mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for UGDH

Gene summary

Basic gene Info.	Gene symbol	UGDH
	Gene name	UDP-glucose 6-dehydrogenase
	Synonyms	GDH\|UDP-GlcDH\|UDPGDH\|UGD
	Cytomap	UCSC genome browser: 4p15.1
	Type of gene	protein-coding
	RefGenes	NM_001184700.1, NM_001184701.1,NM_003359.3,
	Description	UDP-Glc dehydrogenaseUDP-glucose dehydrogenaseuridine diphospho-glucose dehydrogenase
	Modification date	20141207
dbXrefs	MIM : 603370
	HGNC : HGNC
	Ensembl : ENSG00000109814
	HPRD : 04535
	Vega : OTTHUMG00000099371
Protein	UniProt: O60701 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_UGDH
	BioGPS: 7358
Pathway	NCI Pathway Interaction Database: UGDH
	KEGG: UGDH
	REACTOME: UGDH
	Pathway Commons: UGDH
Context	iHOP: UGDH
	ligand binding site mutation search in PubMed: UGDH
	UCL Cancer Institute: UGDH
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

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Ligand binding site mutations for UGDH

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
V132	P133S	COAD	1
Y14	Y14C	HNSC	1
S269	V270G	HNSC	1
I75	D76N	LUAD	1
V15	G16V	LUSC	1
R346	R346K	SKCM	1
R442	R443H	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for UGDH

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
V15	G16V	0.060535747
I75	D76N	-1.6889977
Y14	Y14C	-0.76205723
S269	V270G	-0.7130597
V132	P133S	-0.69516462
R346	R346K	-0.63921594
R442	R443H	-0.37146204

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for UGDH from PDB

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Differential gene expression and gene-gene network for UGDH

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of UGDH and the right PPI network was created from samples without mutations in the LBS of UGDH. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for UGDH

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0023903	Liver Neoplasms	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for UGDH

