mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TOP1
Gene summary
Basic gene Info.Gene symbolTOP1
Gene nametopoisomerase (DNA) I
SynonymsTOPI
CytomapUCSC genome browser: 20q12-q13.1
Type of geneprotein-coding
RefGenesNM_003286.2,
DescriptionDNA topoisomerase 1type I DNA topoisomerase
Modification date20141207
dbXrefs MIM : 126420
HGNC : HGNC
Ensembl : ENSG00000198900
HPRD : 00535
Vega : OTTHUMG00000033057
ProteinUniProt: P11387
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TOP1
BioGPS: 7150
PathwayNCI Pathway Interaction Database: TOP1
KEGG: TOP1
REACTOME: TOP1
Pathway Commons: TOP1
ContextiHOP: TOP1
ligand binding site mutation search in PubMed: TOP1
UCL Cancer Institute: TOP1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006265DNA topological change14594810


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Ligand binding site mutations for TOP1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
K439E438KBLCA1
K374R376QBLCA1
A715Q713HBRCA1
K328,K324K326ICOAD1
K587V588IKIRC1
K374R375IKIRC1
G531G531WLUAD1
N352N352KLUAD1
R708R708LSKCM1
R708D707HSTAD1
R362R362CSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TOP1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K439E438K-1.4335469
K374R376Q-1.2770392
N352N352K-1.1045935
A715Q713H-0.81248637
R362R362C-0.60431597
G531G531W-0.54755062
K587V588I-0.51039174
K328K326I-0.50137478
K324K326I-0.50137478
K374R375I-0.4505856
R708D707H-0.36170668
R708R708L-0.2720772
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TOP1 from PDB

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Differential gene expression and gene-gene network for TOP1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TOP1 and the right PPI network was created from samples without mutations in the LBS of TOP1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TOP1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C3658338Drug-Related Side Effects and Adverse Reactions1Biomarker
umls:C0027651Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TOP1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00762IrinotecanSmall molecule
Approved|investigationalDB01030TopotecanSmall molecule
ExperimentalDB04690CamptothecinSmall molecule
InvestigationalDB04882EdotecarinSmall molecule
Approved|investigationalDB04967LucanthoneSmall molecule
InvestigationalDB05129ElsamitrucinSmall molecule
InvestigationalDB05482LE-SN38Small molecule
Approved|investigationalDB05630Sodium stibogluconateSmall molecule
InvestigationalDB05806BNP 1350Small molecule
InvestigationalDB06069XMT-1001Small molecule
ExperimentalDB073542,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUMSmall molecule
ExperimentalDB081594-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TOP1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids1tl8AA715
NUCNucleic Acids1sc7AK324 A715
NUCNucleic Acids1t8iAK324 K328
NUCNucleic Acids1k4tAK324 K328 A715
NUCNucleic Acids1seuAK324 K328 A715
NUCNucleic Acids1rrjAK324 K328 K439 K587 A715
NUCNucleic Acids1rr8CK328 K587 A715
NUCNucleic Acids1nh3AK374 K587
NUCNucleic Acids1r49AK374 K587 R708
NUCNucleic Acids1a31AK439 K587
NUCNucleic Acids1ej9AK439 K587
NUCNucleic Acids1k4sAK439 K587
NUCNucleic Acids1k4tAK439 K587
NUCNucleic Acids1lpqAK439 K587
NUCNucleic Acids1nh3AK439 K587
NUCNucleic Acids1r49AK439 K587
NUCNucleic Acids1sc7AK439 K587
NUCNucleic Acids1seuAK439 K587
NUCNucleic Acids1t8iAK439 K587
NUCNucleic Acids1tl8AK439 K587
NUCNucleic Acids1lpqAK587
TTGHYDROLYZED PRODUCT OF TOPOTECAN1rr8CN352
TTGHYDROLYZED PRODUCT OF TOPOTECAN1rrjAN352
M384-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE1sc7AN352
