mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for TP53

Gene summary

Basic gene Info.	Gene symbol	TP53
	Gene name	tumor protein p53
	Synonyms	BCC7\|LFS1\|P53\|TRP53
	Cytomap	UCSC genome browser: 17p13.1
	Type of gene	protein-coding
	RefGenes	NM_000546.5, NM_001126112.2,NM_001126113.2,NM_001126114.2,NM_001126115.1, NM_001126116.1,NM_001126117.1,NM_001126118.1,NM_001276695.1, NM_001276696.1,NM_001276697.1,NM_001276698.1,NM_001276699.1, NM_001276760.1,NM_001276761.1,
	Description	antigen NY-CO-13cellular tumor antigen p53mutant tumor protein 53p53 tumor suppressorphosphoprotein p53transformation-related protein 53tumor protein 53
	Modification date	20141222
dbXrefs	MIM : 191170
	HGNC : HGNC
	Ensembl : ENSG00000141510
	HPRD : 01859
	Vega : OTTHUMG00000162125
Protein	UniProt: P04637 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_TP53
	BioGPS: 7157
Pathway	NCI Pathway Interaction Database: TP53
	KEGG: TP53
	REACTOME: TP53
	Pathway Commons: TP53
Context	iHOP: TP53
	ligand binding site mutation search in PubMed: TP53
	UCL Cancer Institute: TP53
Assigned class in mutLBSgeneDB	A: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for TP53.	1. "Archibald KM, Kulbe H, Kwong J, Chakravarty P, Temple J, Chaplin T, Flak MB, McNeish IA, Deen S, Brenton JD, Young BD, Balkwill F. Sequential genetic change at the TP53 and chemokine receptor CXCR4 locus during transformation of human ovarian surface epithelium. Oncogene. 2012 Nov 29;31(48):4987-95. doi:10.1038/onc.2011.653. Epub 2012 Jan 23." 22266861

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	15340061
GO:0000733	DNA strand renaturation	8183576
GO:0006355	regulation of transcription, DNA-templated	7587074
GO:0006461	protein complex assembly	12915590
GO:0006974	cellular response to DNA damage stimulus	14744935
GO:0006983	ER overload response	14744935
GO:0007050	cell cycle arrest	15149599
GO:0008104	protein localization	16507995
GO:0030330	DNA damage response, signal transduction by p53 class mediator	15149599
GO:0031497	chromatin assembly	16322561
GO:0032461	positive regulation of protein oligomerization	12667443
GO:0034613	cellular protein localization	15340061
GO:0042149	cellular response to glucose starvation	14744935
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	14654789
GO:0042981	regulation of apoptotic process	14744935
GO:0043065	positive regulation of apoptotic process	12667443
GO:0043066	negative regulation of apoptotic process	16131611
GO:0045893	positive regulation of transcription, DNA-templated	16322561
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	11672523
GO:0090200	positive regulation of release of cytochrome c from mitochondria	12667443
GO:0097252	oligodendrocyte apoptotic process	7720704

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Ligand binding site mutations for TP53