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Nutraceutical	DB00157	NADH	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of UGDH go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
UPG		UDP-GLUCOSE	2q3e	A	S269 R442
UPG		UDP-GLUCOSE	2q3e	B	S269 R442
UPG		UDP-GLUCOSE	2q3e	C	S269 R442
UPG		UDP-GLUCOSE	2q3e	D	S269 R442
UPG		UDP-GLUCOSE	2q3e	E	S269 R442
UPG		UDP-GLUCOSE	2q3e	F	S269 R442
UPG		UDP-GLUCOSE	2q3e	G	S269 R442
UPG		UDP-GLUCOSE	2q3e	H	S269 R442
UPG		UDP-GLUCOSE	2q3e	I	S269 R442
UPG		UDP-GLUCOSE	2q3e	J	S269 R442
UPG		UDP-GLUCOSE	2q3e	K	S269 R442
UPG		UDP-GLUCOSE	2q3e	L	S269 R442
UGA		UDP-ALPHA-D-GLUCURONIC ACID	2qg4	A	S269 R442
UGA		UDP-ALPHA-D-GLUCURONIC ACID	2qg4	B	S269 R442
UGA		UDP-ALPHA-D-GLUCURONIC ACID	2qg4	C	S269 R442
UGA		UDP-ALPHA-D-GLUCURONIC ACID	2qg4	D	S269 R442
UGA		UDP-ALPHA-D-GLUCURONIC ACID	2qg4	E	S269 R442
UGA		UDP-ALPHA-D-GLUCURONIC ACID	2qg4	F	S269 R442
UGA		UDP-ALPHA-D-GLUCURONIC ACID	2qg4	G	S269 R442
UGA		UDP-ALPHA-D-GLUCURONIC ACID	2qg4	H	S269 R442
UPG		UDP-GLUCOSE	3khu	A	S269 R442
UPG		UDP-GLUCOSE	3khu	B	S269 R442
UPG		UDP-GLUCOSE	3khu	C	S269 R442
UPG		UDP-GLUCOSE	3khu	D	S269 R442
UPG		UDP-GLUCOSE	3khu	E	S269 R442
UPG		UDP-GLUCOSE	3khu	F	S269 R442
UDX		UDP XYLOSE	3prj	A	S269 R442
UDX		UDP XYLOSE	3prj	B	S269 R442
UDX		UDP XYLOSE	3prj	C	S269 R442
UDX		UDP XYLOSE	3prj	D	S269 R442
UDX		UDP XYLOSE	3prj	E	S269 R442
UDX		UDP XYLOSE	3prj	F	S269 R442
UDX		UDP XYLOSE	3ptz	A	S269 R442
UDX		UDP XYLOSE	3ptz	B	S269 R442
UDX		UDP XYLOSE	3ptz	C	S269 R442
UDX		UDP XYLOSE	3ptz	D	S269 R442
UDX		UDP XYLOSE	3ptz	E	S269 R442
UDX		UDP XYLOSE	3ptz	F	S269 R442
UPG		UDP-GLUCOSE	3tdk	A	S269 R442
UPG		UDP-GLUCOSE	3tdk	B	S269 R442
UPG		UDP-GLUCOSE	3tdk	G	S269 R442
UPG		UDP-GLUCOSE	3tdk	H	S269 R442
UPG		UDP-GLUCOSE	3tdk	L	S269 R442
UPG		UDP-GLUCOSE	3tdk	K	S269 R442
UPG		UDP-GLUCOSE	3tdk	F	S269 R442
UPG		UDP-GLUCOSE	3tdk	E	S269 R442
UPG		UDP-GLUCOSE	3tdk	D	S269 R442
UPG		UDP-GLUCOSE	3tdk	C	S269 R442
UPG		UDP-GLUCOSE	3tdk	J	S269 R442
UPG		UDP-GLUCOSE	3tdk	I	S269 R442
UPG		UDP-GLUCOSE	4edf	A	S269 R442
UPG		UDP-GLUCOSE	4edf	B	S269 R442
UPG		UDP-GLUCOSE	4edf	C	S269 R442
UPG		UDP-GLUCOSE	4edf	D	S269 R442
NAD		NAD ZWITTERION	2qg4	A	Y14 V15 I75
NAD		NAD ZWITTERION	2qg4	C	Y14 V15 I75
