mutLBSgeneDB |
Gene summary for UCHL3 |
Gene summary |
Basic gene Info. | Gene symbol | UCHL3 |
Gene name | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) | |
Synonyms | UCH-L3 | |
Cytomap | UCSC genome browser: 13q22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001270952.1, NM_006002.4, | |
Description | ubiquitin carboxyl-terminal hydrolase isozyme L3ubiquitin thioesterase L3ubiquitin thiolesterase | |
Modification date | 20141207 | |
dbXrefs | MIM : 603090 | |
HGNC : HGNC | ||
Ensembl : ENSG00000118939 | ||
HPRD : 04367 | ||
Vega : OTTHUMG00000017090 | ||
Protein | UniProt: P15374 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_UCHL3 | |
BioGPS: 7347 | ||
Pathway | NCI Pathway Interaction Database: UCHL3 | |
KEGG: UCHL3 | ||
REACTOME: UCHL3 | ||
Pathway Commons: UCHL3 | ||
Context | iHOP: UCHL3 | |
ligand binding site mutation search in PubMed: UCHL3 | ||
UCL Cancer Institute: UCHL3 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0030163 | protein catabolic process | 21762696 |
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Ligand binding site mutations for UCHL3 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | Y181 | D180N | COAD | 1 | G24 | E24G | LUAD | 1 | H169 | A169V | STAD | 1 | K21 | P21R | STAD | 1 | Y181 | R179C | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for UCHL3 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for UCHL3 from PDB |
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Differential gene expression and gene-gene network for UCHL3 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for UCHL3 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for UCHL3 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of UCHL3 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GVE | METHYL 4-AMINOBUTANOATE | 1xd3 | A | H169 | GVE | METHYL 4-AMINOBUTANOATE | 1xd3 | C | H169 | MG | MAGNESIUM(2+) | 1xd3 | A | K21 G24 | MG | MAGNESIUM(2+) | 1xd3 | C | Y181 |
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Conservation information for LBS of UCHL3 |
Multiple alignments for P15374 in multiple species |
LBS | AA sequence | # species | Species | C95 | TISNACGTIGL | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | C95 | SVKNACGLYAI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C95 | FTHNACGTVAL | 1 | Drosophila melanogaster | D109 | IANNKDKMHFE | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | D109 | LSNNQSLL--E | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D109 | VANNKE-VDID | 1 | Drosophila melanogaster | D79 | KSQGQDVTSS- | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | D79 | SSTSQQITSSY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D79 | KEVEEQHPED- | 1 | Drosophila melanogaster | E114 | DKMHFESGSTL | 3 | Homo sapiens, Bos taurus, Mus musculus | E114 | SLL--EPGSDL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E114 | E-VDIDRG-VL | 1 | Drosophila melanogaster | E114 | DKMHFESGSAL | 1 | Rattus norvegicus | E149 | IRVTHETSAHE | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | E149 | IKENVQTFS-T | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E149 | FTADHEALAQE | 1 | Drosophila melanogaster | G24 | FLKQLGLHPNW | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | G24 | FAHKLGLKNEW | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G24 | YIHKLGVSPAW | 1 | Drosophila melanogaster | H169 | EKVDLHFIALV | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | H169 | ADTNLHYITYV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H169 | EKVIHHFIALV | 1 | Drosophila melanogaster | I58 | LLLFPITEKYE | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | I58 | VLLFPINE--- | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I58 | ILLFPCSETYE | 1 | Drosophila melanogaster | K108 | AIANNKDKMHF | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | K108 | SLSNNQSLL-- | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K108 | SVANNKE-VDI | 1 | Drosophila melanogaster | K21 | TNQFLKQLGLH | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | K21 | FTNFAHKLGLK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K21 | LTKYIHKLGVS | 1 | Drosophila melanogaster | L168 | DEKVDLHFIAL | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | L168 | TADTNLHYITY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L168 | HEKVIHHFIAL | 1 | Drosophila melanogaster | L25 | LKQLGLHPNWQ | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | L25 | AHKLGLKNEWA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L25 | IHKLGVSPAWS | 1 | Drosophila melanogaster | N93 | KQTISNACGTI | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | N93 | KQSVKNACGLY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N93 | RQFTHNACGTV | 1 | Drosophila melanogaster | Q78 | IKSQGQDVTSS | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | Q78 | KSSTSQQITSS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q78 | IKEVEEQHPED | 1 | Drosophila melanogaster | Q89 | VYFMKQTISNA | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | Q89 | VIWFKQSVKNA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q89 | LFYMRQFTHNA | 1 | Drosophila melanogaster | T81 | QGQDVTSS--V | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | T81 | TSQQITSSYDV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T81 | VEEQHPED--L | 1 | Drosophila melanogaster | V146 | -DAIRVTHETS | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | V146 | LNVIKENVQTF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V146 | -EKFTADHEAL | 1 | Drosophila melanogaster | V166 | SIDEKVDLHFI | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | V166 | EATADTNLHYI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V166 | N-HEKVIHHFI | 1 | Drosophila melanogaster | V166 | NIDEKVDLHFI | 1 | Bos taurus | V80 | SQGQDVTSS-- | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | V80 | STSQQITSSYD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V80 | EVEEQHPED-- | 1 | Drosophila melanogaster | Y181 | VDGHLYELDGR | 4 | Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus | Y181 | ENGGIFELDGR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y181 | KEGTLYELDGR | 1 | Drosophila melanogaster |
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