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
C176	R175H	BRCA	15
C176	R175H	COAD	15
R273	R273H	OV	10
R248	R248W	COAD	8
R248	R248Q	OV	8
E221	Y220C	OV	8
C176	R175H	OV	8
R273	R273H	COAD	7
R283	R282W	HNSC	7
C176	R175H	HNSC	7
R273	R273H	HNSC	7
R273	R273C	OV	7
E221	Y220C	BRCA	6
R248	R248W	BRCA	6
R248	R248Q	GBM	6
R248	R248W	HNSC	6
R273	R273H	STAD	6
R273	R273C	BRCA	5
C176	R175H	GBM	5
M243	G245S	HNSC	5
R248	R248Q	HNSC	5
V157	R158L	LUSC	5
C176	C176Y	OV	5
R283	R282W	OV	5
V157	V157F	OV	5
R273	R273C	STAD	5
C176	R175H	STAD	5
R248	R248W	UCEC	5
C176	C176F	BRCA	4
R273	R273H	BRCA	4
M243	G245S	COAD	4
R273	R273C	COAD	4
R283	R282W	GBM	4
R273	R273H	GBM	4
V157	A159P	LUAD	4
V157	R158L	LUAD	4
S241	S241F	OV	4
R248	R248W	OV	4
R248	R248Q	STAD	4
R283	R282W	STAD	4
R273	R273C	UCEC	4
R248	R248Q	UCEC	4
R273	R273H	UCEC	4
V157	A159V	BLCA	3
K139	C141Y	BRCA	3
M243	G245D	BRCA	3
C238	M237T	COAD	3
R283	R282W	COAD	3
D228	S227P	COAD	3
C275	C275Y	COAD	3
V157	R158H	GBM	3
M243	G245S	GBM	3
E221	Y220C	GBM	3
R248	R248W	GBM	3
V157	V157F	HNSC	3
G279,C277	P278S	HNSC	3
C176	R175H	LUAD	3
R248	R249M	LUAD	3
C238	M237I	LUAD	3
C242	C242F	LUSC	3
R273	R273L	LUSC	3
Q165	Y163C	LUSC	3
V157	V157F	LUSC	3
C176	R175G	LUSC	3
M243	G245S	OV	3
C275	C275Y	OV	3
S241	S241F	SKCM	3
E221	Y220C	UCEC	3
C238	C238Y	BRCA	2
Q165	Y163C	BRCA	2
R283	R282W	BRCA	2
E221	Y220S	BRCA	2
R248	R248Q	BRCA	2
C238	C238F	BRCA	2
F109	F109L	COAD	2
T123	T125M	COAD	2
F109	F109C	COAD	2
M243	G244D	COAD	2
V157	A159V	COAD	2
M243	G244S	COAD	2
V157	R158H	COAD	2
C176	R175C	COAD	2
C238	Y236C	COAD	2
V157	A159P	COAD	2
T155	T155N	GBM	2
C238	C238F	GBM	2
C238	C238Y	GBM	2
L145	V143M	HNSC	2
C238	Y236C	HNSC	2
C238	C238F	HNSC	2
C242	C242F	HNSC	2
C275	C275F	HNSC	2
R273	R273C	HNSC	2
M243	G245V	HNSC	2
R248	R249S	HNSC	2
F109	R110L	HNSC	2
E221	Y220C	HNSC	2
R283	E285K	HNSC	2
C277	C277F	LUAD	2
R280	D281N	LUAD	2
R248	R249G	LUAD	2
F109	R110L	LUAD	2
C275	C275F	LUAD	2
R273	R273L	LUAD	2
L257	E258D	LUAD	2
M243	G244C	LUAD	2
R273	E271K	LUSC	2
E221	Y220C	LUSC	2
M243	G245V	LUSC	2
C238	M237I	OV	2
L257	D259Y	OV	2
Q165	Y163C	OV	2
V157	A159V	OV	2
R273	R273L	OV	2
R273	V272M	OV	2
M243	G245D	OV	2
G279,C277	P278R	OV	2
C176	P177R	OV	2
C238	M237K	OV	2
G279,C277	P278L	OV	2
R248	P250L	OV	2
M243	G245V	OV	2
M243	G244C	OV	2
C238	Y236C	OV	2
M243	G244S	OV	2
E221	Y220C	STAD	2
C176	C176F	STAD	2
V157	R158C	UCEC	2
S241,N239	S240G	UCEC	2
C176	R175H	UCEC	2
M243	G244S	UCEC	2
E221	Y220C	BLCA	1
W146	W146S	BLCA	1
G279	G279R	BLCA	1
K139	K139N	BLCA	1
R273	R273C	BLCA	1
C277	C277F	BLCA	1
C275	C275Y	BLCA	1
C238	C238F	BLCA	1
R273	R273S	BLCA	1
C242	C242F	BLCA	1
R283	E285K	BLCA	1
D148	D148N	BLCA	1
P151	P151H	BLCA	1
V157	A159P	BLCA	1
V157	R158H	BLCA	1
F109	Y107C	BRCA	1
R273	V272M	BRCA	1
G279,C277	P278L	BRCA	1
L257	I255S	BRCA	1
T155	T155P	BRCA	1
E221	Y220H	BRCA	1
G279	G279E	BRCA	1
R248	M246I	BRCA	1
F109	L111P	BRCA	1
R273	R273P	BRCA	1
R280	D281V	BRCA	1
G279,C277	P278T	BRCA	1
M243	G245S	BRCA	1
P151	P151H	BRCA	1
R273,C275	V274F	BRCA	1
V157	R158G	BRCA	1
L257	I255N	BRCA	1
L257	E258Q	BRCA	1
S241	S241C	BRCA	1
F109	Y107D	BRCA	1
R248	N247I	BRCA	1
R280	R280T	BRCA	1
K139	C141R	BRCA	1
T230	I232S	BRCA	1
R273	R273L	BRCA	1
H168	H168P	BRCA	1
G279,C277	P278A	BRCA	1
R283	R282G	BRCA	1
A276	A276P	BRCA	1
V157	V157F	BRCA	1
V157	V157G	BRCA	1
L257	I255F	BRCA	1
R273,C275	V274D	COAD	1
C238	C238Y	COAD	1
C176	C176F	COAD	1
M243	G245D	COAD	1
T123	C124G	COAD	1
K139	C141S	COAD	1
K139	C141Y	COAD	1
L145	V143A	COAD	1
G279,C277	P278R	COAD	1
T230	I232S	COAD	1
G279	G279E	COAD	1
T155,P153	G154C	COAD	1
P152	P152R	COAD	1
G279,C277	P278A	COAD	1
K139	A138V	COAD	1
P151	P151H	COAD	1
R273,C275	V274L	COAD	1
R248	R248Q	COAD	1
K139	C141R	COAD	1
C238	M237I	COAD	1
S241,N239	S240R	COAD	1
T150	T150A	COAD	1
V157	R158C	COAD	1
G279	G279W	COAD	1
L257	D259V	COAD	1
T155	T155I	COAD	1
R248	P250L	COAD	1
N239	N239D	COAD	1
T230	T231I	COAD	1
R273,C275	V274A	COAD	1
R248	M246T	COAD	1
T123	T125A	COAD	1
Q165,Q167	S166L	COAD	1
C238	M237L	COAD	1
A119	A119V	COAD	1
E221	E221G	COAD	1
L257	E258G	COAD	1
P223	E224D	COAD	1
F109	G108C	COAD	1
L257	I255T	COAD	1
C238	C238R	COAD	1
D228	D228G	COAD	1
R273	V272G	COAD	1
E221	E221V	COAD	1
Q165,Q167	S166P	COAD	1
L257	D259Y	COAD	1
V122	V122M	COAD	1
F109	F109S	COAD	1
C242	C242R	COAD	1
T118	S116P	COAD	1
R248	M246V	COAD	1
C176	H178Q	GBM	1
A276	A276V	GBM	1
R280	D281A	GBM	1
R280	D281H	GBM	1
R273	E271K	GBM	1
L257	I255S	GBM	1
Q165	K164E	GBM	1
V157	V157G	GBM	1
R273	R273C	GBM	1
C275	C275Y	GBM	1
C242	C242Y	GBM	1
R248	R249M	GBM	1
R248	M246R	GBM	1
R248	R249T	GBM	1
P152	P152S	GBM	1
M243	G244S	GBM	1
T155,V157	R156C	GBM	1
K139	A138T	GBM	1
R248	R248L	GBM	1
L257	E258D	HNSC	1
T155,V157	R156P	HNSC	1
C242	C242Y	HNSC	1
V157	R158L	HNSC	1
R273	R273S	HNSC	1
C238	M237I	HNSC	1
H168	H168L	HNSC	1
P223	E224D	HNSC	1
R248	R249M	HNSC	1
M243	G245D	HNSC	1
R283	R283P	HNSC	1
R280	R280T	HNSC	1
P151	P151S	HNSC	1
V157	R158H	HNSC	1
R280	R280G	HNSC	1
R273	V272M	HNSC	1
V157	A159V	HNSC	1
C176	C176S	HNSC	1
C238	M237V	HNSC	1
C238	C238S	HNSC	1
R280	R280S	HNSC	1
C176	C176Y	HNSC	1
P151	P151T	HNSC	1
C242	C242S	HNSC	1
Q165	Y163C	HNSC	1
P151	P151H	HNSC	1
R273	E271V	HNSC	1
L257	E258A	HNSC	1
K139	L137Q	HNSC	1
C238	Y236D	HNSC	1
V157	A159P	KICH	1
C275	C275Y	KICH	1
C176	H178Q	KICH	1
N239	N239D	KICH	1
K139	C141W	KICH	1
R248	M246I	KICH	1
R273	R273H	KIRC	1
R248	R248Q	KIRC	1
R280	D281Y	KIRC	1
N239	N239S	KIRC	1
S241	S241C	KIRC	1
R273	V272M	KIRC	1
C176	C176Y	LAML	1
R280	R280G	LAML	1
K139	C141W	LAML	1
R248	R248Q	LAML	1
R273	R273C	LAML	1
R273	V272G	LUAD	1
C176	C176Y	LUAD	1
R280	D281V	LUAD	1
R280	R280I	LUAD	1
T155	T155I	LUAD	1
R280	D281E	LUAD	1
C238	C238Y	LUAD	1
P151	P151S	LUAD	1
F109	L111M	LUAD	1
L257	I255F	LUAD	1
L257	D259Y	LUAD	1
T155,V157	R156P	LUAD	1
C176	P177R	LUAD	1
E221	Y220C	LUAD	1
R248	R249S	LUAD	1
R273,C275	V274F	LUAD	1
S241	S241F	LUAD	1
R283	R283P	LUAD	1
R280	R280T	LUAD	1
F109	F109C	LUAD	1
M243	G245C	LUAD	1
H168	H168L	LUAD	1
M243	G245V	LUAD	1
T230	I232F	LUAD	1
R283	E285K	LUAD	1
R273	V272M	LUAD	1
R280	D281Y	LUAD	1
L145	Q144L	LUAD	1
V157	R158P	LUAD	1
L145	Q144H	LUAD	1
P223	E224D	LUAD	1
R280	R280G	LUAD	1
N239	N239S	LUAD	1
T155,P153	G154V	LUAD	1
R248	R248P	LUAD	1
C176	C176F	LUAD	1
G279,C277	P278H	LUAD	1
Q165	Y163C	LUAD	1
R248	P250L	LUAD	1
Q165	Y163H	LUAD	1
Q165	Y163D	LUAD	1
R283	R282Q	LUSC	1
L257	D259V	LUSC	1
L257	D259Y	LUSC	1
T155	T155P	LUSC	1
C176	C176Y	LUSC	1
P223	E224D	LUSC	1
R248	P250L	LUSC	1
M243	G245C	LUSC	1
R273	R273C	LUSC	1
C176	C176F	LUSC	1
C238	Y236C	LUSC	1
R248	R248W	LUSC	1
R280	R280I	LUSC	1
F109	R110L	LUSC	1
P151	P151R	LUSC	1
C238	M237I	LUSC	1
Q165	K164E	LUSC	1
G279,C277	P278S	LUSC	1
R248	R249W	LUSC	1
R248	R248Q	LUSC	1
R283	T284P	LUSC	1
F109	L111Q	LUSC	1
R280	D281Y	LUSC	1
M243	G245S	LUSC	1
R283	R282W	LUSC	1
R273	R273H	LUSC	1
K139	C141W	LUSC	1
G279,C277	P278L	LUSC	1
V157	R158H	LUSC	1
R248	R248P	LUSC	1
T155,P153	G154V	LUSC	1
M243	G244D	LUSC	1
M243	G244C	LUSC	1
R248	R249S	LUSC	1
R273	R273P	LUSC	1
F109	L111R	LUSC	1
T123	T125P	LUSC	1
R248	R249G	LUSC	1
G279,C277	P278A	LUSC	1
R248	R248L	LUSC	1
V157	R158G	LUSC	1
G279,C277	P278R	LUSC	1
R283	R283P	LUSC	1
R283	R282P	OV	1
C176	C176G	OV	1
L257	L257Q	OV	1
Q165	Y163H	OV	1
C176	H178N	OV	1
A276	A276P	OV	1
G279	G279E	OV	1
R273	R273P	OV	1
F109	F109C	OV	1
C277	C277F	OV	1
R280	R280I	OV	1
L145	L145Q	OV	1
Q165	K164E	OV	1
R280	D281G	OV	1
P151	P151S	OV	1
T155,V157	R156P	OV	1
R273,C275	V274D	OV	1
N239	N239S	OV	1
R248	R249G	OV	1
C176	C176F	OV	1
S241	S241Y	OV	1
G279,C277	P278H	OV	1
C176	C176S	OV	1
R280	D281V	OV	1
T230	I232N	OV	1
R273,C275	V274G	OV	1
L145	L145R	OV	1
M243	G245C	OV	1
T155	T155A	OV	1
R248	R248G	OV	1
C238	C238G	OV	1
M243	G244D	OV	1
R280	D281E	OV	1
P151	P151R	OV	1
C238	C238F	OV	1
T123	T125M	OV	1
K139	A138V	OV	1
S241	S241A	OV	1
M243	G245R	OV	1
R280	D281Y	OV	1
C275	C275S	OV	1
C238	C238Y	OV	1
Q165	Y163N	OV	1
C176	R175H	PRAD	1
R283	R282W	PRAD	1
M243	G245S	PRAD	1
N239	N239D	PRAD	1
R280	R280K	SKCM	1
K120	K120E	SKCM	1
L145	V143E	SKCM	1
G279,C277	P278L	SKCM	1
C176	P177L	SKCM	1
R248	R248W	SKCM	1
L145	V143G	SKCM	1
E221	Y220C	SKCM	1
P152	P152L	SKCM	1
M243	G245R	STAD	1
K139	K139N	STAD	1
H168	H168R	STAD	1
F109	Y107D	STAD	1
C238	C238F	STAD	1
C176	C176Y	STAD	1
R283	E285V	STAD	1
R273	V272M	STAD	1
P151	P151T	STAD	1
F109	L111Q	STAD	1
C242	C242Y	STAD	1
R248	R249S	STAD	1
R248	P250L	STAD	1
F109	G108S	STAD	1
C176	R175C	STAD	1
H168	M169T	STAD	1
R273	E271K	STAD	1
C176	R175G	STAD	1
C238	M237I	STAD	1
T123	T125M	STAD	1
M243	G244C	STAD	1
T230	I232T	UCEC	1
R273	R273S	UCEC	1
P151	P151S	UCEC	1
R248	R249W	UCEC	1
C176	H178D	UCEC	1
R273	V272M	UCEC	1
C238	C238F	UCEC	1
R283	R282W	UCEC	1
C238	C238Y	UCEC	1
N239	N239D	UCEC	1
R280	D281Y	UCEC	1
K139	C141Y	UCEC	1
N239	N239S	UCEC	1
S241	S241P	UCEC	1
R248	R249S	UCEC	1
C238	M237K	UCEC	1
S241	S241C	UCEC	1
G279,C277	P278T	UCEC	1
S241	S241F	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for TP53 from My Cancer Genome.

