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mutLBSgeneDB |
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| Gene summary for HSP90B1 |
 Gene summary |
| Basic gene Info. | Gene symbol | HSP90B1 |
| Gene name | heat shock protein 90kDa beta (Grp94), member 1 | |
| Synonyms | ECGP|GP96|GRP94|HEL-S-125m|HEL35|TRA1 | |
| Cytomap | UCSC genome browser: 12q24.2-q24.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003299.2, | |
| Description | 94 kDa glucose-regulated proteinendoplasminendothelial cell (HBMEC) glycoproteinepididymis luminal protein 35epididymis secretory sperm binding protein Li 125mheat shock protein 90 kDa beta member 1stress-inducible tumor rejection antigen gp96tumor | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 191175 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000166598 | ||
| HPRD : 01860 | ||
| Vega : OTTHUMG00000170118 | ||
| Protein | UniProt: P14625 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HSP90B1 | |
| BioGPS: 7184 | ||
| Pathway | NCI Pathway Interaction Database: HSP90B1 | |
| KEGG: HSP90B1 | ||
| REACTOME: HSP90B1 | ||
| Pathway Commons: HSP90B1 | ||
| Context | iHOP: HSP90B1 | |
| ligand binding site mutation search in PubMed: HSP90B1 | ||
| UCL Cancer Institute: HSP90B1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0001666 | response to hypoxia | 15620698 | GO:0031247 | actin rod assembly | 19000834 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 19000834 | GO:0071318 | cellular response to ATP | 19000834 |
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| Ligand binding site mutations for HSP90B1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A111 | D113E | COAD | 1 | Y200 | Y200F | COAD | 1 | W223 | E224K | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for HSP90B1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | W223 | E224K | -1.0030538 | Y200 | Y200F | -0.46905518 | A111 | D113E | -0.34353756 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for HSP90B1 from PDB |
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| Differential gene expression and gene-gene network for HSP90B1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for HSP90B1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0033578 | Prostatic Neoplasms | 2 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for HSP90B1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved | DB00615 | Rifabutin | Small molecule |  |
| Experimental | DB02103 | 2-Chlorodideoxyadenosine | Small molecule |  |
| Experimental | DB02935 | 1-Methoxy-2-(2-Methoxyethoxy)Ethane | Small molecule |  |
| Experimental | DB03719 | N-Ethyl-5'-Carboxamido Adenosine | Small molecule |  |
| Experimental | DB03758 | Radicicol | Small molecule |  |
| Experimental | DB08464 | METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE | Small molecule |  |
| Experimental | DB08465 | 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of HSP90B1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 2LC | 2-FLUORO-6-[(3S)-TETRAHYDROFURAN-3-YLAMINO]-4-(3,6,6- TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOL-1-YL) BENZAMIDE | 4nh9 | A | A111 Y200 W223 |
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| Conservation information for LBS of HSP90B1 |
| Multiple alignments for P14625 in multiple species |
| LBS | AA sequence | # species | Species | A108 | ELISNASDALD | 7 | Homo sapiens, Caenorhabditis elegans, Gallus gallus, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | A111 | SNASDALDKIR | 7 | Homo sapiens, Caenorhabditis elegans, Gallus gallus, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | D149 | LLHVTDTGVGM | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | D149 | LLHITDTGVGM | 1 | Caenorhabditis elegans | D149 | MLHVTDTGIGM | 1 | Gallus gallus | E158 | GMTREELVKNL | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | E158 | GMTRQDLINNL | 1 | Caenorhabditis elegans | E158 | GMTKEELIKNL | 1 | Gallus gallus | F199 | QFGVGFYSAFL | 6 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | F199 | QFGVGFYAAFL | 1 | Caenorhabditis elegans | I247 | GRGTTITLVLK | 6 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | I247 | KRGTQITLYLK | 1 | Caenorhabditis elegans | M154 | DTGVGMTREEL | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | M154 | DTGVGMTRQDL | 1 | Caenorhabditis elegans | M154 | DTGIGMTKEEL | 1 | Gallus gallus | N107 | RELISNASDAL | 7 | Homo sapiens, Caenorhabditis elegans, Gallus gallus, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | T245 | TLGRGTTITLV | 6 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | T245 | TLKRGTQITLY | 1 | Caenorhabditis elegans | V211 | ADKVIVTSKHN | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | V211 | ADRVVVTTKNN | 1 | Caenorhabditis elegans | V211 | ADRVIVTSKHN | 1 | Gallus gallus | W223 | DTQHIWESDSN | 6 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | W223 | DDQYIWESDSA | 1 | Caenorhabditis elegans | Y200 | FGVGFYSAFLV | 6 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | Y200 | FGVGFYAAFLV | 1 | Caenorhabditis elegans |
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