mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TSTA3
Gene summary
Basic gene Info.Gene symbolTSTA3
Gene nametissue specific transplantation antigen P35B
SynonymsFX|P35B|SDR4E1
CytomapUCSC genome browser: 8q24.3
Type of geneprotein-coding
RefGenesNM_003313.3,
Description3-5 epimerase/4-reductaseGDP-4-keto-6-deoxy-D-mannose epimerase-reductaseGDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductaseGDP-L-fucose synthasered cell NADP(H)-binding proteinshort chain dehydrogenase/reductase family 4E, member 1tissue specifi
Modification date20141207
dbXrefs MIM : 137020
HGNC : HGNC
Ensembl : ENSG00000104522
HPRD : 00654
Vega : OTTHUMG00000165159
ProteinUniProt: Q13630
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TSTA3
BioGPS: 7264
PathwayNCI Pathway Interaction Database: TSTA3
KEGG: TSTA3
REACTOME: TSTA3
Pathway Commons: TSTA3
ContextiHOP: TSTA3
ligand binding site mutation search in PubMed: TSTA3
UCL Cancer Institute: TSTA3
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0019673GDP-mannose metabolic process9525924
GO:0042351'de novo' GDP-L-fucose biosynthetic process9525924


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Ligand binding site mutations for TSTA3

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
M93M93IHNSC1
S114,C116T115ISKCM1
K194H196RSTAD1
R215,P213R214WSTAD1
I252V250ISTAD1
M93V91MSTAD1
Y143S144WUCEC1
N79I80SUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TSTA3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
N79I80S-1.6109906
I252V250I-1.211701
M93V91M-0.92894806
R215R214W-0.71533277
P213R214W-0.71533277
C116T115I-0.59073914
S114T115I-0.59073914
M93M93I-0.56353805
Y143S144W-0.21097974
K194H196R-0.19416307
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TSTA3 from PDB

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Differential gene expression and gene-gene network for TSTA3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TSTA3 and the right PPI network was created from samples without mutations in the LBS of TSTA3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TSTA3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TSTA3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
NutraceuticalDB00157NADHSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TSTA3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
GFBGDP-L-FUCOSE4bl5AC116 Y143 K194 P213 R215 I252
GFBGDP-L-FUCOSE4bl5IC116 Y143 K194 P213 R215 I252
GFBGDP-L-FUCOSE4bl5LC116 Y143 K194 R215
GFBGDP-L-FUCOSE4bl5EC116 Y143 K194 R215 I252
