mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TYMS
Gene summary
Basic gene Info.Gene symbolTYMS
Gene namethymidylate synthetase
SynonymsHST422|TMS|TS
CytomapUCSC genome browser: 18p11.32
Type of geneprotein-coding
RefGenesNM_001071.2,
DescriptionTSasethymidylate synthase
Modification date20141207
dbXrefs MIM : 188350
HGNC : HGNC
Ensembl : ENSG00000176890
HPRD : 01774
Vega : OTTHUMG00000131473
ProteinUniProt: P04818
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TYMS
BioGPS: 7298
PathwayNCI Pathway Interaction Database: TYMS
KEGG: TYMS
REACTOME: TYMS
Pathway Commons: TYMS
ContextiHOP: TYMS
ligand binding site mutation search in PubMed: TYMS
UCL Cancer Institute: TYMS
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for TYMS

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R176R176KCOAD1
F80F80LSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TYMS
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R176R176K-0.94876851
F80F80L-0.81201677
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TYMS from PDB

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Differential gene expression and gene-gene network for TYMS
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TYMS and the right PPI network was created from samples without mutations in the LBS of TYMS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TYMS
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0009404Colorectal Neoplasms47AlteredExpression, Biomarker, GeneticVariation
umls:C0009375Colonic Neoplasms19AlteredExpression, Biomarker, GeneticVariation
umls:C0038356Stomach Neoplasms17AlteredExpression, Biomarker, GeneticVariation
umls:C0007137Carcinoma, Squamous Cell14Biomarker, GeneticVariation
umls:C1458155Breast Neoplasms9AlteredExpression, Biomarker, GeneticVariation
umls:C0034885Rectal Neoplasms9Biomarker, GeneticVariation
umls:C0024305Lymphoma, Non-Hodgkin7Biomarker, GeneticVariation
umls:C2239176Carcinoma, Hepatocellular6AlteredExpression, Biomarker, GeneticVariation
umls:C0024121Lung Neoplasms5Biomarker, GeneticVariation
umls:C0030297Pancreatic Neoplasms3AlteredExpression, Biomarker, GeneticVariation
umls:C0024301Lymphoma, Follicular3Biomarker, GeneticVariation
umls:C0008924Cleft Lip3Biomarker, GeneticVariation
umls:C0008925Cleft Palate3Biomarker, GeneticVariation
umls:C0206754Neuroendocrine Tumors2AlteredExpression, Biomarker
umls:C0919267Ovarian Neoplasms2AlteredExpression, Biomarker
umls:C0018671Head and Neck Neoplasms2Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms1AlteredExpression, Biomarker
umls:C0006111Brain Diseases1Biomarker
umls:C0012243Digestive System Neoplasms1Biomarker
umls:C3658338Drug-Related Side Effects and Adverse Reactions1Biomarker
umls:C0017661Glomerulonephritis, IGA1Biomarker
umls:C0220994Hyperammonemia1Biomarker
umls:C0027643Neoplasm Recurrence, Local1Biomarker
umls:C0027765Nervous System Diseases1Biomarker
umls:C0040411Tongue Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TYMS
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00293RaltitrexedSmall molecule
ApprovedDB00322FloxuridineSmall molecule
ApprovedDB00432TrifluridineSmall molecule
Approved|vet_approvedDB00440TrimethoprimSmall molecule
ApprovedDB00441GemcitabineSmall molecule
ApprovedDB00544FluorouracilSmall molecule
Approved|investigationalDB00642PemetrexedSmall molecule
ApprovedDB00650LeucovorinSmall molecule
Approved|investigationalDB01101CapecitabineSmall molecule
ExperimentalDB01643Thymidine-5'-PhosphateSmall molecule
ExperimentalDB0354110-Propargyl-5,8-Dideazafolic AcidSmall molecule
ExperimentalDB038002'-deoxyuridylic acidSmall molecule
ExperimentalDB04530S,S-(2-Hydroxyethyl)ThiocysteineSmall molecule
InvestigationalDB05116NB1011Small molecule
InvestigationalDB05308ANX-510Small molecule
InvestigationalDB05457OSI-7904LSmall molecule
ApprovedDB06813PralatrexateSmall molecule
ExperimentalDB075776-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINESmall molecule
ExperimentalDB08478N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamideSmall molecule