Tumor protein p53 (TP53) is a gene that codes for a tumor suppressor protein. The protein regulates expression of genesinvolved in cell cycle arrest, apoptosis, senescence, DNA repair, and changes in metabolism (Gene 2014). In cancer, TP53’s normal roles are not fulfilled, leading to cell survival, DNA damage, and cell proliferation. TP53 is the most frequently mutated gene in cancer; it is mutated in about half of all cancers (Genetics Home Reference 2014). TP53 is most frequently mutated in ovarian, colon, and esophageal cancers, although it is significantly mutated in many other cancer types (COSMIC). Strickland, S.A., Kim, A.S. 2015. TP53. My Cancer Genomehttps://www.mycancergenome.org/content/gene/tp53/ (Updated December 2015)

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Protein structure related information for TP53

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
R248	N247I	0.44123146
R280	D281V	0.10228051
R280	D281E	0.087914822
A119	A119V	0.085624008
Q167	S166L	0.055371255
Q165	S166L	0.055371255
G279	G279R	0.051401998
G279	G279W	0.038815426
G279	G279E	0.02424754
T230	T231I	0.004029671
L145	L145Q	-1.7884843
T230	I232N	-1.6927216
T230	I232S	-1.6496924
R273	V272G	-1.6159679
R280	R280G	-1.5823802
T123	T125A	-1.5799886
C238	Y236D	-1.5741252
R280	R280S	-1.5705052
L145	L145R	-1.5558493
R280	R280K	-1.5106393
T230	I232T	-1.5095945
M243	G245S	-1.5093679
P152	P152S	-1.4842484
M243	G245D	-1.454748
K139	K139N	-1.4403836
C238	M237T	-1.4395932
C242	C242S	-1.4236268
C238	M237K	-1.3967598
E221	E221G	-1.3882277
R283	R282G	-1.3872027
C238	Y236C	-1.379064
R280	R280T	-1.3709839
T155	T155N	-1.3646021
K139	L137Q	-1.3479875
L257	I255N	-1.335189
T150	T150A	-1.3282886
T230	I232F	-1.3239524
R273	V274G	-1.3238858
C275	V274G	-1.3238858
P223	E224D	-1.3067282
R248	R248G	-1.2964135
R273	E271K	-1.2943414
M243	G245C	-1.2881699
C176	C176G	-1.2652152
L257	I255S	-1.2601318
V157	V157G	-1.2372881
R283	R282Q	-1.2332047
H168	H168P	-1.2270711
C238	C238G	-1.2241451
M243	G245V	-1.2130118
T155	T155A	-1.2111341
R248	R249G	-1.2094495
T123	T125P	-1.1945216
H168	H168R	-1.1775171
L145	Q144H	-1.177424
C275	V274D	-1.1739382
R273	V274D	-1.1739382
C242	C242Y	-1.1711171
L257	E258G	-1.1599803
C242	C242F	-1.151124
C277	C277F	-1.1504446
L257	I255T	-1.1432196
R273	V274A	-1.1370788
C275	V274A	-1.1370788
K139	A138T	-1.136694
C242	C242R	-1.1365082
R248	R248Q	-1.136464
M243	G245R	-1.1354599
P152	P152R	-1.1345378
C275	C275S	-1.1202084
C176	R175G	-1.1166628
C176	C176S	-1.1152157
L257	E258A	-1.1129563
P151	P151H	-1.1117864
P151	P151S	-1.1101802
C238	M237V	-1.1095958
S241	S241A	-1.1094179
C176	R175H	-1.1087266
W146	W146S	-1.1035714
L257	L257Q	-1.0616103
C238	C238S	-1.0545455
Q165	Y163N	-1.0478075
T123	T125M	-1.0410024
C238	M237I	-1.0291636
P151	P151T	-1.0187024
K139	C141S	-1.0185365
R280	R280I	-1.0178892
R273	R273S	-1.014134
L257	E258Q	-1.0114936
L257	E258D	-1.0073882
R248	R249S	-1.0047248
R273	R273H	-0.99942546
L145	V143G	-0.99170842
R273	V272M	-0.9901801
R283	R282P	-0.98854452
F109	L111Q	-0.98536048
Q165	Y163H	-0.97893475
T155	T155P	-0.96836792
D228	S227P	-0.95912427
V157	R158G	-0.95726327
E221	E221V	-0.9463474
R248	R249T	-0.94470639
R283	R282W	-0.93664617
R273	E271V	-0.92991765
C238	M237L	-0.92890116
L257	I255F	-0.92265071
R248	R248P	-0.91996727
E221	Y220H	-0.90727385
V122	V122M	-0.89472201
H168	H168L	-0.88311906
Q165	Y163D	-0.87952435
G279	P278A	-0.86850193
C277	P278A	-0.86850193
E221	Y220S	-0.86650363
P151	P151R	-0.85987578
C176	C176Y	-0.85829507
C275	C275Y	-0.85686094
T123	C124G	-0.8430408
D148	D148N	-0.84109856
C176	P177R	-0.83831643
V157	A159P	-0.83021755
F109	F109S	-0.82666078
R248	R248W	-0.82181901
C176	C176F	-0.81576335
C275	C275F	-0.81420142
C238	C238Y	-0.79586672
K139	A138V	-0.79101398
C277	P278S	-0.78324005
G279	P278S	-0.78324005
S241	S241C	-0.78241232
F109	L111P	-0.78003926
L145	V143A	-0.77927069
R273	V274F	-0.77832623
C275	V274F	-0.77832623
C176	R175C	-0.77610417
C238	C238F	-0.77315204
P152	P152L	-0.77011045
D228	D228G	-0.75814898
V157	R158H	-0.75779946
K120	K120E	-0.74438529
S241	S241P	-0.74294193
C238	C238R	-0.74135505
G279	P278H	-0.73940287
C277	P278H	-0.73940287
Q165	Y163C	-0.73263737
R283	R283P	-0.72348885
R273	R273P	-0.72309185
F109	L111R	-0.71044699
N239	N239D	-0.70606751
V157	A159V	-0.70220185
T155	T155I	-0.69869425
L257	D259Y	-0.69045917
S241	S241Y	-0.6896448
K139	C141Y	-0.68687583
R273	R273C	-0.67808717
R248	R249W	-0.6725509
V157	V157F	-0.67113294
K139	C141R	-0.66313343
C176	H178N	-0.65581918
L257	D259V	-0.65454798
R248	R249M	-0.64848408
F109	L111M	-0.64495342
K139	C141W	-0.62940634
E221	Y220C	-0.62388851
S241	S241F	-0.62343298
G279	P278T	-0.62232062
C277	P278T	-0.62232062
F109	F109C	-0.60954138
H168	M169T	-0.59891235
N239	N239S	-0.58212119
N239	S240G	-0.55668104
S241	S240G	-0.55668104
V157	R158P	-0.55570515
R283	E285K	-0.55445162
C176	P177L	-0.55260316
R248	M246T	-0.53525744
R248	R248L	-0.5022807
L145	Q144L	-0.48926379
V157	R158C	-0.48647949
L145	V143E	-0.47721026
C176	H178Q	-0.47555968
C176	H178D	-0.46648234
R280	D281G	-0.44400347
F109	Y107D	-0.44103265
C275	V274L	-0.43449135
R273	V274L	-0.43449135
P153	G154C	-0.42710508
T155	G154C	-0.42710508
F109	G108S	-0.41753493
R280	D281A	-0.41528159
Q167	S166P	-0.39779246
Q165	S166P	-0.39779246
C277	P278R	-0.38951953
G279	P278R	-0.38951953
L145	V143M	-0.38499489
R280	D281N	-0.38091774
R248	M246V	-0.36884508
R248	M246R	-0.36502092
R273	R273L	-0.36417523
R283	E285V	-0.35028933
M243	G244S	-0.34284316
R280	D281H	-0.31768233
F109	Y107C	-0.30028122
A276	A276P	-0.29665064
R283	T284P	-0.28832358
T155	G154V	-0.2724623
P153	G154V	-0.2724623
M243	G244D	-0.23648851
F109	G108C	-0.22972074
F109	R110L	-0.22154768
R248	P250L	-0.19459107
R248	M246I	-0.19226039
T118	S116P	-0.1888892
A276	A276V	-0.18794386
V157	R158L	-0.16781574
Q165	K164E	-0.16295945
C277	P278L	-0.15853097
G279	P278L	-0.15853097
F109	F109L	-0.14215741
N239	S240R	-0.13328368
S241	S240R	-0.13328368
M243	G244C	-0.097008628
R280	D281Y	-0.063842998
T155	R156C	-0.059604549
V157	R156C	-0.059604549
T155	R156P	-0.053761091
V157	R156P	-0.053761091

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TP53 from PDB

PDB ID	PDB title	PDB structure
1DT7	SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)

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Differential gene expression and gene-gene network for TP53

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

TP53_BRCA_DE

TP53_COAD_DE

TP53_HNSC_DE

TP53_LUAD_DE

TP53_LUSC_DE

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of TP53 and the right PPI network was created from samples without mutations in the LBS of TP53. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

* In BRCA

* In COAD

* In HNSC

* In LUAD

* In LUSC

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Phenotype information for TP53

