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mutLBSgeneDB |
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| Gene summary for TRIP6 |
 Gene summary |
| Basic gene Info. | Gene symbol | TRIP6 |
| Gene name | thyroid hormone receptor interactor 6 | |
| Synonyms | OIP-1|OIP1|TRIP-6|TRIP6i2|ZRP-1 | |
| Cytomap | UCSC genome browser: 7q22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003302.2, | |
| Description | OPA-interacting protein 1TR-interacting protein 6thyroid hormone receptor interacting protein 6thyroid receptor-interacting protein 6zyxin related protein 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602933 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000087077 | ||
| HPRD : 04242 | ||
| Vega : OTTHUMG00000157029 | ||
| Protein | UniProt: Q15654 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TRIP6 | |
| BioGPS: 7205 | ||
| Pathway | NCI Pathway Interaction Database: TRIP6 | |
| KEGG: TRIP6 | ||
| REACTOME: TRIP6 | ||
| Pathway Commons: TRIP6 | ||
| Context | iHOP: TRIP6 | |
| ligand binding site mutation search in PubMed: TRIP6 | ||
| UCL Cancer Institute: TRIP6 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0008588 | release of cytoplasmic sequestered NF-kappaB | 15657077 |
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| Ligand binding site mutations for TRIP6 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C339 | A340V | COAD | 1 | C279 | Q278R | COAD | 1 | H359 | P360H | STAD | 1 | H359 | Y358C | STAD | 1 | C362 | C362S | STAD | 1 | C310 | T309A | STAD | 1 | C368 | R370C | STAD | 1 | H301 | V299A | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TRIP6 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H301 | V299A | -1.7434258 | C362 | C362S | -1.3688933 | H359 | Y358C | -1.1560921 | C339 | A340V | -0.73015896 | C310 | T309A | -0.7186264 | H359 | P360H | -0.68855591 | C279 | Q278R | -0.67744487 | C368 | R370C | -0.25557267 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TRIP6 from PDB |
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| Differential gene expression and gene-gene network for TRIP6 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TRIP6 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TRIP6 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TRIP6 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of TRIP6 |
| Multiple alignments for Q15654 in multiple species |
| LBS | AA sequence | # species | Species | C279 | EYFGRCGGCGE | 2 | Mus musculus, Bos taurus | C279 | EYFGQCGGCGE | 1 | Homo sapiens | C282 | GRCGGCGEDVV | 2 | Mus musculus, Bos taurus | C282 | GQCGGCGEDVV | 1 | Homo sapiens | C304 | VFHVGCFVCST | 2 | Homo sapiens, Bos taurus | C304 | VFHIGCFVCST | 1 | Mus musculus | C307 | VGCFVCSTCRA | 2 | Homo sapiens, Bos taurus | C307 | IGCFVCSTCRA | 1 | Mus musculus | C310 | FVCSTCRAQLR | 3 | Homo sapiens, Mus musculus, Bos taurus | C328 | ERRAYCESCYV | 2 | Mus musculus, Bos taurus | C328 | ERRAYCEGCYV | 1 | Homo sapiens | C331 | AYCESCYVATL | 2 | Mus musculus, Bos taurus | C331 | AYCEGCYVATL | 1 | Homo sapiens | C339 | ATLEKCATCSQ | 1 | Homo sapiens | C339 | ATLEKCSTCSE | 1 | Mus musculus | C339 | ATLEKCSTCSQ | 1 | Bos taurus | C342 | EKCATCSQPIL | 1 | Homo sapiens | C342 | EKCSTCSEPIL | 1 | Mus musculus | C342 | EKCSTCSQPIL | 1 | Bos taurus | C362 | AYHPGCFTCVV | 3 | Homo sapiens, Mus musculus, Bos taurus | C365 | PGCFTCVVCHR | 3 | Homo sapiens, Mus musculus, Bos taurus | C368 | FTCVVCHRGLD | 3 | Homo sapiens, Mus musculus, Bos taurus | C387 | TSQIHCIEDFH | 3 | Homo sapiens, Mus musculus, Bos taurus | D390 | IHCIEDFHRKF | 3 | Homo sapiens, Mus musculus, Bos taurus | H301 | LDRVFHVGCFV | 2 | Homo sapiens, Bos taurus | H301 | LDRVFHIGCFV | 1 | Mus musculus | H359 | MGKAYHPGCFT | 3 | Homo sapiens, Mus musculus, Bos taurus |
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