mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TSG101
Gene summary
Basic gene Info.Gene symbolTSG101
Gene nametumor susceptibility 101
CytomapUCSC genome browser: 11p15
Type of geneprotein-coding
DescriptionESCRT-I complex subunit TSG101tumor susceptibility gene 10tumor susceptibility gene 101tumor susceptibility gene 101 proteintumor susceptibility protein
Modification date20141207
dbXrefs MIM : 601387
Ensembl : ENSG00000074319
HPRD : 03229
Vega : OTTHUMG00000167725
ProteinUniProt: Q99816
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TSG101
BioGPS: 7251
PathwayNCI Pathway Interaction Database: TSG101
Pathway Commons: TSG101
ContextiHOP: TSG101
ligand binding site mutation search in PubMed: TSG101
UCL Cancer Institute: TSG101
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0043162ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway15611048

Ligand binding site mutations for TSG101

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for TSG101
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TSG101 from PDB

Differential gene expression and gene-gene network for TSG101
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TSG101 and the right PPI network was created from samples without mutations in the LBS of TSG101. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for TSG101
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0346153Breast Cancer, Familial3Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for TSG101
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TSG101 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (ACE,PRO,GLU,PRO,THR,ALA,PRO,PRO,GLU,GLU,NH2)3p9gAD34 K36 P71 S143
IIIPeptide ligand (ACE,PRO,GLU,PRO,THR,ALA,PRO,PRO,GLU,GLU,NH2)3p9hAD34 P71 S143
IIIPeptide ligand (PRO,GLU,PRO,THR,ALA,PRO,PRO,GLU,GLU)3obuAD34 S143
IIIPeptide ligand (PRO,GLU,ALA,THR,ALA,PRO,PRO,GLU,GLU)3obxAD34 S143
IIIPeptide ligand (ILE,LEU,PRO,THR,ALA,PRO,PRO,GLU,TYR)4ejeAD34 S143
IIIPeptide ligand (ILE,LEU,PRO,THR,ALA,PRO,PRO,GLU,TYR)4ejeBD34 S143
IIIPeptide ligand (PRO,GLU,PRO,THR,ALA,PRO,PRO,GLU,GLU)1m4pAP71 S143
IIIPeptide ligand (PRO,GLU,PRO,THR,ALA,PRO,PRO,GLU,GLU)1m4qAP71 S143