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0007097	Carcinoma	928	AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0007137	Carcinoma, Squamous Cell	622	AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C2239176	Carcinoma, Hepatocellular	497	AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0027627	Neoplasm Metastasis	391	AlteredExpression, Biomarker, GeneticVariation
umls:C0001418	Adenocarcinoma	346	AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0007131	Carcinoma, Non-Small-Cell Lung	318	Biomarker, GeneticVariation
umls:C0085390	Li-Fraumeni Syndrome	282	Biomarker, GeneticVariation
umls:C0017638	Glioma	267	AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0302592	Cervix carcinoma	260	Biomarker, GeneticVariation
umls:C1458155	Breast Neoplasms	237	AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0023434	Leukemia, Lymphocytic, Chronic, B-Cell	219	AlteredExpression, Biomarker, GeneticVariation
umls:C0025202	Melanoma	196	AlteredExpression, Biomarker, GeneticVariation
umls:C1168401	Carcinoma, squamous cell of head and neck	170	Biomarker, GeneticVariation
umls:C1261473	Sarcoma	169	AlteredExpression, Biomarker, GeneticVariation
umls:C0001430	Adenoma	147	Biomarker, GeneticVariation
umls:C0024121	Lung Neoplasms	146	AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0004114	Astrocytoma	138	AlteredExpression, Biomarker, GeneticVariation
umls:C0029463	Osteosarcoma	135	Biomarker, GeneticVariation, Therapeutic
umls:C0235974	Pancreatic Carcinoma	122	Biomarker, GeneticVariation
umls:C0014859	Esophageal Neoplasms	118	AlteredExpression, Biomarker, GeneticVariation
umls:C0009404	Colorectal Neoplasms	96	AlteredExpression, Biomarker, GeneticVariation
umls:C0007138	Carcinoma, Transitional Cell	95	AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0279626	Esophageal Squamous Cell Carcinoma	93	Biomarker, GeneticVariation
umls:C0023903	Liver Neoplasms	89	AlteredExpression, Biomarker, GeneticVariation
umls:C0005695	Urinary Bladder Neoplasms	80	AlteredExpression, Biomarker, GeneticVariation
umls:C0007134	Carcinoma, Renal Cell	76	AlteredExpression, Biomarker, GeneticVariation
umls:C2931822	Nasopharyngeal carcinoma	66	Biomarker, GeneticVariation
umls:C0009375	Colonic Neoplasms	63	AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0037286	Skin Neoplasms	58	Biomarker, GeneticVariation
umls:C0038356	Stomach Neoplasms	55	AlteredExpression, Biomarker, GeneticVariation
umls:C0149925	Small Cell Lung Carcinoma	54	AlteredExpression, Biomarker, GeneticVariation
umls:C1961102	Precursor Cell Lymphoblastic Leukemia-Lymphoma	53	AlteredExpression, Biomarker, GeneticVariation
umls:C0206686	Adrenocortical Carcinoma	49	Biomarker, GeneticVariation
umls:C0040136	Thyroid Neoplasms	45	AlteredExpression, Biomarker, GeneticVariation
umls:C0033578	Prostatic Neoplasms	38	AlteredExpression, Biomarker, GeneticVariation
umls:C0279628	Adenocarcinoma Of Esophagus	36	Biomarker, GeneticVariation
umls:C0030297	Pancreatic Neoplasms	31	AlteredExpression, Biomarker, GeneticVariation
umls:C0026640	Mouth Neoplasms	28	Biomarker, GeneticVariation
umls:C0206698	Cholangiocarcinoma	28	AlteredExpression, Biomarker
umls:C1835398	Sarcoma family syndrome of Li and Fraumeni	20	Biomarker, GeneticVariation
umls:C2675080	Li-Fraumeni-Like Syndrome	18	Biomarker, GeneticVariation
umls:C0262584	Carcinoma, Small Cell	15	Biomarker, PostTranslationalModification
umls:C0018923	Hemangiosarcoma	13	Biomarker
umls:C0010606	Carcinoma, Adenoid Cystic	13	Biomarker
umls:C0036341	Schizophrenia	12	Biomarker, GeneticVariation
umls:C0024305	Lymphoma, Non-Hodgkin	12	Biomarker, GeneticVariation
umls:C0033860	Psoriasis	11	Biomarker, GeneticVariation
umls:C0001624	Adrenal Gland Neoplasms	11	Biomarker
umls:C0431109	Choroid Plexus Carcinoma	10	Biomarker, GeneticVariation
umls:C0007117	Carcinoma, Basal Cell	9	AlteredExpression, Biomarker, GeneticVariation
umls:C0022593	Keratosis	9	Biomarker, GeneticVariation
umls:C0022116	Ischemia	8	Biomarker
umls:C0206681	Adenocarcinoma, Clear Cell	8	Biomarker, GeneticVariation
umls:C0007621	Cell Transformation, Neoplastic	7	Biomarker, GeneticVariation
umls:C0040100	Thymoma	6	Biomarker
umls:C0858252	Breast Adenocarcinoma	6	Biomarker, GeneticVariation
umls:C0024117	Pulmonary Disease, Chronic Obstructive	5	Biomarker, GeneticVariation
umls:C0004698	Balkan Nephropathy	5	Biomarker, GeneticVariation
umls:C0002736	Amyotrophic Lateral Sclerosis	5	Biomarker
umls:C0016978	Gallbladder Neoplasms	4	Biomarker, GeneticVariation
umls:C0027672	Neoplastic Syndromes, Hereditary	4	Biomarker, GeneticVariation
umls:C0205770	Papilloma, Choroid Plexus	3	Biomarker, GeneticVariation
umls:C0021361	Infertility, Female	3	Biomarker, GeneticVariation
umls:C0030849	Penile Neoplasms	3	Biomarker, GeneticVariation
umls:C0021364	Infertility, Male	3	Biomarker, GeneticVariation
umls:C0311375	Arsenic Poisoning	3	Biomarker, GeneticVariation
umls:C0007273	Carotid Artery Diseases	2	Biomarker, GeneticVariation
umls:C0042065	Urogenital Neoplasms	2	Biomarker, GeneticVariation
umls:C0020538	Hypertension	2	Biomarker
umls:C0022783	Vulvar Lichen Sclerosus	2	Biomarker
umls:C2609414	Acute Kidney Injury	1	Biomarker
umls:C0007786	Brain Ischemia	1	Biomarker
umls:C0007194	Cardiomyopathy, Hypertrophic	1	Biomarker
umls:C2931713	Chromosome 17 deletion	1	Biomarker
umls:C0011303	Demyelinating Diseases	1	Biomarker
umls:C0013990	Emphysema	1	Biomarker
umls:C1860789	Leukemia, Megakaryoblastic, of Down Syndrome	1	Biomarker
umls:C0023897	Liver Diseases, Parasitic	1	Biomarker
umls:C0023904	Liver Neoplasms, Experimental	1	Biomarker
umls:C0042076	Urologic Neoplasms	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID	AA change	Clinical significance	Origin	Phenotype IDs
27386	R248W	Likely pathogenic;Pathogenic	Germline;unknown	GeneReviews:NBK1311 MedGen:C0085390 Orphanet:ORPHA524 SNOMED CT:428850001 GeneReviews:NBK1311 MedGen:C1835398 OMIM:151623 Orphanet:ORPHA524 MedGen:C0027672 SNOMED CT:699346009
27388	G245C	Pathogenic	Germline	GeneReviews:NBK1311 MedGen:C1835398 OMIM:151623 Orphanet:ORPHA524 MedGen:C0027672 SNOMED CT:699346009
27391	R249S	Pathogenic	Somatic	MedGen:C0302592 OMIM:603956 SNOMED CT:285432005 MedGen:C2239176 OMIM:114550 SNOMED CT:187769009 SNOMED CT:25370001
27392	V157F	Pathogenic	Somatic	MedGen:C2239176 OMIM:114550 SNOMED CT:187769009 SNOMED CT:25370001
27393	C242Y	Pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009 MedGen:C2675080
27394	G245D	Pathogenic	Germline	GeneReviews:NBK1311 MedGen:C0085390 Orphanet:ORPHA524 SNOMED CT:428850001 GeneReviews:NBK1311 MedGen:C1835398 OMIM:151623 Orphanet:ORPHA524 MedGen:C0027672 SNOMED CT:699346009
27395	R248Q	Pathogenic	Germline	GeneReviews:NBK1311 MedGen:C0085390 Orphanet:ORPHA524 SNOMED CT:428850001 GeneReviews:NBK1311 MedGen:C1835398 OMIM:151623 Orphanet:ORPHA524 MedGen:C0027672 SNOMED CT:699346009 MedGen:C1261473 MedGen:C1836482 OMIM:609265 Orphanet:ORPHA524
27398	S241F	Likely pathogenic;Pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009 MedGen:C0029463 OMIM:259500 Orphanet:ORPHA668 SNOMED CT:21708004 MedGen:C0206624
27403	R282W	Likely benign;Pathogenic	Germline	GeneReviews:NBK1311 MedGen:C0085390 Orphanet:ORPHA524 SNOMED CT:428850001 GeneReviews:NBK1311 MedGen:C1835398 OMIM:151623 Orphanet:ORPHA524 MedGen:C0029463 OMIM:259500 Orphanet:ORPHA668 SNOMED CT:21708004 MedGen:C2675080
27404	G245S	Likely pathogenic;Pathogenic	Germline	GeneReviews:NBK1311 MedGen:C0085390 Orphanet:ORPHA524 SNOMED CT:428850001 GeneReviews:NBK1311 MedGen:C1835398 OMIM:151623 Orphanet:ORPHA524 MedGen:C0001418 MedGen:C0027672 SNOMED CT:699346009 MedGen:C0029463 OMIM:259500 Orphanet:ORPHA668 SNOMED CT:2170800
27405	R273H	Pathogenic	Germline;somatic	GeneReviews:NBK1311 MedGen:C1835398 OMIM:151623 Orphanet:ORPHA524 MedGen:C0027672 SNOMED CT:699346009 MedGen:C0238461
27407	R280T	Pathogenic;Uncertain significance	Germline;somatic	GeneReviews:NBK1311 MedGen:C0085390 Orphanet:ORPHA524 SNOMED CT:428850001 MedGen:C2931822 OMIM:607107 Orphanet:ORPHA150
27408	P151T	Likely pathogenic;Pathogenic	Germline;somatic	MedGen:C0027672 SNOMED CT:699346009 MedGen:C0858252
27409	P151S	Pathogenic	Germline;somatic	MedGen:C0858252 MedGen:CN221809
27411	L257Q	Pathogenic	Germline	MedGen:C2675080
27413	R175H	Pathogenic	Germline	GeneReviews:NBK1311 MedGen:C0085390 Orphanet:ORPHA524 SNOMED CT:428850001 GeneReviews:NBK1311 MedGen:C1835398 OMIM:151623 Orphanet:ORPHA524 MedGen:C0027672 SNOMED CT:699346009
27422	Y220S	Pathogenic	Germline	GeneReviews:NBK1311 MedGen:C1835398 OMIM:151623 Orphanet:ORPHA524
27423	E285V	Pathogenic	Germline	MedGen:C0431109 MedGen:C1859973
52763	R273C	Likely pathogenic;Pathogenic;Uncertain significance	Germline;somatic	GeneReviews:NBK1311 MedGen:C0085390 Orphanet:ORPHA524 SNOMED CT:428850001 GeneReviews:NBK1311 MedGen:C1835398 OMIM:151623 Orphanet:ORPHA524 MedGen:C0027672 SNOMED CT:699346009 MedGen:C0376358 OMIM:176807 Orphanet:ORPHA1331 SNOMED CT:399068003
106675	M246V	Likely pathogenic;Pathogenic	Germline;somatic	MedGen:C0027672 SNOMED CT:699346009 MedGen:CN221809
133267	R156C	Uncertain significance	Germline	MedGen:C0027672 SNOMED CT:699346009
133269	R158C	Likely pathogenic;Uncertain significance	Germline	MedGen:C0027672 SNOMED CT:699346009
133271	Y163C	Pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
133276	Y220C	Pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
133279	M246R	Pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
150515	C141Y	Pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
150535	R282G	Pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
150812	K120E	Pathogenic;Uncertain significance	Germline	MedGen:C0027672 SNOMED CT:699346009
150815	V122M	Uncertain significance	Germline	GeneReviews:NBK1311 MedGen:C0085390 Orphanet:ORPHA524 SNOMED CT:428850001 MedGen:C0027672 SNOMED CT:699346009
150855	D281G	Pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
150938	I232T	Likely pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
151595	R249W	Uncertain significance	Germline	MedGen:C0027672 SNOMED CT:699346009
151677	R158H	Pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
151897	Y236D	Pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
152145	G108S	Uncertain significance	Germline	MedGen:C0027672 SNOMED CT:699346009
152371	V143M	Uncertain significance	Germline	MedGen:C0027672 SNOMED CT:699346009
152405	Y107C	Uncertain significance	Germline	MedGen:C0027672 SNOMED CT:699346009
152428	M237I	Likely pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
152480	P152L	Pathogenic	Germline	GeneReviews:NBK1311 MedGen:C0085390 Orphanet:ORPHA524 SNOMED CT:428850001 MedGen:C0027672 SNOMED CT:699346009
176503	S241C	Likely pathogenic	Germline	GeneReviews:NBK1311 MedGen:C1835398 OMIM:151623 Orphanet:ORPHA524
180995	D281V	Pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
181000	C238Y	Likely pathogenic;Uncertain significance	Germline	GeneReviews:NBK1311 MedGen:C0085390 Orphanet:ORPHA524 SNOMED CT:428850001 MedGen:C0027672 SNOMED CT:699346009
181001	M237V	Pathogenic;Uncertain significance	Germline	GeneReviews:NBK1311 MedGen:C0085390 Orphanet:ORPHA524 SNOMED CT:428850001 MedGen:C0027672 SNOMED CT:699346009
181013	A159P	Uncertain significance	Germline	MedGen:C0027672 SNOMED CT:699346009
185350	V272M	Uncertain significance	Germline	MedGen:C0027672 SNOMED CT:699346009
185354	N247I	Uncertain significance	Germline	MedGen:C0027672 SNOMED CT:699346009
185371	C176Y	Likely pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
185375	Y163D	Likely pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
185387	A138V	Uncertain significance	Germline	MedGen:C0027672 SNOMED CT:699346009
185394	T125M	Likely pathogenic	Germline	MedGen:C0027672 SNOMED CT:699346009
213392	C275Y	Likely pathogenic	Germline	GeneReviews:NBK1311 MedGen:C0085390 Orphanet:ORPHA524 SNOMED CT:428850001