ExperimentalDB08479N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamideSmall molecule
ExperimentalDB087346,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TYMS go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
D16RALTITREXED1hvyAF80
D16RALTITREXED1hvyCF80
D16RALTITREXED1hvyDF80
D16RALTITREXED1i00AF80
D16RALTITREXED1i00BF80
LYALY2315141ju6AF80
LYALY2315141ju6BF80
LYALY2315141ju6CF80
LYALY2315141ju6DF80
LYALY2315141jujAF80
LYALY2315141jujBF80
LYALY2315141jujCF80
LYALY2315141jujDF80
0MZ2-{(2Z,5S)-4-HYDROXY-2-[(2E)-(2-HYDROXYBENZYLIDENE) HYDRAZINYLIDENE]-2,5-DIHYDRO-1,3-THIAZOL-5-YL}-N-[3- (TRIFLUOROMETHYL)PHENYL]ACETAMIDE4e28AF80
9MZ2-{(5S)-2-[(2E)-2-(2-HYDROXYBENZYLIDENE)HYDRAZINYL]-4- OXO-4,5-DIHYDRO-1,3-THIAZOL-5-YL}-N-[3- (TRIFLUOROMETHYL)PHENYL]ACETAMIDE4e28AF80
UMPDUMP1hvyAR176
UMPDUMP1hvyBR176
UMPDUMP1hvyCR176
UMPDUMP1hvyDR176
UMPDUMP1i00AR176
UMPDUMP1i00BR176
UMPDUMP1ju6AR176
UMPDUMP1ju6BR176
UMPDUMP1ju6CR176
UMPDUMP1ju6DR176
UMPDUMP1jujAR176
UMPDUMP1jujBR176
UMPDUMP1jujCR176
UMPDUMP1jujDR176
UFP5-FLUORODEOXYURIDINE MONOPHOSPHATE3ejlCR176
UFP5-FLUORODEOXYURIDINE MONOPHOSPHATE3h9kAR176
UFP5-FLUORODEOXYURIDINE MONOPHOSPHATE3h9kBR176
UFP5-FLUORODEOXYURIDINE MONOPHOSPHATE3h9kER176
UMPDUMP3hb8BR176
UMPDUMP3hb8ER176
GSHGLUTATHIONATE(1-)3ob7BR176
GSHGLUTATHIONATE(1-)3ob7ER176


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Conservation information for LBS of TYMS
Multiple alignments for P04818 in multiple species
LBSAA sequence# speciesSpecies
A312IKMEMAV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A312IDMKMAV1Arabidopsis thaliana
A312IEMKMAV1Arabidopsis thaliana
A312IKMKMSV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A312IQMDMAV1Drosophila melanogaster
A312IQMKMSV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C180RRIIMSAWNPS2Arabidopsis thaliana, Arabidopsis thaliana
C180RRIIMCAWNPK2Mus musculus, Rattus norvegicus
C180RRIIMCAWNPR1Homo sapiens
C180RRIILCAWNPK1Bos taurus
C180RRIILSAWNPL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C180RRIIMSAWNPL1Drosophila melanogaster
C180RRIIMSAWNPA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C195MALPPCHALCQ4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
C195MALPPCHMFAQ2Arabidopsis thaliana, Arabidopsis thaliana
C195MALPPCHIFCQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C195MALPPCHCLAQ1Drosophila melanogaster
C195MALPPCHIFSQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D174KTNPDDRRIIM3Homo sapiens, Mus musculus, Rattus norvegicus
D174KNNPDDRRIIM2Arabidopsis thaliana, Arabidopsis thaliana
D174KTNPNDRRIIL1Bos taurus
D174KLNPYDRRIIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D174RNNPSDRRIIM1Drosophila melanogaster
D174KTNPYDRRIIM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D218YQRSGDMGLGV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D218YQRSADMGLGV4Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
D218YQRSCDMGLGV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D49GFKKEDRTGTG2Mus musculus, Rattus norvegicus
D49GVRKDDRTGTG1Homo sapiens
D49GNLKDDRTGTG1Arabidopsis thaliana
D49GNVKNDRTGTG1Arabidopsis thaliana
D49GFRRDDRTGTG1Bos taurus
D49GQSRPDRTGTG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D49GEQRMDRTEVG1Drosophila melanogaster
D49GEFRPDRTGTG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E87KGVLEELLWFI4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E87RGVVEELLWFI2Arabidopsis thaliana, Arabidopsis thaliana
E87RGVLEELLWFI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E87RAVAEELLWFV1Drosophila melanogaster
E87RGIILELLWFL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F142FQWRHFGAKYT2Arabidopsis thaliana, Arabidopsis thaliana
F142FQWRHFGAEYK2Mus musculus, Bos taurus
F142FQWRHFGAEYR1Homo sapiens
F142FQWRHFGADYK1Rattus norvegicus
F142FQWRHFGAQYV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F142FQWRHFGAQYG1Drosophila melanogaster