GDPGUANOSINE-5'-DIPHOSPHATE4b8zCK194 P213 R215
GDPGUANOSINE-5'-DIPHOSPHATE4b8zDK194 P213 R215
GDPGUANOSINE-5'-DIPHOSPHATE4b8zAK194 P213 R215 I252
GDPGUANOSINE-5'-DIPHOSPHATE4b8zBK194 P213 R215 I252
NAPNADP ZWITTERION4b8zAM93 S114 Y143
NAPNADP ZWITTERION4b8zBM93 S114 Y143
NAPNADP ZWITTERION4b8zCM93 S114 Y143
NAPNADP ZWITTERION4b8zDM93 S114 Y143
NDPNADPH4e5yCM93 S114 Y143
NAPNADP ZWITTERION4bl5AM93 S114 Y143
NAPNADP ZWITTERION4bl5BM93 S114 Y143
NAPNADP ZWITTERION4bl5CM93 S114 Y143
NAPNADP ZWITTERION4bl5DM93 S114 Y143
NAPNADP ZWITTERION4bl5FM93 S114 Y143
NAPNADP ZWITTERION4bl5GM93 S114 Y143
NAPNADP ZWITTERION4bl5IM93 S114 Y143
NAPNADP ZWITTERION4bl5KM93 S114 Y143
NAPNADP ZWITTERION4bl5LM93 S114 Y143
NAPNADP ZWITTERION4b8wAM93 Y143
NAPNADP ZWITTERION4bkpAM93 Y143
NAPNADP ZWITTERION4bkpBM93 Y143
NAPNADP ZWITTERION4bkpCM93 Y143
NAPNADP ZWITTERION4bkpDM93 Y143
NAPNADP ZWITTERION4bl5EM93 Y143
NAPNADP ZWITTERION4bl5HM93 Y143
GFBGDP-L-FUCOSE4bl5BN79 C116 Y143 K194 P213 R215 I252
GFBGDP-L-FUCOSE4bl5FN79 C116 Y143 K194 P213 R215 I252
GFBGDP-L-FUCOSE4bl5HN79 C116 Y143 K194 P213 R215 I252
GFBGDP-L-FUCOSE4bl5KN79 C116 Y143 K194 P213 R215 I252
GFBGDP-L-FUCOSE4bl5JN79 C116 Y143 K194 R215 I252
GFBGDP-L-FUCOSE4bl5CN79 S114 C116 Y143 K194 R215 I252
GDPGUANOSINE-5'-DIPHOSPHATE4b8wAP213 R215 I252
GDPGUANOSINE-5'-DIPHOSPHATE4b8wBR215 I252
GFBGDP-L-FUCOSE4bl5GS114 C116 Y143 K194 P213 R215 I252
GFBGDP-L-FUCOSE4bl5DS114 C116 Y143 K194 R215 I252
NAPNADP ZWITTERION4b8wBS114 Y143
NDPNADPH4e5yAS114 Y143
NDPNADPH4e5yBS114 Y143
NDPNADPH4e5yDS114 Y143
NAPNADP ZWITTERION4bl5JS114 Y143


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Conservation information for LBS of TSTA3
Multiple alignments for Q13630 in multiple species
LBSAA sequence# speciesSpecies
A46VSSKDADLTDT1Homo sapiens
A46KTHAELDLTRQ1Arabidopsis thaliana
A46RTHAELDLTRQ1Oryza sativa subsp. japonica
A46AGSKDADLTNL1Drosophila melanogaster
A46VSSKDADLTDA1Mus musculus
A70HVIHLAAMVGG3Homo sapiens, Drosophila melanogaster, Mus musculus
A70YVILAAAKVGG1Arabidopsis thaliana
A70YVVLAAAKVGG1Oryza sativa subsp. japonica
A71VIHLAAMVGGL3Homo sapiens, Drosophila melanogaster, Mus musculus
A71VILAAAKVGGI1Arabidopsis thaliana
A71VVLAAAKVGGI1Oryza sativa subsp. japonica
C112RKVVSCLSTCI2Homo sapiens, Mus musculus
C112KKLLFLGSSCI1Arabidopsis thaliana
C112RKLLFLGSSCI1Oryza sativa subsp. japonica
C112VKVVSCLSTCI1Drosophila melanogaster
C116SCLSTCIFPDK3Homo sapiens, Drosophila melanogaster, Mus musculus
C116FLGSSCIYPKF2Arabidopsis thaliana, Oryza sativa subsp. japonica