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Pharmacological information for TP53

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Approved\|vet_approved	DB00945	Acetylsalicylic acid	Small molecule
Investigational	DB05404	AZD 3355	Small molecule
Experimental	DB08363	1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TP53 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
NUC		Nucleic Acids	2ac0	C	A119 K120
NUC		Nucleic Acids	2ata	D	A119 K120
NUC		Nucleic Acids	3d0a	D	A119 K120
NUC		Nucleic Acids	4hje	B	A119 K120
NUC		Nucleic Acids	4hje	D	A119 K120
NUC		Nucleic Acids	4ibu	B	A119 K120 M243 R248 R283
NUC		Nucleic Acids	3igk	A	A119 K120 Q167 R248 R280
NUC		Nucleic Acids	3igl	A	A119 K120 Q167 R248 R280
NUC		Nucleic Acids	2ac0	A	A119 K120 R248
NUC		Nucleic Acids	2ac0	D	A119 K120 R248
NUC		Nucleic Acids	2ady	A	A119 K120 R248
NUC		Nucleic Acids	2ahi	D	A119 K120 R248
NUC		Nucleic Acids	2ata	C	A119 K120 R248
NUC		Nucleic Acids	3d0a	B	A119 K120 R248
NUC		Nucleic Acids	3kmd	D	A119 K120 R248
NUC		Nucleic Acids	3q05	B	A119 K120 R248
NUC		Nucleic Acids	4ibu	D	A119 K120 R248
NUC		Nucleic Acids	1tup	B	A119 K120 R248 R280
NUC		Nucleic Acids	1tsr	B	A119 K120 R248 R280 R283
NUC		Nucleic Acids	3d0a	A	A119 K120 V122
NUC		Nucleic Acids	4ibu	A	A119 K120 V122
NUC		Nucleic Acids	2ahi	A	A119 K120 V122 R248
NUC		Nucleic Acids	2ahi	C	A119 T123
NUC		Nucleic Acids	2ata	C	A119 T123
NUC		Nucleic Acids	2ac0	C	A119 V122 T123
ZN		ZINC(2+)	1gzh	A	C176 C238 C242
ZN		ZINC(2+)	1gzh	C	C176 C238 C242
ZN		ZINC(2+)	1kzy	A	C176 C238 C242
ZN		ZINC(2+)	1kzy	B	C176 C238 C242
ZN		ZINC(2+)	1tsr	A	C176 C238 C242
ZN		ZINC(2+)	1tsr	B	C176 C238 C242
ZN		ZINC(2+)	1tsr	C	C176 C238 C242
ZN		ZINC(2+)	1tup	A	C176 C238 C242
ZN		ZINC(2+)	1tup	B	C176 C238 C242
ZN		ZINC(2+)	1tup	C	C176 C238 C242
ZN		ZINC(2+)	1uol	A	C176 C238 C242
ZN		ZINC(2+)	1uol	B	C176 C238 C242
ZN		ZINC(2+)	1ycs	A	C176 C238 C242
ZN		ZINC(2+)	2ac0	A	C176 C238 C242
ZN		ZINC(2+)	2ac0	B	C176 C238 C242
ZN		ZINC(2+)	2ac0	C	C176 C238 C242
ZN		ZINC(2+)	2ac0	D	C176 C238 C242
ZN		ZINC(2+)	2ady	A	C176 C238 C242
ZN		ZINC(2+)	2ady	B	C176 C238 C242
ZN		ZINC(2+)	2ahi	A	C176 C238 C242
ZN		ZINC(2+)	2ahi	B	C176 C238 C242
ZN		ZINC(2+)	2ahi	C	C176 C238 C242
ZN		ZINC(2+)	2ahi	D	C176 C238 C242
ZN		ZINC(2+)	2ata	A	C176 C238 C242
ZN		ZINC(2+)	2ata	B	C176 C238 C242
ZN		ZINC(2+)	2ata	C	C176 C238 C242
ZN		ZINC(2+)	2ata	D	C176 C238 C242
ZN		ZINC(2+)	2bim	A	C176 C238 C242
ZN		ZINC(2+)	2bim	B	C176 C238 C242
ZN		ZINC(2+)	2bin	A	C176 C238 C242
ZN		ZINC(2+)	2bio	A	C176 C238 C242
ZN		ZINC(2+)	2bip	A	C176 C238 C242
ZN		ZINC(2+)	2biq	A	C176 C238 C242
ZN		ZINC(2+)	2fej	A	C176 C238 C242
ZN		ZINC(2+)	2h1l	M	C176 C238 C242
ZN		ZINC(2+)	2h1l	N	C176 C238 C242
ZN		ZINC(2+)	2h1l	O	C176 C238 C242
ZN		ZINC(2+)	2h1l	P	C176 C238 C242
ZN		ZINC(2+)	2h1l	Q	C176 C238 C242
ZN		ZINC(2+)	2h1l	R	C176 C238 C242
ZN		ZINC(2+)	2h1l	S	C176 C238 C242
ZN		ZINC(2+)	2h1l	T	C176 C238 C242
ZN		ZINC(2+)	2h1l	U	C176 C238 C242
ZN		ZINC(2+)	2h1l	V	C176 C238 C242
ZN		ZINC(2+)	2h1l	W	C176 C238 C242
ZN		ZINC(2+)	2h1l	X	C176 C238 C242
ZN		ZINC(2+)	2j1w	A	C176 C238 C242
ZN		ZINC(2+)	2j1w	B	C176 C238 C242
ZN		ZINC(2+)	2j1x	A	C176 C238 C242
ZN		ZINC(2+)	2j1x	B	C176 C238 C242
ZN		ZINC(2+)	2j1y	A	C176 C238 C242
ZN		ZINC(2+)	2j1y	B	C176 C238 C242
ZN		ZINC(2+)	2j1y	C	C176 C238 C242
ZN		ZINC(2+)	2j1y	D	C176 C238 C242
ZN		ZINC(2+)	2j1z	A	C176 C238 C242
ZN		ZINC(2+)	2j1z	B	C176 C238 C242
ZN		ZINC(2+)	2j20	A	C176 C238 C242
ZN		ZINC(2+)	2j20	B	C176 C238 C242
ZN		ZINC(2+)	2j21	A	C176 C238 C242
ZN		ZINC(2+)	2j21	B	C176 C238 C242
ZN		ZINC(2+)	2ocj	A	C176 C238 C242
ZN		ZINC(2+)	2ocj	B	C176 C238 C242
ZN		ZINC(2+)	2ocj	C	C176 C238 C242
ZN		ZINC(2+)	2ocj	D	C176 C238 C242
ZN		ZINC(2+)	2pcx	A	C176 C238 C242
ZN		ZINC(2+)	2qvq	A	C176 C238 C242
ZN		ZINC(2+)	2qxa	A	C176 C238 C242
ZN		ZINC(2+)	2qxa	B	C176 C238 C242
ZN		ZINC(2+)	2qxa	C	C176 C238 C242
ZN		ZINC(2+)	2qxa	D	C176 C238 C242
ZN		ZINC(2+)	2qxb	A	C176 C238 C242
ZN		ZINC(2+)	2qxb	B	C176 C238 C242
ZN		ZINC(2+)	2qxb	C	C176 C238 C242
ZN		ZINC(2+)	2qxb	D	C176 C238 C242
ZN		ZINC(2+)	2qxc	A	C176 C238 C242
ZN		ZINC(2+)	2qxc	B	C176 C238 C242
ZN		ZINC(2+)	2qxc	C	C176 C238 C242
ZN		ZINC(2+)	2qxc	D	C176 C238 C242
ZN		ZINC(2+)	2vuk	A	C176 C238 C242
ZN		ZINC(2+)	2vuk	B	C176 C238 C242
ZN		ZINC(2+)	2x0u	A	C176 C238 C242
ZN		ZINC(2+)	2x0u	B	C176 C238 C242
ZN		ZINC(2+)	2x0v	A	C176 C238 C242
ZN		ZINC(2+)	2x0v	B	C176 C238 C242
ZN		ZINC(2+)	2x0w	A	C176 C238 C242
ZN		ZINC(2+)	2x0w	B	C176 C238 C242
ZN		ZINC(2+)	2xwr	A	C176 C238 C242
ZN		ZINC(2+)	2xwr	B	C176 C238 C242
ZN		ZINC(2+)	2ybg	A	C176 C238 C242
ZN		ZINC(2+)	2ybg	B	C176 C238 C242
ZN		ZINC(2+)	2ybg	C	C176 C238 C242
ZN		ZINC(2+)	2ybg	D	C176 C238 C242
ZN		ZINC(2+)	3d05	A	C176 C238 C242
ZN		ZINC(2+)	3d06	A	C176 C238 C242
ZN		ZINC(2+)	3d07	A	C176 C238 C242
ZN		ZINC(2+)	3d07	B	C176 C238 C242
ZN		ZINC(2+)	3d08	A	C176 C238 C242
ZN		ZINC(2+)	3d09	A	C176 C238 C242
ZN		ZINC(2+)	3d0a	A	C176 C238 C242
ZN		ZINC(2+)	3d0a	B	C176 C238 C242
ZN		ZINC(2+)	3d0a	C	C176 C238 C242
ZN		ZINC(2+)	3d0a	D	C176 C238 C242
ZN		ZINC(2+)	3igk	A	C176 C238 C242
ZN		ZINC(2+)	3igl	A	C176 C238 C242
ZN		ZINC(2+)	3kmd	A	C176 C238 C242
ZN		ZINC(2+)	3kmd	B	C176 C238 C242
ZN		ZINC(2+)	3kmd	D	C176 C238 C242
ZN		ZINC(2+)	3kmd	C	C176 C238 C242
ZN		ZINC(2+)	3kz8	A	C176 C238 C242
ZN		ZINC(2+)	3kz8	B	C176 C238 C242
ZN		ZINC(2+)	3q01	A	C176 C238 C242
ZN		ZINC(2+)	3q01	B	C176 C238 C242
ZN		ZINC(2+)	3q05	A	C176 C238 C242
ZN		ZINC(2+)	3q05	B	C176 C238 C242
ZN		ZINC(2+)	3q05	C	C176 C238 C242
ZN		ZINC(2+)	3q05	D	C176 C238 C242
ZN		ZINC(2+)	3q06	A	C176 C238 C242
ZN		ZINC(2+)	3q06	B	C176 C238 C242
ZN		ZINC(2+)	3q06	C	C176 C238 C242
ZN		ZINC(2+)	3q06	D	C176 C238 C242
ZN		ZINC(2+)	3ts8	A	C176 C238 C242
ZN		ZINC(2+)	3ts8	B	C176 C238 C242