F142FQWRHFGAKYK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F225GLGVPFNIASY9Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Rattus norvegicus, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F80TTKRVFWKGVL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F80TTKRVFWRGVV2Arabidopsis thaliana, Arabidopsis thaliana
F80TTKRVFLRGVL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F80TTKRVFFRAVA1Drosophila melanogaster
F80TTKKVFTRGII1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G132EEGDLGPVYGF3Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana
G132QEGDLGPVYGF2Mus musculus, Rattus norvegicus
G132AEGDLGPVYGF1Bos taurus
G132KVGDLGPIYGF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G132AVGDLGPVYGF1Drosophila melanogaster
G132KVGDLGPVYGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G143QWRHFGAKYTD2Arabidopsis thaliana, Arabidopsis thaliana
G143QWRHFGAEYKD2Mus musculus, Bos taurus
G143QWRHFGAEYRD1Homo sapiens
G143QWRHFGADYKD1Rattus norvegicus
G143QWRHFGAQYVD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G143QWRHFGAQYGT1Drosophila melanogaster
G143QWRHFGAKYKT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G217LYQRSGDMGLG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G217MYQRSADMGLG3Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G217LYQRSADMGLG1Drosophila melanogaster
G217LYQRSCDMGLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G222GDMGLGVPFNI4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G222ADMGLGVPFNI4Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
G222CDMGLGVPFNI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H196ALPPCHALCQF4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H196ALPPCHMFAQF2Arabidopsis thaliana, Arabidopsis thaliana
H196ALPPCHIFCQF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H196ALPPCHCLAQF1Drosophila melanogaster
H196ALPPCHIFSQF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H256TLGDAHIYLNH4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H256VIGDAHVYKNH1Arabidopsis thaliana
H256VLGDAHVYKTH1Arabidopsis thaliana
H256VMGDCHIYNDH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H256TMGDTHVYLNH1Drosophila melanogaster
H256TLGDAHVYKDH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I108SKGVKIWDANG2Homo sapiens, Bos taurus
I108SKGVRIWDANG2Mus musculus, Rattus norvegicus
I108EKGIRIWDGNA1Arabidopsis thaliana
I108EKGIHIWDGNA1Arabidopsis thaliana
I108EKGIHIWDGNG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I108AKNVHIWDGNS1Drosophila melanogaster
I108EQGVKIWDGNG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I178DDRRIIMCAWN3Homo sapiens, Mus musculus, Rattus norvegicus
I178DDRRIIMSAWN2Arabidopsis thaliana, Arabidopsis thaliana
I178NDRRIILCAWN1Bos taurus
I178YDRRIILSAWN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I178SDRRIIMSAWN1Drosophila melanogaster
I178YDRRIIMSAWN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K308PHPTIKMEMAV3Homo sapiens, Mus musculus, Rattus norvegicus
K308PHKKIDMKMAV1Arabidopsis thaliana
K308PHKKIEMKMAV1Arabidopsis thaliana
K308PNPTIKMEMAV1Bos taurus
K308PYGPIKMKMSV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K308PHPKIQMDMAV1Drosophila melanogaster
K308PHPRIQMKMSV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K77PLLTTKRVFWK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K77PLLTTKRVFWR2Arabidopsis thaliana, Arabidopsis thaliana
K77PLLTTKRVFLR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K77PLLTTKRVFFR1Drosophila melanogaster
K77PLLTTKKVFTR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L187WNPKDLPLMAL3Mus musculus, Rattus norvegicus, Bos taurus
L187WNPSDLKLMAL2Arabidopsis thaliana, Arabidopsis thaliana
L187WNPRDLPLMAL1Homo sapiens
L187WNPLAIPEMAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L187WNPLDIPKMAL1Drosophila melanogaster
L187WNPADFDKMAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L192LPLMALPPCHA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L192LKLMALPPCHM2Arabidopsis thaliana, Arabidopsis thaliana
L192IPEMALPPCHI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L192IPKMALPPCHC1Drosophila melanogaster
