mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TXN
Gene summary
Basic gene Info.Gene symbolTXN
Gene namethioredoxin
CytomapUCSC genome browser: 9q31
Type of geneprotein-coding
DescriptionADFATL-derived factorSASPTXN delta 3surface-associated sulphydryl proteinthioredoxin delta 3
Modification date20141207
dbXrefs MIM : 187700
Ensembl : ENSG00000136810
HPRD : 01761
Vega : OTTHUMG00000020480
ProteinUniProt: P10599
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TXN
BioGPS: 7295
PathwayNCI Pathway Interaction Database: TXN
Pathway Commons: TXN
ContextiHOP: TXN
ligand binding site mutation search in PubMed: TXN
UCL Cancer Institute: TXN
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0009314response to radiation11118054
GO:0033158regulation of protein import into nucleus, translocation11118054
GO:0043388positive regulation of DNA binding11118054
GO:0055114oxidation-reduction process11118054

Ligand binding site mutations for TXN

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for TXN
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TXN from PDB

Differential gene expression and gene-gene network for TXN
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TXN and the right PPI network was created from samples without mutations in the LBS of TXN. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for TXN
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0023895Liver Diseases2Biomarker, Therapeutic
umls:C0242488Acute Lung Injury1Therapeutic
umls:C0006287Bronchopulmonary Dysplasia1Therapeutic
umls:C0027626Neoplasm Invasiveness1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for TXN
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TXN go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of TXN
Multiple alignments for P10599 in multiple species
LBSAA sequence# speciesSpecies
A92GEFSGANKEKL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A92GKIIGANPTAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A92ERIIGAKKDEL1Arabidopsis thaliana
A92GRIVGADKDEL1Oryza sativa subsp. japonica
A92SRVVGAKKDEL1Oryza sativa subsp. japonica
A92EEFAGANAKRL1Drosophila melanogaster
A92EEIVGANPAKL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A92QEFSGANKEKL1Gallus gallus
C62VDVDDCQDVAA3Bos taurus, Mus musculus, Rattus norvegicus
C62VDVDDCQDVAS1Homo sapiens
C62CDVDESPDIAK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C62LDVDELPDVAK1Arabidopsis thaliana
C62VDVDELAEVAR1Oryza sativa subsp. japonica
C62IDVDELSEVAR1Oryza sativa subsp. japonica
C62VDVDECEDIAM1Drosophila melanogaster
C62VDVDQLSEIAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C62IDVDDAQDVAT1Gallus gallus
C69DVAADCEVKCM2Mus musculus, Rattus norvegicus
C69DVASECEVKCM1Homo sapiens
C69DIAKECEVTAM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C69DVAKEFNVTAM1Arabidopsis thaliana
C69EVARTWRVEAM1Oryza sativa subsp. japonica
C69EVARQWKVEAM1Oryza sativa subsp. japonica
C69DIAMEYNISSM1Drosophila melanogaster
C69EIAAEAGVHAM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C69DVATHCDVKCM1Gallus gallus
D61EVDVDDCQDVA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D61KCDVDESPDIA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D61KLDVDELPDVA1Arabidopsis thaliana
D61KVDVDELAEVA1Oryza sativa subsp. japonica
D61KIDVDELSEVA1Oryza sativa subsp. japonica
D61KVDVDECEDIA1Drosophila melanogaster
D61KVDVDQLSEIA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D61EIDVDDAQDVA1Gallus gallus
E6MVKLIESKEAF2Mus musculus, Rattus norvegicus
E6MVKQIESKTAF1Homo sapiens
E6SITKLTNLTEF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E6RVLKFSSSARW1Arabidopsis thaliana
E6AVVAVHSKAKW1Oryza sativa subsp. japonica
E6RVVAVHSTATW1Oryza sativa subsp. japonica
E6TNLHFHLQADL1Drosophila melanogaster
E6MVKQVSDSSEF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E6MVKSVGNLADF1Gallus gallus
E68QDVAADCEVKC2Mus musculus, Rattus norvegicus
E68QDVASECEVKC1Homo sapiens
E68PDIAKECEVTA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E68PDVAKEFNVTA1Arabidopsis thaliana
E68AEVARTWRVEA1Oryza sativa subsp. japonica
E68SEVARQWKVEA1Oryza sativa subsp. japonica
E68EDIAMEYNISS1Drosophila melanogaster
E68SEIAAEAGVHA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E68QDVATHCDVKC1Gallus gallus
F80PTFQFFKKGQK2Homo sapiens, Bos taurus
F80PTFQFYKKGQK2Mus musculus, Rattus norvegicus