ZN		ZINC(2+)	3ts8	C	C176 C238 C242
ZN		ZINC(2+)	3ts8	D	C176 C238 C242
ZN		ZINC(2+)	4agl	A	C176 C238 C242
ZN		ZINC(2+)	4agl	B	C176 C238 C242
ZN		ZINC(2+)	4agm	A	C176 C238 C242
ZN		ZINC(2+)	4agm	B	C176 C238 C242
ZN		ZINC(2+)	4agn	A	C176 C238 C242
ZN		ZINC(2+)	4agn	B	C176 C238 C242
ZN		ZINC(2+)	4ago	A	C176 C238 C242
ZN		ZINC(2+)	4ago	B	C176 C238 C242
ZN		ZINC(2+)	4agp	A	C176 C238 C242
ZN		ZINC(2+)	4agp	B	C176 C238 C242
ZN		ZINC(2+)	4agq	A	C176 C238 C242
ZN		ZINC(2+)	4agq	B	C176 C238 C242
ZN		ZINC(2+)	3zme	A	C176 C238 C242
ZN		ZINC(2+)	3zme	B	C176 C238 C242
ZN		ZINC(2+)	4hje	A	C176 C238 C242
ZN		ZINC(2+)	4hje	B	C176 C238 C242
ZN		ZINC(2+)	4hje	C	C176 C238 C242
ZN		ZINC(2+)	4hje	D	C176 C238 C242
ZN		ZINC(2+)	4kvp	A	C176 C238 C242
ZN		ZINC(2+)	4kvp	B	C176 C238 C242
ZN		ZINC(2+)	4kvp	C	C176 C238 C242
ZN		ZINC(2+)	4kvp	D	C176 C238 C242
ZN		ZINC(2+)	4lo9	A	C176 C238 C242
ZN		ZINC(2+)	4lo9	B	C176 C238 C242
ZN		ZINC(2+)	4lo9	C	C176 C238 C242
ZN		ZINC(2+)	4lo9	D	C176 C238 C242
ZN		ZINC(2+)	4loe	A	C176 C238 C242
ZN		ZINC(2+)	4loe	B	C176 C238 C242
ZN		ZINC(2+)	4loe	C	C176 C238 C242
ZN		ZINC(2+)	4loe	D	C176 C238 C242
ZN		ZINC(2+)	4lof	A	C176 C238 C242
ZN		ZINC(2+)	4ibq	A	C176 C238 C242
ZN		ZINC(2+)	4ibq	B	C176 C238 C242
ZN		ZINC(2+)	4ibq	C	C176 C238 C242
ZN		ZINC(2+)	4ibq	D	C176 C238 C242
ZN		ZINC(2+)	4ibs	A	C176 C238 C242
ZN		ZINC(2+)	4ibs	B	C176 C238 C242
ZN		ZINC(2+)	4ibs	C	C176 C238 C242
ZN		ZINC(2+)	4ibs	D	C176 C238 C242
ZN		ZINC(2+)	4ibt	A	C176 C238 C242
ZN		ZINC(2+)	4ibt	B	C176 C238 C242
ZN		ZINC(2+)	4ibt	C	C176 C238 C242
ZN		ZINC(2+)	4ibt	D	C176 C238 C242
ZN		ZINC(2+)	4ibu	A	C176 C238 C242
ZN		ZINC(2+)	4ibu	B	C176 C238 C242
ZN		ZINC(2+)	4ibu	C	C176 C238 C242
ZN		ZINC(2+)	4ibu	D	C176 C238 C242
ZN		ZINC(2+)	4ibv	A	C176 C238 C242
ZN		ZINC(2+)	4ibw	A	C176 C238 C242
ZN		ZINC(2+)	4iby	A	C176 C238 C242
ZN		ZINC(2+)	4iby	B	C176 C238 C242
ZN		ZINC(2+)	4ibz	A	C176 C238 C242
ZN		ZINC(2+)	4ibz	B	C176 C238 C242
ZN		ZINC(2+)	4ibz	C	C176 C238 C242
ZN		ZINC(2+)	4ibz	D	C176 C238 C242
ZN		ZINC(2+)	4ijt	A	C176 C238 C242
ZN		ZINC(2+)	4mzi	A	C176 C238 C242
ZN		ZINC(2+)	4mzr	A	C176 C238 C242
ZN		ZINC(2+)	4mzr	B	C176 C238 C242
ZN		ZINC(2+)	4mzr	C	C176 C238 C242
ZN		ZINC(2+)	4mzr	D	C176 C238 C242
ZN		ZINC(2+)	2mej	B	C176 C238 C242
ZN		ZINC(2+)	4qo1	B	C176 C238 C242
ZN		ZINC(2+)	5a7b	A	C176 C238 C242
ZN		ZINC(2+)	5a7b	B	C176 C238 C242
ZN		ZINC(2+)	5ab9	A	C176 C238 C242
ZN		ZINC(2+)	5ab9	B	C176 C238 C242
ZN		ZINC(2+)	5aba	A	C176 C238 C242
ZN		ZINC(2+)	5aba	B	C176 C238 C242
ZN		ZINC(2+)	5aoi	A	C176 C238 C242
ZN		ZINC(2+)	5aoi	B	C176 C238 C242
ZN		ZINC(2+)	5aoj	A	C176 C238 C242
ZN		ZINC(2+)	5aoj	B	C176 C238 C242
ZN		ZINC(2+)	5aok	A	C176 C238 C242
ZN		ZINC(2+)	5aok	B	C176 C238 C242
ZN		ZINC(2+)	5aol	A	C176 C238 C242
ZN		ZINC(2+)	5aol	B	C176 C238 C242
ZN		ZINC(2+)	5aom	A	C176 C238 C242
ZN		ZINC(2+)	5aom	B	C176 C238 C242
ZN		ZINC(2+)	5ecg	A	C176 C238 C242
ZN		ZINC(2+)	5ecg	B	C176 C238 C242
UFV		3-BROMO-5-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE	5aol	A	F109 L145 V157 E221 T230 L257
NUC		Nucleic Acids	1tsr	C	K120
NUC		Nucleic Acids	1tup	C	K120
NUC		Nucleic Acids	3d0a	C	K120
NUC		Nucleic Acids	3q06	B	K120
NUC		Nucleic Acids	3q06	C	K120
NUC		Nucleic Acids	4ibu	C	K120
NUC		Nucleic Acids	4mzr	B	K120
NUC		Nucleic Acids	2ac0	C	K120 N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	2ahi	D	K120 N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	2ata	B	K120 N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	2ahi	C	K120 N239 S241 R273 C275 A276 C277 R280
NUC		Nucleic Acids	2ahi	B	K120 R248
NUC		Nucleic Acids	2ahi	C	K120 R248
NUC		Nucleic Acids	2ata	A	K120 R248
NUC		Nucleic Acids	3kmd	A	K120 R248
NUC		Nucleic Acids	3kmd	B	K120 R248
NUC		Nucleic Acids	3kmd	C	K120 R248
NUC		Nucleic Acids	3q05	C	K120 R248
NUC		Nucleic Acids	3ts8	B	K120 R248
NUC		Nucleic Acids	3ts8	C	K120 R248
NUC		Nucleic Acids	4hje	A	K120 R248
NUC		Nucleic Acids	4hje	C	K120 R248
NUC		Nucleic Acids	4mzr	C	K120 R248
NUC		Nucleic Acids	3kz8	A	K120 R248 R280
NUC		Nucleic Acids	3kz8	B	K120 R248 R280
NUC		Nucleic Acids	2ady	A	K120 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	2ady	B	K120 S241 R248 R273 C275 A276 C277 R280
UL7		1-{1-[(3-BROMO-5-CHLORO-2-HYDROXYPHENYL)METHYL] PIPERIDIN-4-YL}PIPERIDIN-4-OL	5aba	A	L145 D148 T150 E221 P223 T230
P86		2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4,6-DIIODOPHENOL	4agm	A	L145 D148 T150 P151 E221 P223 T230
UL7		1-{1-[(3-BROMO-5-CHLORO-2-HYDROXYPHENYL)METHYL] PIPERIDIN-4-YL}PIPERIDIN-4-OL	5aba	B	L145 D148 T150 P151 E221 P223 T230
FY8		N-(5-CHLORANYL-2-OXIDANYL-PHENYL)PIPERIDINE- 4-CARBOXAMIDE	5aom	A	L145 D148 T150 P151 E221 P223 T230
FY8		N-(5-CHLORANYL-2-OXIDANYL-PHENYL)PIPERIDINE- 4-CARBOXAMIDE	5aom	B	L145 D148 T150 P151 E221 P223 T230
KMN		2-[[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL]-6-ETHYNYL- 4-(3-PHENOXYPROP-1-YNYL)PHENOL	5a7b	B	L145 D148 T150 P151 P152 E221 P223
P74		TERT-BUTYL [3-(3-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4-HYDROXY-5-IODOPHENYL)PROP-2-YN-1-YL]CARBAMATE	4ago	A	L145 D148 T150 P151 P152 E221 P223 T230
P51		2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-6-IODO-4-(3-PHENOXYPROP-1-YN-1-YL)PHENOL	4agp	A	L145 D148 T150 P151 P152 E221 P223 T230
P96		2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-6-IODO-4-[3-(PHENYLAMINO)PROP-1-YN-1-YL]PHENOL	4agq	A	L145 D148 T150 P151 P152 E221 P223 T230
KMN		2-[[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL]-6-ETHYNYL- 4-(3-PHENOXYPROP-1-YNYL)PHENOL	5a7b	A	L145 D148 T150 P151 P152 E221 P223 T230
NXG		2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4-(3-HYDROXYPROP-1-YN-1-YL)-6-IODOPHENOL	4agn	A	L145 D148 T150 P151 P152 P153 E221 P223 T230
NXG		2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4-(3-HYDROXYPROP-1-YN-1-YL)-6-IODOPHENOL	4agn	B	L145 D148 T150 P151 P152 P153 E221 P223 T230