SA32,10-DIHYDROXY-12-(BETA-D-GLUCOPYRANOSYL)-6,7,12,13-TETRAHYDROINDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE1seuAN352
NUCNucleic Acids1a35AN352 R362 K374 K587
NUCNucleic Acids1k4sAR362 K374 G531 K587 R708
NUCNucleic Acids1a31AR362 K374 K587
NUCNucleic Acids1ej9AR362 K374 K587
NUCNucleic Acids1k4tAR362 K374 K587
NUCNucleic Acids1rr8CR362 K374 K587
NUCNucleic Acids1rrjAR362 K374 K587
NUCNucleic Acids1sc7AR362 K374 K587
NUCNucleic Acids1seuAR362 K374 K587
NUCNucleic Acids1t8iAR362 K374 K587
NUCNucleic Acids1a36AR362 K374 K587 R708
NUCNucleic Acids1tl8AR362 K374 K587 R708
NUCNucleic Acids1a35AR362 K439 K587
NUCNucleic Acids1a36AR362 K439 K587


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Conservation information for LBS of TOP1
Multiple alignments for P11387 in multiple species
LBSAA sequence# speciesSpecies
A351HRERIANFKIE2Mus musculus, Rattus norvegicus
A351HKERIANFKIE1Homo sapiens
A351VKEKIGNFRVE1Arabidopsis thaliana
A351HRQKVANFRIE1Caenorhabditis elegans
A351HKEKIGNFRLE1Drosophila melanogaster
A351RREQVGNFKVE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A351RKEKVGNFRIE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A489KLALRAGNEKE3Homo sapiens, Mus musculus, Rattus norvegicus
A489KLALRAGNEKD3Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster
A489VFALRAGGEKS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A489VFALRAGNEKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A586MEGLTAKVFRT4Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus
A586VPGLTAKVFRT1Arabidopsis thaliana
A586MDGLTVKVFRT1Caenorhabditis elegans
A586MPGLTAKVFRT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A586MDGLSAKVFRT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A635CNHQRAPPKTF3Homo sapiens, Mus musculus, Rattus norvegicus
A635CNHQRTVSKTH1Arabidopsis thaliana
A635CNHQRAVSKGF1Caenorhabditis elegans
A635CNHQRSVPKSH1Drosophila melanogaster
A635CNHQRTVTKGH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A635CNHQRSVTKNH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A715ENKQIALGTSK4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
A715DLKTVALGTSK1Arabidopsis thaliana
A715ENKTIALGTSK1Drosophila melanogaster
A715ENSQVSLGTSK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A715ENKTTALGTSK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D533DFPGKDSIRYY3Drosophila melanogaster, Mus musculus, Rattus norvegicus
D533DFLGKDSIRYY2Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D533DFLGKDSIQYV1Arabidopsis thaliana
D533DFLGKDSIRYF1Caenorhabditis elegans
D533DFLGKDSIRFY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E356ANFKIEPPGLF3Homo sapiens, Mus musculus, Rattus norvegicus
E356GNFRVEPPGLF1Arabidopsis thaliana
E356ANFRIEPPGVF1Caenorhabditis elegans
E356GNFRLEPPGLF1Drosophila melanogaster
E356GNFKVEPPDLF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E356GNFRIEPPGLF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E418LVSWTENIQ-G3Homo sapiens, Mus musculus, Rattus norvegicus
E418LAFWADPINPK1Arabidopsis thaliana
E418LCSWTESVL-G1Caenorhabditis elegans
E418LASWIENVQ-G1Drosophila melanogaster
E418LAMWRENIF-N1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E418LATWHENIN-N1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F361EPPGLFRGRGN3Homo sapiens, Mus musculus, Rattus norvegicus
F361EPPGLFRGRGE2Arabidopsis thaliana, Drosophila melanogaster
F361EPPGVFRGRGG1Caenorhabditis elegans
F361EPPDLFRGRGA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F361EPPGLFRGRGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F640APPKTFEKSMM3Homo sapiens, Mus musculus, Rattus norvegicus