D277DTTKSDGQFKK1Homo sapiens
D277DCTKPDGTPRK1Arabidopsis thaliana
D277DSSKPDGTPRK1Oryza sativa subsp. japonica
D277DTSKSDGQYKK1Drosophila melanogaster
D277DSTKSDGQYKK1Mus musculus
D47SSKDADLTDTA1Homo sapiens
D47THAELDLTRQA1Arabidopsis thaliana
D47THAELDLTRQS1Oryza sativa subsp. japonica
D47GSKDADLTNLA1Drosophila melanogaster
D47SSKDADLTDAA1Mus musculus
F77MVGGLFRNIKY2Homo sapiens, Mus musculus
F77KVGGIHANNTY1Arabidopsis thaliana
F77KVGGIHANSTF1Oryza sativa subsp. japonica
F77MVGGLFHNMNN1Drosophila melanogaster
G14RILVTGGSGLV2Homo sapiens, Mus musculus
G14KIFVAGHRGLV1Arabidopsis thaliana
G14KVFVAGHRGLV1Oryza sativa subsp. japonica
G14KVLVTGGTGLV1Drosophila melanogaster
G17VAGHRGLVGSA2Arabidopsis thaliana, Oryza sativa subsp. japonica
G17VTGGSGLVGKA1Homo sapiens
G17VTGGTGLVGKA1Drosophila melanogaster
G17VTGGSGLVGRA1Mus musculus
G185FNIEDGHVLPG2Homo sapiens, Mus musculus
G185FHPENSHVLPA2Arabidopsis thaliana, Oryza sativa subsp. japonica
G185YNPEVSHVIPG1Drosophila melanogaster
G190GHVLPGLIHKV2Homo sapiens, Mus musculus
G190SHVLPALMRRF1Arabidopsis thaliana
G190SHVLPALIRRF1Oryza sativa subsp. japonica
G190SHVIPGMIYRM1Drosophila melanogaster
G209EVVVWGTGSPL2Arabidopsis thaliana, Oryza sativa subsp. japonica
G209LTV-WGTGNPR1Homo sapiens
G209FTV-FGSGMPL1Drosophila melanogaster
G209LTV-WGTGKPR1Mus musculus
G74LAAMVGGLFRN2Homo sapiens, Mus musculus
G74AAAKVGGIHAN2Arabidopsis thaliana, Oryza sativa subsp. japonica
G74LAAMVGGLFHN1Drosophila melanogaster
G75AAMVGGLFRNI2Homo sapiens, Mus musculus
G75AAKVGGIHANN1Arabidopsis thaliana
G75AAKVGGIHANS1Oryza sativa subsp. japonica
G75AAMVGGLFHNM1Drosophila melanogaster
H186NIEDGHVLPGL2Homo sapiens, Mus musculus
H186HPENSHVLPAL2Arabidopsis thaliana, Oryza sativa subsp. japonica
H186NPEVSHVIPGM1Drosophila melanogaster
I252EDEVSIKEAAE2Homo sapiens, Mus musculus
I252GQEVTIRELAE1Arabidopsis thaliana
I252GSEVTIKELAE1Oryza sativa subsp. japonica
I252VQEVTIFEVAQ1Drosophila melanogaster
K147GYSYAKRMIDV2Homo sapiens, Mus musculus
K147WYAIAKIAGIK1Arabidopsis thaliana
K147WYAVAKIAGIK1Oryza sativa subsp. japonica
K147GYSYAKRLIDV1Drosophila melanogaster
K194PGLIHKVH---2Homo sapiens, Mus musculus
K194PALMRRFH---1Arabidopsis thaliana
K194PALIRRFH---1Oryza sativa subsp. japonica
K194PGMIYRMHQLV1Drosophila melanogaster
K282DGTPRKLMDSS2Arabidopsis thaliana, Oryza sativa subsp. japonica
K282DGQFKKTASNS1Homo sapiens
K282DGQYKKTASNA1Drosophila melanogaster
K282DGQYKKTASNG1Mus musculus
K44VFVSSKDADLT2Homo sapiens, Mus musculus