F80PTFVLGKDGQL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F80PTFVLVKRGKE1Arabidopsis thaliana
F80PTFVLARGGEE1Oryza sativa subsp. japonica
F80PTFVLIKGGKE1Oryza sativa subsp. japonica
F80PTFVFLKNGVK1Drosophila melanogaster
F80PSFFLYKNGEK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F80PTFQFYKNGKK1Gallus gallus
G91VGEFSGANKEK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G91IGKIIGANPTA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G91IERIIGAKKDE1Arabidopsis thaliana
G91VGRIVGADKDE1Oryza sativa subsp. japonica
G91VSRVVGAKKDE1Oryza sativa subsp. japonica
G91VEEFAGANAKR1Drosophila melanogaster
G91IEEIVGANPAK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G91VQEFSGANKEK1Gallus gallus
I38GPCKMIKPFFH5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
I38GPCKMMQPHLT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I38GPCRMIEPAIH1Arabidopsis thaliana
I38GPCKMMEPVFK1Oryza sativa subsp. japonica
I38GPCRFIEPAFK1Oryza sativa subsp. japonica
I38GPCKMISPKLV1Drosophila melanogaster
I38GPCKAIAPKFE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M37CGPCKMIKPFF5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
M37CGPCKMMQPHL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M37CGPCRMIEPAI1Arabidopsis thaliana
M37CGPCKMMEPVF1Oryza sativa subsp. japonica
M37CGPCRFIEPAF1Oryza sativa subsp. japonica
M37CGPCKMISPKL1Drosophila melanogaster
M37CGPCKAIAPKF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P75EVKCMPTFQFF2Homo sapiens, Bos taurus
P75EVKCMPTFQFY2Mus musculus, Rattus norvegicus
P75EVTAMPTFVLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P75NVTAMPTFVLV1Arabidopsis thaliana
P75RVEAMPTFVLA1Oryza sativa subsp. japonica
P75KVEAMPTFVLI1Oryza sativa subsp. japonica
P75NISSMPTFVFL1Drosophila melanogaster
P75GVHAMPSFFLY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P75DVKCMPTFQFY1Gallus gallus
Q63DVDDCQDVAAD2Mus musculus, Rattus norvegicus
Q63DVDDCQDVASE1Homo sapiens
Q63DVDESPDIAKE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q63DVDELPDVAKE1Arabidopsis thaliana
Q63DVDELAEVART1Oryza sativa subsp. japonica
Q63DVDELSEVARQ1Oryza sativa subsp. japonica
Q63DVDECEDIAME1Drosophila melanogaster
Q63DVDQLSEIAAE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q63DVDDAQDVATH1Gallus gallus
Q78CMPTFQFFKKG2Homo sapiens, Bos taurus
Q78CMPTFQFYKKG2Mus musculus, Rattus norvegicus
Q78AMPTFVLGKDG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q78AMPTFVLVKRG1Arabidopsis thaliana
Q78AMPTFVLARGG1Oryza sativa subsp. japonica
Q78AMPTFVLIKGG1Oryza sativa subsp. japonica
Q78SMPTFVFLKNG1Drosophila melanogaster
Q78AMPSFFLYKNG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q78CMPTFQFYKNG1Gallus gallus
S7VKLIESKEAFQ2Mus musculus, Rattus norvegicus
S7VKQIESKTAFQ1Homo sapiens
S7ITKLTNLTEFR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S7VLKFSSSARWQ1Arabidopsis thaliana
S7VVAVHSKAKWD1Oryza sativa subsp. japonica
S7VVAVHSTATWD1Oryza sativa subsp. japonica
S7NLHFHLQADLD1Drosophila melanogaster
S7VKQVSDSSEFK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S7VKSVGNLADFE1Gallus gallus
S90KVGEFSGANKE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S90LIGKIIGANPT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S90EIERIIGAKKD1Arabidopsis thaliana
S90EVGRIVGADKD1Oryza sativa subsp. japonica
S90EVSRVVGAKKD1Oryza sativa subsp. japonica
S90KVEEFAGANAK1Drosophila melanogaster
S90KIEEIVGANPA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S90KVQEFSGANKE1Gallus gallus
T30VDFSATWCGPC5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
T30IDFYATWCGPC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T30VDFSASWCGPC1Arabidopsis thaliana
T30IDFSASWCGPC1Oryza sativa subsp. japonica
T30IDFSATWCGPC1Oryza sativa subsp. japonica
T30LDFFATWCGPC1Drosophila melanogaster
T30VDFFATWCGPC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V65DDCQDVAADCE2Mus musculus, Rattus norvegicus
V65DDCQDVASECE1Homo sapiens
V65DESPDIAKECE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V65DELPDVAKEFN1Arabidopsis thaliana
V65DELAEVARTWR1Oryza sativa subsp. japonica
V65DELSEVARQWK1Oryza sativa subsp. japonica
V65DECEDIAMEYN1Drosophila melanogaster
V65DQLSEIAAEAG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V65DDAQDVATHCD1Gallus gallus

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