P74		TERT-BUTYL [3-(3-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4-HYDROXY-5-IODOPHENYL)PROP-2-YN-1-YL]CARBAMATE	4ago	B	L145 D148 T150 P151 P152 P153 E221 P223 T230
P51		2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-6-IODO-4-(3-PHENOXYPROP-1-YN-1-YL)PHENOL	4agp	B	L145 D148 T150 P151 P152 P153 E221 P223 T230
P96		2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-6-IODO-4-[3-(PHENYLAMINO)PROP-1-YN-1-YL]PHENOL	4agq	B	L145 D148 T150 P151 P152 P153 E221 P223 T230
QC5		2-(4-(4-FLUOROPHENYL)-5-(1H-PYRROL-1-YL)-1H- PYRAZOL-1-YL)-N,N-DIMETHYLETHANAMINE	3zme	A	L145 D148 T150 P151 P153 E221 P223 T230
92O		7-ETHYL-3-(PIPERIDIN-4-YL)-1H-INDOLE	5ab9	A	L145 D148 T150 P223 D228 T230
P83		1-(9-ETHYL-9H-CARBAZOL-3-YL)-N-METHYLMETHANAMINE	2vuk	B	L145 T150 P151 E221 P223 D228 T230
X0V		3,4-DIAMINOBENZOTRIFLUORIDE	2x0v	B	L145 T150 P151 E221 P223 T230
P84		2,4-BIS(IODANYL)-6-[[METHYL-(1-METHYLPIPERIDIN-4-YL)AMINO]METHYL}PHENOL	4agl	A	L145 T150 P151 E221 P223 T230
P84		2,4-BIS(IODANYL)-6-[[METHYL-(1-METHYLPIPERIDIN-4-YL)AMINO]METHYL}PHENOL	4agl	B	L145 T150 P151 E221 P223 T230
GOH		5-[2-CYCLOPROPYL-5-(1H-PYRROL-1-YL)-1,3- OXAZOL-4-YL]-1H-1,2,3,4-TETRAZOLE	5aok	A	L145 T150 P151 P152 E221 P223 T230
GOH		5-[2-CYCLOPROPYL-5-(1H-PYRROL-1-YL)-1,3- OXAZOL-4-YL]-1H-1,2,3,4-TETRAZOLE	5aok	B	L145 T150 P151 P152 E221 P223 T230
X0U		6,7-DIHYDRO-[1,4]DIOXINO[2,3-F][1,3]BENZOTHIAZOL-2-AMINE	2x0u	B	L145 T150 P151 P152 T155 P223 T230
QC5		2-(4-(4-FLUOROPHENYL)-5-(1H-PYRROL-1-YL)-1H- PYRAZOL-1-YL)-N,N-DIMETHYLETHANAMINE	3zme	B	L145 T150 P151 P153 E221 P223 T230
92O		7-ETHYL-3-(PIPERIDIN-4-YL)-1H-INDOLE	5ab9	B	L145 T150 P151 P223 D228 T230
P86		2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4,6-DIIODOPHENOL	4agm	B	L145 W146 D148 T150 P151 E221 P223 T230
Y0V		2-HYDROXY-3,5-DIIODO-4-(1H-PYRROL-1-YL) BENZOIC ACID	5aoj	A	L145 W146 T150 P151 E221 P223 T230
Y0V		2-HYDROXY-3,5-DIIODO-4-(1H-PYRROL-1-YL) BENZOIC ACID	5aoj	B	L145 W146 T150 P151 E221 P223 T230
NUC		Nucleic Acids	4ibw	A	N239 S241 R248 C275 A276 C277 R280
NUC		Nucleic Acids	2ac0	A	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	2ac0	D	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	2ata	C	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	2ata	D	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3d0a	C	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3d0a	D	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3kmd	A	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3kmd	B	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3kmd	D	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3kmd	C	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	4hje	A	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	4hje	C	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	4hje	D	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	4mzr	B	N239 S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	2ahi	A	N239 S241 R248 R273 C275 A276 R280
FY8		N-(5-CHLORANYL-2-OXIDANYL-PHENYL)PIPERIDINE- 4-CARBOXAMIDE	5aom	B	P151 P152 P153 T155
FY8		N-(5-CHLORANYL-2-OXIDANYL-PHENYL)PIPERIDINE- 4-CARBOXAMIDE	5aom	A	P151 P152 P153 T155 E221
NUC		Nucleic Acids	1tsr	A	Q165 Q167 H168
NUC		Nucleic Acids	1tup	A	Q165 Q167 H168
NUC		Nucleic Acids	4mzr	A	R248 R283
NUC		Nucleic Acids	3q06	C	S241 A276 C277 R280
NUC		Nucleic Acids	4ibu	B	S241 C275 A276 C277 R280
NUC		Nucleic Acids	4ibu	C	S241 C275 A276 C277 R280
NUC		Nucleic Acids	4ibu	D	S241 C275 A276 C277 R280
NUC		Nucleic Acids	4ibv	A	S241 C275 A276 C277 R280
NUC		Nucleic Acids	1tsr	C	S241 R248
NUC		Nucleic Acids	1tup	C	S241 R248
NUC		Nucleic Acids	4ibu	A	S241 R248 C275 A276 C277 R280
NUC		Nucleic Acids	1tsr	B	S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	1tup	B	S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	2ac0	B	S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	2ahi	B	S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3q05	B	S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3q06	B	S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3ts8	A	S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3ts8	D	S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	4hje	B	S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	4mzr	D	S241 R248 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3d0a	A	S241 R248 R273 C275 A276 R280
NUC		Nucleic Acids	3q05	A	S241 R248 R273 C275 A276 R280
NUC		Nucleic Acids	3q05	C	S241 R248 R273 C275 A276 R280
NUC		Nucleic Acids	3ts8	C	S241 R248 R273 C275 A276 R280
NUC		Nucleic Acids	4mzr	C	S241 R273 A276 C277 R280
NUC		Nucleic Acids	2ata	A	S241 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3d0a	B	S241 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3q05	D	S241 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3q06	A	S241 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3q06	D	S241 R273 C275 A276 C277 R280
NUC		Nucleic Acids	3ts8	B	S241 R273 C275 A276 R280
NUC		Nucleic Acids	4mzr	A	S241 R273 C275 A276 R280
NUC		Nucleic Acids	2ac0	B	T118 A119 K120 R248 G279 R280 R283
NUC		Nucleic Acids	2ady	B	T118 A119 K120 R248 R283
NUC		Nucleic Acids	2ahi	A	T123 K139
RZH		2-(5-BROMO-7-ETHYL-2-METHYL-1H-INDOLE-3-YL) ETHAN-1-AMIN	5aoi	B	T150 P151 P152 E221 P223
92O		7-ETHYL-3-(PIPERIDIN-4-YL)-1H-INDOLE	5ab9	A	T150 P151 P152 P153
92O		7-ETHYL-3-(PIPERIDIN-4-YL)-1H-INDOLE	5ab9	B	T150 P151 P152 P153
X0V		3,4-DIAMINOBENZOTRIFLUORIDE	2x0v	B	T150 P151 P152 P153 T155 E221
X0W		5,6-DIMETHOXY-2-METHYL-BENZOTHIAZOLE	2x0w	B	T150 P151 P223
NUC		Nucleic Acids	3q05	A	V122 R248 R283
NUC		Nucleic Acids	3q06	A	V122 R248 R283
NUC		Nucleic Acids	3q05	D	V122 R283
NUC		Nucleic Acids	2ac0	A	V122 T123
NUC		Nucleic Acids	2ata	A	V122 T123