F640TVSKTHGAQIE1Arabidopsis thaliana
F640AVSKGFDESMQ1Caenorhabditis elegans
F640SVPKSHEKSME1Drosophila melanogaster
F640TVTKGHAQTVE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F640SVTKNHDVQME1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G363PGLFRGRGNHP3Homo sapiens, Mus musculus, Rattus norvegicus
G363PGLFRGRGEHP2Arabidopsis thaliana, Drosophila melanogaster
G363PGVFRGRGGHP1Caenorhabditis elegans
G363PDLFRGRGAHP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G363PGLFRGRGSHP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G490LALRAGNEKEE3Homo sapiens, Mus musculus, Rattus norvegicus
G490LALRAGNEKDD1Arabidopsis thaliana
G490LALRAGNEKDV1Caenorhabditis elegans
G490LALRAGNEKDE1Drosophila melanogaster
G490FALRAGGEKSE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G490FALRAGNEKGE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G531EFDFLGKDSIR2Homo sapiens, Caenorhabditis elegans
G531EFDFPGKDSIR2Mus musculus, Rattus norvegicus
G531KFDFLGKDSIQ1Arabidopsis thaliana
G531VFDFPGKDSIR1Drosophila melanogaster
G531IFDFLGKDSIR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G531VFDFLGKDSIR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G717KQIALGTSKLN4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
G717KTVALGTSKIN1Arabidopsis thaliana
G717KTIALGTSKLN1Drosophila melanogaster
G717SQVSLGTSKIN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G717KTTALGTSKIN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H266AKMLDHEYTTK3Homo sapiens, Mus musculus, Rattus norvegicus
H266AVMRETDYYTK1Arabidopsis thaliana
H266AGVLDHEYSTK1Caenorhabditis elegans
H266AKMLNHDYCTK1Drosophila melanogaster
H266AALLESDHAKN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H266AAMLETDHAKN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H367RGRGNHPKMGM3Homo sapiens, Mus musculus, Rattus norvegicus
H367RGRGEHPKMGK1Arabidopsis thaliana
H367RGRGGHPKMGL1Caenorhabditis elegans
H367RGRGEHPKMGM1Drosophila melanogaster
H367RGRGAHPKTGK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H367RGRGSHPKTGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I424IQ-GSIKYIML3Homo sapiens, Mus musculus, Rattus norvegicus
I424INPKEFKYVFL1Arabidopsis thaliana
I424VL-GQNKYIML1Caenorhabditis elegans
I424VQ-GQVKYIML1Drosophila melanogaster
I424IF-NSFKYVRL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I424IN-NNVKYVFL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I535PGKDSIRYYNK2Mus musculus, Rattus norvegicus
I535LGKDSIRYYNK1Homo sapiens
I535LGKDSIQYVNT1Arabidopsis thaliana
I535LGKDSIRYFNR1Caenorhabditis elegans
I535PGKDSIRYYNE1Drosophila melanogaster
I535LGKDSIRFYQE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I535LGKDSIRYYNE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K216-PEGIKWKFLE3Homo sapiens, Mus musculus, Rattus norvegicus
K216GDGQKKWTTLV1Arabidopsis thaliana
K216-PAGVKWNSLQ1Caenorhabditis elegans
K216-ADGVKWSTLE1Drosophila melanogaster
K216-DDTIKWVTLK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K216-DDTQKWTTLE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K321RKQMSKEEKLK3Homo sapiens, Mus musculus, Rattus norvegicus
K321KKQMSTEEKKA1Arabidopsis thaliana
K321RKAMTKEEKLK1Caenorhabditis elegans
K321RKAASKEEKLI1Drosophila melanogaster
K321KKQLTSQEKKQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K321KKSMPKEQKKA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K324MSKEEKLKIKE3Homo sapiens, Mus musculus, Rattus norvegicus
K324MSTEEKKALKE1Arabidopsis thaliana
K324MTKEEKLKIKE1Caenorhabditis elegans
K324ASKEEKLIKKN1Drosophila melanogaster