K44VLKTHAELDLT1Arabidopsis thaliana
K44VVRTHAELDLT1Oryza sativa subsp. japonica
K44FFAGSKDADLT1Drosophila melanogaster
L113KVVSCLSTCIF3Homo sapiens, Drosophila melanogaster, Mus musculus
L113KLLFLGSSCIY2Arabidopsis thaliana, Oryza sativa subsp. japonica
L18AGHRGLVGSAI2Arabidopsis thaliana, Oryza sativa subsp. japonica
L18TGGSGLVGKAI1Homo sapiens
L18TGGTGLVGKAL1Drosophila melanogaster
L18TGGSGLVGRAI1Mus musculus
L191HVLPGLIHKVH2Homo sapiens, Mus musculus
L191HVLPALMRRFH1Arabidopsis thaliana
L191HVLPALIRRFH1Oryza sativa subsp. japonica
L191HVIPGMIYRMH1Drosophila melanogaster
L48SKDADLTDTAQ1Homo sapiens
L48HAELDLTRQAD1Arabidopsis thaliana
L48HAELDLTRQSD1Oryza sativa subsp. japonica
L48SKDADLTNLAA1Drosophila melanogaster
L48SKDADLTDAAQ1Mus musculus
L69THVIHLAAMVG3Homo sapiens, Drosophila melanogaster, Mus musculus
L69VYVILAAAKVG1Arabidopsis thaliana
L69RYVVLAAAKVG1Oryza sativa subsp. japonica
L76AMVGGLFRNIK2Homo sapiens, Mus musculus
L76AKVGGIHANNT1Arabidopsis thaliana
L76AKVGGIHANST1Oryza sativa subsp. japonica
L76AMVGGLFHNMN1Drosophila melanogaster
M93RKNVHMNDNVL1Homo sapiens
M93GVNLQIQTNVI1Arabidopsis thaliana
M93AANLQIQTNVV1Oryza sativa subsp. japonica
M93RNNLLINDNVL1Drosophila melanogaster
M93RKNVHINDNVL1Mus musculus
N140PPHNSNFGYSY1Homo sapiens
N140SLEPTNEWYAI1Arabidopsis thaliana
N140PLEPTNEWYAV1Oryza sativa subsp. japonica
N140PPHPSNYGYSY1Drosophila melanogaster
N140PPHSSNFGYSY1Mus musculus
N172AVIPTNVFGPH1Homo sapiens
N172SGMPTNLYGPN1Arabidopsis thaliana
N172SAMPTNLYGPQ1Oryza sativa subsp. japonica
N172SVIPCNIFGPH1Drosophila melanogaster
N172AVIPTNVFGPY1Mus musculus
N79GGLFRNIKYNL2Homo sapiens, Mus musculus
N79GGIHANNTYPA1Arabidopsis thaliana
N79GGIHANSTFPA1Oryza sativa subsp. japonica
N79GGLFHNMNNNL1Drosophila melanogaster
P170FTAVIPTNVFG2Homo sapiens, Mus musculus
P170AISGMPTNLYG1Arabidopsis thaliana
P170AISAMPTNLYG1Oryza sativa subsp. japonica
P170YTSVIPCNIFG1Drosophila melanogaster
P213WGTGSPLREFL2Arabidopsis thaliana, Oryza sativa subsp. japonica
P213WGTGNPRRQFI1Homo sapiens
P213FGSGMPLRQFV1Drosophila melanogaster
P213WGTGKPRRQFI1Mus musculus
R215TGSPLREFLHV2Arabidopsis thaliana, Oryza sativa subsp. japonica
R215TGNPRRQFIYS1Homo sapiens
R215SGMPLRQFVYS1Drosophila melanogaster
R215TGKPRRQFIYS1Mus musculus
R88NLDFWRKNVHM1Homo sapiens
R88PADFIGVNLQI1Arabidopsis thaliana
R88PADFIAANLQI1Oryza sativa subsp. japonica
R88NLDFLRNNLLI1Drosophila melanogaster
R88NLDFWRKNVHI1Mus musculus
R9---SMRILVTG2Homo sapiens, Mus musculus
R9SDKSAKIFVAG1Arabidopsis thaliana