L192FDKMALPPCHI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L221SGDMGLGVPFN4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L221SADMGLGVPFN4Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
L221SCDMGLGVPFN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M179DRRIIMSAWNP4Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M179DRRIIMCAWNP3Homo sapiens, Mus musculus, Rattus norvegicus
M179DRRIILCAWNP1Bos taurus
M179DRRIILSAWNP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M190KDLPLMALPPC3Mus musculus, Rattus norvegicus, Bos taurus
M190SDLKLMALPPC2Arabidopsis thaliana, Arabidopsis thaliana
M190RDLPLMALPPC1Homo sapiens
M190LAIPEMALPPC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M190LDIPKMALPPC1Drosophila melanogaster
M190ADFDKMALPPC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M311TIKMEMAV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M311KIDMKMAV1Arabidopsis thaliana
M311KIEMKMAV1Arabidopsis thaliana
M311PIKMKMSV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M311KIQMDMAV1Drosophila melanogaster
M311RIQMKMSV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N112KIWDANGSRDF2Homo sapiens, Bos taurus
N112RIWDANGSRDF2Mus musculus, Rattus norvegicus
N112RIWDGNASRAY1Arabidopsis thaliana
N112HIWDGNASREY1Arabidopsis thaliana
N112HIWDGNGSREF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N112HIWDGNSSREF1Drosophila melanogaster
N112KIWDGNGSREY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N226LGVPFNIASYA6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N226LGVPFNIASYS3Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P133EGDLGPVYGFQ6Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Rattus norvegicus, Bos taurus
P133VGDLGPVYGFQ2Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P133VGDLGPIYGFQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P193PLMALPPCHAL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
P193KLMALPPCHMF2Arabidopsis thaliana, Arabidopsis thaliana
P193PEMALPPCHIF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P193PKMALPPCHCL1Drosophila melanogaster
P193DKMALPPCHIF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P194LMALPPCHALC4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
P194LMALPPCHMFA2Arabidopsis thaliana, Arabidopsis thaliana
P194EMALPPCHIFC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P194KMALPPCHCLA1Drosophila melanogaster
P194KMALPPCHIFS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P224MGLGVPFNIAS9Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Rattus norvegicus, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q138PVYGFQWRHFG8Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q138PIYGFQWRHFG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q160GQGVDQLQKVI3Mus musculus, Rattus norvegicus, Bos taurus
Q160GQGVDQLQRVI1Homo sapiens
Q160GQGFDQLLDVI1Arabidopsis thaliana
Q160GQGFDQLVDVI1Arabidopsis thaliana
Q160NKGVDQLAQVI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q160GKGIDQLRQVI1Drosophila melanogaster
Q160GQGIDQLKQVI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q214SCQLYQRSGDM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Q214SCQMYQRSADM2Arabidopsis thaliana, Arabidopsis thaliana
Q214SSMMYQRSADM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q214SCQLYQRSADM1Drosophila melanogaster
Q214SCLLYQRSCDM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R163VDQLQKVIDTI3Mus musculus, Rattus norvegicus, Bos taurus
R163VDQLQRVIDTI1Homo sapiens
R163FDQLLDVINKI1Arabidopsis thaliana
R163FDQLVDVIDKI1Arabidopsis thaliana
R163VDQLAQVISTL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R163IDQLRQVIDTI1Drosophila melanogaster
R163IDQLKQVIHKL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R175TNPDDRRIIMC3Homo sapiens, Mus musculus, Rattus norvegicus
R175NNPDDRRIIMS2Arabidopsis thaliana, Arabidopsis thaliana
R175TNPNDRRIILC1Bos taurus
R175LNPYDRRIILS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R175NNPSDRRIIMS1Drosophila melanogaster
R175TNPYDRRIIMS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R176NPDDRRIIMCA3Homo sapiens, Mus musculus, Rattus norvegicus
