:C0033578Prostatic Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TLR5
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TLR5 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
FUCALPHA-L-FUCOPYRANOSE3j0aAC36
FUCALPHA-L-FUCOPYRANOSE3j0aBC36


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Conservation information for LBS of TLR5
Multiple alignments for O60602 in multiple species
LBSAA sequence# speciesSpecies


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