Conservation information for LBS of TSG101
Multiple alignments for Q99816 in multiple species
LBSAA sequence# speciesSpecies
D19KYKYRD----L3Homo sapiens, Mus musculus, Rattus norvegicus
D19SVPYEESNKWL1Arabidopsis thaliana
D19ALPYAENTKSL1Arabidopsis thaliana
D34IAMYKDLKPVL2Mus musculus, Rattus norvegicus
D34ITLYKDLKPVL1Homo sapiens
D34ISSYPSLEPKT1Arabidopsis thaliana
D34ISSYTSLDPKT1Arabidopsis thaliana
E138VIFGEEPPVFS2Mus musculus, Rattus norvegicus
E138VVFGDEPPVFS1Homo sapiens
E138AAFARDPPLYS1Arabidopsis thaliana
E138AAFSRDPPLYS1Arabidopsis thaliana
F142EEPPVFSRPTV2Mus musculus, Rattus norvegicus
F142DEPPVFSRP-I1Homo sapiens
F142RDPPLYSRR--1Arabidopsis thaliana
F142RDPPLYSQR--1Arabidopsis thaliana
G57LVNLTGTIPVR2Mus musculus, Rattus norvegicus
G57LLQADGTIPMP2Arabidopsis thaliana, Arabidopsis thaliana
G57LMNLTGTIPVP1Homo sapiens
H102KTGK-HVDANG3Homo sapiens, Mus musculus, Rattus norvegicus
H102KRPHAHVTPSG1Arabidopsis thaliana
H102KRPHSNVSPSG1Arabidopsis thaliana
I70GNIYNIPICLW2Mus musculus, Rattus norvegicus
I70GNTYNIPICLW1Homo sapiens
I70GVTYNIPVIIW1Arabidopsis thaliana
I70GVSYNIPVVIW1Arabidopsis thaliana
K16--SKYKYRD--3Homo sapiens, Mus musculus, Rattus norvegicus
K16GPSSVPYEESN1Arabidopsis thaliana
K16GPSALPYAENT1Arabidopsis thaliana
K36MYKDLKPVLDS2Mus musculus, Rattus norvegicus
K36LYKDLKPVLDS1Homo sapiens
K36SYPSLEPKTAS1Arabidopsis thaliana
K36SYTSLDPKTAT1Arabidopsis thaliana
K90PICFVKPTSSM3Homo sapiens, Mus musculus, Rattus norvegicus
K90PCVYVNPTADM1Arabidopsis thaliana
K90PCVYVNPTRDM1Arabidopsis thaliana
M95KPTSSMTIKTG3Homo sapiens, Mus musculus, Rattus norvegicus
M95NPTADMIIKRP1Arabidopsis thaliana
M95NPTRDMIIKRP1Arabidopsis thaliana
N69RGNIYNIPICL2Mus musculus, Rattus norvegicus
N69RGNTYNIPICL1Homo sapiens
N69HGVTYNIPVII1Arabidopsis thaliana
N69QGVSYNIPVVI1Arabidopsis thaliana
P139IFGEEPPVFSR2Mus musculus, Rattus norvegicus
P139VFGDEPPVFSR1Homo sapiens
P139AFARDPPLYSR1Arabidopsis thaliana
P139AFSRDPPLYSQ1Arabidopsis thaliana
P71NIYNIPICLWL2Mus musculus, Rattus norvegicus
P71NTYNIPICLWL1Homo sapiens
P71VTYNIPVIIWL1Arabidopsis thaliana
P71VSYNIPVVIWL1Arabidopsis thaliana
R18SKYKYRD----3Homo sapiens, Mus musculus, Rattus norvegicus
R18SSVPYEESNKW1Arabidopsis thaliana
R18SALPYAENTKS1Arabidopsis thaliana
R64IPVRYRGNIYN2Mus musculus, Rattus norvegicus
R64IPVPYRGNTYN1Homo sapiens
R64IPMPFHGVTYN1Arabidopsis thaliana
R64IPMPFQGVSYN1Arabidopsis thaliana
S143EPPVFSRPTVS2Mus musculus, Rattus norvegicus
S143EPPVFSRP-IS1Homo sapiens
S143DPPLYSRR---1Arabidopsis thaliana
S143DPPLYSQR---1Arabidopsis thaliana
S49FNDGSSRELVN2Mus musculus, Rattus norvegicus
S49FNDGSSRELMN1Homo sapiens
S49HNDGRSVNLLQ1Arabidopsis thaliana
S49HNDGRSVILLQ1Arabidopsis thaliana
T56ELVNLTGTIPV2Mus musculus, Rattus norvegicus
T56ELMNLTGTIPV1Homo sapiens
T56NLLQADGTIPM1Arabidopsis thaliana
T56ILLQADGTIPM1Arabidopsis thaliana
T58VNLTGTIPVRY2Mus musculus, Rattus norvegicus
T58LQADGTIPMPF2Arabidopsis thaliana, Arabidopsis thaliana
T58MNLTGTIPVPY1Homo sapiens
T92CFVKPTSSMTI3Homo sapiens, Mus musculus, Rattus norvegicus
T92VYVNPTADMII1Arabidopsis thaliana
T92VYVNPTRDMII1Arabidopsis thaliana
T96PTSSMTIKTGK3Homo sapiens, Mus musculus, Rattus norvegicus
T96PTADMIIKRPH1Arabidopsis thaliana
T96PTRDMIIKRPH1Arabidopsis thaliana
V141GEEPPVFSRPT2Mus musculus, Rattus norvegicus
V141GDEPPVFSRP-1Homo sapiens
V141ARDPPLYSRR-1Arabidopsis thaliana
V141SRDPPLYSQR-1Arabidopsis thaliana
V61TGTIPVRYRGN2Mus musculus, Rattus norvegicus
V61TGTIPVPYRGN1Homo sapiens
V61DGTIPMPFHGV1Arabidopsis thaliana
V61DGTIPMPFQGV1Arabidopsis thaliana
Y63TIPVRYRGNIY2Mus musculus, Rattus norvegicus
Y63TIPVPYRGNTY1Homo sapiens
Y63TIPMPFHGVTY1Arabidopsis thaliana
Y63TIPMPFQGVSY1Arabidopsis thaliana
Y68YRGNIYNIPIC2Mus musculus, Rattus norvegicus
Y68YRGNTYNIPIC1Homo sapiens
Y68FHGVTYNIPVI1Arabidopsis thaliana
Y68FQGVSYNIPVV1Arabidopsis thaliana

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