R176NPDDRRIIMSA2Arabidopsis thaliana, Arabidopsis thaliana
R176NPNDRRIILCA1Bos taurus
R176NPYDRRIILSA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R176NPSDRRIIMSA1Drosophila melanogaster
R176NPYDRRIIMSA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R215CQLYQRSGDMG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R215CQMYQRSADMG2Arabidopsis thaliana, Arabidopsis thaliana
R215SMMYQRSADMG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R215CQLYQRSADMG1Drosophila melanogaster
R215CLLYQRSCDMG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R50FKKEDRTGTGT2Mus musculus, Rattus norvegicus
R50VRKDDRTGTGT1Homo sapiens
R50NLKDDRTGTGT1Arabidopsis thaliana
R50NVKNDRTGTGT1Arabidopsis thaliana
R50FRRDDRTGTGT1Bos taurus
R50QSRPDRTGTGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R50EQRMDRTEVGT1Drosophila melanogaster
R50EFRPDRTGTGT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R78LLTTKRVFWKG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R78LLTTKRVFWRG2Arabidopsis thaliana, Arabidopsis thaliana
R78LLTTKRVFLRG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R78LLTTKRVFFRA1Drosophila melanogaster
R78LLTTKKVFTRG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S216QLYQRSGDMGL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S216QMYQRSADMGL2Arabidopsis thaliana, Arabidopsis thaliana
S216MMYQRSADMGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S216QLYQRSADMGL1Drosophila melanogaster
S216LLYQRSCDMGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T167QKVIDTIKTNP3Mus musculus, Rattus norvegicus, Bos taurus
T167QRVIDTIKTNP1Homo sapiens
T167LDVINKIKNNP1Arabidopsis thaliana
T167VDVIDKIKNNP1Arabidopsis thaliana
T167AQVISTLKLNP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T167RQVIDTIRNNP1Drosophila melanogaster
T167KQVIHKLKTNP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T51KKEDRTGTGTL2Mus musculus, Rattus norvegicus
T51RKDDRTGTGTL1Homo sapiens
T51LKDDRTGTGTL1Arabidopsis thaliana
T51VKNDRTGTGTL1Arabidopsis thaliana
T51RRDDRTGTGTL1Bos taurus
T51SRPDRTGTGTR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T51QRMDRTEVGTL1Drosophila melanogaster
T51FRPDRTGTGTL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V164DQLQKVIDTIK3Mus musculus, Rattus norvegicus, Bos taurus
V164DQLQRVIDTIK1Homo sapiens
V164DQLLDVINKIK1Arabidopsis thaliana
V164DQLVDVIDKIK1Arabidopsis thaliana
V164DQLAQVISTLK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V164DQLRQVIDTIR1Drosophila melanogaster
V164DQLKQVIHKLK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V79LTTKRVFWKGV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V79LTTKRVFWRGV2Arabidopsis thaliana, Arabidopsis thaliana
V79LTTKRVFLRGV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V79LTTKRVFFRAV1Drosophila melanogaster
V79LTTKKVFTRGI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W109KGVKIWDANGS2Homo sapiens, Bos taurus
W109KGVRIWDANGS2Mus musculus, Rattus norvegicus
W109KGIRIWDGNAS1Arabidopsis thaliana
W109KGIHIWDGNAS1Arabidopsis thaliana
W109KGIHIWDGNGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W109KNVHIWDGNSS1Drosophila melanogaster
W109QGVKIWDGNGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W182IIMSAWNPSDL2Arabidopsis thaliana, Arabidopsis thaliana
W182IIMCAWNPKDL2Mus musculus, Rattus norvegicus
W182IIMCAWNPRDL1Homo sapiens
W182IILCAWNPKDL1Bos taurus
W182IILSAWNPLAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W182IIMSAWNPLDI1Drosophila melanogaster
W182IIMSAWNPADF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y135DLGPVYGFQWR8Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y135DLGPIYGFQWR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y258GDAHIYLNHIE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y258GDAHVYKNHVR1Arabidopsis thaliana
Y258GDAHVYKTHVR1Arabidopsis thaliana
Y258GDCHIYNDHLE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y258GDTHVYLNHVE1Drosophila melanogaster
Y258GDAHVYKDHID1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)


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