mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for UBE2B
Gene summary
Basic gene Info.Gene symbolUBE2B
Gene nameubiquitin-conjugating enzyme E2B
SynonymsE2-17kDa|HHR6B|HR6B|RAD6B|UBC2
CytomapUCSC genome browser: 5q31.1
Type of geneprotein-coding
RefGenesNM_003337.3,
DescriptionE2 proteinRAD6 homolog Bubiquitin carrier protein Bubiquitin-conjugating enzyme E2 Bubiquitin-conjugating enzyme E2-17 kDaubiquitin-conjugating enzyme E2B (RAD6 homolog)ubiquitin-protein ligase B
Modification date20141207
dbXrefs MIM : 179095
HGNC : HGNC
Ensembl : ENSG00000119048
HPRD : 01533
Vega : OTTHUMG00000129120
ProteinUniProt: P63146
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_UBE2B
BioGPS: 7320
PathwayNCI Pathway Interaction Database: UBE2B
KEGG: UBE2B
REACTOME: UBE2B
Pathway Commons: UBE2B
ContextiHOP: UBE2B
ligand binding site mutation search in PubMed: UBE2B
UCL Cancer Institute: UBE2B
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006301postreplication repair14981545
GO:0006511ubiquitin-dependent protein catabolic process10373550
GO:0006974cellular response to DNA damage stimulus14981545
GO:0016567protein ubiquitination10373550
GO:0042493response to drug14981545
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process10373550
GO:0043951negative regulation of cAMP-mediated signaling10373550
GO:0051865protein autoubiquitination19123975
GO:0070534protein K63-linked ubiquitination20061386
GO:0070936protein K48-linked ubiquitination20061386
GO:0070979protein K11-linked ubiquitination20061386


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Ligand binding site mutations for UBE2B
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Q35I33TKIRC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for UBE2B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Q35I33T-1.8203204
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for UBE2B from PDB

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Differential gene expression and gene-gene network for UBE2B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of UBE2B and the right PPI network was created from samples without mutations in the LBS of UBE2B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for UBE2B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for UBE2B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of UBE2B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (LYS,TYR,ARG,LYS,LYS,HIS,LYS,SER,GLU,PHE,GLN,LEU,LEU,VAL,ASP,GLN,ALA,ARG,LYS,GLY,TYR)2ybfAQ35


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Conservation information for LBS of UBE2B
Multiple alignments for P63146 in multiple species
LBSAA sequence# speciesSpecies
A38IMQWNAVIFGP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A38VMVWNAMIIGP2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A38VMLWNAVIIGP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A38VMIWNAMIIGP1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D151EQSWNDS----4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D151EDSWES-----1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D151EKSWEDDMEDM1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D151EKSWEDDMDDM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D151EKSWEDDLKDM1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D50GTPFEDGTFKL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D50DTPYEDGTFRL3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D50DTPFEDGTFKL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E30SGAPSENNIMQ4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E30SASPLPDNVMV2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E30SASPVSDNVML1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E30SASPLPDNVMI1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E49EGTPFEDGTFK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E49ADTPYEDGTFR3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E49ADTPFEDGTFK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F41WNAVIFGPEGT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F41WNAMIIGPADT3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F41WNAVIIGPADT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G23EDPPVGVSGAP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G23EDAPPGVSASP2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G23QDPPAGVSASP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G23EDSPPGVSASP1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G26PVGVSGAPSEN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G26PPGVSASPLPD3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G26PAGVSASPVSD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G42NAVIFGPEGTP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G42NAMIIGPADTP3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G42NAVIIGPADTP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K54EDGTFKLVIEF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K54EDGTFRLLLEF3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K54EDGTFKLVLSF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L55DGTFKLVIEFS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L55DGTFRLLLEFD3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L55DGTFKLVLSFD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L73PTVRFLSKMFH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L73PHVKFLSEMFH3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L73PLVKFVSTMFH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N37NIMQWNAVIFG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N37NVMVWNAMIIG2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N37NVMLWNAVIIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N37NVMIWNAMIIG1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q35ENNIMQWNAVI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q35PDNVMVWNAMI2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q35SDNVMLWNAVI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q35PDNVMIWNAMI1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S28Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 /
S25PPVGVSGAPSE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S25APPGVSASPLP2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S25PPAGVSASPVS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S25SPPGVSASPLP1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S29VSGAPSENNIM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S29VSASPLPDNVM3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S29VSASPVSDNVM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V39MQWNAVIFGPE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
V39MVWNAMIIGPA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V39MLWNAVIIGPA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V39MIWNAMIIGPA1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)


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