K324LTSQEKKQIRL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K324MPKEQKKAIKQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K328EKLKIKEENEK3Homo sapiens, Mus musculus, Rattus norvegicus
K328EKKALKEEKMK1Arabidopsis thaliana
K328EKLKIKEEKEA1Caenorhabditis elegans
K328EKLIKKNENEA1Drosophila melanogaster
K328EKKQIRLEREK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K328QKKAIKQKKDE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K354RIANFKIEPPG3Homo sapiens, Mus musculus, Rattus norvegicus
K354KIGNFRVEPPG1Arabidopsis thaliana
K354KVANFRIEPPG1Caenorhabditis elegans
K354KIGNFRLEPPG1Drosophila melanogaster
K354QVGNFKVEPPD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K354KVGNFRIEPPG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K374KMGMLKRRIMP3Homo sapiens, Mus musculus, Rattus norvegicus
K374KMGKLKKRIHP1Arabidopsis thaliana
K374KMGLIKKRIMP1Caenorhabditis elegans
K374KMGMIKRRIQA1Drosophila melanogaster
K374KTGKLKRRVNP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K374KTGSLKRRVYP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K425Q-GSIKYIMLN3Homo sapiens, Mus musculus, Rattus norvegicus
K425NPKEFKYVFLG1Arabidopsis thaliana
K425L-GQNKYIMLN1Caenorhabditis elegans
K425Q-GQVKYIMLN1Drosophila melanogaster
K425F-NSFKYVRLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K425N-NNVKYVFLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K436PSSRIKGEKDW3Homo sapiens, Mus musculus, Rattus norvegicus
K436AGSSLKGLSDK1Arabidopsis thaliana
K436PSSKIKGEKDF1Caenorhabditis elegans
K436PSSKLKGEKDH1Drosophila melanogaster
K436ANSSLKGQSDY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K436AGSSLKGQSDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K439RIKGEKDWQKY3Homo sapiens, Mus musculus, Rattus norvegicus
K439SLKGLSDKEKY1Arabidopsis thaliana
K439KIKGEKDFEKY1Caenorhabditis elegans
K439KLKGEKDHIKY1Drosophila melanogaster
K439SLKGQSDYKKF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K439SLKGQSDLKKY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K443EKDWQKYETAR3Homo sapiens, Mus musculus, Rattus norvegicus
K443LSDKEKYEKAR1Arabidopsis thaliana
K443EKDFEKYETAR1Caenorhabditis elegans
K443EKDHIKYETAR1Drosophila melanogaster
K443QSDYKKFEKAR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K443QSDLKKYEKSR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K493RAGNEKEEGET3Homo sapiens, Mus musculus, Rattus norvegicus
K493RAGNEKDD-DE1Arabidopsis thaliana
K493RAGNEKDVDEA1Caenorhabditis elegans
K493RAGNEKDE-DQ1Drosophila melanogaster
K493RAGGEKSE-DE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K493RAGNEKGE-DE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K532FDFLGKDSIRY3Homo sapiens, Caenorhabditis elegans, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K532FDFPGKDSIRY3Drosophila melanogaster, Mus musculus, Rattus norvegicus
K532FDFLGKDSIQY1Arabidopsis thaliana
K532FDFLGKDSIRF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K587EGLTAKVFRTY4Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus
K587PGLTAKVFRTY2Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K587DGLTVKVFRTY1Caenorhabditis elegans
K587DGLSAKVFRTY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K638QRAPPKTFEKS3Homo sapiens, Mus musculus, Rattus norvegicus
K638QRTVSKTHGAQ1Arabidopsis thaliana
K638QRAVSKGFDES1Caenorhabditis elegans
K638QRSVPKSHEKS1Drosophila melanogaster
K638QRTVTKGHAQT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K638QRSVTKNHDVQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K650MNLQSKIDAKK2Mus musculus, Rattus norvegicus
K650MNLQTKIDAKK1Homo sapiens
K650EKLTARIEELK1Arabidopsis thaliana
K650QKLEQKIKDKK1Caenorhabditis elegans
K650ENLKEKIKAKR1Drosophila melanogaster
