mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for UCHL3
Gene summary
Basic gene Info.Gene symbolUCHL3
Gene nameubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
CytomapUCSC genome browser: 13q22.2
Type of geneprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase isozyme L3ubiquitin thioesterase L3ubiquitin thiolesterase
Modification date20141207
dbXrefs MIM : 603090
Ensembl : ENSG00000118939
HPRD : 04367
Vega : OTTHUMG00000017090
ProteinUniProt: P15374
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_UCHL3
BioGPS: 7347
PathwayNCI Pathway Interaction Database: UCHL3
Pathway Commons: UCHL3
ContextiHOP: UCHL3
ligand binding site mutation search in PubMed: UCHL3
UCL Cancer Institute: UCHL3
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0030163protein catabolic process21762696

Ligand binding site mutations for UCHL3
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for UCHL3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for UCHL3 from PDB

Differential gene expression and gene-gene network for UCHL3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of UCHL3 and the right PPI network was created from samples without mutations in the LBS of UCHL3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for UCHL3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for UCHL3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of UCHL3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of UCHL3
Multiple alignments for P15374 in multiple species
LBSAA sequence# speciesSpecies
C95TISNACGTIGL4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
C95SVKNACGLYAI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C95FTHNACGTVAL1Drosophila melanogaster
D109IANNKDKMHFE4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
D109LSNNQSLL--E1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D109VANNKE-VDID1Drosophila melanogaster
D79KSQGQDVTSS-4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
D79SSTSQQITSSY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D79KEVEEQHPED-1Drosophila melanogaster
E114DKMHFESGSTL3Homo sapiens, Bos taurus, Mus musculus
E114SLL--EPGSDL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E114E-VDIDRG-VL1Drosophila melanogaster
E114DKMHFESGSAL1Rattus norvegicus
E149IRVTHETSAHE4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
E149IKENVQTFS-T1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E149FTADHEALAQE1Drosophila melanogaster
G24FLKQLGLHPNW4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
G24FAHKLGLKNEW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G24YIHKLGVSPAW1Drosophila melanogaster
H169EKVDLHFIALV4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
H169ADTNLHYITYV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H169EKVIHHFIALV1Drosophila melanogaster
I58LLLFPITEKYE4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
I58VLLFPINE---1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I58ILLFPCSETYE1Drosophila melanogaster
K108AIANNKDKMHF4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
K108SLSNNQSLL--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K108SVANNKE-VDI1Drosophila melanogaster
K21TNQFLKQLGLH4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
K21FTNFAHKLGLK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K21LTKYIHKLGVS1Drosophila melanogaster
L168DEKVDLHFIAL4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
L168TADTNLHYITY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L168HEKVIHHFIAL1Drosophila melanogaster
L25LKQLGLHPNWQ4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
L25AHKLGLKNEWA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L25IHKLGVSPAWS1Drosophila melanogaster
N93KQTISNACGTI4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
N93KQSVKNACGLY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N93RQFTHNACGTV1Drosophila melanogaster
Q78IKSQGQDVTSS4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
Q78KSSTSQQITSS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q78IKEVEEQHPED1Drosophila melanogaster
Q89VYFMKQTISNA4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
Q89VIWFKQSVKNA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q89LFYMRQFTHNA1Drosophila melanogaster
T81QGQDVTSS--V4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
T81TSQQITSSYDV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T81VEEQHPED--L1Drosophila melanogaster
V146-DAIRVTHETS4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
V146LNVIKENVQTF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V146-EKFTADHEAL1Drosophila melanogaster
V166SIDEKVDLHFI3Homo sapiens, Rattus norvegicus, Mus musculus
V166EATADTNLHYI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V166N-HEKVIHHFI1Drosophila melanogaster
V166NIDEKVDLHFI1Bos taurus
V80SQGQDVTSS--4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
V80STSQQITSSYD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V80EVEEQHPED--1Drosophila melanogaster
Y181VDGHLYELDGR4Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
Y181ENGGIFELDGR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y181KEGTLYELDGR1Drosophila melanogaster

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