NAD		NAD ZWITTERION	2qg4	E	Y14 V15 I75
NAD		NAD ZWITTERION	2qg4	G	Y14 V15 I75
NAD		NAD ZWITTERION	2q3e	A	Y14 V15 I75 R346
NAD		NAD ZWITTERION	2q3e	B	Y14 V15 I75 R346
NAD		NAD ZWITTERION	2q3e	C	Y14 V15 I75 R346
NAD		NAD ZWITTERION	2q3e	D	Y14 V15 I75 R346
NAD		NAD ZWITTERION	2q3e	E	Y14 V15 I75 R346
NAD		NAD ZWITTERION	2q3e	F	Y14 V15 I75 R346
NAD		NAD ZWITTERION	2q3e	I	Y14 V15 I75 R346
NAD		NAD ZWITTERION	2q3e	J	Y14 V15 I75 R346
NAD		NAD ZWITTERION	2q3e	K	Y14 V15 I75 R346
NAD		NAD ZWITTERION	2qg4	B	Y14 V15 I75 R346
NAD		NAD ZWITTERION	2qg4	D	Y14 V15 I75 R346
NAD		NAD ZWITTERION	2qg4	F	Y14 V15 I75 R346
NAD		NAD ZWITTERION	2qg4	H	Y14 V15 I75 R346
NAD		NAD ZWITTERION	3ptz	A	Y14 V15 I75 V132 R346
NAD		NAD ZWITTERION	3ptz	E	Y14 V15 I75 V132 R346
NAD		NAD ZWITTERION	3tdk	F	Y14 V15 I75 V132 R346
NAD		NAD ZWITTERION	2q3e	G	Y14 V15 R346
NAD		NAD ZWITTERION	2q3e	H	Y14 V15 R346
NAD		NAD ZWITTERION	2q3e	L	Y14 V15 R346
UPG		UDP-GLUCOSE	3khu	A	Y14 V15 R346
UPG		UDP-GLUCOSE	3khu	B	Y14 V15 R346
UPG		UDP-GLUCOSE	3khu	C	Y14 V15 R346
UPG		UDP-GLUCOSE	3khu	D	Y14 V15 R346
UPG		UDP-GLUCOSE	3khu	E	Y14 V15 R346
UPG		UDP-GLUCOSE	3khu	F	Y14 V15 R346
NAI		NADH	3prj	F	Y14 V15 R346
NAD		NAD ZWITTERION	3tdk	I	Y14 V15 R346
NAI		NADH	3prj	A	Y14 V15 V132 R346
NAI		NADH	3prj	B	Y14 V15 V132 R346
NAI		NADH	3prj	C	Y14 V15 V132 R346
NAI		NADH	3prj	D	Y14 V15 V132 R346
NAI		NADH	3prj	E	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3ptz	B	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3ptz	C	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3ptz	D	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3ptz	F	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3tdk	A	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3tdk	B	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3tdk	G	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3tdk	H	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3tdk	L	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3tdk	K	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3tdk	E	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3tdk	D	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3tdk	C	Y14 V15 V132 R346
NAD		NAD ZWITTERION	3tdk	J	Y14 V15 V132 R346