K650EKANNRIQELE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K650ERFAERIKALQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K746EKIYNKTQREK3Homo sapiens, Mus musculus, Rattus norvegicus
K746EKIFTKSLLEK1Arabidopsis thaliana
K746EKVFTKTHREK1Caenorhabditis elegans
K746EKIFNKTQRTK1Drosophila melanogaster
K746EKIFTKTLREK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K746EKLFSKTIRDK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L647KSMMNLQSKID2Mus musculus, Rattus norvegicus
L647KSMMNLQTKID1Homo sapiens
L647AQIEKLTARIE1Arabidopsis thaliana
L647ESMQKLEQKIK1Caenorhabditis elegans
L647KSMENLKEKIK1Drosophila melanogaster
L647QTVEKANNRIQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L647VQMERFAERIK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L716NKQIALGTSKL4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
L716LKTVALGTSKI1Arabidopsis thaliana
L716NKTIALGTSKL1Drosophila melanogaster
L716NSQVSLGTSKI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L716NKTTALGTSKI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L721LGTSKLNYLDP4Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus
L721LGTSKINYIDP2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L721LGTSKINYLDP1Arabidopsis thaliana
L721LGTSKLNYIDP1Caenorhabditis elegans
M428SIKYIMLNPSS3Homo sapiens, Mus musculus, Rattus norvegicus
M428EFKYVFLGAGS1Arabidopsis thaliana
M428QNKYIMLNPSS1Caenorhabditis elegans
M428QVKYIMLNPSS1Drosophila melanogaster
M428SFKYVRLAANS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M428NVKYVFLAAGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N352RERIANFKIEP2Mus musculus, Rattus norvegicus
N352KERIANFKIEP1Homo sapiens
N352KEKIGNFRVEP1Arabidopsis thaliana
N352RQKVANFRIEP1Caenorhabditis elegans
N352KEKIGNFRLEP1Drosophila melanogaster
N352REQVGNFKVEP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N352KEKVGNFRIEP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N491ALRAGNEKEEG3Homo sapiens, Mus musculus, Rattus norvegicus
N491ALRAGNEKDD-1Arabidopsis thaliana
N491ALRAGNEKDVD1Caenorhabditis elegans
N491ALRAGNEKDE-1Drosophila melanogaster
N491ALRAGGEKSE-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N491ALRAGNEKGE-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N574NTGILNKHLQD3Homo sapiens, Mus musculus, Rattus norvegicus
N574DTSKLNAHLKE1Arabidopsis thaliana
N574DTATLNDHLRS1Caenorhabditis elegans
N574NTQVLNEHLKE1Drosophila melanogaster
N574DPSILNKYLQN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N574STNSLNKYLTS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N646EKSMMNLQSKI2Mus musculus, Rattus norvegicus
N646EKSMMNLQTKI1Homo sapiens
N646GAQIEKLTARI1Arabidopsis thaliana
N646DESMQKLEQKI1Caenorhabditis elegans
N646EKSMENLKEKI1Drosophila melanogaster
N646AQTVEKANNRI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N646DVQMERFAERI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N722GTSKLNYLDPR4Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus
N722GTSKINYIDPR2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N722GTSKINYLDPR1Arabidopsis thaliana
N722GTSKLNYIDPR1Caenorhabditis elegans
N745IEKIYNKTQRE3Homo sapiens, Mus musculus, Rattus norvegicus
N745IEKIFTKSLLE1Arabidopsis thaliana
N745LEKVFTKTHRE1Caenorhabditis elegans
N745IEKIFNKTQRT1Drosophila melanogaster
N745IEKIFTKTLRE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N745IEKLFSKTIRD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P357NFKIEPPGLFR3Homo sapiens, Mus musculus, Rattus norvegicus
P357NFRVEPPGLFR1Arabidopsis thaliana
P357NFRIEPPGVFR1Caenorhabditis elegans
P357NFRLEPPGLFR1Drosophila melanogaster