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Conservation information for LBS of TP53

Multiple alignments for P04637 in multiple species

LBS	AA sequence	# species	Species
A119	LHSGTAKSVTC	2	Homo sapiens, Macaca mulatta
A119	LQSGTAKSVMC	2	Mus musculus, Rattus norvegicus
A119	LQSGTAKSVTC	1	Bos taurus
A119	LHSGTAKSVTW	1	Canis lupus familiaris
A276	EVRVCACPGRD	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
C176	EVVRRCPHHER	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
C229	EVGSDCTTIHY	2	Homo sapiens, Macaca mulatta
C229	EVGSDYTTIHY	2	Rattus norvegicus, Canis lupus familiaris
C229	EAGSEYTTIHY	1	Mus musculus
C229	EIDSECTTIHY	1	Bos taurus
C238	HYNYMCNSSCM	3	Homo sapiens, Canis lupus familiaris, Macaca mulatta
C238	HYKYMCNSSCM	2	Mus musculus, Rattus norvegicus
C238	HYNFMCNSSCM	1	Bos taurus
C242	MCNSSCMGGMN	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
C275	FEVRVCACPGR	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
C277	VRVCACPGRDR	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
D148	VQLWVDSTPPP	2	Homo sapiens, Macaca mulatta
D148	VQLWVSATPPA	1	Mus musculus
D148	VQLWVTSTPPP	1	Rattus norvegicus
D148	VQLWVDSPPPP	1	Bos taurus
D148	VQLWVSSPPPP	1	Canis lupus familiaris
D228	PEVGSDCTTIH	2	Homo sapiens, Macaca mulatta
D228	PEVGSDYTTIH	2	Rattus norvegicus, Canis lupus familiaris
D228	PEAGSEYTTIH	1	Mus musculus
D228	PEIDSECTTIH	1	Bos taurus
E221	VVVPYEPPEVG	4	Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta
E221	VVVPYEPPEAG	1	Mus musculus
E221	VVVPYESPEID	1	Bos taurus
F109	QGNYGFHLGFL	2	Mus musculus, Rattus norvegicus
F109	QGSYGFRLGFL	1	Homo sapiens
F109	PGNYGFRLGFL	1	Bos taurus
F109	PGTYGFRLGFL	1	Canis lupus familiaris
F109	HGSYGFRLGFL	1	Macaca mulatta
G279	VCACPGRDRRT	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
H168	YKQSQHMTEVV	2	Homo sapiens, Macaca mulatta
H168	YKKSQHMTEVV	2	Mus musculus, Rattus norvegicus
H168	YKKLEHMTEVV	1	Bos taurus
H168	YKKSEFVTEVV	1	Canis lupus familiaris
K120	HSGTAKSVTCT	2	Homo sapiens, Macaca mulatta
K120	QSGTAKSVMCT	2	Mus musculus, Rattus norvegicus
K120	QSGTAKSVTCT	1	Bos taurus
K120	HSGTAKSVTWT	1	Canis lupus familiaris
K139	FCQLAKTCPVQ	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
L145	TCPVQLWVDST	2	Homo sapiens, Macaca mulatta
L145	TCPVQLWVSAT	1	Mus musculus
L145	TCPVQLWVTST	1	Rattus norvegicus
L145	TCPVQLWVDSP	1	Bos taurus
L145	TCPVQLWVSSP	1	Canis lupus familiaris
L257	LTIITLEDSSG	5	Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta
L257	LTIITLEDSCG	1	Bos taurus
M243	CNSSCMGGMNR	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
N239	YNYMCNSSCMG	3	Homo sapiens, Canis lupus familiaris, Macaca mulatta
N239	YKYMCNSSCMG	2	Mus musculus, Rattus norvegicus
N239	YNFMCNSSCMG	1	Bos taurus
P151	WVDSTPPPGTR	1	Homo sapiens
P151	WVSATPPAGSR	1	Mus musculus
P151	WVTSTPPPGTR	1	Rattus norvegicus
P151	WVDSPPPPGTR	1	Bos taurus
P151	WVSSPPPPNTC	1	Canis lupus familiaris
P151	WVDSTPPPGSR	1	Macaca mulatta
P152	VDSTPPPGTRV	1	Homo sapiens
P152	VSATPPAGSRV	1	Mus musculus
P152	VTSTPPPGTRV	1	Rattus norvegicus
P152	VDSPPPPGTRV	1	Bos taurus
P152	VSSPPPPNTCV	1	Canis lupus familiaris
P152	VDSTPPPGSRV	1	Macaca mulatta
P153	DSTPPPGTRVR	1	Homo sapiens
P153	SATPPAGSRVR	1	Mus musculus
P153	TSTPPPGTRVR	1	Rattus norvegicus
P153	DSPPPPGTRVR	1	Bos taurus
P153	SSPPPPNTCVR	1	Canis lupus familiaris
P153	DSTPPPGSRVR	1	Macaca mulatta
P222	VVPYEPPEVGS	4	Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta
P222	VVPYEPPEAGS	1	Mus musculus
P222	VVPYESPEIDS	1	Bos taurus
P223	VPYEPPEVGSD	4	Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta
P223	VPYEPPEAGSE	1	Mus musculus
P223	VPYESPEIDSE	1	Bos taurus
Q165	MAIYKQSQHMT	2	Homo sapiens, Macaca mulatta
Q165	MAIYKKSQHMT	2	Mus musculus, Rattus norvegicus
Q165	MAIYKKLEHMT	1	Bos taurus
Q165	MAIYKKSEFVT	1	Canis lupus familiaris
Q167	IYKQSQHMTEV	2	Homo sapiens, Macaca mulatta
Q167	IYKKSQHMTEV	2	Mus musculus, Rattus norvegicus
Q167	IYKKLEHMTEV	1	Bos taurus
Q167	IYKKSEFVTEV	1	Canis lupus familiaris
R248	MGGMNRRPILT	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
R273	NSFEVRVCACP	4	Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta
R273	DSFEVRVCACP	2	Mus musculus, Rattus norvegicus
R280	CACPGRDRRTE	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
R283	PGRDRRTEEEN	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
S121	SGTAKSVTCTY	3	Homo sapiens, Bos taurus, Macaca mulatta
S121	SGTAKSVMCTY	2	Mus musculus, Rattus norvegicus
S121	SGTAKSVTWTY	1	Canis lupus familiaris
S149	QLWVDSTPPPG	2	Homo sapiens, Macaca mulatta
S149	QLWVSATPPAG	1	Mus musculus
S149	QLWVTSTPPPG	1	Rattus norvegicus
S149	QLWVDSPPPPG	1	Bos taurus
S149	QLWVSSPPPPN	1	Canis lupus familiaris
S241	YMCNSSCMGGM	5	Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta
S241	FMCNSSCMGGM	1	Bos taurus
T118	FLHSGTAKSVT	3	Homo sapiens, Canis lupus familiaris, Macaca mulatta
T118	FLQSGTAKSVM	2	Mus musculus, Rattus norvegicus
T118	FLQSGTAKSVT	1	Bos taurus
T123	TAKSVTCTYSP	3	Homo sapiens, Bos taurus, Macaca mulatta
T123	TAKSVMCTYSP	1	Mus musculus
T123	TAKSVMCTYSI	1	Rattus norvegicus
T123	TAKSVTWTYSP	1	Canis lupus familiaris
T150	LWVDSTPPPGT	1	Homo sapiens
T150	LWVSATPPAGS	1	Mus musculus
T150	LWVTSTPPPGT	1	Rattus norvegicus
T150	LWVDSPPPPGT	1	Bos taurus
T150	LWVSSPPPPNT	1	Canis lupus familiaris
T150	LWVDSTPPPGS	1	Macaca mulatta
T155	TPPPGTRVRAM	2	Homo sapiens, Rattus norvegicus
T155	TPPAGSRVRAM	1	Mus musculus
T155	PPPPGTRVRAM	1	Bos taurus
T155	PPPPNTCVRAM	1	Canis lupus familiaris
T155	TPPPGSRVRAM	1	Macaca mulatta
T230	VGSDCTTIHYN	2	Homo sapiens, Macaca mulatta
T230	AGSEYTTIHYK	1	Mus musculus
T230	VGSDYTTIHYK	1	Rattus norvegicus
T230	IDSECTTIHYN	1	Bos taurus
T230	VGSDYTTIHYN	1	Canis lupus familiaris
V122	GTAKSVTCTYS	3	Homo sapiens, Bos taurus, Macaca mulatta
V122	GTAKSVMCTYS	2	Mus musculus, Rattus norvegicus
V122	GTAKSVTWTYS	1	Canis lupus familiaris
V147	PVQLWVDSTPP	2	Homo sapiens, Macaca mulatta
V147	PVQLWVSATPP	1	Mus musculus
V147	PVQLWVTSTPP	1	Rattus norvegicus
V147	PVQLWVDSPPP	1	Bos taurus
V147	PVQLWVSSPPP	1	Canis lupus familiaris
V157	PPGTRVRAMAI	3	Homo sapiens, Rattus norvegicus, Bos taurus
V157	PAGSRVRAMAI	1	Mus musculus
V157	PPNTCVRAMAI	1	Canis lupus familiaris
V157	PPGSRVRAMAI	1	Macaca mulatta
W146	CPVQLWVDSTP	2	Homo sapiens, Macaca mulatta
W146	CPVQLWVSATP	1	Mus musculus
W146	CPVQLWVTSTP	1	Rattus norvegicus
W146	CPVQLWVDSPP	1	Bos taurus
W146	CPVQLWVSSPP	1	Canis lupus familiaris