mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for UBE2G2
Gene summary
Basic gene Info.Gene symbolUBE2G2
Gene nameubiquitin-conjugating enzyme E2G 2
CytomapUCSC genome browser: 21q22.3
Type of geneprotein-coding
Descriptionubiquitin carrier protein G2ubiquitin conjugating enzyme 7ubiquitin conjugating enzyme G2ubiquitin-conjugating enzyme E2 G2ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7)ubiquitin
Modification date20141207
dbXrefs MIM : 603124
Ensembl : ENSG00000184787
HPRD : 04387
Vega : OTTHUMG00000089179
ProteinUniProt: P60604
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_UBE2G2
BioGPS: 7327
PathwayNCI Pathway Interaction Database: UBE2G2
Pathway Commons: UBE2G2
ContextiHOP: UBE2G2
ligand binding site mutation search in PubMed: UBE2G2
UCL Cancer Institute: UBE2G2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0044257cellular protein catabolic process21628527
GO:0070936protein K48-linked ubiquitination20061386

Ligand binding site mutations for UBE2G2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for UBE2G2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for UBE2G2 from PDB

Differential gene expression and gene-gene network for UBE2G2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of UBE2G2 and the right PPI network was created from samples without mutations in the LBS of UBE2G2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for UBE2G2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for UBE2G2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of UBE2G2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of UBE2G2
Multiple alignments for P60604 in multiple species
LBSAA sequence# speciesSpecies
A26PEGIVAGPMNE3Homo sapiens, Mus musculus, Bos taurus
A26PPGIVAGPKSE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A26PDGITAGPSNE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E31AGPMNEENFFE3Homo sapiens, Mus musculus, Bos taurus
E31AGPKSENNIFI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E31AGPSNEDDFFT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E38NFFEWEALIMG3Homo sapiens, Mus musculus, Bos taurus
E38NIFIWDCLIQG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E38DFFTWDCLIQG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E45LIMGPEDTCFE3Homo sapiens, Mus musculus, Bos taurus
E45LIQGPPDTPYA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E45LIQGPDGTPFE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E50EDTCFEFGVFP3Homo sapiens, Mus musculus, Bos taurus
E50PDTPYADGVFN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E50DGTPFEGGLYP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F51DTCFEFGVFPA3Homo sapiens, Mus musculus, Bos taurus
F51DTPYADGVFNA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F51GTPFEGGLYPA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G164VQKSLGL3Homo sapiens, Mus musculus, Bos taurus
G164ILKSLGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G164ARKTLGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G23LNPPEGIVAGP3Homo sapiens, Mus musculus, Bos taurus
G23KDSPPGIVAGP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G23ENGPDGITAGP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G27EGIVAGPMNEE3Homo sapiens, Mus musculus, Bos taurus
G27PGIVAGPKSEN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G27DGITAGPSNED1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I24NPPEGIVAGPM3Homo sapiens, Mus musculus, Bos taurus
I24DSPPGIVAGPK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I24NGPDGITAGPS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L16AEYKQLTLNPP3Homo sapiens, Mus musculus, Bos taurus
L16KELQQLIKDSP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L16KEYKELTENGP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L163IVQKSLGL3Homo sapiens, Mus musculus, Bos taurus
L163SILKSLGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L163LARKTLGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L40FEWEALIMGPE3Homo sapiens, Mus musculus, Bos taurus
L40FIWDCLIQGPP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L40FTWDCLIQGPD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L6MAGTALKRLMA3Homo sapiens, Mus musculus, Bos taurus
L6MSKTAQKRLLK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L6SKAMALRRLMK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M42WEALIMGPEDT3Homo sapiens, Mus musculus, Bos taurus
M42WDCLIQGPPDT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M42WDCLIQGPDGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N30VAGPMNEENFF3Homo sapiens, Mus musculus, Bos taurus
N30VAGPKSENNIF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N30TAGPSNEDDFF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P20QLTLNPPEGIV3Homo sapiens, Mus musculus, Bos taurus
P20QLIKDSPPGIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P20ELTENGPDGIT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P21LTLNPPEGIVA3Homo sapiens, Mus musculus, Bos taurus
P21LIKDSPPGIVA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P21LTENGPDGITA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P28GIVAGPMNEEN3Homo sapiens, Mus musculus, Bos taurus
P28GIVAGPKSENN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P28GITAGPSNEDD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q160AKQIVQKSLGL3Homo sapiens, Mus musculus, Bos taurus
Q160VKLSILKSLGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q160VRRLARKTLGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S162QIVQKSLGL3Homo sapiens, Mus musculus, Bos taurus
S162LSILKSLGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S162RLARKTLGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T17EYKQLTLNPPE3Homo sapiens, Mus musculus, Bos taurus
T17ELQQLIKDSPP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T17EYKELTENGPD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V159IAKQIVQKSLG2Homo sapiens, Mus musculus
V159QVKLSILKSLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V159VVRRLARKTLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V159VAKQIVQKSLG1Bos taurus
V25PPEGIVAGPMN3Homo sapiens, Mus musculus, Bos taurus
V25SPPGIVAGPKS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V25GPDGITAGPSN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V53CFEFGVFPAIL3Homo sapiens, Mus musculus, Bos taurus
V53PYADGVFNAKL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V53PFEGGLYPATL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y13RLMAEYKQLTL3Homo sapiens, Mus musculus, Bos taurus
Y13RLLKELQQLIK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y13RLMKEYKELTE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)

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