R9ADKGGKVFVAG1Oryza sativa subsp. japonica
R9---MKKVLVTG1Drosophila melanogaster
S114VVSCLSTCIFP3Homo sapiens, Drosophila melanogaster, Mus musculus
S114LLFLGSSCIYP2Arabidopsis thaliana, Oryza sativa subsp. japonica
S16FVAGHRGLVGS2Arabidopsis thaliana, Oryza sativa subsp. japonica
S16LVTGGSGLVGK1Homo sapiens
S16LVTGGTGLVGK1Drosophila melanogaster
S16LVTGGSGLVGR1Mus musculus
S276FDTTKSDGQFK1Homo sapiens
S276WDCTKPDGTPR1Arabidopsis thaliana
S276WDSSKPDGTPR1Oryza sativa subsp. japonica
S276CDTSKSDGQYK1Drosophila melanogaster
S276FDSTKSDGQYK1Mus musculus
S42DWVFVSSKDAD1Homo sapiens
S42NLVLKTHAELD1Arabidopsis thaliana
S42NVVVRTHAELD1Oryza sativa subsp. japonica
S42QWFFAGSKDAD1Drosophila melanogaster
S42EWVFVSSKDAD1Mus musculus
S43WVFVSSKDADL2Homo sapiens, Mus musculus
S43LVLKTHAELDL1Arabidopsis thaliana
S43VVVRTHAELDL1Oryza sativa subsp. japonica
S43WFFAGSKDADL1Drosophila melanogaster
T171TAVIPTNVFGP2Homo sapiens, Mus musculus
T171ISGMPTNLYGP1Arabidopsis thaliana
T171ISAMPTNLYGP1Oryza sativa subsp. japonica
T171TSVIPCNIFGP1Drosophila melanogaster
T49KDADLTDTAQT1Homo sapiens
T49AELDLTRQADV1Arabidopsis thaliana
T49AELDLTRQSDV1Oryza sativa subsp. japonica
T49KDADLTNLAAT1Drosophila melanogaster
T49KDADLTDAAQT1Mus musculus
V173VIPTNVFGPHD1Homo sapiens
V173GMPTNLYGPND1Arabidopsis thaliana
V173AMPTNLYGPQD1Oryza sativa subsp. japonica
V173VIPCNIFGPHD1Drosophila melanogaster
V173VIPTNVFGPYD1Mus musculus
V187IEDGHVLPGLI2Homo sapiens, Mus musculus
V187PENSHVLPALM1Arabidopsis thaliana
V187PENSHVLPALI1Oryza sativa subsp. japonica
V187PEVSHVIPGMI1Drosophila melanogaster
V19GGSGLVGKAIQ1Homo sapiens
V19GHRGLVGSAIV1Arabidopsis thaliana
V19GHRGLVGSAIL1Oryza sativa subsp. japonica
V19GGTGLVGKALE1Drosophila melanogaster
V19GGSGLVGRAIQ1Mus musculus
V207GSALTV-WGTG1Homo sapiens
V207GAEEVVVWGTG1Arabidopsis thaliana
V207NAAEVVVWGTG1Oryza sativa subsp. japonica
V207DKVFTV-FGSG1Drosophila melanogaster
V207DSALTV-WGTG1Mus musculus
V73HLAAMVGGLFR2Homo sapiens, Mus musculus
V73LAAAKVGGIHA2Arabidopsis thaliana, Oryza sativa subsp. japonica
V73HLAAMVGGLFH1Drosophila melanogaster
W208ALTV-WGTGNP1Homo sapiens
W208EEVVVWGTGSP1Arabidopsis thaliana
W208AEVVVWGTGSP1Oryza sativa subsp. japonica
W208VFTV-FGSGMP1Drosophila melanogaster
W208ALTV-WGTGKP1Mus musculus
Y143NSNFGYSYAKR1Homo sapiens
Y143PTNEWYAIAKI1Arabidopsis thaliana
Y143PTNEWYAVAKI1Oryza sativa subsp. japonica
Y143PSNYGYSYAKR1Drosophila melanogaster
Y143SSNFGYSYAKR1Mus musculus


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