P357NFKVEPPDLFR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P357NFRIEPPGLFR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P636NHQRAPPKTFE3Homo sapiens, Mus musculus, Rattus norvegicus
P636NHQRTVSKTHG1Arabidopsis thaliana
P636NHQRAVSKGFD1Caenorhabditis elegans
P636NHQRSVPKSHE1Drosophila melanogaster
P636NHQRTVTKGHA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P636NHQRSVTKNHD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q421WTENIQ-GSIK3Homo sapiens, Mus musculus, Rattus norvegicus
Q421WADPINPKEFK1Arabidopsis thaliana
Q421WTESVL-GQNK1Caenorhabditis elegans
Q421WIENVQ-GQVK1Drosophila melanogaster
Q421WRENIF-NSFK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q421WHENIN-NNVK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q578LNKHLQDLMEG3Homo sapiens, Mus musculus, Rattus norvegicus
Q578LNAHLKELVPG1Arabidopsis thaliana
Q578LNDHLRSLMDG1Caenorhabditis elegans
Q578LNEHLKELMEG1Drosophila melanogaster
Q578LNKYLQNYMPG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q578LNKYLTSLMDG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R316AQSEARKQMSK2Mus musculus, Rattus norvegicus
R316AQTEARKQMSK1Homo sapiens
R316EEKEKKKQMST1Arabidopsis thaliana
R316EQREIRKAMTK1Caenorhabditis elegans
R316AESEKRKAASK1Drosophila melanogaster
R316LQKEQKKQLTS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R316QKREEKKSMPK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R349DNHRERIANFK2Mus musculus, Rattus norvegicus
R349DNHKERIANFK1Homo sapiens
R349DGVKEKIGNFR1Arabidopsis thaliana
R349DGHRQKVANFR1Caenorhabditis elegans
R349DGHKEKIGNFR1Drosophila melanogaster
R349DGRREQVGNFK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R349DGRKEKVGNFR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R362PPGLFRGRGNH3Homo sapiens, Mus musculus, Rattus norvegicus
R362PPGLFRGRGEH2Arabidopsis thaliana, Drosophila melanogaster
R362PPGVFRGRGGH1Caenorhabditis elegans
R362PPDLFRGRGAH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R362PPGLFRGRGSH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R364GLFRGRGNHPK3Homo sapiens, Mus musculus, Rattus norvegicus
R364GLFRGRGEHPK2Arabidopsis thaliana, Drosophila melanogaster
R364GVFRGRGGHPK1Caenorhabditis elegans
R364DLFRGRGAHPK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R364GLFRGRGSHPK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R488DKLALRAGNEK6Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus
R488DVFALRAGGEK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R488DVFALRAGNEK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R590TAKVFRTYNAS6Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R590TVKVFRTYNAS1Caenorhabditis elegans
R590SAKVFRTYNAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R634LCNHQRAPPKT3Homo sapiens, Mus musculus, Rattus norvegicus
R634ICNHQRTVSKT1Arabidopsis thaliana
R634LCNHQRAVSKG1Caenorhabditis elegans
R634LCNHQRSVPKS1Drosophila melanogaster
R634LCNHQRTVTKG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R634LCNHQRSVTKN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R708VQATDREENKQ3Homo sapiens, Mus musculus, Rattus norvegicus
R708RDMHTKEDLKT1Arabidopsis thaliana
R708ISRTDKDENKQ1Caenorhabditis elegans
R708LQETDRDENKT1Drosophila melanogaster
R708IQLKDKEENSQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R708TQMIDKDENKT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S643KTFEKSMMNLQ3Homo sapiens, Mus musculus, Rattus norvegicus
S643KTHGAQIEKLT1Arabidopsis thaliana
S643KGFDESMQKLE1Caenorhabditis elegans
S643KSHEKSMENLK1Drosophila melanogaster
S643KGHAQTVEKAN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S643KNHDVQMERFA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S719IALGTSKLNYL4Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus