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Conservation information for LBS of UGDH

Multiple alignments for O60701 in multiple species

LBS	AA sequence	# species	Species
A164	NPEFLAEGTAI	10	Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
A164	NPEFLAEGTAM	1	Caenorhabditis elegans
C112	KYIEACARRIV	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
C112	TYWESAARMIA	3	Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
C112	TYWESAARIIA	1	Oryza sativa subsp. japonica
C112	KYVESVSRTIA	1	Caenorhabditis elegans
C112	KYVESAARMIA	1	Drosophila melanogaster
C276	GFGGSCFQKDV	5	Homo sapiens, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus
C276	GFGGSCFQKDI	5	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster
C276	GFGGGCFQKDV	1	Rattus norvegicus
D36	EVAVVDISVPR	3	Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
D36	RVTVVDVNEAR	2	Mus musculus, Rattus norvegicus
D36	RVTVVDVNESR	1	Homo sapiens
D36	EVVVVDISAPR	1	Oryza sativa subsp. japonica
D36	TVTVVDMNTAK	1	Caenorhabditis elegans
D36	VITLVDKSSER	1	Drosophila melanogaster
D36	QVTVVDVNEAR	1	Gallus gallus
D36	RVTVVDINESR	1	Bos taurus
E161	VLSNPEFLAEG	6	Homo sapiens, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
E161	ILSNPEFLAEG	5	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster
E165	PEFLAEGTAIK	6	Homo sapiens, Arabidopsis thaliana, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
E165	PEFLAEGTAIQ	1	Oryza sativa subsp. japonica
E165	PEFLAEGTAIE	1	Arabidopsis thaliana
E165	PEFLAEGTAIA	1	Arabidopsis thaliana
E165	PEFLAEGTAMK	1	Caenorhabditis elegans
E165	PEFLAEGTAIN	1	Drosophila melanogaster
F162	LSNPEFLAEGT	11	Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
F265	RIGNKFLKASV	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
F265	RIGPKFLNSSV	2	Arabidopsis thaliana, Arabidopsis thaliana
F265	RIGSKFLQASV	2	Caenorhabditis elegans, Drosophila melanogaster
F265	RIGPRFLSASV	1	Oryza sativa subsp. japonica
F265	RIGSKFLNASV	1	Arabidopsis thaliana
F272	KASVGFGGSCF	4	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus
F272	NSSVGFGGSCF	2	Arabidopsis thaliana, Arabidopsis thaliana
F272	QASVGFGGSCF	2	Caenorhabditis elegans, Drosophila melanogaster
F272	SASVGFGGSCF	1	Oryza sativa subsp. japonica
F272	NASVGFGGSCF	1	Arabidopsis thaliana
F272	KASVGFGGGCF	1	Rattus norvegicus
F277	FGGSCFQKDVL	5	Homo sapiens, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus
F277	FGGSCFQKDIL	5	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster
F277	FGGGCFQKDVL	1	Rattus norvegicus
F338	ILGFAFKKDTG	6	Homo sapiens, Arabidopsis thaliana, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
F338	VLGFAFKKDTG	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
F338	IFGFAFKKNTG	1	Caenorhabditis elegans
F338	ILGFAFKKNTG	1	Drosophila melanogaster
G11	KICCIGAGYVG	9	Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G11	KVVCVGAGYVG	1	Caenorhabditis elegans
G11	KVCCIGAGYVG	1	Drosophila melanogaster
G13	CCIGAGYVGGP	10	Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G13	VCVGAGYVGGP	1	Caenorhabditis elegans
G273	ASVGFGGSCFQ	8	Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus
G273	SSVGFGGSCFQ	2	Arabidopsis thaliana, Arabidopsis thaliana
G273	ASVGFGGGCFQ	1	Rattus norvegicus
I10	KKICCIGAGYV	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
I10	VKICCIGAGYV	4	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
I10	SKVVCVGAGYV	1	Caenorhabditis elegans
I10	MKVCCIGAGYV	1	Drosophila melanogaster
I231	FLAQRISSINS	7	Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
I231	FLAQRISSVNA	4	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
I75	FFSTDVEKHVR	3	Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
I75	FFSTNIDDAIK	2	Homo sapiens, Bos taurus
I75	FFSTNIDDAIR	2	Mus musculus, Rattus norvegicus
I75	FFSTDVERHVA	1	Oryza sativa subsp. japonica
I75	FFSSDIPKAIA	1	Caenorhabditis elegans
I75	FFSTDIETAIK	1	Drosophila melanogaster
I75	FFSTSIDDAIR	1	Gallus gallus
K220	SSELSKLAANA	5	Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus
K220	SAELSKLAANA	4	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
K220	SSELSKLVANA	1	Caenorhabditis elegans
K220	SSELSKLTANA	1	Bos taurus
K267	GNKFLKASVGF	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
K267	GPKFLNSSVGF	2	Arabidopsis thaliana, Arabidopsis thaliana
K267	GSKFLQASVGF	2	Caenorhabditis elegans, Drosophila melanogaster
K267	GPRFLSASVGF	1	Oryza sativa subsp. japonica
K267	GSKFLNASVGF	1	Arabidopsis thaliana
K279	GSCFQKDILNL	5	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster
K279	GSCFQKDVLNL	4	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus
K279	GSCFQKDVLSL	1	Caenorhabditis elegans
K279	GGCFQKDVLNL	1	Rattus norvegicus
K339	LGFAFKKDTGD	9	Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
K339	FGFAFKKNTGD	1	Caenorhabditis elegans
K339	LGFAFKKNTGD	1	Drosophila melanogaster
L163	SNPEFLAEGTA	11	Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
L227	AANAFLAQRIS	9	Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus
L227	VANAFLAQRIS	1	Caenorhabditis elegans
L227	TANAFLAQRIS	1	Bos taurus
L266	IGNKFLKASVG	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
L266	IGPKFLNSSVG	2	Arabidopsis thaliana, Arabidopsis thaliana
L266	IGSKFLQASVG	2	Caenorhabditis elegans, Drosophila melanogaster
L266	IGPRFLSASVG	1	Oryza sativa subsp. japonica
L266	IGSKFLNASVG	1	Arabidopsis thaliana
N224	SKLAANAFLAQ	9	Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus
N224	SKLVANAFLAQ	1	Caenorhabditis elegans
N224	SKLTANAFLAQ	1	Bos taurus
N38	AVVDISVPRIN	3	Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
N38	TVVDVNEARIN	3	Gallus gallus, Mus musculus, Rattus norvegicus
N38	TVVDVNESRIN	1	Homo sapiens
N38	VVVDISAPRIE	1	Oryza sativa subsp. japonica
N38	TVVDMNTAKIA	1	Caenorhabditis elegans
N38	TLVDKSSERIA	1	Drosophila melanogaster
N38	TVVDINESRIN	1	Bos taurus
N90	VFISVNTPTKT	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
N90	VFVSVNTPTKT	4	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
N90	IFISVNTPTKM	1	Caenorhabditis elegans
N90	IFISVNTPTKT	1	Drosophila melanogaster
P92	ISVNTPTKTYG	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
P92	VSVNTPTKTRG	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
P92	VSVNTPTKTTG	1	Arabidopsis thaliana
P92	ISVNTPTKMYG	1	Caenorhabditis elegans
P92	ISVNTPTKTCG	1	Drosophila melanogaster
R346	DTGDTRESSSI	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
R346	DTGDTRETPAI	4	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
R346	NTGDTRESSAI	1	Caenorhabditis elegans
R346	NTGDTRETAAI	1	Drosophila melanogaster
R41	DISVPRINAWN	3	Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
R41	DVNEARINAWN	3	Gallus gallus, Mus musculus, Rattus norvegicus
R41	DVNESRINAWN	1	Homo sapiens
R41	DISAPRIEGWN	1	Oryza sativa subsp. japonica
R41	DMNTAKIAEWN	1	Caenorhabditis elegans
R41	DKSSERIAQWN	1	Drosophila melanogaster
R41	DINESRINAWN	1	Bos taurus
R442	FIFDGRRVLDG	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R442	FLFDGRNVVD-	1	Oryza sativa subsp. japonica
R442	FVFDGRNVVD-	1	Arabidopsis thaliana
R442	FIFDGRNIMN-	1	Arabidopsis thaliana
R442	FVFDGRNIMN-	1	Arabidopsis thaliana
R442	AIFDGRLILD-	1	Caenorhabditis elegans
R442	YIFDGRKILD-	1	Drosophila melanogaster
R442	FIFDGRRVLDD	1	Gallus gallus
S130	IVTEKSTVPVR	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
S130	IVVEKSTVPVK	5	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans
S130	IVVEKSTVPVR	1	Drosophila melanogaster
S269	KFLKASVGFGG	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
S269	KFLNSSVGFGG	2	Arabidopsis thaliana, Arabidopsis thaliana
S269	KFLQASVGFGG	2	Caenorhabditis elegans, Drosophila melanogaster
S269	RFLSASVGFGG	1	Oryza sativa subsp. japonica
S269	KFLNASVGFGG	1	Arabidopsis thaliana
S275	VGFGGSCFQKD	10	Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus
S275	VGFGGGCFQKD	1	Rattus norvegicus
S88	DLVFISVNTPT	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
S88	DIVFVSVNTPT	3	Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
S88	DLIFISVNTPT	2	Caenorhabditis elegans, Drosophila melanogaster
S88	GIVFVSVNTPT	1	Oryza sativa subsp. japonica
T131	VTEKSTVPVRA	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
T131	VVEKSTVPVKT	4	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
T131	VVEKSTVPVKA	1	Caenorhabditis elegans
T131	VVEKSTVPVRA	1	Drosophila melanogaster
T91	FISVNTPTKTY	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
T91	FVSVNTPTKTR	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
T91	FVSVNTPTKTT	1	Arabidopsis thaliana
T91	FISVNTPTKMY	1	Caenorhabditis elegans
T91	FISVNTPTKTC	1	Drosophila melanogaster
V132	TEKSTVPVRAA	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
V132	VEKSTVPVKTA	4	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
V132	VEKSTVPVKAA	1	Caenorhabditis elegans
V132	VEKSTVPVRAA	1	Drosophila melanogaster
V15	IGAGYVGGPTC	6	Homo sapiens, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
V15	IGAGYVGGPTM	4	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
V15	VGAGYVGGPTC	1	Caenorhabditis elegans
V37	VAVVDISVPRI	3	Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
V37	VTVVDVNEARI	3	Gallus gallus, Mus musculus, Rattus norvegicus
V37	VTVVDVNESRI	1	Homo sapiens
V37	VVVVDISAPRI	1	Oryza sativa subsp. japonica
V37	VTVVDMNTAKI	1	Caenorhabditis elegans
V37	ITLVDKSSERI	1	Drosophila melanogaster
V37	VTVVDINESRI	1	Bos taurus
V89	LVFISVNTPTK	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
V89	IVFVSVNTPTK	4	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
V89	LIFISVNTPTK	2	Caenorhabditis elegans, Drosophila melanogaster
Y108	AADLKYIEACA	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
Y108	AADLTYWESAA	4	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
Y108	APDLKYVESVS	1	Caenorhabditis elegans
Y108	AADLKYVESAA	1	Drosophila melanogaster
Y14	CIGAGYVGGPT	10	Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
Y14	CVGAGYVGGPT	1	Caenorhabditis elegans