S719VALGTSKINYL1Arabidopsis thaliana
S719IALGTSKLNYI1Caenorhabditis elegans
S719VSLGTSKINYI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S719TALGTSKINYI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T313YFKAQSEARKQ2Mus musculus, Rattus norvegicus
T313YFKAQTEARKQ1Homo sapiens
T313WHLEEKEKKKQ1Arabidopsis thaliana
T313YQKEQREIRKA1Caenorhabditis elegans
T313YFQAESEKRKA1Drosophila melanogaster
T313YFQLQKEQKKQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T313HFEQKREEKKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T411HDNKVTWLVSW3Homo sapiens, Mus musculus, Rattus norvegicus
T411HDNTVTWLAFW1Arabidopsis thaliana
T411HDNTVTWLCSW1Caenorhabditis elegans
T411HDNTVTWLASW1Drosophila melanogaster
T411HDNTVQWLAMW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T411HDNTVTWLATW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T498KEEGETADTVG3Homo sapiens, Mus musculus, Rattus norvegicus
T498KDD-DEADTVG1Arabidopsis thaliana
T498KDVDEAADTVG1Caenorhabditis elegans
T498KDE-DQADTVG1Drosophila melanogaster
T498KSE-DEADTVG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T498KGE-DEADTVG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T501GETADTVGCCS3Homo sapiens, Mus musculus, Rattus norvegicus
T501-DEADTVGCCS2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T501-DEADTVGCCT1Arabidopsis thaliana
T501DEAADTVGCCS1Caenorhabditis elegans
T501-DQADTVGCCS1Drosophila melanogaster
T585LMEGLTAKVFR4Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus
T585LVPGLTAKVFR1Arabidopsis thaliana
T585LMDGLTVKVFR1Caenorhabditis elegans
T585YMPGLTAKVFR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T585LMDGLSAKVFR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T718QIALGTSKLNY4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
T718TVALGTSKINY1Arabidopsis thaliana
T718TIALGTSKLNY1Drosophila melanogaster
T718QVSLGTSKINY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T718TTALGTSKINY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T747KIYNKTQREKF3Homo sapiens, Mus musculus, Rattus norvegicus
T747KIFTKSLLEKF1Arabidopsis thaliana
T747KVFTKTHREKF1Caenorhabditis elegans
T747KIFNKTQRTKF1Drosophila melanogaster
T747KIFTKTLREKF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T747KLFSKTIRDKF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V410RHDNKVTWLVS3Homo sapiens, Mus musculus, Rattus norvegicus
V410KHDNTVTWLAF1Arabidopsis thaliana
V410RHDNTVTWLCS1Caenorhabditis elegans
V410RHDNTVTWLAS1Drosophila melanogaster
V410RHDNTVQWLAM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V410KHDNTVTWLAT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W412DNKVTWLVSWT3Homo sapiens, Mus musculus, Rattus norvegicus
W412DNTVTWLAFWA1Arabidopsis thaliana
W412DNTVTWLCSWT1Caenorhabditis elegans
W412DNTVTWLASWI1Drosophila melanogaster
W412DNTVQWLAMWR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W412DNTVTWLATWH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y426-GSIKYIMLNP3Homo sapiens, Mus musculus, Rattus norvegicus
Y426PKEFKYVFLGA1Arabidopsis thaliana
Y426-GQNKYIMLNP1Caenorhabditis elegans
Y426-GQVKYIMLNP1Drosophila melanogaster
Y426-NSFKYVRLAA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y426-NNVKYVFLAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y723TSKLNYLDPRI4Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus
Y723TSKINYIDPRL2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y723TSKINYLDPRI1Arabidopsis thaliana
Y723TSKLNYIDPRI1Caenorhabditis elegans


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